HFE genotypes, haemochromatosis diagnosis and clinical outcomes at age 80 years: a prospective cohort study in the UK Biobank
Conclusions Male and female p.C282Y homozygotes experienced greater excess morbidity than previously documented, including those undiagnosed with haemochromatosis in the community. As haemochromatosis diagnosis rates were low at baseline despite treatment being considered effective, trials of screening to identify people with p.C282Y homozygosity early appear justified. (Source: BMJ Open)
Source: BMJ Open - March 13, 2024 Category: General Medicine Authors: Lucas, M. R., Atkins, J. L., Pilling, L. C., Shearman, J. D., Melzer, D. Tags: Open access, Epidemiology Source Type: research

Cascade screening in HBOC and Lynch syndrome: guidelines and procedures in a UK centre
We present time trends (1990 –2020) of identification of index cases with germline CPG variants and numbers of subsequent cascade tests, forBRCA1,BRCA2, and the Lynch genes (MLH1,MSH2,MSH6 andPMS2). ForBRCA1/2 there was a definite increase in the proportion of index cases with ovarian cancer only and pre-symptomatic index tests both doubling from 16 to 32% and 3.2 to  >  8% respectively. A mean of 1.73–1.74 additional family tests were generated for eachBRCA1/2 index case within 2 years. Overall close to one positive cascade test was generated per index case resulting in  >  1000 risk reducing surgery ope...
Source: Familial Cancer - March 13, 2024 Category: Cancer & Oncology Source Type: research

Development and validation of a random forest algorithm for source attribution of animal and human Salmonella Typhimurium and monophasic variants of S. Typhimurium isolates in England and Wales utilising whole genome sequencing data
Source attribution has traditionally involved combining epidemiological data with different pathogen characterisation methods, including 7-gene multi locus sequence typing (MLST) or serotyping, however, these approaches have limited resolution. In contrast, whole genome sequencing data provide an overview of the whole genome that can be used by attribution algorithms. Here, we applied a random forest (RF) algorithm to predict the primary sources of human clinical Salmonella Typhimurium (S. Typhimurium) and monophasic variants (monophasic S. Typhimurium) isolates. To this end, we utilised single nucleotide polymorphism dive...
Source: Frontiers in Microbiology - March 12, 2024 Category: Microbiology Source Type: research

Qualitative study of challenges with recruitment of hospitals into a cluster controlled trial of clinical decision support in Australia
Conclusion Hospital participation in controlled cluster trials of CDS is hindered by perceptions that adopting an EMR without CDS is risky for both patients and organisations. The improvements in safety expected to follow CDS implementation makes it challenging and counterintuitive for hospitals to implement EMR without incorporating CDS alerts for the purposes of a research trial. To counteract these barriers, clear communication regarding the evidence base and rationale for a controlled trial is needed. (Source: BMJ Open)
Source: BMJ Open - March 12, 2024 Category: General Medicine Authors: Baysari, M. T., Van Dort, B. A., Stanceski, K., Hargreaves, A., Zheng, W. Y., Moran, M., Day, R. O., Li, L., Westbrook, J., Hilmer, S. N. Tags: Open access, Health informatics Source Type: research

Measuring clinician experience in value-based healthcare initiatives: a 10-item core clinician experience measure (CEM-10)
ConclusionsThe CEM-10 provides a core set of common clinician experience measurement items that can be used to compare clinician's experiences of providing care between and within cohorts. The CEM-10 may be supported by additional items relevant to particular initiatives when evaluating VBHC outcomes.PMID:38467113 | DOI:10.1071/AH24003 (Source: Australian Health Review)
Source: Australian Health Review - March 11, 2024 Category: Hospital Management Authors: Reema Harrison Louise A Ellis Maryam Sina Ramya Walsan Rebecca Mitchell Ramesh Walpola Glen Maberly Catherine Chan Liz Hay Source Type: research

Measuring clinician experience in value-based healthcare initiatives: a 10-item core clinician experience measure (CEM-10)
ConclusionsThe CEM-10 provides a core set of common clinician experience measurement items that can be used to compare clinician's experiences of providing care between and within cohorts. The CEM-10 may be supported by additional items relevant to particular initiatives when evaluating VBHC outcomes.PMID:38467113 | DOI:10.1071/AH24003 (Source: Australian Health Review)
Source: Australian Health Review - March 11, 2024 Category: Hospital Management Authors: Reema Harrison Louise A Ellis Maryam Sina Ramya Walsan Rebecca Mitchell Ramesh Walpola Glen Maberly Catherine Chan Liz Hay Source Type: research

Emergence of Poultry-Associated Human Salmonella enterica Serovar Abortusovis Infections, New South Wales, Australia
M. Payne et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - March 11, 2024 Category: Infectious Diseases Source Type: research

Rivastigmine for the management of anticholinergic delirium
. (Source: Clinical Toxicology)
Source: Clinical Toxicology - March 11, 2024 Category: Toxicology Authors: Angela L. ChiewAmanda G. HolfordBetty S. H. ChanKatherine Z. Isoardia Department of Clinical Toxicology, Prince of Wales Hospital, Randwick, Australiab Faculty of Medicine, Prince of Wales Hospital Clinical School, University of NSW, Randwick, Australiac Source Type: research

Neuro-Ophthalmic Literature Review
Volume 48, Issue 2, April 2024, Page 152-158 . (Source: Neuro-Ophthalmology)
Source: Neuro-Ophthalmology - March 11, 2024 Category: Opthalmology Authors: David A. BellowsNoel C.Y. ChanJohn J. ChenHui-Chen ChengCollin McClellandMichael S. VaphiadesXiaojun Zhanga The Medical Eye Center, Manchester, New Hampshire, USAb Department of Ophthalmology & Visual Sciences, Prince of Wales Hospital & Alice Ho Miu Li Source Type: research

Enabling the examination of long-term mortality trends by educational level for England and Wales in a time-consistent and internationally comparable manner
Studying long-term trends in educational inequalities in health is important for monitoring and policy evaluation. Data issues regarding the allocation of people to educational groups hamper the study and inte... (Source: Population Health Metrics)
Source: Population Health Metrics - March 9, 2024 Category: Epidemiology Authors: Fanny Janssen, Wanda Van Hemelrijck, Eva Kagenaar and Alison Sizer Tags: Research Source Type: research

Do they stay, or do they go? Children presenting to five emergency departments across New South Wales, Australia with acute burn injuries: a retrospective review
Conclusion Most children who presented to the hospital with a burn injury were not admitted. Often the details of these burns were poorly recorded and a complete picture of the true burden of burn injury in children, especially the ongoing care given outside the acute hospital setting, is missing. This information is crucial, as it would inform future models of care as the paradigm shifts rapidly towards primary, ambulatory and outpatient models of care. (Source: BMJ Open)
Source: BMJ Open - March 8, 2024 Category: General Medicine Authors: Phillips, W., Southern, E., Cattell, C., Owens, P., Jaques, M., Melbourne, G., Kezhekkekara, S., Frost, S. A. Tags: Open access, Paediatrics Source Type: research

Tobacco sales through vending machines: Insights from owners and managers of Australian alcohol-licenced premises with different licencing schemes
CONCLUSION: The study provides the first evidence on the attitudes of owners/managers to the importance of tobacco sales, revealing that the vast majority of those owners/managers do not believe that tobacco sales are important for their venue.IMPLICATIONS FOR PUBLIC HEALTH: The presence of tobacco vending machines implicitly promotes tobacco products and therefore contravenes Australia's obligations under the World Health Organization Framework Convention on Tobacco Control. The results provide powerful evidence that restrictions on tobacco sales can be implemented without major financial damage to those vendors.PMID:3845...
Source: Australian and New Zealand Journal of Public Health - March 7, 2024 Category: International Medicine & Public Health Authors: Christina Watts Suzan Burton Natalia Lizama Lorena Chapman Francine Garlin Michelle Daley Sam Egger Source Type: research

Tobacco sales through vending machines: Insights from owners and managers of Australian alcohol-licenced premises with different licencing schemes
CONCLUSION: The study provides the first evidence on the attitudes of owners/managers to the importance of tobacco sales, revealing that the vast majority of those owners/managers do not believe that tobacco sales are important for their venue.IMPLICATIONS FOR PUBLIC HEALTH: The presence of tobacco vending machines implicitly promotes tobacco products and therefore contravenes Australia's obligations under the World Health Organization Framework Convention on Tobacco Control. The results provide powerful evidence that restrictions on tobacco sales can be implemented without major financial damage to those vendors.PMID:3845...
Source: Australian and New Zealand Journal of Public Health - March 7, 2024 Category: International Medicine & Public Health Authors: Christina Watts Suzan Burton Natalia Lizama Lorena Chapman Francine Garlin Michelle Daley Sam Egger Source Type: research

Tobacco sales through vending machines: Insights from owners and managers of Australian alcohol-licenced premises with different licencing schemes
CONCLUSION: The study provides the first evidence on the attitudes of owners/managers to the importance of tobacco sales, revealing that the vast majority of those owners/managers do not believe that tobacco sales are important for their venue.IMPLICATIONS FOR PUBLIC HEALTH: The presence of tobacco vending machines implicitly promotes tobacco products and therefore contravenes Australia's obligations under the World Health Organization Framework Convention on Tobacco Control. The results provide powerful evidence that restrictions on tobacco sales can be implemented without major financial damage to those vendors.PMID:3845...
Source: Australian and New Zealand Journal of Public Health - March 7, 2024 Category: International Medicine & Public Health Authors: Christina Watts Suzan Burton Natalia Lizama Lorena Chapman Francine Garlin Michelle Daley Sam Egger Source Type: research

Tobacco sales through vending machines: Insights from owners and managers of Australian alcohol-licenced premises with different licencing schemes
CONCLUSION: The study provides the first evidence on the attitudes of owners/managers to the importance of tobacco sales, revealing that the vast majority of those owners/managers do not believe that tobacco sales are important for their venue.IMPLICATIONS FOR PUBLIC HEALTH: The presence of tobacco vending machines implicitly promotes tobacco products and therefore contravenes Australia's obligations under the World Health Organization Framework Convention on Tobacco Control. The results provide powerful evidence that restrictions on tobacco sales can be implemented without major financial damage to those vendors.PMID:3845...
Source: Australian and New Zealand Journal of Public Health - March 7, 2024 Category: International Medicine & Public Health Authors: Christina Watts Suzan Burton Natalia Lizama Lorena Chapman Francine Garlin Michelle Daley Sam Egger Source Type: research