Outcomes of Best-Practice Guided Digital Mental Health Interventions for Youth and Young Adults with Emerging Symptoms: Part I. A Systematic Review of Socioemotional Outcomes and Recommendations
Clin Child Fam Psychol Rev. 2024 Mar 15. doi: 10.1007/s10567-024-00469-4. Online ahead of print.ABSTRACTYouth-specific digital mental health interventions (DMHI) represent an emerging field of study, and aim to increase access, improve socioemotional outcomes, and, where required, support triage to targeted interventions. However, prior reviews have reported inconsistent findings on the clinical effectiveness of such interventions in young adults (12-25 years). Further, shortfalls remain for the impact of guided interventions based on the mode of delivery and the type of human support personnel (e.g., professional or peer)...
Source: Clinical Child and Family Psychology Review - March 15, 2024 Category: Psychiatry & Psychology Authors: Jessica E Opie An Vuong Ellen T Welsh Richard Gray Natalie Pearce Sonia Marchionda Rachel Mutch Hanan Khalil Source Type: research

Applicability and impact of the COMPASS trial in a Canadian population of patients with atherosclerotic disease
In the COMPASS trial, low-dose rivaroxaban with aspirin improved cardiovascular outcomes in patients with atherosclerotic cardiovascular disease (ASCVD). We aimed to assess the potential clinical implications of this therapy in a generalizable population. (Source: Atherosclerosis)
Source: Atherosclerosis - March 15, 2024 Category: Cardiology Authors: Robert C. Welsh, Pishoy Gouda, Doug Dover, Kevin R. Bainey, Finlay A. McAlister, Padma Kaul Source Type: research

Genetic Factors Largely Shape Cold or Callous Child Behaviors at Younger Ages
Symptoms of callousness and emotional coldness in children —which can be risk factors for conduct disorder and antisocial personality disorder—are more likely influenced by genetics rather than harsh or poor parenting, according to areport inAJP in Advance.The findings suggest that one-time interventions aimed at teaching better parenting skills alone may be insufficient, wrote Patrizia Pezzoli, Ph.D., of University College London and colleagues. “Rather than discouraging parenting interventions, these findings suggest that combining parent support with child-focused strategies targeting behaviors that may elicit neg...
Source: Psychiatr News - March 14, 2024 Category: Psychiatry Source Type: research

Are your earliest childhood memories still lurking in your mind —or gone forever?
Related podcast Why babies forget, and how fear lingers in the brain BY Sarah Crespi , Sara Reardon Podcast 14 Mar 2024 You might think you remember taking a trip to Disneyland when you were 18 months old, or that time you had chickenpox when you were 2—but you almost certainly don’t. However real they may seem, your earliest treasured memories were probably implanted by seeing photos or hearing your parents’...
Source: Science of Aging Knowledge Environment - March 14, 2024 Category: Geriatrics Source Type: research

Best practice for embryology staffing in HFEA licensed assisted conception centres-guidance from Association of Reproductive & Clinical Scientists
Volume 27, Issue 1, December 2024 . (Source: Human Fertility)
Source: Human Fertility - March 14, 2024 Category: Reproduction Medicine Authors: Jason KasraieHannah Kennedya The Shropshire and Mid-Wales Fertility Centre, The Shrewsbury and Telford Hospitals NHS Trust and the University of Chester, Shropshire, UKb The University of Chester & University Centre Shrewsbury, UKc The Bristol Centre for Source Type: research

HFE genotypes, haemochromatosis diagnosis and clinical outcomes at age 80 years: a prospective cohort study in the UK Biobank
Conclusions Male and female p.C282Y homozygotes experienced greater excess morbidity than previously documented, including those undiagnosed with haemochromatosis in the community. As haemochromatosis diagnosis rates were low at baseline despite treatment being considered effective, trials of screening to identify people with p.C282Y homozygosity early appear justified. (Source: BMJ Open)
Source: BMJ Open - March 13, 2024 Category: General Medicine Authors: Lucas, M. R., Atkins, J. L., Pilling, L. C., Shearman, J. D., Melzer, D. Tags: Open access, Epidemiology Source Type: research

Cascade screening in HBOC and Lynch syndrome: guidelines and procedures in a UK centre
We present time trends (1990 –2020) of identification of index cases with germline CPG variants and numbers of subsequent cascade tests, forBRCA1,BRCA2, and the Lynch genes (MLH1,MSH2,MSH6 andPMS2). ForBRCA1/2 there was a definite increase in the proportion of index cases with ovarian cancer only and pre-symptomatic index tests both doubling from 16 to 32% and 3.2 to  >  8% respectively. A mean of 1.73–1.74 additional family tests were generated for eachBRCA1/2 index case within 2 years. Overall close to one positive cascade test was generated per index case resulting in  >  1000 risk reducing surgery ope...
Source: Familial Cancer - March 13, 2024 Category: Cancer & Oncology Source Type: research

Development and validation of a random forest algorithm for source attribution of animal and human Salmonella Typhimurium and monophasic variants of S. Typhimurium isolates in England and Wales utilising whole genome sequencing data
Source attribution has traditionally involved combining epidemiological data with different pathogen characterisation methods, including 7-gene multi locus sequence typing (MLST) or serotyping, however, these approaches have limited resolution. In contrast, whole genome sequencing data provide an overview of the whole genome that can be used by attribution algorithms. Here, we applied a random forest (RF) algorithm to predict the primary sources of human clinical Salmonella Typhimurium (S. Typhimurium) and monophasic variants (monophasic S. Typhimurium) isolates. To this end, we utilised single nucleotide polymorphism dive...
Source: Frontiers in Microbiology - March 12, 2024 Category: Microbiology Source Type: research

Qualitative study of challenges with recruitment of hospitals into a cluster controlled trial of clinical decision support in Australia
Conclusion Hospital participation in controlled cluster trials of CDS is hindered by perceptions that adopting an EMR without CDS is risky for both patients and organisations. The improvements in safety expected to follow CDS implementation makes it challenging and counterintuitive for hospitals to implement EMR without incorporating CDS alerts for the purposes of a research trial. To counteract these barriers, clear communication regarding the evidence base and rationale for a controlled trial is needed. (Source: BMJ Open)
Source: BMJ Open - March 12, 2024 Category: General Medicine Authors: Baysari, M. T., Van Dort, B. A., Stanceski, K., Hargreaves, A., Zheng, W. Y., Moran, M., Day, R. O., Li, L., Westbrook, J., Hilmer, S. N. Tags: Open access, Health informatics Source Type: research

Measuring clinician experience in value-based healthcare initiatives: a 10-item core clinician experience measure (CEM-10)
ConclusionsThe CEM-10 provides a core set of common clinician experience measurement items that can be used to compare clinician's experiences of providing care between and within cohorts. The CEM-10 may be supported by additional items relevant to particular initiatives when evaluating VBHC outcomes.PMID:38467113 | DOI:10.1071/AH24003 (Source: Australian Health Review)
Source: Australian Health Review - March 11, 2024 Category: Hospital Management Authors: Reema Harrison Louise A Ellis Maryam Sina Ramya Walsan Rebecca Mitchell Ramesh Walpola Glen Maberly Catherine Chan Liz Hay Source Type: research

Measuring clinician experience in value-based healthcare initiatives: a 10-item core clinician experience measure (CEM-10)
ConclusionsThe CEM-10 provides a core set of common clinician experience measurement items that can be used to compare clinician's experiences of providing care between and within cohorts. The CEM-10 may be supported by additional items relevant to particular initiatives when evaluating VBHC outcomes.PMID:38467113 | DOI:10.1071/AH24003 (Source: Australian Health Review)
Source: Australian Health Review - March 11, 2024 Category: Hospital Management Authors: Reema Harrison Louise A Ellis Maryam Sina Ramya Walsan Rebecca Mitchell Ramesh Walpola Glen Maberly Catherine Chan Liz Hay Source Type: research

Emergence of Poultry-Associated Human Salmonella enterica Serovar Abortusovis Infections, New South Wales, Australia
M. Payne et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - March 11, 2024 Category: Infectious Diseases Source Type: research

Rivastigmine for the management of anticholinergic delirium
. (Source: Clinical Toxicology)
Source: Clinical Toxicology - March 11, 2024 Category: Toxicology Authors: Angela L. ChiewAmanda G. HolfordBetty S. H. ChanKatherine Z. Isoardia Department of Clinical Toxicology, Prince of Wales Hospital, Randwick, Australiab Faculty of Medicine, Prince of Wales Hospital Clinical School, University of NSW, Randwick, Australiac Source Type: research

Neuro-Ophthalmic Literature Review
Volume 48, Issue 2, April 2024, Page 152-158 . (Source: Neuro-Ophthalmology)
Source: Neuro-Ophthalmology - March 11, 2024 Category: Opthalmology Authors: David A. BellowsNoel C.Y. ChanJohn J. ChenHui-Chen ChengCollin McClellandMichael S. VaphiadesXiaojun Zhanga The Medical Eye Center, Manchester, New Hampshire, USAb Department of Ophthalmology & Visual Sciences, Prince of Wales Hospital & Alice Ho Miu Li Source Type: research