Factor-VIII/von-Willebrand-factor/Rituximab
(Source: Reactions Weekly)
Source: Reactions Weekly - March 1, 2024 Category: Drugs & Pharmacology Source Type: research
The pathogenesis of cancer-associated thrombosis
Int J Hematol. 2024 Feb 29. doi: 10.1007/s12185-024-03735-x. Online ahead of print.ABSTRACTPatients with cancer have a higher risk of venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), compared to the general population. Cancer-associated thrombosis (CAT) is a thrombotic event that occurs as a complication of cancer or cancer therapy. Major factors determining VTE risk in cancer patients include not only treatment history and patient characteristics, but also cancer type and site. Cancer types can be broadly divided into three groups based on VTE risk: high risk (pancreatic, ova...
Source: International Journal of Hematology - February 29, 2024 Category: Hematology Authors: Kohei Tatsumi Source Type: research
The pathogenesis of cancer-associated thrombosis
Int J Hematol. 2024 Feb 29. doi: 10.1007/s12185-024-03735-x. Online ahead of print.ABSTRACTPatients with cancer have a higher risk of venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), compared to the general population. Cancer-associated thrombosis (CAT) is a thrombotic event that occurs as a complication of cancer or cancer therapy. Major factors determining VTE risk in cancer patients include not only treatment history and patient characteristics, but also cancer type and site. Cancer types can be broadly divided into three groups based on VTE risk: high risk (pancreatic, ova...
Source: International Journal of Hematology - February 29, 2024 Category: Hematology Authors: Kohei Tatsumi Source Type: research
EGR1 transcriptionally regulates SVEP1 to promote proliferation and migration in human coronary artery smooth muscle cells
Mol Biol Rep. 2024 Feb 26;51(1):365. doi: 10.1007/s11033-024-09322-x.ABSTRACTA low-frequency variant of sushi, von Willebrand factor type A, EGF, and pentraxin domain-containing protein 1 (SVEP1) is associated with the risk of coronary artery disease, as determined by a genome-wide association study. SVEP1 induces vascular smooth muscle cell proliferation and an inflammatory phenotype to promote atherosclerosis. In the present study, qRT‒PCR demonstrated that the mRNA expression of SVEP1 was significantly increased in atherosclerotic plaques compared to normal tissues. Bioinformatics revealed that EGR1 was a transcriptio...
Source: Mol Biol Cell - February 27, 2024 Category: Molecular Biology Authors: Qiang Tian Jia-He Chen Yi Ding Xin-Yu Wang Jia-Yun Qiu Qian Cao Li-Li Zhuang Rui Jin Guo-Ping Zhou Source Type: research
EGR1 transcriptionally regulates SVEP1 to promote proliferation and migration in human coronary artery smooth muscle cells
Mol Biol Rep. 2024 Feb 26;51(1):365. doi: 10.1007/s11033-024-09322-x.ABSTRACTA low-frequency variant of sushi, von Willebrand factor type A, EGF, and pentraxin domain-containing protein 1 (SVEP1) is associated with the risk of coronary artery disease, as determined by a genome-wide association study. SVEP1 induces vascular smooth muscle cell proliferation and an inflammatory phenotype to promote atherosclerosis. In the present study, qRT‒PCR demonstrated that the mRNA expression of SVEP1 was significantly increased in atherosclerotic plaques compared to normal tissues. Bioinformatics revealed that EGR1 was a transcriptio...
Source: Molecular Biology Reports - February 27, 2024 Category: Molecular Biology Authors: Qiang Tian Jia-He Chen Yi Ding Xin-Yu Wang Jia-Yun Qiu Qian Cao Li-Li Zhuang Rui Jin Guo-Ping Zhou Source Type: research
Injectable Tissue-Specific Hydrogel System for Pulp-Dentin Regeneration
In conclusion, the collagen-based concentric construct modified by growth factors guided the specific lineage differentiation of DPSCs and promoted pulp-dentin tissue regeneration in vivo.PMID:38410924 | DOI:10.1177/00220345241226649 (Source: Cell Research)
Source: Cell Research - February 27, 2024 Category: Cytology Authors: Y Han J Xu H Chopra Z Zhang N Dubey W L Dissanayaka J E N ör M C Bottino Source Type: research
EGR1 transcriptionally regulates SVEP1 to promote proliferation and migration in human coronary artery smooth muscle cells
Mol Biol Rep. 2024 Feb 26;51(1):365. doi: 10.1007/s11033-024-09322-x.ABSTRACTA low-frequency variant of sushi, von Willebrand factor type A, EGF, and pentraxin domain-containing protein 1 (SVEP1) is associated with the risk of coronary artery disease, as determined by a genome-wide association study. SVEP1 induces vascular smooth muscle cell proliferation and an inflammatory phenotype to promote atherosclerosis. In the present study, qRT‒PCR demonstrated that the mRNA expression of SVEP1 was significantly increased in atherosclerotic plaques compared to normal tissues. Bioinformatics revealed that EGR1 was a transcriptio...
Source: Atherosclerosis - February 27, 2024 Category: Cardiology Authors: Qiang Tian Jia-He Chen Yi Ding Xin-Yu Wang Jia-Yun Qiu Qian Cao Li-Li Zhuang Rui Jin Guo-Ping Zhou Source Type: research
Bleeding Disorder of Unknown Cause: A Diagnosis of Exclusion
Hamostaseologie. 2024 Feb 27. doi: 10.1055/a-2263-5706. Online ahead of print.ABSTRACTPatients with an unexplained mild to moderate bleeding tendency are diagnosed with bleeding disorder of unknown cause (BDUC), a classification reached after ruling out other mild to moderate bleeding disorders (MBD) including von Willebrand disease (VWD), platelet function defects (PFDs), coagulation factor deficiencies (CFDs), and non-hemostatic causes for bleeding. This review outlines our diagnostic approach to BDUC, a diagnosis of exclusion, drawing on current guidelines and insights from the Vienna Bleeding Biobank (VIBB). According ...
Source: Hamostaseologie - February 27, 2024 Category: Hematology Authors: Dino Mehic Johanna Gebhart Ingrid Pabinger Source Type: research
EGR1 transcriptionally regulates SVEP1 to promote proliferation and migration in human coronary artery smooth muscle cells
Mol Biol Rep. 2024 Feb 26;51(1):365. doi: 10.1007/s11033-024-09322-x.ABSTRACTA low-frequency variant of sushi, von Willebrand factor type A, EGF, and pentraxin domain-containing protein 1 (SVEP1) is associated with the risk of coronary artery disease, as determined by a genome-wide association study. SVEP1 induces vascular smooth muscle cell proliferation and an inflammatory phenotype to promote atherosclerosis. In the present study, qRT‒PCR demonstrated that the mRNA expression of SVEP1 was significantly increased in atherosclerotic plaques compared to normal tissues. Bioinformatics revealed that EGR1 was a transcriptio...
Source: Mol Biol Cell - February 27, 2024 Category: Molecular Biology Authors: Qiang Tian Jia-He Chen Yi Ding Xin-Yu Wang Jia-Yun Qiu Qian Cao Li-Li Zhuang Rui Jin Guo-Ping Zhou Source Type: research
EGR1 transcriptionally regulates SVEP1 to promote proliferation and migration in human coronary artery smooth muscle cells
Mol Biol Rep. 2024 Feb 26;51(1):365. doi: 10.1007/s11033-024-09322-x.ABSTRACTA low-frequency variant of sushi, von Willebrand factor type A, EGF, and pentraxin domain-containing protein 1 (SVEP1) is associated with the risk of coronary artery disease, as determined by a genome-wide association study. SVEP1 induces vascular smooth muscle cell proliferation and an inflammatory phenotype to promote atherosclerosis. In the present study, qRT‒PCR demonstrated that the mRNA expression of SVEP1 was significantly increased in atherosclerotic plaques compared to normal tissues. Bioinformatics revealed that EGR1 was a transcriptio...
Source: Molecular Biology Reports - February 27, 2024 Category: Molecular Biology Authors: Qiang Tian Jia-He Chen Yi Ding Xin-Yu Wang Jia-Yun Qiu Qian Cao Li-Li Zhuang Rui Jin Guo-Ping Zhou Source Type: research
Bleeding Disorder of Unknown Cause: A Diagnosis of Exclusion
Hamostaseologie. 2024 Feb 27. doi: 10.1055/a-2263-5706. Online ahead of print.ABSTRACTPatients with an unexplained mild to moderate bleeding tendency are diagnosed with bleeding disorder of unknown cause (BDUC), a classification reached after ruling out other mild to moderate bleeding disorders (MBD) including von Willebrand disease (VWD), platelet function defects (PFDs), coagulation factor deficiencies (CFDs), and non-hemostatic causes for bleeding. This review outlines our diagnostic approach to BDUC, a diagnosis of exclusion, drawing on current guidelines and insights from the Vienna Bleeding Biobank (VIBB). According ...
Source: Hamostaseologie - February 27, 2024 Category: Hematology Authors: Dino Mehic Johanna Gebhart Ingrid Pabinger Source Type: research
Involvement of peptidylarginine deiminase 4 in eosinophil extracellular trap formation and contribution to citrullinated histone signal in thrombi
CONCLUSIONS: As in NETosis, PAD4 can catalyze the formation of EETs. Inhibition of PAD4 decreases EET formation, supporting the future utility of PAD4 inhibitors as possible antithrombotic agents.PMID:38395360 | DOI:10.1016/j.jtha.2024.02.010 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - February 23, 2024 Category: Hematology Authors: Kimberly Martinod Frederik Denorme Severien Meyers Marilena Crescente Stijn Van Bruggen Mathias Stroobants Patrick M Siegel Ramesh Grandhi Katharina Glatz Thilo Witsch Source Type: research
A noncanonical splicing variant c.875-5 T & gt; G in von Willebrand factor causes in-frame exon skipping and type 2A von Willebrand disease
CONCLUSIONS: The VWF splicing site variant (c.875-5 T > G) causes propeptide truncation, severely compromising VWF multimer assembly and tubular storage.PMID:38387303 | DOI:10.1016/j.thromres.2024.02.002 (Source: Cell Research)
Source: Cell Research - February 22, 2024 Category: Cytology Authors: Qian Liang Ziqi Zhang Biying Ding Yanyan Shao Qiulan Ding Jing Dai Xiaobo Hu Wenman Wu Xuefeng Wang Source Type: research
VWD domain stabilization by autocatalytic Asp ‐Pro cleavage
In this study, we investigated the structural and biophysical consequences of Asp-Pro peptide cleavage in a representative FCGBP VWD domain. We found that endogenous Asp-Pro cleavage increases the resistance of the domain to exogenous proteolytic degradation. Tertiary structural interactions made by the newly generated chain termini, as revealed by a crystal structure of an FCGBP segment containing the VWD domain, may explain this observation. Notably, the Gly-Asp peptide bond, upstream of the cleavage site, assumed thecis configuration in the structure. In addition to these local features of the cleavage site, a global or...
Source: Protein Science - February 21, 2024 Category: Biochemistry Authors: Noa Yeshaya,
Prashant Kumar Gupta,
Orly Dym,
David Morgenstern,
Dan Thomas Major,
Deborah Fass Tags: RESEARCH ARTICLE Source Type: research
