Mental health in persons with von Willebrand disease in the United States - A large national database study
CONCLUSIONS: Our study shows that mental health disorders in PwvWD are a significant health burden, and that burden is increased with documented bleeding symptoms. It is important that primary care physicians and hematologists caring for this population recognize this increased risk, and appropriately screen and refer to mental health professionals.PMID:38453024 | DOI:10.1016/j.jtha.2024.02.015 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - March 7, 2024 Category: Hematology Authors: Andrew Tran Emily Waller Joana M Mack Shelley E Crary Divyaswathi Citla-Sridhar Source Type: research
Self ‐Assembled DNA Composite‐Engineered Mesenchymal Stem Cells for Improved Skin‐Wound Repair
A novel, self-assembled DNA-based composite designed to enhance mesenchymal stem cell (MSC) therapy for skin wound healing is presented. The composites demonstrate the ability to promote MSC engraftment at wound sites, enhance their proangiogenic viability, and accelerate wound closure. This stem cell-based therapeutic strategy of engineered DNA composites represents a promising platform for optimizing wound repair and tissue regeneration. AbstractThe direct use of mesenchymal stem cells (MSCs) as therapeutics for skin injuries is a promising approach, yet it still faces several obstacles, including limited adhesion, reten...
Source: Small - March 5, 2024 Category: Nanotechnology Authors: Zhuoting Li,
Yiming Wang,
Hong Wang,
Haiyan Wang,
Yingxu Shang,
Shihua Wang,
Qin Han,
Jing Li,
Robert Chunhua Zhao,
Qiao Jiang,
Baoquan Ding Tags: Research Article Source Type: research
Procedural outcomes in children with mild type 1 von Willebrand disease
CONCLUSION: Pediatric patients with mild type 1 VWD can safely undergo procedures using a tailored approach. Bleeding complications were uncommon, with the majority following IUD placement.PMID:38440264 | PMC:PMC10909640 | DOI:10.1016/j.rpth.2024.102334 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - March 5, 2024 Category: Hematology Authors: Samuel Heery Karen Zimowski Sadie F Mason Michael H White Stefanie DiGiandomenico Caroline Trotter Robert F Sidonio Megan C Brown Source Type: research
Analyzing and modeling massive transfusion strategies and the role of fibrinogen-How much is the patient actually receiving?
DISCUSSION: Differences observed between modeled transfusion strategies provide key insights into potential opportunities to provide patients with precision transfusion strategy.PMID:38433522 | DOI:10.1111/trf.17774 (Source: Transfusion)
Source: Transfusion - March 4, 2024 Category: Hematology Authors: Nadia M Keltner Melissa M Cushing Thorsten Haas Philip C Spinella Source Type: research
Associations of plasma proteomics and age-related outcomes with brain age in a diverse cohort
Geroscience. 2024 Mar 4. doi: 10.1007/s11357-024-01112-4. Online ahead of print.ABSTRACTMachine learning models are increasingly being used to estimate "brain age" from neuroimaging data. The gap between chronological age and the estimated brain age gap (BAG) is potentially a measure of accelerated and resilient brain aging. Brain age calculated in this fashion has been shown to be associated with mortality, measures of physical function, health, and disease. Here, we estimate the BAG using a voxel-based elastic net regression approach, and then, we investigate its associations with mortality, cognitive status, and measure...
Source: Atherosclerosis - March 4, 2024 Category: Cardiology Authors: Ramon Casanova Keenan A Walker Jamie N Justice Andrea Anderson Michael R Duggan Jenifer Cordon Ryan T Barnard Lingyi Lu Fang-Chi Hsu Sanaz Sedaghat Anna Prizment Stephen B Kritchevsky Lynne E Wagenknecht Timothy M Hughes Source Type: research
Analyzing and modeling massive transfusion strategies and the role of fibrinogen-How much is the patient actually receiving?
DISCUSSION: Differences observed between modeled transfusion strategies provide key insights into potential opportunities to provide patients with precision transfusion strategy.PMID:38433522 | DOI:10.1111/trf.17774 (Source: Transfusion)
Source: Transfusion - March 4, 2024 Category: Hematology Authors: Nadia M Keltner Melissa M Cushing Thorsten Haas Philip C Spinella Source Type: research
Impact of allele-selective silencing of von Willebrand factor in mice based on a single nucleotide allelic difference in von Willebrand factor
Von Willebrand factor (VWF) plays a pathophysiological role in hemostatic disorders. Partial inhibition of the VWF gene through small interfering RNA (siRNA)-mediated allele-selective silencing could be a promising therapeutic strategy. For von Willebrand disease, allele-selectively inhibiting dominant-negative VWF-alleles might ameliorate the phenotype. For thrombotic disorders, partial VWF reduction can lower thrombotic risk, while avoiding bleeding. Previously, we demonstrated the feasibility of Vwf-silencing in homozygous C57BL/6J (B6) or 129S1/SvImJ (129S) mice. (Source: Thrombosis Research)
Source: Thrombosis Research - March 4, 2024 Category: Hematology Authors: Yvonne K. Jongejan, Noa A. Linthorst, Elisa Schrader Echeverri, Sebastiaan N.J. Laan, Richard J. Dirven, James E. Dahlman, Bart J.M. van Vlijmen, C écile V. Denis, Jeroen C.J. Eikenboom Source Type: research
A career in solving clinical-pathological conundrums: Heyde syndrome, anti-platelet factor 4 disorders, and microvascular limb ischemic necrosis
Int J Lab Hematol. 2024 Mar 3. doi: 10.1111/ijlh.14261. Online ahead of print.ABSTRACTHematology is a clinical specialty with strong roots in the laboratory; accordingly, the lab can help solve perplexing clinical problems. This review highlights clinical-pathological conundrums addressed during my 35-year hematology career at McMaster University. Heyde syndrome is the association between aortic stenosis and bleeding gastrointestinal (GI) angiodysplasia where the bleeding is usually cured by aortic valve replacement; the chance reading of a neonatal study showing reversible deficiency of high-molecular-weight (HMW) multime...
Source: International Journal of Laboratory Hematology - March 3, 2024 Category: Hematology Authors: Theodore E Warkentin Source Type: research
A career in solving clinical-pathological conundrums: Heyde syndrome, anti-platelet factor 4 disorders, and microvascular limb ischemic necrosis
Int J Lab Hematol. 2024 Mar 3. doi: 10.1111/ijlh.14261. Online ahead of print.ABSTRACTHematology is a clinical specialty with strong roots in the laboratory; accordingly, the lab can help solve perplexing clinical problems. This review highlights clinical-pathological conundrums addressed during my 35-year hematology career at McMaster University. Heyde syndrome is the association between aortic stenosis and bleeding gastrointestinal (GI) angiodysplasia where the bleeding is usually cured by aortic valve replacement; the chance reading of a neonatal study showing reversible deficiency of high-molecular-weight (HMW) multime...
Source: International Journal of Laboratory Hematology - March 3, 2024 Category: Hematology Authors: Theodore E Warkentin Source Type: research
Factor-VIII/von-Willebrand-factor/Rituximab
(Source: Reactions Weekly)
Source: Reactions Weekly - March 1, 2024 Category: Drugs & Pharmacology Source Type: research
The pathogenesis of cancer-associated thrombosis
Int J Hematol. 2024 Feb 29. doi: 10.1007/s12185-024-03735-x. Online ahead of print.ABSTRACTPatients with cancer have a higher risk of venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), compared to the general population. Cancer-associated thrombosis (CAT) is a thrombotic event that occurs as a complication of cancer or cancer therapy. Major factors determining VTE risk in cancer patients include not only treatment history and patient characteristics, but also cancer type and site. Cancer types can be broadly divided into three groups based on VTE risk: high risk (pancreatic, ova...
Source: International Journal of Hematology - February 29, 2024 Category: Hematology Authors: Kohei Tatsumi Source Type: research
The pathogenesis of cancer-associated thrombosis
Int J Hematol. 2024 Feb 29. doi: 10.1007/s12185-024-03735-x. Online ahead of print.ABSTRACTPatients with cancer have a higher risk of venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), compared to the general population. Cancer-associated thrombosis (CAT) is a thrombotic event that occurs as a complication of cancer or cancer therapy. Major factors determining VTE risk in cancer patients include not only treatment history and patient characteristics, but also cancer type and site. Cancer types can be broadly divided into three groups based on VTE risk: high risk (pancreatic, ova...
Source: International Journal of Hematology - February 29, 2024 Category: Hematology Authors: Kohei Tatsumi Source Type: research
EGR1 transcriptionally regulates SVEP1 to promote proliferation and migration in human coronary artery smooth muscle cells
Mol Biol Rep. 2024 Feb 26;51(1):365. doi: 10.1007/s11033-024-09322-x.ABSTRACTA low-frequency variant of sushi, von Willebrand factor type A, EGF, and pentraxin domain-containing protein 1 (SVEP1) is associated with the risk of coronary artery disease, as determined by a genome-wide association study. SVEP1 induces vascular smooth muscle cell proliferation and an inflammatory phenotype to promote atherosclerosis. In the present study, qRT‒PCR demonstrated that the mRNA expression of SVEP1 was significantly increased in atherosclerotic plaques compared to normal tissues. Bioinformatics revealed that EGR1 was a transcriptio...
Source: Mol Biol Cell - February 27, 2024 Category: Molecular Biology Authors: Qiang Tian Jia-He Chen Yi Ding Xin-Yu Wang Jia-Yun Qiu Qian Cao Li-Li Zhuang Rui Jin Guo-Ping Zhou Source Type: research
EGR1 transcriptionally regulates SVEP1 to promote proliferation and migration in human coronary artery smooth muscle cells
Mol Biol Rep. 2024 Feb 26;51(1):365. doi: 10.1007/s11033-024-09322-x.ABSTRACTA low-frequency variant of sushi, von Willebrand factor type A, EGF, and pentraxin domain-containing protein 1 (SVEP1) is associated with the risk of coronary artery disease, as determined by a genome-wide association study. SVEP1 induces vascular smooth muscle cell proliferation and an inflammatory phenotype to promote atherosclerosis. In the present study, qRT‒PCR demonstrated that the mRNA expression of SVEP1 was significantly increased in atherosclerotic plaques compared to normal tissues. Bioinformatics revealed that EGR1 was a transcriptio...
Source: Molecular Biology Reports - February 27, 2024 Category: Molecular Biology Authors: Qiang Tian Jia-He Chen Yi Ding Xin-Yu Wang Jia-Yun Qiu Qian Cao Li-Li Zhuang Rui Jin Guo-Ping Zhou Source Type: research
