Transcriptional and functional profiling identifies inflammation and endothelial to mesenchymal transition as potential drivers for phenotypic heterogeneity within a cohort of Endothelial Colony Forming Cells
CONCLUSION: We observed a range of different RNA expression patterns between ECFC clones mostly associated with inflammation and clear differences in WPB count and structure. We developed a qPCR panel which can be used for the characterization of ECFC clones which is essential for the correct analysis of pathogenic mechanisms in vascular disorders.PMID:38574861 | DOI:10.1016/j.jtha.2024.03.018 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 4, 2024 Category: Hematology Authors: Sebastiaan N J Laan Suzan de Boer Richard J Dirven Iris van Moort Thomas B Kuipers Hailiang Mei Ruben Bierings Jeroen Eikenboom SYMPHONY consortium Source Type: research
Transcriptional and functional profiling identifies inflammation and endothelial to mesenchymal transition as potential drivers for phenotypic heterogeneity within a cohort of Endothelial Colony Forming Cells
CONCLUSION: We observed a range of different RNA expression patterns between ECFC clones mostly associated with inflammation and clear differences in WPB count and structure. We developed a qPCR panel which can be used for the characterization of ECFC clones which is essential for the correct analysis of pathogenic mechanisms in vascular disorders.PMID:38574861 | DOI:10.1016/j.jtha.2024.03.018 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - April 4, 2024 Category: Hematology Authors: Sebastiaan N J Laan Suzan de Boer Richard J Dirven Iris van Moort Thomas B Kuipers Hailiang Mei Ruben Bierings Jeroen Eikenboom SYMPHONY consortium Source Type: research
Asymmetric dimethylarginine correlates with indicators of prethrombotic state in patients with nonvalvular atrial fibrillation
ConclusionsOur findings suggested that ADMA correlated with the prethrombotic state in NVAF and that reduction of ADMA levels in NVAF patients may be a novel therapeutic strategy for thrombosis risk reduction. (Source: Pacing and Clinical Electrophysiology : PACE)
Source: Pacing and Clinical Electrophysiology : PACE - April 2, 2024 Category: Cardiology Authors: Zhaona Du,
Wenbo Jiang,
Chengyun Yu,
Ming Zhang,
Wei Xia Tags: ORIGINAL ARTICLE Source Type: research
Endothelial PTP1B Deletion Promotes VWF Exocytosis and Venous Thromboinflammation
CONCLUSIONS: Our findings show that endothelial PTP1B deletion promotes venous thromboinflammation by enhancing SNAP23 phosphorylation, endothelial VWF exocytosis, and neutrophil recruitment.PMID:38563147 | DOI:10.1161/CIRCRESAHA.124.324214 (Source: Circulation Research)
Source: Circulation Research - April 2, 2024 Category: Cardiology Authors: Konstantinos Zifkos Magdalena L Bochenek Rajinikanth Gogiraju Stephane Robert Denise Pedrosa Klytaimnistra Kiouptsi Kateryna Moiko Mathias Wagner Felix Mahfoud Philippe Poncelet Thomas M ünzel Wolfram Ruf Christoph Reinhardt Laurence Panicot-Dubois Chris Source Type: research
Endothelial PTP1B Deletion Promotes VWF Exocytosis and Venous Thromboinflammation
CONCLUSIONS: Our findings show that endothelial PTP1B deletion promotes venous thromboinflammation by enhancing SNAP23 phosphorylation, endothelial VWF exocytosis, and neutrophil recruitment.PMID:38563147 | DOI:10.1161/CIRCRESAHA.124.324214 (Source: Circulation Research)
Source: Circulation Research - April 2, 2024 Category: Cardiology Authors: Konstantinos Zifkos Magdalena L Bochenek Rajinikanth Gogiraju Stephane Robert Denise Pedrosa Klytaimnistra Kiouptsi Kateryna Moiko Mathias Wagner Felix Mahfoud Philippe Poncelet Thomas M ünzel Wolfram Ruf Christoph Reinhardt Laurence Panicot-Dubois Chris Source Type: research
Endothelial PTP1B Deletion Promotes VWF Exocytosis and Venous Thromboinflammation
CONCLUSIONS: Our findings show that endothelial PTP1B deletion promotes venous thromboinflammation by enhancing SNAP23 phosphorylation, endothelial VWF exocytosis, and neutrophil recruitment.PMID:38563147 | DOI:10.1161/CIRCRESAHA.124.324214 (Source: Circulation Research)
Source: Circulation Research - April 2, 2024 Category: Cardiology Authors: Konstantinos Zifkos Magdalena L Bochenek Rajinikanth Gogiraju Stephane Robert Denise Pedrosa Klytaimnistra Kiouptsi Kateryna Moiko Mathias Wagner Felix Mahfoud Philippe Poncelet Thomas M ünzel Wolfram Ruf Christoph Reinhardt Laurence Panicot-Dubois Chris Source Type: research
Endothelial PTP1B Deletion Promotes VWF Exocytosis and Venous Thromboinflammation
CONCLUSIONS: Our findings show that endothelial PTP1B deletion promotes venous thromboinflammation by enhancing SNAP23 phosphorylation, endothelial VWF exocytosis, and neutrophil recruitment.PMID:38563147 | DOI:10.1161/CIRCRESAHA.124.324214 (Source: Circulation Research)
Source: Circulation Research - April 2, 2024 Category: Cardiology Authors: Konstantinos Zifkos Magdalena L Bochenek Rajinikanth Gogiraju Stephane Robert Denise Pedrosa Klytaimnistra Kiouptsi Kateryna Moiko Mathias Wagner Felix Mahfoud Philippe Poncelet Thomas M ünzel Wolfram Ruf Christoph Reinhardt Laurence Panicot-Dubois Chris Source Type: research
Endothelial PTP1B Deletion Promotes VWF Exocytosis and Venous Thromboinflammation
CONCLUSIONS: Our findings show that endothelial PTP1B deletion promotes venous thromboinflammation by enhancing SNAP23 phosphorylation, endothelial VWF exocytosis, and neutrophil recruitment.PMID:38563147 | DOI:10.1161/CIRCRESAHA.124.324214 (Source: Circulation Research)
Source: Circulation Research - April 2, 2024 Category: Cardiology Authors: Konstantinos Zifkos Magdalena L Bochenek Rajinikanth Gogiraju Stephane Robert Denise Pedrosa Klytaimnistra Kiouptsi Kateryna Moiko Mathias Wagner Felix Mahfoud Philippe Poncelet Thomas M ünzel Wolfram Ruf Christoph Reinhardt Laurence Panicot-Dubois Chris Source Type: research
Endothelial PTP1B Deletion Promotes VWF Exocytosis and Venous Thromboinflammation
CONCLUSIONS: Our findings show that endothelial PTP1B deletion promotes venous thromboinflammation by enhancing SNAP23 phosphorylation, endothelial VWF exocytosis, and neutrophil recruitment.PMID:38563147 | DOI:10.1161/CIRCRESAHA.124.324214 (Source: Circulation Research)
Source: Circulation Research - April 2, 2024 Category: Cardiology Authors: Konstantinos Zifkos Magdalena L Bochenek Rajinikanth Gogiraju Stephane Robert Denise Pedrosa Klytaimnistra Kiouptsi Kateryna Moiko Mathias Wagner Felix Mahfoud Philippe Poncelet Thomas M ünzel Wolfram Ruf Christoph Reinhardt Laurence Panicot-Dubois Chris Source Type: research
Role of Acquired Von Willebrand Syndrome in the Development of Bleeding Complications in Patients Treated Using Right Ventricular Microaxial Flow Pump Devices: A Retrospective Cohort Study
Purpose: Axial flow pumps are standard treatment in cases of cardiogenic shock and high-risk interventions in cardiology and cardiac surgery, although the optimal anticoagulation strategy remains unclear. We evaluated whether laboratory findings could predict bleeding complications and acquired von Willebrand syndrome (avWS) among patients who were treated using axial flow pumps. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , S. Reda, H. R ühl, T. Nils, S. Kreyer, G.D. Duerr, E. Charitos, M. Medina, S. Zimmer, C. Putensen, H. Treede Source Type: research
Impact of a Novel Accessory for Left Ventricular Assist Devices on Hemolysis and Degradation of Von Willebrand Factor In Vitro
Purpose: We develop an accessory for left ventricular assist devices (LVADs) redirecting the blood from the pump through the LV and across the aortic valve. The effects of the accessory on hemolysis and thrombogenicity are unknown. We quantified the hemolytic effect and von Willebrand factor (vWF) degradation in vitro. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: F. Meissner, D. Eichelkraut, M. Schimmel, M. Buechsel, , H. Vestner, M. Costa Galbas, M. Czerny, W. Bothe Source Type: research
Assessment of Primary Hemostasis During Lung Transplantation Procedure with Use of Intraoperational Extracorporeal Membrane Oxygenation (ECMO) Support
Purpose: The aim of this study was to assess primary hemostasis during short-term ECMO support, in patients undergoing lung trasnplantation, using PFA and laboratory tests for diagnosis of von Willebrand factor deficiency. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , A. Francesconi, M. Durila Source Type: research
