High-Dose IV Vitamin C Does Not Speed Resolution of Septic Shock
FRIDAY, Jan. 24, 2020 -- Treatment with intravenous vitamin C, hydrocortisone, and thiamine does not improve the duration of time alive and vasopressor administration-free compared with intravenous hydrocortisone alone among patients with septic... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 24, 2020 Category: Pharmaceuticals Source Type: news
Vitamin Cocktail for Sepsis Fails; PPI for Stress Ulcer Prevention May Be Risky: ICU Studies Vitamin Cocktail for Sepsis Fails; PPI for Stress Ulcer Prevention May Be Risky: ICU Studies
A major new study of intensive care unit (ICU) patients with septic shock failed to find a benefit of giving an intravenous cocktail of vitamin C, hydrocortisone and thiamine, relative to hydrocortisone alone.Reuters Health Information (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - January 22, 2020 Category: Intensive Care Tags: Critical Care News Source Type: news
Vitamin C-B1-steroid combo linked to lower septic shock mortality in kids
(Ann& Robert H. Lurie Children's Hospital of Chicago) Treating septic shock in children with a combination of intravenous vitamin C, vitamin B1 and hydrocortisone (a commonly used steroid) is associated with lower mortality, according to a study from Ann& Robert H. Lurie Children's Hospital of Chicago. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 21, 2020 Category: International Medicine & Public Health Source Type: news
VITAMINS trial report on vitamin C, hydrocortisone, thiamine for septic shock
(JAMA Network) In this randomized clinical trial of about 200 patients with septic shock, combination treatment with intravenous vitamin C, hydrocortisone and thiamine compared with intravenous hydrocortisone alone didn't significantly improve the amount of time patients were alive and free of medicines that raise blood pressure (vasopressors) over seven days. The study findings are being released to coincide with presentation at the Critical Care Reviews Meeting 2020 in Belfast, Northern Ireland. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 17, 2020 Category: International Medicine & Public Health Source Type: news
Aging with alcohol-related brain damage: critical brain circuits associated with cognitive dysfunction - Nunes PT, Kipp BT, Reitz NL, Savage LM.
Alcoholism is associated with brain damage and impaired cognitive functioning. The relative contributions of different etiological factors, such as alcohol, thiamine deficiency and age vulnerability, to the development of alcohol-related neuropathology and... (Source: SafetyLit)
Source: SafetyLit - November 23, 2019 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Vitamin C and Thiamine for Sepsis and Septic Shock
Sepsis and septic shock are medical emergencies resulting in significant morbidity and mortality. Intravenous (IV) vitamin C, thiamine, and hydrocortisone have shown promise in reducing hospital mortality. The Memphis Veterans Affairs Medical Center (VAMC) similarly implemented this regimen, called the vitamin C protocol, for patients presenting in sepsis or septic shock in the intensive care unit (ICU). Although no significant mortality benefit was observed, the vitamin C protocol was not associated with patient harm. In this Veteran population, there was reduced ICU length of stay, suggesting possible benefit. Th...
Source: Current Awareness Service for Health (CASH) - September 19, 2019 Category: Consumer Health News Source Type: news
Usability of intravenous thiamine injection test compared with odor stick identification test for Japanese patients with severe traumatic brain injury - Yamaki T, Oka N, Odaki M, Kobayashi S.
OBJECTIVE: Olfactory dysfunction is often observed after severe traumatic brain injury (sTBI). Its diagnosis is difficult because patients with sTBI have a communication disability following impaired consciousness and communication disorder. The intravenou... (Source: SafetyLit)
Source: SafetyLit - July 23, 2019 Category: International Medicine & Public Health Tags: TBI Source Type: news
Vitamin C, Hydrocortisone, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Analysis of Real-World Application
A recent study suggested mortality benefits using vitamin C, hydrocortisone, and thiamine combination therapy (triple therapy) in addition to standard care in patients with severe sepsis and septic shock. In order to further evaluate the effects of triple therapy in real-world clinical practice, we conducted a retrospective observational cohort study at an academic tertiary care hospital. When compared to standard care, triple therapy did not improve hospital or ICU mortality in patients with septic shock. A randomized controlled trial evaluating the effects of triple therapy is necessary prior to implementing vita...
Source: Current Awareness Service for Health (CASH) - May 29, 2019 Category: Consumer Health News Source Type: news
Medical News Today: Everything you need to know about beriberi
Beriberi is a potentially life-threatening condition that occurs when a person has a severe thiamine deficiency. Learn more about the risk factors and symptoms here. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 24, 2019 Category: Consumer Health News Tags: Nutrition / Diet Source Type: news
Emergency care physician says vitamin C can cure patients from sepsis
Dr Paul Marik, a critical-care physician based in Virginia, says he believes he may have found a cure for the life-threatening infection sepsis: an IV of vitamin C, steroids and thiamine. (Source: the Mail online | Health)
Source: the Mail online | Health - January 8, 2019 Category: Consumer Health News Source Type: news
Hydrocortisone, Ascorbic Acid and Thiamine (HAT Therapy) for the Treatment of Sepsis. Focus on Ascorbic Acid
The authors of this journal article state that sepsis is a devastating disease that carries an enormous toll in terms of human suffering and lives lost. They say that over 100 novel pharmacologic agents that targeted specific molecules or pathways have failed to improve the outcome of sepsis. Preliminary data suggests that the combination of Hydrocortisone, Ascorbic Acid and Thiamine (HAT therapy) may reduce organ failure and mortality in patients with sepsis and septic shock. HAT therapy is based on the concept that a combination of readily available, safe and cheap agents, which target multiple components of the host ' s...
Source: Current Awareness Service for Health (CASH) - December 28, 2018 Category: Consumer Health News Source Type: news
Emerging Adjunctive Approach for the Treatment of Sepsis: Vitamin C and Thiamine.
The authors of this journal article say that evidence is emerging that parenteral administration of high-dose vitamin C and thiamine may be a beneficial adjuvant therapy of severe sepsis and septic shock. Despite modern practices in critical care medicine, sepsis and severe sepsis remain a leading cause of morbidity and mortality in the critical care unit. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - December 28, 2018 Category: Consumer Health News Source Type: news
The J.M. Smucker Company Issues Voluntary Recall of Specific Lots of 9Lives ® Protein Plus® Wet, Canned Cat Food Due to Low Levels of Thiamine (Vitamin B1)
The J.M. Smucker Company today announced a voluntary recall of specific lots of 9Lives ® Protein Plus® wet, canned cat food due to possible low levels of thiamine (Vitamin B1). No illnesses related to this issue have been reported to date and the product is being recalled out of an abundance of caution. (Source: Food and Drug Administration)
Source: Food and Drug Administration - December 10, 2018 Category: Food Science Source Type: news
The J.M. Smucker Company Issues Voluntary Recall of Specific Lots of 9Lives ® Protein Plus ® Wet, Canned Cat Food Due to Low Levels of Thiamine (Vitamin B1)
The J.M. Smucker Company today announced a voluntary recall of specific lots of 9Lives ® Protein Plus ® wet, canned cat food due to possible low levels of thiamine (Vitamin B1). No illnesses related to this issue have been reported to date and the product is being recalled out of an abundance of caution. (Source: Food and Drug Administration)
Source: Food and Drug Administration - December 10, 2018 Category: Food Science Source Type: news
Ascorbic acid, corticosteroids, and thiamine in sepsis: a review of the biologic rationale and the present state of clinical evaluation
This review states that the combination of thiamine, ascorbic acid, and hydrocortisone has recently emerged as a potential adjunctive therapy to antibiotics, infectious source control, and supportive care for patients with sepsis and septic shock. In the present manuscript, the authors provide a comprehensive review of the pathophysiologic basis and supporting research for each element of the thiamine, ascorbic acid, and hydrocortisone drug combination in sepsis. In addition, they describe potential areas of synergy between these therapies and discuss the strengths/weaknesses of the two studies to date which have ev...
Source: Current Awareness Service for Health (CASH) - November 16, 2018 Category: Consumer Health News Source Type: news
