Fight Aging! Newsletter, January 2nd 2023
In conclusion, circulating monocytes in older adults exhibit increased expression of activation, adhesion, and migration markers, but decreased expression of co-inhibitory molecules.
MERTK Inhibition Increases Bone Density via Increased Osteoblast Activity
https://www.fightaging.org/archives/2022/12/mertk-inhibition-increases-bone-density-via-increased-osteoblast-activity/
Bone density results from the balance of constant activity on the part of osteoblasts and osteoclasts, the former building bone, the latter breaking it down. With advancing age, the balance of activity shifts to favor osteoclasts, pro...
Source: Fight Aging! - January 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Look Back at 2022: Progress Towards the Treatment of Aging as a Medical Condition
At the end of 2022, we can reflect on the fact that we are steadily entering a new era of medicine, one in which mechanisms of aging are targeted rather than ignored. It is a profound change, one that will change the shape of a human life and ultimately the human condition by eliminating the greatest sources of suffering and death in the world. Year after year, we see increased funding, ongoing progress towards therapies capable of slowing aging or reversing aspects of aging, and a growing taxonomy of such potential therapies and their target mechanisms.
The view of aging in the medical community and public at large...
Source: Fight Aging! - December 30, 2022 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
Dynamic Duo Degrees: NIGMS-Funded Programs Support M.D./D.V.M.-Ph.D. Training
Amelia Wilhelm. Credit: Courtesy of Amelia Wilhelm.
“Being able to ground your research in questions coming directly from your patients and their families is so meaningful and a huge part of why I’m interested in becoming a clinician-scientist,” says Amelia Wilhelm, an M.D.-Ph.D. student in the NIGMS-supported Medical Scientist Training Program (MSTP) at the University of Washington in Seattle. MSTPs prepare students to combine clinical practice and rigorous scientific research in their future careers.
Continuing the Family Tradition in Science
As a child of two scientists, Amelia was exposed to research and ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - November 30, 2022 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Profiles Training Source Type: blogs
Celebrating Peer Review Week at BMC: How Peer Review can help uphold research integrity
Maintaining research integrity requires a whole community: from the beginning of the scientific process to the publication of the results, multiple actors – funders, researchers, institutions, publishers – are involved. In reality, no single group is solely responsible for upholding research to high standards and a variety of stakeholders need to remain vigilant. However, it is the last stage of the scientific process, the communication of scientific research, where robust peer review acts as one of the last gatekeepers for research integrity. Here we discuss how as open access BMC journals (part of Springer Na...
Source: BioMed Central Blog - September 20, 2022 Category: General Medicine Authors: Nicola Stead Tags: Biology Health Medical Evidence Medicine Open Access Publishing innovation open peer review peer review week publication misconduct Registered Reports results-free peer review Transparent peer review Source Type: blogs
Fight Aging! Newsletter, September 5th 2022
Conclusion
Coupled with the animal data, and the existing human trial data for safety, the results here suggests that someone should run a formal, controlled trial of flagellin immunization in older people, 65 and over. The goal would be to see whether (a) this sort of outcome holds up in a larger group of people, and (b) there is a meaningful impact on chronic inflammation and other parameters of health that are known to be affected by the aging of the gut microbiome.
The most interesting part of the data is perhaps the decline in microbial diversity, when considered against the gains elsewhere. Microbial dive...
Source: Fight Aging! - September 4, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Elongated Isoform of Aquaporin-4 Can Enhance Clearance of Amyloid- β from the Brain
Researchers here report on an interesting discovery relating to the way in which aquaporin-4 functions in clearance of molecular waste from the brain. An uncommon isoform of aquaporin-4 has a role in clearing excess amyloid-β, and possibly many other forms of molecular waste. Given that a failure of clearance of molecular waste from the brain is apparently involved in many neurodegenerative conditions, approaches that enhance clearance are promising. Increased amounts of this more effective isoform can be achieved via a variety of strategies in mice, and in mice engineered to generate excess amyloid-β, this results in a ...
Source: Fight Aging! - September 2, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The League of VetaHumanz: Encouraging Kids to Use Their Powers for Good!
Pink Phoenix, alter ego of Dr. Sandra San Miguel, preparing to pass out Vaccine SuperPower Packs described later in this post. Credit: Courtesy of Dr. Sandra San Miguel.
“I’m Pink Phoenix, leader of the Vetahumanz League of superheroes, and it’s the best job in the world.” The League of VetaHumanz is a superhero league for veterinarians, founded and led by Pink Phoenix, the alter ego of Sandra San Miguel, D.V.M., Ph.D. Through support from the NIGMS Science Education Partnership Award (SEPA) program, the league seeks to diversify the veterinary profession.
Members of the league work with elementary students ac...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - June 8, 2022 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist STEM Education COVID-19 Profiles Training Source Type: blogs
Fight Aging! Newsletter, March 28th 2022
In conclusion, we summarized here evidence for a novel therapeutic approach to exploit the incredible ability of mitochondria to engage multifaceted neuroprotective stress response triggered by partial complex I inhibition. This approach promises relief for multiple human conditions, and to promote healthy aging to delay the onset of neurogenerative diseases, AD in particular, where age is the greatest risk factor. There is a mounting body of evidence generated in model organisms and humans in support of the safety of chronic application of complex I inhibitors. However, a better understanding of the molecular mechanisms i...
Source: Fight Aging! - March 27, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An Approach to Growing the Cryonics Industry: Build a Hospital First, then Add Cryonics Services
My attention was recently drawn to Cryopets, a newly formed cryonics provider that has a novel approach to nudging the cryonics industry closer to the mainstream. As regular readers know, cryonics is the low-temperature storage of patients immediately following death, aimed at preservation of the fine structure of brain tissue that stores the data of the mind. Given a high quality preservation, and then indefinite maintenance at low temperature, at some point the societies of the high-tech future will have the capability to revive those patients. There is nothing magical about it; it "just" requires mature molecular nanote...
Source: Fight Aging! - March 25, 2022 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
Fight Aging! Newsletter, January 24th 2022
In conclusion, senolytic drugs have shown promising results in the elimination of senescent cells and in alleviating various diseases in animal models. However, in patients, there is a paucity in data on the efficacy and safety of senotherapeutics from clinical trials, including systemic effects and side-effects. In this regard it is important to assess the specificity of senolytics in killing targeted senescent cells and their cytotoxic effects, to identify reliable markers for intervention responses, to elucidate interactions with comorbidities and other drugs, and to standardise administration protocols.
FOXO3...
Source: Fight Aging! - January 23, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
More Funding for the Dog Aging Project
There is a growing enthusiasm for aging research and the development of interventions aimed at slowing or reversing aging. This has reached the point at which people with significant resources are becoming involved, and thus the more prominent projects in the research and development communities are gaining support that would have been hard to find just a few short years ago. This new funding for the Dog Aging Project is a good example of the growing level of support for work on aging, undertaken by people who have bought into the vision of a future in which medical technology allows for much longer, healthier lives for al...
Source: Fight Aging! - January 18, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Digital Health For Pets – The Future Of Veterinary Care
The past year has brought an unprecedented surge in pet adoption in major cities and even in rural areas all around the world. As many people think of their pets as their children, it’s no surprise these animals also get their momentum in digital health. But what it means exactly and what our buzzwords like telemedicine, wearable devices and even smart health tools mean in the pet-setting – we dive deep to find out.
It’s not only that the number of pets adopted grew significantly over the past 18 months – it’s also how pets, in general, received that much-needed boost regarding their immediate health issues. T...
Source: The Medical Futurist - October 14, 2021 Category: Information Technology Authors: Judit Kuszkó Tags: Forecast Lifestyle medicine Health Sensors & Trackers Portable Medical Diagnostics Telemedicine & Smartphones veterinary care vets pets dogs cat horse Source Type: blogs
Is There A Place For Facebook In Healthcare?
Data privacy scandals, help in rigging elections, spreading fake news on COVID and vaccines: Facebook has been through a lot and users are not happy with the social media giant’s performance. However, Mark Zuckerberg’s company does not only have a political and social impact, but it’s also getting quite relevant in healthcare.
We looked around what Facebook currently does in healthcare and evaluated whether those are viable ways to follow in the future.
Facebook: from trust issues to healthcare
The social media machine built on “sophisticated, computer-driven engines for extracting users’ person...
Source: The Medical Futurist - September 7, 2021 Category: Information Technology Authors: berci.mesko Tags: Bioethics Security & Privacy AI facebook future Health Healthcare Innovation social media technology VR fake news smart healthcare Mark Zuckerberg Source Type: blogs
Fight Aging! Newsletter, August 9th 2021
In conclusion, the present study supports that some age-related diseases as well as education are causally related to longevity and highlights several new targets for achieving longevity, including management of venous thromboembolism, appropriate intake of sugar, and control of body fat. Our results warrant further studies to elucidate the underlying mechanisms of these reported causal associations.
Pol III Inhibition Extends Longevity in Short-Lived Species
https://www.fightaging.org/archives/2021/08/pol-iii-inhibition-extends-longevity-in-short-lived-species/
As this paper notes, Pol III is downstrea...
Source: Fight Aging! - August 8, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An Interview with George Church on Gene Therapy and the Treatment of Aging as Medical Condition
George Church is a noted geneticist, involved in a number of gene therapy projects that relate to aging in some way - though largely through manipulation of metabolism to slow aging rather than by directly attacking the root causes of aging. Gene therapy tends to lend itself to adjustment of cellular metabolism first and foremost, raising or lowering expression of regulatory proteins, but there are certainly ways in which it can be used to produce repair of damage rather than changes in cell behavior to override reactions to that damage. Church is clearly one of those who thinks that the viable path for aging is to produce...
Source: Fight Aging! - August 5, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
