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Preventive noninvasive vagal nerve stimulation reduces insufficient sleep-induced depression by improving the autonomic nervous system
CONCLUSIONS: Using VNS as a preventive treatment for depression-risk individuals with insufficient sleep shows promise. It not only broadens the potential applications of VNS but also sheds light on its mechanism-particularly its role in enhancing vagal nerve function and balancing the ANS, as evidenced by HRV measurements.PMID:38412716 | DOI:10.1016/j.biopha.2024.116344 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 27, 2024 Category: Drugs & Pharmacology Authors: Sai-Nan Ma Xiao-Hong Liu Wei-Song Cai Source Type: research

Vagus nerve stimulation and heart rate variability: A scoping review of a somatic oscillatory signal
Clin Neurophysiol. 2024 Feb 16;160:95-107. doi: 10.1016/j.clinph.2024.02.011. Online ahead of print.ABSTRACTThe goal of this review is to synthesize the literature on vagus nerve stimulator (VNS)-related changes in heart rate variability (HRV) in patients with drug-resistant epilepsy (DRE) and assess the role of these changes in seizure relief. A scoping literature review was performed with the following inclusion criteria: primary articles written in English, involved implantable VNS in humans, and had HRV as a primary outcome. Twenty-nine studies were retrieved, however with considerable heterogeneity in study methods. T...
Source: Clinical Neurophysiology - February 27, 2024 Category: Neurology Authors: Caitlin R Wessel Cemal Karakas Zulfi Haneef Ian Mutchnick Source Type: research

Tonic and phasic transcutaneous auricular vagus nerve stimulation both evoke rapid and transient pupil dilation
Transcutaneous auricular vagus nerve stimulation (tVNS or taVNS) is a non-invasive method of electrical stimulation of the afferent pathway of the vagus nerve, suggested to drive changes in putative physiological markers of noradrenergic activity, including pupil dilation. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 27, 2024 Category: Neurology Authors: Lina Skora, Anna Marzecov á, Gerhard Jocham Source Type: research

Neuron-Microglia Interaction is Involved in Anti-inflammatory Response by Vagus Nerve Stimulation in the Prefrontal Cortex of Rats Injected with Polyinosinic:Polycytidylic Acid
This study suggests that VNS may play a role in regulating neuroinflammation and somatosensory and cognitive functions in poly(I:C)-injected animals. (Source: Molecular Neurobiology)
Source: Molecular Neurobiology - February 22, 2024 Category: Neurology Source Type: research

Evaluating the efficacy and acceptability of vagus nerve stimulation for fibromyalgia: a PRISMA-compliant protocol for a systematic review and meta-analysis
ConclusionThe findings of our study are anticipated to ascertain the efficacy and acceptability of VNS as a promising treatment option for fibromyalgia. This will not only fill current research gap but also identify potential areas for future research. The findings will provide essential guidance for evidence-based treatment decisions for fibromyalgia, benefiting both patients and clinicians. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 21, 2024 Category: Neurology Source Type: research

Right-sided vagus nerve stimulation for drug-resistant epilepsy: a systematic review of the literature and perspectives
Epilepsy is a common chronic neurological disorder that affects more than 50 million people worldwide [1]. Antiseizure medications are effective in approximately two-thirds of cases, leaving a third of patients with uncontrolled epileptic seizures [2]. If patients do not qualify for resective epilepsy surgery, neuromodulation strategies, such as vagus nerve stimulation (VNS) or deep-brain stimulation (DBS), are effective options to be considered [3]. The use of VNS was approved for epilepsy by European Union in 1994, followed by the United States of America in 1997, Canada in 1998, China in 2008, and Japan in 2010 [4]. (So...
Source: Seizure: European Journal of Epilepsy - February 19, 2024 Category: Neurology Authors: Meissa HAMZA, Romain CARRON, Maxine DIBU É, Alessandro MOIRAGHI, Sami BARRIT, Cristina FILIPESCU, Elisabeth LANDRÉ, Martine GAVARET, Philippe DOMENECH, Johan PALLUD, Marc ZANELLO Tags: Review Source Type: research

Ameliorating effects of transcutaneous auricular vagus nerve stimulation on a mouse model of constipation-predominant irritable bowel syndrome
Neurobiol Dis. 2024 Feb 16:106440. doi: 10.1016/j.nbd.2024.106440. Online ahead of print.ABSTRACTLimited treatment options have been shown to alter the natural course of constipation-predominant irritable bowel syndrome (IBS-C). Therefore, safer and more effective approaches are urgently needed. We investigated the effects of transcutaneous auricular vagus nerve stimulation (taVNS) in a mouse model of IBS-C. In the current study, C57BL/6 mice were randomly divided into normal control, IBS-C model control, sham-electrostimulation (sham-ES), taVNS, and drug treatment groups. The effects of taVNS on fecal pellet number, fecal...
Source: Neurobiology of Disease - February 18, 2024 Category: Neurology Authors: Jie Liu Qian Dai Tong Qu Jun Ma Chaolan Lv Haitao Wang Yue Yu Source Type: research

Ameliorating effects of transcutaneous auricular vagus nerve stimulation on a mouse model of constipation-predominant irritable bowel syndrome
Neurobiol Dis. 2024 Feb 16;193:106440. doi: 10.1016/j.nbd.2024.106440. Online ahead of print.ABSTRACTLimited treatment options have been shown to alter the natural course of constipation-predominant irritable bowel syndrome (IBS-C). Therefore, safer and more effective approaches are urgently needed. We investigated the effects of transcutaneous auricular vagus nerve stimulation (taVNS) in a mouse model of IBS-C. In the current study, C57BL/6 mice were randomly divided into normal control, IBS-C model control, sham-electrostimulation (sham-ES), taVNS, and drug treatment groups. The effects of taVNS on fecal pellet number, f...
Source: Neurobiology of Disease - February 18, 2024 Category: Neurology Authors: Jie Liu Qian Dai Tong Qu Jun Ma Chaolan Lv Haitao Wang Yue Yu Source Type: research

Erratum to: Efficacy and safety of vagus nerve stimulation on upper extremity motor function in patients with stroke: A meta-analysis of randomized controlled trials
NeuroRehabilitation. 2024 Feb 16. doi: 10.3233/NRE-236008. Online ahead of print.NO ABSTRACTPMID:38363630 | DOI:10.3233/NRE-236008 (Source: NeuroRehabilitation)
Source: NeuroRehabilitation - February 16, 2024 Category: Rehabilitation Authors: Tianqi Wei Xiangyang Ge Lingfeng Lu Jing Li Panpan Xu Qinfeng Wu Source Type: research

Clinical application of transcutaneous auricular vagus nerve stimulation: a scoping review
CONCLUSION: There is growing evidence for taVNS therapeutic effect. taVNS appears safe and tolerable. Sham protocols need evaluation. Standardised and comprehensive reporting of both stimulation parameters and adverse events is required. Two different questionnaires have been proposed to evaluate adverse events and the effectiveness of sham methods in blinding participants.PMID:38362860 | DOI:10.1080/09638288.2024.2313123 (Source: Disability and Rehabilitation)
Source: Disability and Rehabilitation - February 16, 2024 Category: Rehabilitation Authors: Ashraf N H Gerges Ellen Williams Susan Hillier Jeric Uy Taya Hamilton Saran Chamberlain Brenton Hordacre Source Type: research