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The protective effect of vagus nerve stimulation against myocardial ischemia/reperfusion injury: pooled review from preclinical studies
Conclusion: VNS offers a protective role against myocardial I/R injury and emerges as a promising therapeutic strategy for future clinical application. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 14, 2023 Category: Drugs & Pharmacology Source Type: research

Revision and removal of vagus nerve stimulation systems: twenty-five years ’ experience
ConclusionsVNS therapy is safe and well-tolerated. VNS revision and removal surgeries occur in less than 5% of cases. More importantly, attention to detail and good surgical technique at the time of the index surgery can increase patient satisfaction, minimize the need for further surgeries, and improve acceptance of the VNS technology. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - November 14, 2023 Category: Neurosurgery Source Type: research

Magnetic vagus nerve stimulation alleviates myocardial ischemia-reperfusion injury by the inhibition of pyroptosis through the M2AChR/OGDHL/ROS axis in rats
Myocardial ischemia-reperfusion (I/R) injury is accompanied by an imbalance in the cardiac autonomic nervous system, characterized by over-activated sympathetic tone and reduced vagal nerve activity. In our pr... (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - November 14, 2023 Category: Nanotechnology Authors: Yao Lu, Kaiyan Chen, Wei Zhao, Yan Hua, Siyuan Bao, Jian Zhang, Tianyu Wu, Gaoyuan Ge, Yue Yu, Jianfei Sun and Fengxiang Zhang Tags: Research Source Type: research

Use of non-invasive transcutaneous auricular vagus nerve stimulation: neurodevelopmental and sensory follow-up
ConclusionThis is the first report of neurodevelopmental follow-up in infants who received taVNS-paired feeding. They had similar developmental outcomes as historical control infants failing oral feeds who received G-tubes. Our data suggests that infants who attained full oral feeds had better sensory processing. (Source: Frontiers in Human Neuroscience)
Source: Frontiers in Human Neuroscience - November 9, 2023 Category: Neuroscience Source Type: research

Device therapy for patients with atrial fibrillation and heart failure with preserved ejection fraction
AbstractDevice therapy is a nonpharmacological approach that presents a crucial advancement for managing patients with atrial fibrillation (AF) and heart failure with preserved ejection fraction (HFpEF). This review investigated the impact of device-based interventions and emphasized their potential for optimizing treatment for this complex patient demographic. Cardiac resynchronization therapy, augmented by atrioventricular node ablation with His-bundle pacing or left bundle-branch pacing, is effective for enhancing cardiac function and establishing atrioventricular synchrony. Cardiac contractility modulation and vagus ne...
Source: Heart Failure Reviews - November 8, 2023 Category: Cardiology Source Type: research

Alternative metrics for characterizing longer-term clinical outcomes in difficult-to-treat depression: II. Sensitivity to treatment effects
CONCLUSION: In difficult-to-treat depression, integrative symptom severity-based and time-based measures are sensitive and informative outcomes for assessing between-group treatment effects, while metrics based on remission status are not.PMID:37927051 | DOI:10.1177/00048674231209837 (Source: The Australian and New Zealand Journal of Psychiatry)
Source: The Australian and New Zealand Journal of Psychiatry - November 6, 2023 Category: Psychiatry Authors: Scott T Aaronson Harold A Sackeim Mei Jiang Sarah Badejo Teresa Greco Mark T Bunker Charles R Conway Koen Demyttenaere Allan H Young R Hamish McAllister-Williams A John Rush Source Type: research

A Randomized, Double ‐Blind, Sham‐Controlled, Clinical Trial of Auricular Vagus Nerve Stimulation for the Treatment of Active Rheumatoid Arthritis: comment on the article by Baker et al
(Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - October 30, 2023 Category: Rheumatology Authors: Cynthia Aranow, Timir Datta ‐Chadhuri, Ulf Andersson, Sangeeta Chavan, Kevin J Tracey Tags: Letters Source Type: research

Subtle Pulse Electro-biological Recovery Apparatus (SPERA) as anti-inflammatory treatment for COVID-19 - A Proof of Concept Study
Conclusion: aVNS therapy may be an effective and safe intervention in COVID-19 hospitalised patients, however further research is warranted. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 27, 2023 Category: Respiratory Medicine Authors: Frent, S.-M., Giles, G., Paroczai, D., Tudorache, V., Marincu, I., Raduna, O., Herban, S., Marcu, M., Pater, F., Law, F., Wise, M., Oancea, C. Tags: Respiratory infections and bronchiectasis Source Type: research

Refractory status epilepticus arrested by vagus nerve stimulation
Pract Neurol. 2023 Oct 24:pn-2023-003896. doi: 10.1136/pn-2023-003896. Online ahead of print.ABSTRACTA 54-year-old man developed altered mental state and generalised tonic-clonic seizures after 1 week of upper respiratory tract symptoms and diarrhoea, having been previously well. His MR scan of brain showed multifocal progressive T2 cortical signal changes. He was diagnosed with new-onset refractory status epilepticus (NORSE), initially treated as being secondary to autoimmune/paraneoplastic limbic encephalitis, although subsequent investigations were negative. His seizures and electrographic epileptiform activity continue...
Source: Practical Neurology - October 24, 2023 Category: Neurology Authors: Sadaf Mehboob Soorya Mukkadayil Sureshkumar Linford Fernandes Elizabeth Wright Munni Ray John Goodden Melissa Maguire Source Type: research

Transcutaneous electrical vagus nerve stimulation to suppress premature ventricular complexes (TREAT PVC): study protocol for a multi-center, double-blind, randomized controlled trial
The autonomic nervous system can be responsible for the initiation and maintenance of arrhythmias. Low-level tragus stimulation (LLTS), a noninvasive form of autonomic neuromodulation, has been shown to be eff... (Source: Trials)
Source: Trials - October 23, 2023 Category: General Medicine Authors: Cheng Cai, Nan Wu, Gang Yang, Shu Yang, Wenjie Liu, Minglong Chen and Sunny S. Po Tags: Study protocol Source Type: research

Vagus nerve stimulation for treating developmental and epileptic encephalopathy in young children
ConclusionsOur study suggested that VNS was a generally effective adjunct treatment for DEE. Although the predictive factors for VNS efficacy remain unclear, it should be emphasized that patients with ES are not suitable candidates for epilepsy surgery. Further investigations are needed to validate the present results. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - October 20, 2023 Category: Neurology Source Type: research

Exploring the potential of vagus nerve stimulation in treating brain diseases: a review of immunologic benefits and neuroprotective efficacy
AbstractThe vagus nerve serves as a critical connection between the central nervous system and internal organs. Originally known for its effectiveness in treating refractory epilepsy, vagus nerve stimulation (VNS) has shown potential for managing other brain diseases, including ischaemic stroke, traumatic brain injury, Parkinson's disease, and Alzheimer's disease. However, the precise mechanisms of VNS and its benefits for brain diseases are not yet fully understood. Recent studies have found that VNS can inhibit inflammation, promote neuroprotection, help maintain the integrity of the blood-brain barrier, have multisystem...
Source: European Journal of Medical Research - October 19, 2023 Category: Research Source Type: research