Efficacy and Safety of Vagus Nerve Stimulation in Stroke Rehabilitation: A Systematic Review and Meta-Analysis
Conclusion: VNS may be an effective and safe adjunct to standard rehabilitation for post-stroke recovery; however, its clinical significance and long-term efficacy and safety remain unclear.Cerebrovasc Dis (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - September 27, 2022 Category: Neurology Source Type: research

Effects and neuroprotective mechanisms of vagus nerve stimulation on cognitive impairment with traumatic brain injury in animal studies: A systematic review and meta-analysis
ConclusionThe present review showed that VNS can effectively promote cognitive impairment and neuropathology in animal models of TBI. We hope that the results of this systematic review can be applied to improve the methodological quality of animal experiments on TBI, which will provide more important and conclusive evidence on the clinical value of VNS. To further confirm these results, there is a need for high-quality TBI animal studies with sufficient sample size and a more comprehensive outcome evaluation.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021290797, identifier: ...
Source: Frontiers in Neurology - September 27, 2022 Category: Neurology Source Type: research

Transcutaneous vagus nerve stimulation - A brief introduction and overview
Invasive cervical vagus nerve stimulation (VNS) is approved for the treatment of epilepsies, depression, obesity, and for stroke-rehabilitation. The procedure requires surgery, has side-effects, is expensive and not readily available. Consequently, transcutaneous VNS (tVNS) has been developed 20  years ago as non-invasive, less expensive, and easily applicable alternative. Since the vagus nerve reaches the skin at the outer acoustic canal and ear, and reflex-responses such as the ear-cough-reflex or the auriculo-cardiac reflex have been observed upon auricular stimulation, the ear seems w ell suited for tVNS. (Source: Au...
Source: Autonomic Neuroscience: Basic and Clinical - September 27, 2022 Category: Neuroscience Authors: Max J. Hilz Tags: Review Source Type: research

Transcutaneous vagus nerve stimulation and the realm of its therapeutic hopes and physiologic enigmas
Vagus nerve stimulation (VNS) is an established treatment option for patients with treatment resistant epilepsy and depression. However, the procedure is invasive and has side-effects. Transcutaneous vagus nerve stimulation (tVNS) is a non-invasive alternative. Particularly transcutaneous stimulation at the outer ear is gaining increasing interest. While the scope of therapeutic tVNS applications is expanding, there are still questions regarding the optimal stimulation parameters and site as well as the physiology and pathways of auricular tVNS. (Source: Autonomic Neuroscience: Basic and Clinical)
Source: Autonomic Neuroscience: Basic and Clinical - September 27, 2022 Category: Neuroscience Authors: Max J. Hilz, Armin Bolz Tags: Editorial Source Type: research

Noninvasive vagus nerve stimulation modulates trigeminal but not extracephalic somatosensory perception: functional evidence for a trigemino-vagal system in humans
This study used a randomized, single-blind, sham-controlled, crossover design and comprised 3 projects with 3 independent cohorts of healthy participants. Project I (n = 15) was explorative. Six quantitative sensory test parameters, including mechanical pain threshold (MPT), were measured over the left V1 dermatome and forearm and compared before and after unilateral nVNS. Projects II (n = 20) and III (n = 21) were preregistered online (https://osf.io/r4jb9). Quantitative sensory test parameters were compared over the left (Project II) or bilateral V1 and V3 dermatomes (Project III), respectively, in addition to the left f...
Source: Pain - September 20, 2022 Category: Anesthesiology Tags: Research Paper Source Type: research

An ASIC System for Closed-Loop Blood Pressure Modulation Through Right Cervical Vagus Nerve Stimulation
Conclusion: By combining this stimulation therapy with a pressure sensor, we present a novel closed-loop, electroceutical system that has the potential to monitor and modulate blood pressure. Significance: We present a drug-free, potentially side-effect-free electroceutical therapeutic for managing resistant hypertension. (Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - September 20, 2022 Category: Biomedical Engineering Source Type: research

Corrections to “A Numerical Model of the Acute Cardiac Effects Provoked by Cervical Vagus Nerve Stimulation”
In the above paper [1] there are minor errors in several equations, which we correct here. There is also an error in Fig. 5, which we also correct here. (Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - September 20, 2022 Category: Biomedical Engineering Source Type: research

Vagus nerve stimulation as a novel treatment for systemic lupus erythematous: study protocol for a randomised, parallel-group, sham-controlled investigator-initiated clinical trial, the SLE-VNS study
This study investigates whether adjuvant tVNS improves measures of fatigue (primary end point), AD, clinical disease activity, inflammation, pain, organ function and quality of life. Hence, this study will contribute to the understanding of AD as a potentially important precursor of fatigue, disease activity, progression and complications in SLE, and how tVNS mechanistically may attenuate this. As adjuvant tVNS use may reduce the need for traditional immunosuppressive therapy, this trial may prompt a shift in the treatment of SLE and potentially other autoimmune disorders. Methods and analysis Eighty-four patients with SL...
Source: BMJ Open - September 20, 2022 Category: General Medicine Authors: Zinglersen, A. H., Drange, I. L., Myhr, K. A., Fuchs, A., Pfeiffer-Jensen, M., Brock, C., Jacobsen, S. Tags: Open access, Rheumatology Source Type: research

The efficacy and safety of transcutaneous auricular vagus nerve stimulation in patients with mild cognitive impairment: A double blinded randomized clinical trial
There are 9.9 million new cases of dementia in the world every year. Short-term conversion rate from mild cognitive impairment (MCI) to dementia is between 20% and 40%, but long-term in 5 –10 years ranges from 60% to 100%. It is particularly important to prevent or prolong the development of MCI into dementia. Both auriculotherapy and vagus nerve stimulation are effective on improving cognitive functions. However, there is no double blinded randomized clinical trial to support the effectiveness of transcutaneous electrical stimulation of auricular acupuncture points in patients with MCI. (Source: BRAIN STIMULATION: Basic...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - September 20, 2022 Category: Neurology Authors: Lei Wang, Jinling Zhang, Chunlei Guo, Jiakai He, Shuai Zhang, Yu Wang, Zhao Yanan, Liang Li, Junying Wang, Liwei Hou, Shaoyuan Li, Yifei Wang, Lixiao Hao, Yufeng Zhao, Mozheng Wu, Jiliang Fang, Peijing Rong Source Type: research

Transcutaneous Vagus Nerve Stimulation Combined with Rehabilitation Training in the Intervention of Upper Limb Movement Disorders After Stroke: A Systematic Review
(Source: Neuropsychiatric Disease and Treatment)
Source: Neuropsychiatric Disease and Treatment - September 16, 2022 Category: Psychiatry Tags: Neuropsychiatric Disease and Treatment Source Type: research

Vagus Nerve Stimulation Promotes Motor Learning in Animal Model: A Potential Method for Post-Stroke Recovery
No abstract available (Source: Neurology Today)
Source: Neurology Today - September 15, 2022 Category: Neurology Tags: At the Bench Source Type: research

Specialized Pro-Resolving Mediators as Resolution Pharmacology for the Control of Pain and Itch
Annu Rev Pharmacol Toxicol. 2022 Sep 13. doi: 10.1146/annurev-pharmtox-051921-084047. Online ahead of print.ABSTRACTSpecialized pro-resolving mediators (SPMs), including resolvins, protectins, and maresins, are endogenous lipid mediators that are synthesized from omega-3 polyunsaturated fatty acids during the acute phase or resolution phase of inflammation. Synthetic SPMs possess broad safety profiles and exhibit potent actions in resolving inflammation in preclinical models. Accumulating evidence in the past decade has demonstrated powerful analgesia of exogenous SPMs in rodent models of inflammatory, neuropathic, and can...
Source: Cancer Control - September 13, 2022 Category: Cancer & Oncology Authors: Ru-Rong Ji Source Type: research

Specialized Pro-Resolving Mediators as Resolution Pharmacology for the Control of Pain and Itch
Annu Rev Pharmacol Toxicol. 2022 Sep 13. doi: 10.1146/annurev-pharmtox-051921-084047. Online ahead of print.ABSTRACTSpecialized pro-resolving mediators (SPMs), including resolvins, protectins, and maresins, are endogenous lipid mediators that are synthesized from omega-3 polyunsaturated fatty acids during the acute phase or resolution phase of inflammation. Synthetic SPMs possess broad safety profiles and exhibit potent actions in resolving inflammation in preclinical models. Accumulating evidence in the past decade has demonstrated powerful analgesia of exogenous SPMs in rodent models of inflammatory, neuropathic, and can...
Source: Annual Review of Pharmacology and Toxicology - September 13, 2022 Category: Drugs & Pharmacology Authors: Ru-Rong Ji Source Type: research

Specialized Pro-Resolving Mediators as Resolution Pharmacology for the Control of Pain and Itch
Annu Rev Pharmacol Toxicol. 2022 Sep 13. doi: 10.1146/annurev-pharmtox-051921-084047. Online ahead of print.ABSTRACTSpecialized pro-resolving mediators (SPMs), including resolvins, protectins, and maresins, are endogenous lipid mediators that are synthesized from omega-3 polyunsaturated fatty acids during the acute phase or resolution phase of inflammation. Synthetic SPMs possess broad safety profiles and exhibit potent actions in resolving inflammation in preclinical models. Accumulating evidence in the past decade has demonstrated powerful analgesia of exogenous SPMs in rodent models of inflammatory, neuropathic, and can...
Source: Pharmacological Reviews - September 13, 2022 Category: Drugs & Pharmacology Authors: Ru-Rong Ji Source Type: research

Specialized Pro-Resolving Mediators as Resolution Pharmacology for the Control of Pain and Itch
Annu Rev Pharmacol Toxicol. 2022 Sep 13. doi: 10.1146/annurev-pharmtox-051921-084047. Online ahead of print.ABSTRACTSpecialized pro-resolving mediators (SPMs), including resolvins, protectins, and maresins, are endogenous lipid mediators that are synthesized from omega-3 polyunsaturated fatty acids during the acute phase or resolution phase of inflammation. Synthetic SPMs possess broad safety profiles and exhibit potent actions in resolving inflammation in preclinical models. Accumulating evidence in the past decade has demonstrated powerful analgesia of exogenous SPMs in rodent models of inflammatory, neuropathic, and can...
Source: Annual Review of Pharmacology and Toxicology - September 13, 2022 Category: Drugs & Pharmacology Authors: Ru-Rong Ji Source Type: research