STELARA ® (ustekinumab) Demonstrated Sustained Symptomatic and Corticosteroid-Free Remission Rates in Adults with Moderately to Severely Active Ulcerative Colitis at Nearly Three Years in Long-Term Extension of Phase 3 Trial
SPRING HOUSE, PENNSYLVANIA, July 9, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced new three-year data from the long-term extension (LTE) of the STELARA® (ustekinumab) Phase 3 UNIFI study. The data demonstrated the majority (55.2 percent) of adult patients with moderately to severely active ulcerative colitis (UC) who initially responded to treatment with STELARA sustained symptomatic remissiona rates at nearly three years (week 152).1 Furthermore, a majority (96.4 percent) of the patients in symptomatic remissiona at week 152 were corticosteroid-free. These data are being presented...
Source: Johnson and Johnson - July 9, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news
Women with recurrent UTIs voice 'fear and frustration' over treatment options
(Wolters Kluwer Health) Women with recurrent urinary tract infections (UTIs) experience frustration related to their treatment - particularly the risks from repeated use of antibiotics, according to a focus group study in The Journal of Urology ® , Official Journal of the American Urological Association (AUA). The journal is published in the Lippincott portfolio by Wolters Kluwer. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 8, 2021 Category: International Medicine & Public Health Source Type: news
A promising new target for urinary tract infections and kidney stones
(Tokyo Medical and Dental University) Researchers from Tokyo Medical and Dental University (TMDU) have found that the urinary secretion of uromodulin, a kidney-specific protein, can be increased by the hormone vasopressin via certain signaling pathways. Increasing the urinary secretion of uromodulin may protect against urinary tract infections and kidney stones, while the resulting lower uromodulin levels in kidney cells may help to prevent hypertension and chronic kidney disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 17, 2021 Category: International Medicine & Public Health Source Type: news
Maternal Sepsis: presentation, course, treatment and outcomes
The current adult definition of sepsis and septic shock, as developed in 1992, does not adequately define sepsis in the pregnant and peripartum women due to the alteration of sepsis presentation in the maternal population. The purpose of this study was to determine potential causative factors for sepsis with the aim of prevention and reducing morbidity and mortality. Study Design and Methods: A descriptive observational design via a retrospective medical record review was used with a convenience sample of 22 women who were identified after admission as having sepsis. The setting was the labor and delivery unit of a large u...
Source: Current Awareness Service for Health (CASH) - June 9, 2021 Category: Consumer Health News Source Type: news
From meat-production to urinary tract infections
(Instituto de Tecnologia Qu í mica e Biol ó gica Ant ó nio Xavier da Universidade NOVA de Lisboa ITQB NOVA) In young women, Staphylococcus saprophyticus is a main cause of urinary tract infections (UTI), reaching 20% prevalence. Understanding the epidemiology of this microorganism can help identify its origin, distribution, causes, and risk factors. Now, ITQB NOVA researchers led by Maria Miragaia showed evidence that Staphylococcus saprophyticus can originate in food, namely in the meat-production chain. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - June 7, 2021 Category: Biology Source Type: news
Janssen Presents Results of First Head-to-Head Study of Biologic Therapies in Patients with Moderate to Severe Crohn ’s Disease
SPRING HOUSE, PENNSYLVANIA, May 23, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced efficacy and safety data for STELARA® (ustekinumab) in Crohn’s disease (CD) and ulcerative colitis (UC),1-4including data from the SEAVUE study, the first head-to-head study of biologic therapies in patients with CD, presented in a Clinical Science Late-Breaking Abstract Plenary session.1 SEAVUE data showed treatment with STELARA demonstrated high rates of clinical remission, corticosteroid-free remission, clinical response and endoscopic response through one year in biologic-naïve patients with mo...
Source: Johnson and Johnson - May 24, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news
Keep Antibiotics Unchanged in Breakthrough UTIs Keep Antibiotics Unchanged in Breakthrough UTIs
Changing the continuous antibiotic prophylactic agent had no significant effect on the risk of a second infection in children with breakthrough urinary tract infections, a small study showed.Medscape Medical News (Source: Medscape Infectious Diseases Headlines)
Source: Medscape Infectious Diseases Headlines - May 18, 2021 Category: Infectious Diseases Tags: Pediatrics News Source Type: news
New antimicrobial surface reduces bacteria build-up on medical instruments
(Monash University) Patient infection from urinary catheters are a global health concern. In a world-first, Monash University researchers have developed a new 3D antimicrobial surface to reduce bacterial build-up. The study saw a reduction in bacteria colonisation for three leading Urinary Tract Infection (UTI) pathogens, including E. coli. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - May 18, 2021 Category: Infectious Diseases Source Type: news
Comparing mortality between positive and negative blood culture results: an inverse probability of treatment weighting analysis of a multicenter cohort, BMC Infectious Diseases
Conclusions: Culture-positive sepsis patients had comparable early mortality but worse late mortality than culture-negative sepsis patients in this cohort. Persistent Staphylococcal bacteremia may have contributed to the increased late mortality. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 9, 2021 Category: Consumer Health News Source Type: news
How to get rid of a urine infection: 7 simple UTI home remedies
URINARY tract infections - also known as UTIs - are painful and annoying but are unfortunately very easy to contract. Here's how you can get rid of your urine infection using home remedies. (Source: Daily Express - Health)
Source: Daily Express - Health - March 23, 2021 Category: Consumer Health News Source Type: news
Amid COVID, potentially avoidable hospitalizations for other conditions fell far more for whites than Blacks
During the first six months of the pandemic, as people attempted to stay away from hospitals caring for those sick with COVID-19, potentially avoidable hospitalizations for non-COVID-19 –related conditions fell far more among white patients than Black patients, according to a new study that looked at admissions to UCLA Health hospitals.The findings indicate that the COVID-19 crisis has exacerbated existing racial health care disparities and suggest that during the pandemic, African Americans may have had worse access than whites to outpatient care that could have helped prevent deterioration of their non –COVID-19 heal...
Source: UCLA Newsroom: Health Sciences - March 19, 2021 Category: Universities & Medical Training Source Type: news
Consumer Health: What do you know about kidney infections?
March is National Kidney Month, which makes this a good time to learn more about urinary tract and kidney infections. A urinary tract infection (UTI) is an infection in any part of your urinary system -- your kidneys, ureters, bladder and urethra. Most infections involve the lower urinary tract -- the bladder and the urethra. [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - March 9, 2021 Category: Databases & Libraries Source Type: news
What Causes a Urinary Tract Infection in a Child?
Title: What Causes a Urinary Tract Infection in a Child?Category: Diseases and ConditionsCreated: 3/8/2021 12:00:00 AMLast Editorial Review: 3/8/2021 12:00:00 AM (Source: MedicineNet Kids Health General)
Source: MedicineNet Kids Health General - March 8, 2021 Category: Pediatrics Source Type: news
Speeding treatment for urinary tract infections in children
(UT Southwestern Medical Center) DALLAS - March 8, 2021 - A study led by UT Southwestern and Children's Health researchers defines parameters for the number of white blood cells that must be present in children's urine at different concentrations to suggest a urinary tract infection (UTI). The findings, published recently inPediatrics, could help speed treatment of this common condition and prevent potentially lifelong complications. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 8, 2021 Category: International Medicine & Public Health Source Type: news
A Vaccine Against UTIs? New Mouse Study Brings Shot Closer
FRIDAY, March 5, 2021 -- Many women suffer through countless urinary tract infections (UTIs), but a new study in mice offers hope that a vaccine could one day bring their nightmares to an end. " Although several vaccines against UTIs have been... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - March 5, 2021 Category: General Medicine Source Type: news
