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Influence of exercise on quantity and deformability of immune cells in multiple sclerosis
ConclusionPeople with multiple sclerosis (PwMS) treated with alemtuzumab, fingolimod, and natalizumab respond to acute exercise with a comparable temporal pattern characterized by the increase of immune cell subsets as HCs. The magnitude of response is influenced by exercise intensity. Exercise-mediated effects should be considered when interpreting laboratory values in patients on immunomodulatory therapy. The impact of exercise on biophysical properties should be further elucidated. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - May 18, 2023 Category: Neurology Source Type: research

Anti-GABA-A Receptor Antibody-Mediated Epilepsia Partialis Continua After Treatment With Alemtuzumab: A Case Report
We present a young woman with prediagnosis of relapse remitting multiple sclerosis (MS), treated with interferons, natalizumab, and alemtuzumab. Six months after one and only cycle of alemtuzumab, speech arrest and behavioral changes with aggressive and anxious traits appeared. She showed increasing motor convulsions resulting in focal status epilepticus. Results Anti–GABA-A receptor antibodies in CSF and serum were confirmed in different external laboratories, in a more extensive analysis after antibodies against NMDAR, CASPR2, LGI1, GABABR, and AMPAR were ruled out during in-house examination. Clinical condition i...
Source: Neurology Neuroimmunology and Neuroinflammation - May 18, 2023 Category: Neurology Authors: Ratuszny, D., Skripuletz, T., Stüber, T., Valizada, E., Gehring, K., Ertl, P., Müller, J. A., Wattjes, M. P., Feuerhake, F., Sühs, K.-W. Tags: Autoimmune diseases, Status epilepticus, Multiple sclerosis Clinical/Scientific Note Source Type: research

Disease-modifying therapies and cost-of-illness progression among people newly diagnosed with multiple sclerosis: a national register-based cohort study covering treatment initiation with interferons, glatiramer acetate or natalizumab
Conclusions Similar trends over time for healthcare costs and productivity losses were identified across the DMT subgroups. PwMS on NAT maintained their work capacity for a longer time compared with those on GA, potentially leading to lower disability pension costs over time. COI serves as an objective measure to explore the importance of DMTs in maintaining low levels of progression of MS over time. (Source: BMJ Open)
Source: BMJ Open - May 16, 2023 Category: General Medicine Authors: Karampampa, K., Gyllensten, H., Friberg, E., Murley, C., Kavaliunas, A., Hillert, J., Olsson, T., Alexanderson, K. Tags: Open access, Health economics Source Type: research