Substandard Drugs And The Fight Against TB: The Challenge And The Opportunity
Poorly manufactured and fraudulent medicines kill thousands of people around the world each year. For infectious diseases like malaria and HIV, shoddy medicines also accelerate drug resistance and dramatically alter the course of epidemics. With few new drugs under development, recent progress against these major killers in the poorest countries is precarious. Bad drugs have become a big problem for one major infectious disease in particular: tuberculosis. If we don’t solve this issue, we may see the gains we’ve made against TB slip away. According to the World Health Organization, global TB cases continued o...
Source: Health Affairs Blog - April 15, 2013 Category: Health Medicine and Bioethics Commentators Authors: Agnes Binagwaho Tags: All Categories Blog Effectiveness Global Health Nonmedical Determinants Pharma Policy Public Health Source Type: blogs

Thinking Globally
It's an artificial occasion, but then again, most occasions are artificial. With about 1,000 days to go until the target date for the UN's Millennium Development goals, the organization is making a marketing push and they are getting some attention. Not in the United States, of course, where people generally don't give a rat's ass about the rest of the world. But BMJ, among other durn furriners, has marked the occasion with a couple of commentaries.Charles Kenney of the Center for Global Development  considers what new set of goals should be established once the 2015 target has passed. Summarizing progress so far, we ...
Source: Stayin' Alive - April 8, 2013 Category: Health Medicine and Bioethics Commentators Source Type: blogs

Drug Shortages: Despite Gains, Many Drugs are Still in Short Supply
A recent article from Bloomberg noted that “as shortages of sterile injectables persist, the makeup of that part of the industry is in flux.”  To address the current marketplace struggles,  Mylan has agreed to buy Agila Specialties, the injectables unit of Strides Arcolab, for $1.6 billion, and analysts think Claris Lifesciences could be next, saying “it is a matter of supply and demand.”    Claris has five (5) FDA-sanctioned manufacturing facilities in Ahmedabad, and an analyst tells Bloomberg it might be worth about $500 million.  Claris has “a ready-made ...
Source: Policy and Medicine - April 8, 2013 Category: Health Medicine and Bioethics Commentators Authors: Thomas Sullivan Source Type: blogs

Tuberculosis Made Easy
(Source: EverythingHealth)
Source: EverythingHealth - March 29, 2013 Category: Consumer Health News Source Type: blogs

Tuberculosis Made Easy
Tuberculosis (TB) is a contageous infection that is caused by a bacterium called Mycobacterium tuberculosis. One third of the world population has been infected with TB and it caused over 1.5 million deaths in 2010.  We don't hear as much about TB in the developed world but new infections in third world countries occur at a rate of about 1 per second.    Risk factors for TB are: A weakened (Source: EverythingHealth)
Source: EverythingHealth - March 28, 2013 Category: Consumer Health News Authors: Toni Brayer, MD Source Type: blogs

Ulcerative colitis tamed
Traci posted this wonderful story of her dramatic relief from years of ulcerative colitis: Dr. Davis, For 24+ years I have suffered from Ulcerative Colitis (UC). This past Christmas, my stepmother recommend that I read your Wheat Belly book. I did because I had decided to remove carbs from my diet at the beginning of the year. She said your book would be a great supplement to my carb reduction. I had no idea that by reading your book my symptoms of UC would disappear!!! Normally, I am treated with a medicine called Remicade which is administered via IV. Usually I receive this medicine every 2 months. Guess what??? It&rsqu...
Source: Wheat Belly Blog - March 6, 2013 Category: Cardiology Authors: Dr. Davis Tags: Ulcerative colitis Source Type: blogs

New Smaller, Cheaper PCR Machine for Disease Diagnosis in Remote Parts of The World
Back in 2006, researchers at Caltech created a relatively small and cheap PCR machine that was commercialized as the Eco device and sold for $13,000. This was a breakthrough, allowing public health professionals to screen people effectively during a viral epidemic like that experienced from H5N1 bird flu.While cheap enough and not too big for diagnostic work at a hospital, the Eco was still too bulky to use in areas where proper clinics don’t exist and the device required a bit of professional expertise to operate. To help tame disease in the world’s remote areas, and allow PCR testing to be performed by j...
Source: Medgadget - February 27, 2013 Category: Technology Consultants Authors: Gene Ostrovsky Tags: Diagnostics in the news... Source Type: blogs

Don't miss the Posterior Element Potts Spine-MRI
In spinal T.B. a vertebral column is mostly  affected in three distinct patterns, paradiscal, central  and anterior in decreasing frequency. The classical  picture of the spinal T.B is paradiscal pattern in which  two adjacent vertebral bodies are affected with or without  paravertebral and epidural collections. An extremely rare and atypical feature of spinal  T.B is isolated posterior elements affection. Also,atypical  forms of tuberculosis including isolated posterior vertebral  arch affection are reported in increasing frequency in HIV  immunocompromised subjects. This is a ...
Source: Sumer's Radiology Site - February 26, 2013 Category: Radiologists Authors: Sumer Sethi Source Type: blogs

Addiction Rehab: Everything is Broken
Down the rabbit hole in search of effective treatment. When I first began researching drugs and addiction years ago, a Seattle doctor told me something memorable. “It’s as if you had cancer,” she said, “and your doctor’s sole method of treatment consisted of putting you in a weekly self-help group.” I’ve got nothing against weekly self-help groups, to be sure. But as Ivan Oransky, executive editor of Reuters Health and a blogger at Retraction Watch, told me as recently as least year, addiction treatment appeared to be “all selling and self-diagnosis. They’re selling y...
Source: Addiction Inbox - February 26, 2013 Category: Addiction Authors: Dirk Hanson Source Type: blogs

Miliary TB-HRCT
This is a case of clinically suspected TB, with fever and CXR reported as negative. HRCT showed small miliary nodules. We believe that in the appropriate clinical situation, miliary tuberculosis may be suggested on HRCT. Moreover, in cases with no evidence of miliary nodules on the chest radiograph, HRCT scan may depict miliary nodules in the lung parenchyma. Second opinion case by Teleradiology Providers From Sumer's Radiology Site -The Top Radiology Magazine. Teleradiology Providers at Mail us at (Source: Sumer's Radiology Site)
Source: Sumer's Radiology Site - February 15, 2013 Category: Radiologists Authors: Sumer Sethi Source Type: blogs

Happy Valentines Day! STI studies and sexual health resources
The studies reveal new infection data, some of it available for the first time, for the eight most common STIs — chlamydia, gonorrhea, syphilis, herpes, human papillomavirus (HPV), hepatitis B, HIV, and trichomoniasis. The studies, which estimate infection rates and medical costs related to STIs, were published in the journal Sexually Transmitted Diseases. To read an article about the studies: The CDC has a website where you can learn more about STIs as well as search by zipcode for a clinic that offers STI testing as well as HIV testing the HPV vaccines.  To search visit here:&nbs...
Source: BHIC - February 14, 2013 Category: Databases & Libraries Authors: Monica Rogers Tags: General Health Information Literacy HIV/AIDS Public Health Websites Source Type: blogs

Orrin Hatch, AbbVie & Lobbying The Global Fund
In a world fraught with clashes over medication prices and intellectual property rights, the many efforts to make AIDS drugs accessible to poor nations is inevitably accompanied by considerable politicking. But the intense, behind-the-scenes maneuvering over affordability and compulsory licenses generally does not land on the public radar, especially when it involves a US Senator, a big drugmaker and an influential non-profit. However, an interesting episode concerning Orrin Hatch, the Utah Republican, has surfaced in which he appeared to be carrying water for the US pharmaceutical industry, specifically Abbott Laboratorie...
Source: Pharmalot - February 14, 2013 Category: Pharma Commentators Authors: Ed Silverman Tags: Uncategorized Abbott Laboratories Abbvie AIDS Bayer Compulsory Licenses Compulsory Licensing Hillary Clinton HIV Malaria Orrin Hatch TB Tuberculosis Source Type: blogs

2013 edition of GIDEON eBooks with maps
The 2013 edition of GIDEON eBooks has been released. This new edition includes distribution maps for each disease. A example of the distribution map of Tuberculosis is included below. The entire series now contains 105,467 pages of text, graphs and maps in 419 eBooks. The GIDEON eBook titles are divided into two series. The country series, offers a complete text devoted to the Infectious Diseases of every individual country. In addition there are 2 other eBooks. Infectious Diseases of the World covers the worldwide status of every disease including distribution maps. Infectious Diseases and Bioterrorism includes all Infect...
Source: GIDEON blog - February 13, 2013 Category: Databases & Libraries Authors: Uri Blackman Tags: Ebooks Source Type: blogs

2012: Banner Year for New Drugs
Fueled by new cancer therapeutics, last year the annual new molecular and biological entity approval count from the U.S. Food and Drug Administration (FDA) saw its highest year since 1997. One-third of the novel products approved by the FDA’s Center for Drug Evaluation and Research (CDER) are used to treat cancers of the blood, breast, colon, prostate, skin and thyroid. As part of the U.S. Food and Drug Administration (FDA), the Center for Drug Evaluation and Research (CDER) promotes and protects the health of Americans by assuring that all prescription and over-the-counter drugs are safe and effecti...
Source: Highlight HEALTH - February 13, 2013 Category: Medical Scientists Authors: Walter Jessen, Ph.D. Source Type: blogs

Pharmalot… Pharmalittle… Good Morning
Good morning, folks, and how are you today? A spot of snow has descended on the frosty Pharmalot corporate campus, where we have dusted off the official Pharmalot limousine that chauffeurs the short people to the schoolhouses. As usual, the great morning rush is under way. We have a feeling you can relate. So time to get started. Grab a cup of stimulation and attack your to-do list before it attacks you. Here are some fresh tidbits and, of course, we hope you have a meaningful day. Stay in touch… A Key Trial For A Tuberculosis Vaccine Fails (Reuters) Sanofi Says EU Approves Zaltrap For Bowel Cancer (Reuters) Glaxo S...
Source: Pharmalot - February 5, 2013 Category: Pharma Commentators Authors: Ed Silverman Tags: Uncategorized Alnylam Cholesterol Doxil Endo Health Solutions FDA GlaxoSmithKline Heptitis C Idenix Pharmaceuticals Medicines Company RNAi Sanofi TB Tuberculosis Vaccines Zaltrap Source Type: blogs

Pharmalot… Pharmalittle… The Weekend Nears
And so, another working week is about to draw to a close. Not a moment too soon, yes? This is, as you know, our treasured signal to daydream about weekend plans. Our agenda is filled with chores and paperwork, but we do hope to spend time with the short people and catch up on some napping. As for you, anything special planned? You could do something novel, pun intended, and visit your local library, while it still exists. Or hang with a favorite person. And of course, there is always that big football game. Whatever you do, have a grand time, but be safe. See you soon… Merck Delays Filing Of Osteoperosis Drug (Reute...
Source: Pharmalot - February 1, 2013 Category: Pharma Commentators Authors: Ed Silverman Tags: Uncategorized Amgen Avastin Bristol-Myres Squibb Celsion Dialysis IPO Liver Cancer Medicare Merck Overian Cancer Pfizer Roche TB Tuberculosis Vaccines Zoetis Source Type: blogs

Antibiotics: When Science And Wishful Thinking Collide
Antibiotic resistance is a major concern confronting our health care system, and there is tremendous pressure on the Food and Drug Administration (FDA) to “do something” about it. Unfortunately, the FDA is responding by approving drugs that are likely to do more harm than good. FDA advisory committees are supposed to provide independent advice from experts across the country, but recent meetings have left observers wondering whether too many FDA advisory committee members are providing neither scientific nor independent advice, and whether the committee process itself is fundamentally flawed. These concerns do...
Source: Health Affairs Blog - January 25, 2013 Category: Health Medicine and Bioethics Commentators Authors: Diana Zuckerman Tags: All Categories Consumers Effectiveness Global Health Patient Safety Pharma Policy Public Health Source Type: blogs

More Joys of Electronic Medical Records
Go up to your favorite emergency department staff member and ask them what they think of “twofers.” Depending on that person’s mood, chances are that you’ll get anything from a scowl to a punch in the gut in response. Two patients from the same family both needing emergent medical care at the exact same time? It still happens … car accidents, fires, maybe a stomach bug. But it can be frustrating. There’s a saying in emergency medicine that the likelihood of a true emergency is inversely proportional to the number of patients in the family registering to be seen. That being said, a &ldqu...
Source: WhiteCoat's Call Room - January 22, 2013 Category: Emergency Medicine Doctors Authors: WhiteCoat Tags: CMS Medical-Legal Medicare Source Type: blogs

USMLE Questions – Characteristic Disease Findings
The United States Medical Licensing Examination (USMLE) is designed to emphasize knowledge of clinical scenarios and clinical pearls, even on Step I. Listed below are some commonly encountered disease findings and characteristics. Feature Disease 45, X chromosome Turner’s syndrome 5-HIAA increased in urine Carcinoid syndrome Aganglionic rectum Hirschsrpung’s disease Apple-core sign on barium enema Colon cancer Arched back (opisthotonos) Tetanus Argyll-Robertson pupil Syphilis Ash leaf on forehead Tuberous sclerosis Auer rods  Acute myelogenous leukemia Austin Flint murmur Aortic r...
Source: Inside Surgery - January 18, 2013 Category: Surgeons Authors: Editor Tags: Surgpedia USMLE diseases findings VMA water hammer pulse Source Type: blogs

FDA approves 2 new drugs at the end of 2012
On the last day of 2012, the FDA approved 2 new drugs: Fulyzaq (crofelemer) to relieve symptoms of diarrhea in HIV/AIDS patients taking antiretroviral therapy, a combination of medicines used to treat HIV infection. Fulyzaq is distributed by Salix Pharmaceuticals, based in Raleigh, N.C. under license from Napo Pharmaceuticals, Inc. Sirturo (bedaquiline) as part of combination therapy to treat adults with multi-drug resistant pulmonary tuberculosis (TB) when other alternatives are not available. Sirturo is manufactured by Janssen Therapeutics, a division of Janssen Products LP, based in Titusville, N.J. (So...
Source: Medicine and Technology by Dr. Joseph Kim - January 2, 2013 Category: Technology Consultants Tags: FDA new drugs AIDS infectious diseases HIV Source Type: blogs

Prescription Drugs on TV
You’ve probably seen television commercials advertising prescription drugs for any number of things—from fibromyalgia (fi-bro-my-al-ja) to depression. Usually these ads end with an announcer running through a long list of dangerous side effects and warnings so fast that viewers can’t possibly get all of them, even when they include death. Did you know that the United States and New Zealand are the only countries in the world that allow prescription drug companies to market medications directly to the public? Some drug companies even use celebrity spokespersons, such as pro golfer Phil Mickelson who appear...
Source: NIDA Drugs and Health Blog - October 18, 2011 Category: Addiction Authors: Sara Bellum Source Type: blogs

UN Summit on Non-Communicable Diseases: All Talk, Little Action
What causes 63% of all deaths in the world? If you guessed AIDS, tuberculosis or malaria, you'd be wrong. It's actually non-communicable diseases, with the top four being cancer, diabetes, heart disease and lung disease. It costs governments billi... (Source: Diabetes Mine)
Source: Diabetes Mine - September 28, 2011 Category: Endocrinology Authors: Allison Blass Source Type: blogs

Transcript of Dr. Bihari Video
00:00 to 02.26—Dr. Bihari gives his background and credentials. Dr. Bihari: My medical training started at Harvard Medical School. I graduated in 1957. Then I trained in Internal Medicine at one of the Harvard teaching hospitals in Boston, Beth Israel, and then in Neurology at Massachusetts General in Boston. Then I went to the National Institutes of Health for two years doing brain physiology—brain research. I did another residency training in Psychiatry in New York, at Columbia Presbyterian Medical Center and then, over the following five or six years, I got very involved in working in Drug Addiction. By 197...
Source: HONEST MEDICINE: My Dream for the Future - May 16, 2011 Category: Consumer Health News Authors: JuliaS1573 at (Julia Schopick) Tags: Anecdotal Treatments HONEST MEDICINE Integrative Medicine Low Dose Naltrexone Obituaries Source Type: blogs

Meet Carolyn Bertozzi
Profiles Carolyn Bertozzi, a chemical biologist who studies glycans and tuberculosis bacteria. (Source: NIGMS Chemistry of Health)
Source: NIGMS Chemistry of Health - September 28, 2009 Category: Biochemistry Source Type: blogs