Human Lung Tissue Implanted on the Chick Chorioallantoic Membrane as a Novel In Vivo Model of IPF
Am J Respir Cell Mol Biol. 2022 May 25. doi: 10.1165/rcmb.2022-0037MA. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with no curative pharmacological treatment. Current preclinical models fail to accurately reproduce human pathophysiology and are therefore poor predictors of clinical outcomes. Here, we investigated whether the chick embryo chorioallantoic membrane (CAM) assay supports the implantation of xenografts derived from IPF lung tissue and primary IPF lung fibroblasts and can be used to evaluate the efficacy of antifibrotic drugs. We demonstrate that IPF x...
Source: Am J Respir Cell Mol... - May 25, 2022 Category: Respiratory Medicine Authors: Alexis Perreault Kelly Harper M égane Lebel Martine Charbonneau Damien Adam Emmanuelle Brochiero Andr é M Cantin Martin Leduc Lyne Gagnon Claire M Dubois Source Type: research

Human Lung Tissue Implanted on the Chick Chorioallantoic Membrane as a Novel In Vivo Model of IPF
Am J Respir Cell Mol Biol. 2022 May 25. doi: 10.1165/rcmb.2022-0037MA. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with no curative pharmacological treatment. Current preclinical models fail to accurately reproduce human pathophysiology and are therefore poor predictors of clinical outcomes. Here, we investigated whether the chick embryo chorioallantoic membrane (CAM) assay supports the implantation of xenografts derived from IPF lung tissue and primary IPF lung fibroblasts and can be used to evaluate the efficacy of antifibrotic drugs. We demonstrate that IPF x...
Source: American Journal of Respiratory Cell and Molecular Biology - May 25, 2022 Category: Molecular Biology Authors: Alexis Perreault Kelly Harper M égane Lebel Martine Charbonneau Damien Adam Emmanuelle Brochiero Andr é M Cantin Martin Leduc Lyne Gagnon Claire M Dubois Source Type: research

PPAR α regulates the expression of human arylacetamide deacetylase involved in drug hydrolysis and lipid metabolism
In conclusion, this study demonstrated the regulation of human AADAC by PPAR α and its significance in lipid accumulation.PMID:35314168 | DOI:10.1016/j.bcp.2022.115010 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - March 22, 2022 Category: Drugs & Pharmacology Authors: Tomomi Morikawa Tatsuki Fukami Saki Gotoh-Saito Masataka Nakano Miki Nakajima Source Type: research

PPAR α regulates the expression of human arylacetamide deacetylase involved in drug hydrolysis and lipid metabolism
In conclusion, this study demonstrated the regulation of human AADAC by PPAR α and its significance in lipid accumulation.PMID:35314168 | DOI:10.1016/j.bcp.2022.115010 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - March 22, 2022 Category: Drugs & Pharmacology Authors: Tomomi Morikawa Tatsuki Fukami Saki Gotoh-Saito Masataka Nakano Miki Nakajima Source Type: research

Comparative Bioavailability Study of Solid Self Nanoemulsifying Drug Delivery System (S-SNEDDS) of Fenofibric Acid in Healthy Male Subjects
Conclusions: S-SNEDDS increased the dissolution rate in acid medium and absorption rate of fenofibric acid but did not increase the extent of fenofibric acid absorption. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - February 8, 2022 Category: Internal Medicine Source Type: research

Comparative Bioavailability Study of Solid Self-Nanoemulsifying Drug Delivery System of Fenofibric Acid in Healthy Male Subjects
Conclusions: S-SNEDDS increased the dissolution rate in acid medium and absorption rate of fenofibric acid but did not increase the extent of fenofibric acid absorption. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - February 8, 2022 Category: Internal Medicine Source Type: research

The Hyperlipidaemic Drug Fenofibrate Significantly Reduces Infection by SARS-CoV-2 in Cell Culture Models
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has caused a significant number of fatalities and worldwide disruption. To identify drugs to repurpose to treat SARS-CoV-2 infections, we established a screen to measure the dimerization of angiotensin-converting enzyme 2 (ACE2), the primary receptor for the virus. This screen identified fenofibric acid, the active metabolite of fenofibrate. Fenofibric acid also destabilized the receptor-binding domain (RBD) of the viral spike protein and inhibited RBD binding to ACE2 in enzyme-linked immunosorbent assay (ELISA) and whole cell-binding assays. Fenofib...
Source: Frontiers in Pharmacology - August 6, 2021 Category: Drugs & Pharmacology Source Type: research

Discovery of 4-benzyloxy and 4-(2-phenylethoxy) chalcone fibrate hybrids as novel PPAR α agonists with anti-hyperlipidemic and antioxidant activities: Design, synthesis and in vitro/in vivo biological evaluation
Bioorg Chem. 2021 Jul 16;115:105170. doi: 10.1016/j.bioorg.2021.105170. Online ahead of print.ABSTRACTIn the current work, a series of novel 4-benzyloxy and 4-(2-phenylethoxy) chalcone fibrate hybrids (10a-o) and (11a-e) were synthesized and evaluated as new PPARα agonists in order to find new agents with higher activity and fewer side effects. The 2-propanoic acid derivative 10a and the 2-butanoic acid congener 10i showed the best overall PPARα agonistic activity showing Emax% values of 50.80 and 90.55%, respectively, and EC50 values of 8.9 and 25.0 μM, respectively, compared to fenofibric acid with Emax = 100% and EC5...
Source: Bioorganic Chemistry - July 31, 2021 Category: Chemistry Authors: Rasha M Hassan Mona E Aboutabl Manuela Bozzi Mohammed F El-Behairy Ahmed M El Kerdawy Beatrice Sampaolese Claudia Desiderio Federica Vincenzoni Francesca Sciandra Iman A Y Ghannam Source Type: research

Targeting Peroxisome Proliferator-Activated Receptor- α (PPAR- α) to Reduce Paclitaxel-Induced Peripheral Neuropathy.
CONCLUSIONS AND IMPLICATIONS: Taken together, our results show for the first time the therapeutic potential (prevention and reversal) of fibrates in PIPN and opens to a potential pharmacological repurposing of these drugs. PMID: 33434562 [PubMed - as supplied by publisher] (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - January 9, 2021 Category: Neurology Authors: Caillaud M, Patel NH, White A, Wood M, Contreras KM, Toma W, Alkhlaif Y, Roberts JL, Tran TH, Jackson AB, Poklis J, Gewirtz DA, Imad Damaj M Tags: Brain Behav Immun Source Type: research

Cancers, Vol. 13, Pages 69: A Fenofibrate Diet Prevents Paclitaxel-Induced Peripheral Neuropathy in Mice
Conclusions: Taken together, our results show the therapeutic potential of fenofibrate in the prevention of PIPN development. (Source: Cancers)
Source: Cancers - December 29, 2020 Category: Cancer & Oncology Authors: Martial Caillaud Nipa H. Patel Wisam Toma Alyssa White Danielle Thompson Jared Mann Tammy H. Tran Jane L. Roberts Justin L. Poklis John W. Bigbee Xianjun Fang David A. Gewirtz M. Imad Damaj Tags: Article Source Type: research

Ozonation of 47 organic micropollutants in secondary treated municipal effluents: Direct and indirect kinetic reaction rates and modelling.
Abstract Micropollutants like pharmaceuticals, hormones and pesticides are still found in treated municipal wastewater. An effective way to degrade micropollutants is to use oxidants such as ozone or hydroxyl radicals. We designed an innovative experimental protocol combining batch experiments and a study of a full-scale WWTP to understand and predict the removal via ozonation of typical micropollutants present in secondary treated effluents. First, the direct and indirect ozonation of 47 organic micropollutants was scrutinized, then a model was developed and calibrated to simulate the ozone transfers and ...
Source: Chemosphere - November 29, 2020 Category: Chemistry Authors: Mathon B, Coquery M, Liu Z, Penru Y, Guillon A, Esperanza M, Miège C, Choubert JM Tags: Chemosphere Source Type: research

Predicting the environmental emissions arising from conventional and nanotechnology-related pharmaceutical drug products.
Abstract Today, environmental pollution with pharmaceutical drugs and their metabolites poses a major threat to the aquatic ecosystems. Active substances such as fenofibrate, are processed to pharmaceutical drug formulations before they are degraded by the human body and released into the wastewater. Compared to the conventional product Lipidil® 200, the pharmaceutical product Lipidil 145 One® and Ecocaps take advantage of nanotechnology to improve uptake and bioavailability of the drug in humans.In the present approach, a combination of in vitro drug release studies and physiologically-based biopharmace...
Source: Environmental Research - September 23, 2020 Category: Environmental Health Authors: Jung F, Thurn M, Krollik K, Gao FG, Hering I, Eilebrecht E, Emara Y, Weiler M, Günday-Türeli N, Türeli E, Parnham MJ, Wacker MG Tags: Environ Res Source Type: research

Synthesis and Evaluation of Fenofibric Acid Ester Derivatives: Studies of Different Formulation with Their Bioavailability and Absorption Conditions
A series of fenofibric acid ester pro-drugs (JF-1-7) were synthesized. The pharmacokinetic properties of these pro-drugs were examined after oral administration to rats at a dose of 20 mg kg-1 to evaluate the relative bioavailability in rats. The bioavailability of the ester compounds, JF-1, 2, 3, 4, 5, 6, and 7, was significantly higher than that of fenofibrate. In particular, JF-2 proved to be most promising. The oral administration (20 mg kg-1) of JF-2 showed a relative bioavailability of approximately 272.8% compared to fenofibrate. (Source: Journal of the Brazilian Chemical Society)
Source: Journal of the Brazilian Chemical Society - January 20, 2020 Category: Chemistry Source Type: research

Canonical Wnt Signaling Promotes Neovascularization through Determination of Endothelial Progenitor Cell Fate via Metabolic Profile Regulation
This study found that EPC metabolic profile is a direct determinant of EPC fate. The Wnt signaling pathway regulates EPC metabolism, EPC fate and subsequently, new vessel formation. These findings reveal a new function of Wnt signaling in regulating mitochondrial function in EPC. This study also suggests a potential significance of EPC metabolic profile as a diagnostic marker and therapeutic target for diseases caused by abnormal blood vessel formation.© AlphaMed Press 2019 (Source: Stem Cells)
Source: Stem Cells - June 23, 2019 Category: Stem Cells Authors: Yan Shao, Jianglei Chen, Willard Freeman, Li ‐jie Dong, Zhi‐hui Zhang, Manhong Xu, Fangfang Qiu, Yanhong Du, Juping Liu, Xiao‐rong Li, Jian‐xing Ma Tags: Tissue ‐Specific Stem Cells Source Type: research