Overcoming Cancer Resistance to Platinum Drugs by Inhibiting Cholesterol Metabolism
Angew Chem Int Ed Engl. 2023 Aug 23:e202309043. doi: 10.1002/anie.202309043. Online ahead of print.ABSTRACTDrug resistance is a serious challenge for platinum anticancer drugs. Platinum complexes may get over the drug resistance via a distinct mechanism of action. Cholesterol is a key factor contributing to the drug resistance. Inhibiting cellular cholesterol synthesis and uptake provides an alternative strategy for cancer treatment. Platinum(IV) complexes FP and DFP with fenofibric acid as axial ligand(s) were designed to combat the drug resistance through regulating cholesterol metabolism besides damaging DNA. In additio...
Source: Angewandte Chemie - August 24, 2023 Category: Chemistry Authors: Ying Wang Linxiang Cai Hui Li Hnahua Chen Tao Yang Yehong Tan Zijian Guo Xiaoyong Wang Source Type: research

Overcoming Cancer Resistance to Platinum Drugs by Inhibiting Cholesterol Metabolism
Angew Chem Int Ed Engl. 2023 Aug 23:e202309043. doi: 10.1002/anie.202309043. Online ahead of print.ABSTRACTDrug resistance is a serious challenge for platinum anticancer drugs. Platinum complexes may get over the drug resistance via a distinct mechanism of action. Cholesterol is a key factor contributing to the drug resistance. Inhibiting cellular cholesterol synthesis and uptake provides an alternative strategy for cancer treatment. Platinum(IV) complexes FP and DFP with fenofibric acid as axial ligand(s) were designed to combat the drug resistance through regulating cholesterol metabolism besides damaging DNA. In additio...
Source: Angewandte Chemie - August 24, 2023 Category: Chemistry Authors: Ying Wang Linxiang Cai Hui Li Hnahua Chen Tao Yang Yehong Tan Zijian Guo Xiaoyong Wang Source Type: research

A Mendelian randomization study for drug repurposing reveals bezafibrate and fenofibric acid as potential osteoporosis treatments
Conclusion: The present study provided evidence that BZF and FBA can increase BMD, suggesting their potential effects in preventing and treating OP. These findings potentially pave the way for future studies that may allow personalized selection of lipid-lowering drugs for those at risk of OP. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - July 20, 2023 Category: Drugs & Pharmacology Source Type: research

A Randomized Trial of Lipid Metabolism Modulation with Fenofibrate for Acute Coronavirus Disease 2019
Conclusion Among patients with COVID-19, fenofibrate has no significant effect on various clinically relevant outcomes.PMID:35982675 | PMC:PMC9387540 | DOI:10.21203/rs.3.rs-1933913/v1 (Source: Cell Research)
Source: Cell Research - August 19, 2022 Category: Cytology Authors: Julio Chirinos Patricio Lopez-Jaramillo Evangelos Giamarellos-Bourboulis Gonzalo D ávila-Del-Carpio Abdul Bizri Jaime Andrade-Villanueva Oday Salman Carlos Cure-Cure Nelson Rosado-Santander Mario Cornejo Giraldo Luz Gonz ález-Hernández Rima Moghnieh Ra Source Type: research

Human Lung Tissue Implanted on the Chick Chorioallantoic Membrane as a Novel In Vivo Model of IPF
Am J Respir Cell Mol Biol. 2022 May 25. doi: 10.1165/rcmb.2022-0037MA. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with no curative pharmacological treatment. Current preclinical models fail to accurately reproduce human pathophysiology and are therefore poor predictors of clinical outcomes. Here, we investigated whether the chick embryo chorioallantoic membrane (CAM) assay supports the implantation of xenografts derived from IPF lung tissue and primary IPF lung fibroblasts and can be used to evaluate the efficacy of antifibrotic drugs. We demonstrate that IPF x...
Source: American Journal of Respiratory Cell and Molecular Biology - May 25, 2022 Category: Molecular Biology Authors: Alexis Perreault Kelly Harper M égane Lebel Martine Charbonneau Damien Adam Emmanuelle Brochiero Andr é M Cantin Martin Leduc Lyne Gagnon Claire M Dubois Source Type: research

Human Lung Tissue Implanted on the Chick Chorioallantoic Membrane as a Novel In Vivo Model of IPF
Am J Respir Cell Mol Biol. 2022 May 25. doi: 10.1165/rcmb.2022-0037MA. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with no curative pharmacological treatment. Current preclinical models fail to accurately reproduce human pathophysiology and are therefore poor predictors of clinical outcomes. Here, we investigated whether the chick embryo chorioallantoic membrane (CAM) assay supports the implantation of xenografts derived from IPF lung tissue and primary IPF lung fibroblasts and can be used to evaluate the efficacy of antifibrotic drugs. We demonstrate that IPF x...
Source: Am J Respir Cell Mol... - May 25, 2022 Category: Respiratory Medicine Authors: Alexis Perreault Kelly Harper M égane Lebel Martine Charbonneau Damien Adam Emmanuelle Brochiero Andr é M Cantin Martin Leduc Lyne Gagnon Claire M Dubois Source Type: research

Human Lung Tissue Implanted on the Chick Chorioallantoic Membrane as a Novel In Vivo Model of IPF
Am J Respir Cell Mol Biol. 2022 May 25. doi: 10.1165/rcmb.2022-0037MA. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with no curative pharmacological treatment. Current preclinical models fail to accurately reproduce human pathophysiology and are therefore poor predictors of clinical outcomes. Here, we investigated whether the chick embryo chorioallantoic membrane (CAM) assay supports the implantation of xenografts derived from IPF lung tissue and primary IPF lung fibroblasts and can be used to evaluate the efficacy of antifibrotic drugs. We demonstrate that IPF x...
Source: American Journal of Respiratory Cell and Molecular Biology - May 25, 2022 Category: Molecular Biology Authors: Alexis Perreault Kelly Harper M égane Lebel Martine Charbonneau Damien Adam Emmanuelle Brochiero Andr é M Cantin Martin Leduc Lyne Gagnon Claire M Dubois Source Type: research

Human Lung Tissue Implanted on the Chick Chorioallantoic Membrane as a Novel In Vivo Model of IPF
Am J Respir Cell Mol Biol. 2022 May 25. doi: 10.1165/rcmb.2022-0037MA. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with no curative pharmacological treatment. Current preclinical models fail to accurately reproduce human pathophysiology and are therefore poor predictors of clinical outcomes. Here, we investigated whether the chick embryo chorioallantoic membrane (CAM) assay supports the implantation of xenografts derived from IPF lung tissue and primary IPF lung fibroblasts and can be used to evaluate the efficacy of antifibrotic drugs. We demonstrate that IPF x...
Source: Mol Biol Cell - May 25, 2022 Category: Molecular Biology Authors: Alexis Perreault Kelly Harper M égane Lebel Martine Charbonneau Damien Adam Emmanuelle Brochiero Andr é M Cantin Martin Leduc Lyne Gagnon Claire M Dubois Source Type: research

Human Lung Tissue Implanted on the Chick Chorioallantoic Membrane as a Novel In Vivo Model of IPF
Am J Respir Cell Mol Biol. 2022 May 25. doi: 10.1165/rcmb.2022-0037MA. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with no curative pharmacological treatment. Current preclinical models fail to accurately reproduce human pathophysiology and are therefore poor predictors of clinical outcomes. Here, we investigated whether the chick embryo chorioallantoic membrane (CAM) assay supports the implantation of xenografts derived from IPF lung tissue and primary IPF lung fibroblasts and can be used to evaluate the efficacy of antifibrotic drugs. We demonstrate that IPF x...
Source: Am J Respir Cell Mol... - May 25, 2022 Category: Respiratory Medicine Authors: Alexis Perreault Kelly Harper M égane Lebel Martine Charbonneau Damien Adam Emmanuelle Brochiero Andr é M Cantin Martin Leduc Lyne Gagnon Claire M Dubois Source Type: research

Human Lung Tissue Implanted on the Chick Chorioallantoic Membrane as a Novel In Vivo Model of IPF
Am J Respir Cell Mol Biol. 2022 May 25. doi: 10.1165/rcmb.2022-0037MA. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with no curative pharmacological treatment. Current preclinical models fail to accurately reproduce human pathophysiology and are therefore poor predictors of clinical outcomes. Here, we investigated whether the chick embryo chorioallantoic membrane (CAM) assay supports the implantation of xenografts derived from IPF lung tissue and primary IPF lung fibroblasts and can be used to evaluate the efficacy of antifibrotic drugs. We demonstrate that IPF x...
Source: Am J Respir Cell Mol... - May 25, 2022 Category: Respiratory Medicine Authors: Alexis Perreault Kelly Harper M égane Lebel Martine Charbonneau Damien Adam Emmanuelle Brochiero Andr é M Cantin Martin Leduc Lyne Gagnon Claire M Dubois Source Type: research

Human Lung Tissue Implanted on the Chick Chorioallantoic Membrane as a Novel In Vivo Model of IPF
Am J Respir Cell Mol Biol. 2022 May 25. doi: 10.1165/rcmb.2022-0037MA. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with no curative pharmacological treatment. Current preclinical models fail to accurately reproduce human pathophysiology and are therefore poor predictors of clinical outcomes. Here, we investigated whether the chick embryo chorioallantoic membrane (CAM) assay supports the implantation of xenografts derived from IPF lung tissue and primary IPF lung fibroblasts and can be used to evaluate the efficacy of antifibrotic drugs. We demonstrate that IPF x...
Source: American Journal of Respiratory Cell and Molecular Biology - May 25, 2022 Category: Molecular Biology Authors: Alexis Perreault Kelly Harper M égane Lebel Martine Charbonneau Damien Adam Emmanuelle Brochiero Andr é M Cantin Martin Leduc Lyne Gagnon Claire M Dubois Source Type: research

Human Lung Tissue Implanted on the Chick Chorioallantoic Membrane as a Novel In Vivo Model of IPF
Am J Respir Cell Mol Biol. 2022 May 25. doi: 10.1165/rcmb.2022-0037MA. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with no curative pharmacological treatment. Current preclinical models fail to accurately reproduce human pathophysiology and are therefore poor predictors of clinical outcomes. Here, we investigated whether the chick embryo chorioallantoic membrane (CAM) assay supports the implantation of xenografts derived from IPF lung tissue and primary IPF lung fibroblasts and can be used to evaluate the efficacy of antifibrotic drugs. We demonstrate that IPF x...
Source: Am J Respir Cell Mol... - May 25, 2022 Category: Respiratory Medicine Authors: Alexis Perreault Kelly Harper M égane Lebel Martine Charbonneau Damien Adam Emmanuelle Brochiero Andr é M Cantin Martin Leduc Lyne Gagnon Claire M Dubois Source Type: research

Human Lung Tissue Implanted on the Chick Chorioallantoic Membrane as a Novel In Vivo Model of IPF
Am J Respir Cell Mol Biol. 2022 May 25. doi: 10.1165/rcmb.2022-0037MA. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with no curative pharmacological treatment. Current preclinical models fail to accurately reproduce human pathophysiology and are therefore poor predictors of clinical outcomes. Here, we investigated whether the chick embryo chorioallantoic membrane (CAM) assay supports the implantation of xenografts derived from IPF lung tissue and primary IPF lung fibroblasts and can be used to evaluate the efficacy of antifibrotic drugs. We demonstrate that IPF x...
Source: American Journal of Respiratory Cell and Molecular Biology - May 25, 2022 Category: Molecular Biology Authors: Alexis Perreault Kelly Harper M égane Lebel Martine Charbonneau Damien Adam Emmanuelle Brochiero Andr é M Cantin Martin Leduc Lyne Gagnon Claire M Dubois Source Type: research

Human Lung Tissue Implanted on the Chick Chorioallantoic Membrane as a Novel In Vivo Model of IPF
Am J Respir Cell Mol Biol. 2022 May 25. doi: 10.1165/rcmb.2022-0037MA. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with no curative pharmacological treatment. Current preclinical models fail to accurately reproduce human pathophysiology and are therefore poor predictors of clinical outcomes. Here, we investigated whether the chick embryo chorioallantoic membrane (CAM) assay supports the implantation of xenografts derived from IPF lung tissue and primary IPF lung fibroblasts and can be used to evaluate the efficacy of antifibrotic drugs. We demonstrate that IPF x...
Source: Am J Respir Cell Mol... - May 25, 2022 Category: Respiratory Medicine Authors: Alexis Perreault Kelly Harper M égane Lebel Martine Charbonneau Damien Adam Emmanuelle Brochiero Andr é M Cantin Martin Leduc Lyne Gagnon Claire M Dubois Source Type: research

Human Lung Tissue Implanted on the Chick Chorioallantoic Membrane as a Novel In Vivo Model of IPF
Am J Respir Cell Mol Biol. 2022 May 25. doi: 10.1165/rcmb.2022-0037MA. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with no curative pharmacological treatment. Current preclinical models fail to accurately reproduce human pathophysiology and are therefore poor predictors of clinical outcomes. Here, we investigated whether the chick embryo chorioallantoic membrane (CAM) assay supports the implantation of xenografts derived from IPF lung tissue and primary IPF lung fibroblasts and can be used to evaluate the efficacy of antifibrotic drugs. We demonstrate that IPF x...
Source: American Journal of Respiratory Cell and Molecular Biology - May 25, 2022 Category: Molecular Biology Authors: Alexis Perreault Kelly Harper M égane Lebel Martine Charbonneau Damien Adam Emmanuelle Brochiero Andr é M Cantin Martin Leduc Lyne Gagnon Claire M Dubois Source Type: research