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Are Biobetters Better?
Biosimilars and biobetters are both variants of a biologic drug, however, while biosimilars are close copies of the originator, biobetters have been improved, for example, in terms of efficacy, safety, tolerability or dosing regimen.Regulators consider biobetters as new products and so afford them the same patent protection as any originator, however, this means they require the same clinical and non-clinical data packages. Conversely, a reduced clinical data package is an attractive element for the development of biosimilars.Given the cost of development and the time pressure to bring a biobetter to market before biosimil...
Source: EyeForPharma - July 3, 2017 Category: Pharmaceuticals Authors: James Wright Source Type: news

Poison in the garden: poisonous plants relevant to clinical toxicology - Rabe C, Schmoll S, Eyer F.
[Abstract unavailable] Language: de... (Source: SafetyLit)
Source: SafetyLit - July 3, 2017 Category: International Medicine & Public Health Tags: Home and Consumer Product Safety Source Type: news

Self-administration of methamphetamine alters gut biomarkers of toxicity - Flack A, Persons AL, Kousik SM, Napier TC, Moszczynska A.
Methamphetamine (METH) is a highly abused psychostimulant that is associated with an increased risk for developing Parkinson's disease (PD). This enhanced vulnerability likely relates to the toxic effects of METH that overlap with PD pathology, e.g., aberr... (Source: SafetyLit)
Source: SafetyLit - July 3, 2017 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Baker's yeast can help plants cope with soil contamination
(Instituto Gulbenkian de Ciencia) Most plant species, including crops, cannot tolerate the toxic effects of soil pollutants, which dramatically impair their growth and development. In a study now published in Scientific Reports, a research team led by Paula Duque from the Instituto Gulbenkian de Ciencia (IGC; Portugal) discovered that two genes from baker's yeast can increase plant resistance to a broad range of toxic substances, enabling their growth in contaminated soils. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - July 3, 2017 Category: Biology Source Type: news

Key genes in nitrogen utilization in tobacco identified
(R&D at British American Tobacco) A newly created genetic roadmap for tobacco has been used to identify two mutated genes implicated in the way some types of tobacco use nitrogen. This could help in the development of tobacco and ultimately tobacco products containing lower levels of toxicants. This could also aid in the development of crops that require less chemical fertilizers. This roadmap lays out 64 percent of the tobacco genome, compared to just 20 percent in previous attempts. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 3, 2017 Category: International Medicine & Public Health Source Type: news

Left-wing publisher Mother Jones wants you to eat more toxic GMOs, inject your children with more vaccines and hate Donald Trump
(Natural News) Meandering through the latest mainstream media headlines these days, one is hard-pressed to find even a semblance of objective truth on virtually any topic. It’s all anti-Trump, pro-G.M.O., and pro-vaccine propaganda, it seems, including at the left-leaning news publication Mother Jones where such positions are regularly brow-beaten into readers at an excruciating pace.... (Source: NaturalNews.com)
Source: NaturalNews.com - July 1, 2017 Category: Consumer Health News Source Type: news

Toxicology Rounds: Supportive Care in Toxicology: Not as Easy as A-B-C
No abstract available (Source: Emergency Medicine News)
Source: Emergency Medicine News - July 1, 2017 Category: Emergency Medicine Tags: Toxicology Rounds Source Type: news

Building Mental Wellness and Psychosocial Resilience for Climate Change
American Public Health Association. 06/12/2017 This one-hour, 52-minute webinar discusses long-term strategies needed to cope with the strain that rising, ongoing climate change has on mental health and psychosocial well-being. Speakers illustrate how public health professionals can help build widespread resilience for the traumas and toxic stresses of climate change. Topics include extreme weather events, chronic health conditions caused by climate change, and food insecurity. (Video or Multimedia) (Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health)
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - June 30, 2017 Category: International Medicine & Public Health Authors: The U.S. National Library of Medicine Source Type: news

Building Mental Wellness and Psychosocial Resilience for Climate Change
Recorded workshop from June 2017 illustrated how public health professionals can help build widespread resilience for the traumas and toxic stresses of climate change. (Source: HSR Information Central)
Source: HSR Information Central - June 30, 2017 Category: International Medicine & Public Health Source Type: news

These elephants just saved a baby calf from drowning, demonstrating planning, intelligence and compassion
(Natural News) Nature is full of marvels, from the spectacular display of the Northern Lights to the power of the sun to help our bodies produce miraculous Vitamin D. That is why it is such an outrage when people destroy what nature has given us, whether it’s via fracking, pollution, or spraying toxic weed killers... (Source: NaturalNews.com)
Source: NaturalNews.com - June 29, 2017 Category: Consumer Health News Source Type: news

50,000 metal hip replacement patients RECALLED to hospital for X-rays over toxic fears
THOUSANDS of patients with ‘metal on metal’ hips are being recalled for tests after experts revealed they could be toxic. (Source: Daily Express - Health)
Source: Daily Express - Health - June 29, 2017 Category: Consumer Health News Source Type: news

Pesticides damage survival of bee colonies, landmark study shows
The world ’s largest ever field trial demonstrates widely used insecticides harm both honeybees and wild bees, increasing calls for a banWidely used insecticides damage the survival of honeybee colonies, the world ’s largest ever field trial has shown for the first time, as well as harming wild bees.The farm-based research, along with a second new study, also suggests widespread contamination of entire landscapes and a toxic “cocktail effect” from multiple pesticides.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - June 29, 2017 Category: Science Authors: Damian Carrington Environment editor Tags: Pesticides Bees Farming Insects Wildlife Environment World news Zoology Science Source Type: news

'Metal-on-metal' hip implant patients recalled for tests over toxicity fears
Alert issued by regulatory agency calls for for MRI scans and blood tests on expanded pool from 56,000 patients using devices believed to be at risk of bone or muscle damageThousands of patients with “metal-on-metal” hip implants will be recalled for a battery of tests, including MRI scans and blood tests, due to concerns over toxicity.Thealert, issued by the Medicines and Healthcare products Regulatory Agency (MHRA), expands the pool of patients believed to be at risk of bone or muscle damage from the devices, which have been implanted in around 56,000 patients in the UK.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - June 29, 2017 Category: Science Authors: Hannah Devlin Science correspondent Tags: Medical research Health Science Society Biology UK news Source Type: news

Toxicity warning: ‘Metal on metal’ hip replacement patients recalled for X-rays
THOUSANDS of patients with ‘metal on metal’ hips are being recalled for tests after experts revealed they could be toxic. (Source: Daily Express - Health)
Source: Daily Express - Health - June 29, 2017 Category: Consumer Health News Source Type: news

More than 50,000 with 'toxic' metal hip implants at risk
In an unprecedented step, the Medicines and Healthcare products Regulatory Agency issued an alert over the safety of the metal on metal hip implants and said they may need to be recalled. (Source: the Mail online | Health)
Source: the Mail online | Health - June 29, 2017 Category: Consumer Health News Source Type: news

Summer holiday warning: Suncream can turn ‘TOXIC’ if you swim in a chlorinated pool
HEATWAVE weather or some exotic sun on holiday makes going for a swim to cool off very appealing. (Source: Daily Express - Health)
Source: Daily Express - Health - June 29, 2017 Category: Consumer Health News Source Type: news

5 times Big Food tried to force-feed us toxic products but lost miserably
(Natural News) In a series on innovation in the food industry, Food Dive recently highlighted some of the industry’s biggest failures, and Natural News is here to celebrate the fact that the American public did not fall victim to these questionable products. Here are the top food industry fails: New Coke In a textbook example... (Source: NaturalNews.com)
Source: NaturalNews.com - June 29, 2017 Category: Consumer Health News Source Type: news

Watch out: That new Walmart cantaloupe was developed by Monsanto
(Natural News) There are millions of reasons not to purchase any product produced with the Monsanto name. Whether it’s a genetically engineered (GE) seed, or a fruit or vegetable that they sprayed with their highly toxic pesticides and herbicides, they have spent billions of dollars lying about the safety of their products. Take, for example, the new cantaloupe... (Source: NaturalNews.com)
Source: NaturalNews.com - June 29, 2017 Category: Consumer Health News Source Type: news

Don't swim while wearing sunscreen!
A compound used in the protective lotions, called avobenzone, turns toxic when it reacts with chlorine and ultraviolet rays, researchers at the Lomonosov Moscow State University discovered. (Source: the Mail online | Health)
Source: the Mail online | Health - June 29, 2017 Category: Consumer Health News Source Type: news

Improving the response to toxic inhalation disasters - Burki TK.
[Abstract unavailable] Language: en... (Source: SafetyLit)
Source: SafetyLit - June 29, 2017 Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news

Test identifies breast cancer patients with lowest risk of death
(University of California - San Francisco) A molecular test can pinpoint which patients will have a very low risk of death from breast cancer even 20 years after diagnosis and tumor removal, according to a new clinical study led by UC San Francisco in collaboration with colleagues in Sweden. As a result, 'ultralow' risk patients could be treated less aggressively and overtreatment avoided, leading to fewer toxic effects. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 29, 2017 Category: Cancer & Oncology Source Type: news

How safe is vaping?
On the heels of another damning statistic against tobacco — it kills more than 7 million people each year, the World Health Organizationsaid recently— come questions about whether vaping is a healthier substitute.The idea that they could be stems from the fact that e-cigarettes and other vaping devices can supply nicotine without tobacco or other additives and byproducts, like smoke, that are in a traditional cigarette. A2014 survey of 19,000 e-cigarette users found that 88 percent believed e-cigarettes were at least safer than regular cigarettes and 11 percent believed e-cigarettes were harmless. More rec...
Source: UCLA Newsroom: Health Sciences - June 29, 2017 Category: Universities & Medical Training Source Type: news

Cholera vaccine faces major test in Yemen
(Source: ScienceNOW)
Source: ScienceNOW - June 29, 2017 Category: Science Authors: Kupferschmidt, K. Tags: Asia/Pacific News, Epidemiology, Pharmacology, Toxicology In Depth Source Type: news

Chronic exposure to neonicotinoids reduces honey bee health near corn crops
Experiments linking neonicotinoids and declining bee health have been criticized for not simulating realistic exposure. Here we quantified the duration and magnitude of neonicotinoid exposure in Canada’s corn-growing regions and used these data to design realistic experiments to investigate the effect of such insecticides on honey bees. Colonies near corn were naturally exposed to neonicotinoids for up to 4 months—the majority of the honey bee’s active season. Realistic experiments showed that neonicotinoids increased worker mortality and were associated with declines in social immunity and increased quee...
Source: ScienceNOW - June 29, 2017 Category: Science Authors: Tsvetkov, N., Samson-Robert, O., Sood, K., Patel, H. S., Malena, D. A., Gajiwala, P. H., Maciukiewicz, P., Fournier, V., Zayed, A. Tags: Ecology reports Source Type: news

Emission of volatile organic compounds from petunia flowers is facilitated by an ABC transporter
This study provides direct proof of a biologically mediated mechanism of volatile emission. (Source: ScienceNOW)
Source: ScienceNOW - June 29, 2017 Category: Science Authors: Adebesin, F., Widhalm, J. R., Boachon, B., Lefevre, F., Pierman, B., Lynch, J. H., Alam, I., Junqueira, B., Benke, R., Ray, S., Porter, J. A., Yanagisawa, M., Wetzstein, H. Y., Morgan, J. A., Boutry, M., Schuurink, R. C., Dudareva, N. Tags: Botany reports Source Type: news

Occupational chemical exposures: a collaboration between the Georgia Poison Center and the Occupational Safety and Health Administration - Tustin AW, Jones A, Lopez GP, Ketcham GR, Hodgson MJ.
CONTEXT: In the United States, regional poison centers frequently receive calls about toxic workplace exposures. Most poison centers do not share call details routinely with governmental regulatory agencies. Worker health and safety could be enhanced if re... (Source: SafetyLit)
Source: SafetyLit - June 28, 2017 Category: International Medicine & Public Health Tags: Occupational Issues Source Type: news

Overview of forensic toxicology, yesterday, today and in the future - Chung H, Choe S.
BACKGROUND: The scope of forensic toxicology has been tremendously expanded over the past 50 years. From two general sections forensic toxicology can be further classified into 8-9 sections. METHODS: The most outstanding improvement in forensic tox... (Source: SafetyLit)
Source: SafetyLit - June 28, 2017 Category: International Medicine & Public Health Tags: Commentary Source Type: news

New legal requirements for submission of product information to poisons centres in EU member states - de Groot R, Brekelmans P, Desel H, de Vries I.
INTRODUCTION: In the past eight years, the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT) has been intensively involved in a European Commission led process to develop EU legislation on the information of hazardous products tha... (Source: SafetyLit)
Source: SafetyLit - June 28, 2017 Category: International Medicine & Public Health Tags: Jurisprudence, Laws, Legislation, Policies, Rules Source Type: news

Artificial meat warning: It's mostly made from MSG, GMOs and toxic ingredients that harm the planet
(Natural News) GREENWASHING Alert: Artificial meat is positioned as “saving the planet” but it’s almost all made from the very same GMOs and toxic herbicides and pesticides that are killing the planet. While I’m a strong opponent of the cruel and inhumane treatment of animals in CAFOs and confined meat factories, the greenwashing of the... (Source: NaturalNews.com)
Source: NaturalNews.com - June 27, 2017 Category: Consumer Health News Source Type: news

Airplane cabin air found contaminated with toxic chemicals that really can damage your health
(Natural News) You probably know at least one person who has a fear of flying. Whether it comes out of concerns about terrorism or worries over crashing, these people can usually be placated to some extent by looking at statistics showing how unlikely these events are to occur on their flight. However, there is one... (Source: NaturalNews.com)
Source: NaturalNews.com - June 27, 2017 Category: Consumer Health News Source Type: news

Mechanisms of hepatocellular toxicity associated with new psychoactive synthetic cathinones - Luethi D, Liechti ME, Kr ähenbühl S.
Synthetic cathinones are a new class of psychostimulant substances. Rarely, they can cause liver injury but associated mechanisms are not completely elucidated. In order to increase our knowledge about mechanisms of hepatotoxicity, we investigated the effe... (Source: SafetyLit)
Source: SafetyLit - June 27, 2017 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Drug-induced physeal abnormalities in preclinical toxicity studies - Frazier KS.
Most toxic physeal changes are characterized microscopically by altered chondrocyte development, proliferation, or maturation in the growth plate and eventually result in disordered appositional bone growth. Many therapeutic drugs directly or indirectly ta... (Source: SafetyLit)
Source: SafetyLit - June 27, 2017 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

You Need To Give Up These Toxic Habits If You Want To Be Confident And Successful
Confidence plays a huge role in your success  —  eliminating these bad habits will immediately boost your self-esteem. (Source: Healthy Living - The Huffington Post)
Source: Healthy Living - The Huffington Post - June 27, 2017 Category: Consumer Health News Source Type: news

German man developed severe rash from eating raw mushrooms
A German man, 50, was diagnosed with flagellate dermatitis, a toxic reaction caused by eating shiitake mushrooms raw ­or undercooked. Only 100 cases have been reported worldwide. (Source: the Mail online | Health)
Source: the Mail online | Health - June 27, 2017 Category: Consumer Health News Source Type: news

iMedicalApps: Toxicology App Is a Handy Reference
(MedPage Today) -- California Poison Control& AgileMD app informs on 25 toxins (Source: MedPage Today Emergency Medicine)
Source: MedPage Today Emergency Medicine - June 27, 2017 Category: Emergency Medicine Source Type: news

Differential abundance of CK1{alpha} provides selectivity for pharmacological CK1{alpha} activators to target WNT-dependent tumors
Constitutive WNT activity drives the growth of various human tumors, including nearly all colorectal cancers (CRCs). Despite this prominence in cancer, no WNT inhibitor is currently approved for use in the clinic largely due to the small number of druggable signaling components in the WNT pathway and the substantial toxicity to normal gastrointestinal tissue. We have shown that pyrvinium, which activates casein kinase 1α (CK1α), is a potent inhibitor of WNT signaling. However, its poor bioavailability limited the ability to test this first-in-class WNT inhibitor in vivo. We characterized a novel small-molecule ...
Source: Signal Transduction Knowledge Environment - June 27, 2017 Category: Science Authors: Li, B., Orton, D., Neitzel, L. R., Astudillo, L., Shen, C., Long, J., Chen, X., Kirkbride, K. C., Doundoulakis, T., Guerra, M. L., Zaias, J., Fei, D. L., Rodriguez-Blanco, J., Thorne, C., Wang, Z., Jin, K., Nguyen, D. M., Sands, L. R., Marchetti, F., Abre Tags: STKE Research Articles Source Type: news

Drinking water in North Carolina being tested for toxic substance
At a plant 80 miles upstream from Wilmington, North Carolina, a substance called GenX is manufactured by DuPont and Chemours. Company officials recently revealed that the chemical has been released into the river for nearly four decades. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - June 26, 2017 Category: Consumer Health News Source Type: news

American Heart Association wants you to stop using butter and start using toxic vegetable oils again
(Natural News) The American Heart Association has just issued some curious advice to cardiologists, saying that people should stop consuming butter and replace it with vegetable oils instead. While it’s not surprising to see a group with strong ties to Big Pharma promoting such careless advice, it is very concerning to think of the potential... (Source: NaturalNews.com)
Source: NaturalNews.com - June 26, 2017 Category: Consumer Health News Source Type: news

Can coffee machines and kettles spread toxic spores?
Conclusion This laboratory study suggests that under humid conditions, indoor surfaces like wallpaper may be colonised by fungi that produce toxic particles – some of which may be small enough to be inhaled. But it's important that these findings aren't taken too far out of context at this stage. The study was carried out in highly experimental circumstances where both temperature and humidity were optimised for maximal fungal growth. We can't know for sure that these circumstances would be typical of indoor environments, even bathrooms or kitchens, if they're well ventilated. The UK media has applied these findin...
Source: NHS News Feed - June 26, 2017 Category: Consumer Health News Tags: Heart/lungs Lifestyle/exercise Source Type: news

Meal Prepping May Actually Be Sabotaging Your Diet
Portioning your weekly meals into plastic or even BPA-free containers packs some major risks. Among them is weight gain. If your Sunday nights are dedicated to meal prepping for the week ahead, you’re part of a mighty group of health nuts. The planning ahead of meals is a main tip of weight loss coaches, food bloggers and nutritionists. Indeed, meal prepping’s popularity has exploded on social media. On Instagram alone there are 5.5 million photos tagged #mealprep and 1.1 million tagged #foodprep. While perfectly portioned-out food for seven days does make for the perfect #foodporn snapshot, meal preppers are ...
Source: Healthy Living - The Huffington Post - June 26, 2017 Category: Consumer Health News Source Type: news

Biosimilar for HER2-Positive Breast Cancer Equivalent to Trastuzumab
A biosimilar to trastuzumab known as CT-P6 showed equivalent efficacy and similar toxicity to the original agent in patients with HER2-positive breast cancer. (Source: CancerNetwork)
Source: CancerNetwork - June 26, 2017 Category: Cancer & Oncology Authors: Dave Levitan Tags: Breast Cancer HER2-Positive Breast Cancer News Source Type: news

Assessing the toxicological significance of new psychoactive substances in fatalities - Elliott S, Sedefov R, Evans-Brown M.
[Abstract unavailable] Language: en... (Source: SafetyLit)
Source: SafetyLit - June 26, 2017 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Cardiovascular Toxicity of Illicit Anabolic-Androgenic Steroids Cardiovascular Toxicity of Illicit Anabolic-Androgenic Steroids
How might long-term illicit use of anabolic-androgenic steroids contribute to cardiovascular disease?Circulation (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 26, 2017 Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news

Thwarting metastasis by breaking cancer's legs with gold rods
(Georgia Institute of Technology) Your cancer has metastasized. No one wants to ever hear that. Now researchers have developed a method to thwart cell migration and thus halt metastasis in vitro. In past tests in vivo, the treatment has wiped out tumors with no observable signs of toxicity or recurrence. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 26, 2017 Category: Cancer & Oncology Source Type: news

WINNING: Fluoride Action Network has forced U.S. courts to review fluoride toxicity in drinking water
(Natural News) Fluoride Action Network (FAN) filed a pivotal lawsuit in the U.S. District Court for the North District of California against the United States Environmental Protection Agency (EPA) as a rebuttal to the government agency’s denial of a petition that the non-government organization had issued under Section 21 of the Toxic Substances Control Act... (Source: NaturalNews.com)
Source: NaturalNews.com - June 25, 2017 Category: Consumer Health News Source Type: news

Extra-Virgin Olive Oil Protects Brain Tissue Against Alzheimer's In New Study
Science scores another win for olive oil: in an animal study, it protected brain tissue from the toxic substances thought to cause Alzheimer's disease (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - June 25, 2017 Category: Pharmaceuticals Authors: David DiSalvo, Contributor Source Type: news

Extra Virgin Olive Oil Protects Brain Tissue Against Alzheimer's In New Study
Science scores another win for olive oil: in an animal study, it protected brain tissue from the toxic substances thought to cause Alzheimer's disease (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - June 25, 2017 Category: Pharmaceuticals Authors: David DiSalvo, Contributor Source Type: news

Sleep Deprivation Is Killing You (And Making You Fat In The Process)
The next time you tell yourself that you'll sleep when you're dead, realize that you're making a decision that can make that day come much sooner. Pushing late into the night is a health and productivity killer. According to the Division of Sleep Medicine at the Harvard Medical School, the short-term productivity gains from skipping sleep to work are quickly washed away by the detrimental effects of sleep deprivation on your mood, ability to focus, and access to higher-level brain functions for days to come. The negative effects of sleep deprivation are so great that people who are drunk outperform those lacking sleep. Why...
Source: Healthy Living - The Huffington Post - June 24, 2017 Category: Consumer Health News Source Type: news

Scientists make water bottles the old-fashioned way to see if they were toxic to early Californians
If the ubiquity of pollutants in modern life has you yearning for the simpler ways of California ’s early residents, an unusual scientific experiment may prompt you to reconsider.After constructing water vessels using the methods of prehistoric people who lived on the Channel Islands, researchers... (Source: Los Angeles Times - Science)
Source: Los Angeles Times - Science - June 24, 2017 Category: Science Authors: Mira Abed Source Type: news

Chinese expert consensus on the medical measures for inhalation injury due to the poisoning smoke grenade explosion in 2017 - Division Of Poisoning And Treatment Chinese Society Of Toxicology, Meng Q, Qiu Z.
[Abstract unavailable] Language: zh... (Source: SafetyLit)
Source: SafetyLit - June 24, 2017 Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news