Balto and Togo during the cold winter of Alaska (1925): the two canine heroes in the fight against diphtheria.
In recent years, diphtheria has re-emerged in areas with inadequate vaccination coverage, and Europe has not been spared with several cases among migrants. Diphtheria is a potentially fatal infection caused mainly by toxigenic strains of Corynebacterium diphtheriae. Due to the high mortality rate, especially among young children, the fight against diphtheria is considered one of the first conquests of immunization. In the history of medicine, there is a unique case of an unconventional response to a diphtheria outbreak in which sled dogs were used to overcome the supply difficulties of diphtheria antitoxin. The mass media ...
Source: Journal of Preventive Medicine and Hygiene - April 15, 2024 Category: International Medicine & Public Health Authors: Omar Simonetti, Lavinia Cosimi, Marco Cigana, Mariano Martini, Stefano Di Bella, Arturo Penco Source Type: research
Epidemiological and virological surveillance of the prevention of mother-to-child transmission of HIV among pregnant women in Togo
In 2015, Togo introduced the “test-and-treat” strategy for the prevention of mother-to-child transmission (PMTCT) of HIV. Pediatric HIV infection remains a public health problem in Togo, with a mother-to-child... (Source: BMC Pregnancy and Childbirth)
Source: BMC Pregnancy and Childbirth - April 15, 2024 Category: OBGYN Authors: Kokou Tegueni, Fifonsi Adjidossi Gbeasor-Komlanvi, Oumarou I. Wone Adama, Arnold Junior Sadio, Amivi Phyllis Amenyah-Ehlan, Claver Anoumou Dagnra and Didier Koumavi Ekouevi Tags: Research Source Type: research
Decentralising DOT for drug-susceptible TB from the health facilities to the community level in Togo
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - April 3, 2024 Category: Respiratory Medicine Authors: Dogo, F.M. Ate, S. Agossou, K. Menon, S. Fiogb é, A.A. Akpadja, K. Adjoh, S.K. Veronese, V. Merle, C.S. Koura, K.G. Tags: ORIGINAL ARTICLES Source Type: research
Efficacy of artemether-lumefantrine and dihydroartemisinin-piperaquine and prevalence of molecular markers of anti-malarial drug resistance in children in Togo in 2021
This study assessed ... (Source: Malaria Journal)
Source: Malaria Journal - April 3, 2024 Category: Infectious Diseases Authors: Ameyo Monique Dorkenoo, Marian Warsame, Essoham Ataba, Manani Hemou, Kossi Yakpa, Efoe Sossou, M ’badi Mitigmsagou, Carmel Diwaba Teou, Emmanuelle Caspar, Laurence Ma, Koffi Edem Djadou, Tinah Atcha-Oubou, Charlotte Rasmussen and Didier Menard Tags: Research Source Type: research
Population-specific variations in < em > KCNH2 < /em > predispose patients to delayed ventricular repolarization upon dihydroartemisinin-piperaquine therapy
Antimicrob Agents Chemother. 2024 Mar 28:e0139023. doi: 10.1128/aac.01390-23. Online ahead of print.ABSTRACTDihydroartemisinin-piperaquine is efficacious for the treatment of uncomplicated malaria and its use is increasing globally. Despite the positive results in fighting malaria, inhibition of the Kv11.1 channel (hERG; encoded by the KCNH2 gene) by piperaquine has raised concerns about cardiac safety. Whether genetic factors could modulate the risk of piperaquine-mediated QT prolongations remained unclear. Here, we first profiled the genetic landscape of KCNH2 variability using data from 141,614 individuals. Overall, we ...
Source: Antimicrobial Agents and Chemotherapy - March 28, 2024 Category: Microbiology Authors: Mahamadou D Camara Yitian Zhou Antoine Dara Mamadou M T ékété Ta ís Nóbrega de Sousa S ékou Sissoko Laurent Demb élé Nouhoun Ouologuem Amadou Hamidou Togo Mohamed L Alhousseini Bakary Fofana Issaka Sagara Abdoulaye A Djimde Pedro J Gil Volker M La Source Type: research
Population-specific variations in < em > KCNH2 < /em > predispose patients to delayed ventricular repolarization upon dihydroartemisinin-piperaquine therapy
Antimicrob Agents Chemother. 2024 Mar 28:e0139023. doi: 10.1128/aac.01390-23. Online ahead of print.ABSTRACTDihydroartemisinin-piperaquine is efficacious for the treatment of uncomplicated malaria and its use is increasing globally. Despite the positive results in fighting malaria, inhibition of the Kv11.1 channel (hERG; encoded by the KCNH2 gene) by piperaquine has raised concerns about cardiac safety. Whether genetic factors could modulate the risk of piperaquine-mediated QT prolongations remained unclear. Here, we first profiled the genetic landscape of KCNH2 variability using data from 141,614 individuals. Overall, we ...
Source: Antimicrobial Agents and Chemotherapy - March 28, 2024 Category: Microbiology Authors: Mahamadou D Camara Yitian Zhou Antoine Dara Mamadou M T ékété Ta ís Nóbrega de Sousa S ékou Sissoko Laurent Demb élé Nouhoun Ouologuem Amadou Hamidou Togo Mohamed L Alhousseini Bakary Fofana Issaka Sagara Abdoulaye A Djimde Pedro J Gil Volker M La Source Type: research
Sheet-like interstitial cells connect epithelial and smooth muscle cells in the mouse prostate
Acta Histochem. 2024 Mar 13;126(3):152153. doi: 10.1016/j.acthis.2024.152153. Online ahead of print.ABSTRACTEpithelial-stromal relationship in the prostate gland is crucial for maintaining homeostasis, including functional differentiation, proliferation, and quiescence. Pathological stromal changes are believed to cause benign prostatic hyperplasia (BPH). The prostate stromal tissue is known to have several subtypes of interstitial cells that connect the epithelium and smooth muscle. However, the characteristics of their morphology and connection patterns are not fully understood. Therefore, we aimed to investigated the th...
Source: Acta Histochemica - March 14, 2024 Category: Biochemistry Authors: Yoshihiro Kawaguchi Keisuke Ohta Tasuku Hiroshige Kei-Ichiro Uemura Akinobu Togo Kei-Ichiro Nakamura Tsukasa Igawa Source Type: research
Sheet-like interstitial cells connect epithelial and smooth muscle cells in the mouse prostate
Acta Histochem. 2024 Mar 13;126(3):152153. doi: 10.1016/j.acthis.2024.152153. Online ahead of print.ABSTRACTEpithelial-stromal relationship in the prostate gland is crucial for maintaining homeostasis, including functional differentiation, proliferation, and quiescence. Pathological stromal changes are believed to cause benign prostatic hyperplasia (BPH). The prostate stromal tissue is known to have several subtypes of interstitial cells that connect the epithelium and smooth muscle. However, the characteristics of their morphology and connection patterns are not fully understood. Therefore, we aimed to investigated the th...
Source: Acta Histochemica - March 14, 2024 Category: Biochemistry Authors: Yoshihiro Kawaguchi Keisuke Ohta Tasuku Hiroshige Kei-Ichiro Uemura Akinobu Togo Kei-Ichiro Nakamura Tsukasa Igawa Source Type: research
Genomic characterization of SARS-CoV-2 in Guinea, West Africa
by Mamadou Saliou Sow, Josue Togo, Lacy M. Simons, Souleymane Taran Diallo, Mohamed Lamine Magassouba, Mamadou Bhoye Keita, Anou Moise Somboro, Youssouf Coulibaly, Egon A. Ozer, Judd F. Hultquist, Robert Leo Murphy, Almoustapha Issiaka Maiga, Mamoudou Maiga, Ramon Lorenzo-Redondo
SARS-CoV-2 has claimed several million lives since its emergence in late 2019. The ongoing evolution of the virus has resulted in the periodic emergence of new viral variants with distinct fitness advantages, including enhanced transmission and immune escape. While several SARS-CoV-2 variants of c oncern trace their origins back to the African co...
Source: PLoS One - March 6, 2024 Category: Biomedical Science Authors: Mamadou Saliou Sow Source Type: research
IDF23-0390 Predictive factors of diabetes complications in Haho health district, Togo, 2020 –2021
(Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - March 1, 2024 Category: Endocrinology Authors: E.M. Akara, A.A.M.E. Tchalla, T. Tchamdja Tags: Other Complications Source Type: research
IDF23-0118 Knowledge, Attitudes and Practices of Diabetic Patients on Ocular Complications of Diabetes in Lom é (Togo)
(Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - March 1, 2024 Category: Endocrinology Authors: K. Kodjo, M. Fotso, K. Klouvi, K. Djagadou Tags: Eye Complications Source Type: research
The hedonic overdrive model best explains high-fat diet-induced obesity in C57BL/6 mice
CONCLUSIONS: The hedonic overdrive model fit the data best. The other two models were not supported.PMID:38410048 | DOI:10.1002/oby.23991 (Source: Obesity)
Source: Obesity - February 27, 2024 Category: Eating Disorders & Weight Management Authors: Lin Gao Sumei Hu Dengbao Yang Lu Wang Jacques Togo Yingga Wu Baoguo Li Min Li Guanlin Wang Xueying Zhang Li Li Yanchao Xu Moshen Mazidi Elspeth Couper Andrew Whittington-Davies Chaoqun Niu John R Speakman Source Type: research
The hedonic overdrive model best explains high-fat diet-induced obesity in C57BL/6 mice
CONCLUSIONS: The hedonic overdrive model fit the data best. The other two models were not supported.PMID:38410048 | DOI:10.1002/oby.23991 (Source: Obesity)
Source: Obesity - February 27, 2024 Category: Eating Disorders & Weight Management Authors: Lin Gao Sumei Hu Dengbao Yang Lu Wang Jacques Togo Yingga Wu Baoguo Li Min Li Guanlin Wang Xueying Zhang Li Li Yanchao Xu Moshen Mazidi Elspeth Couper Andrew Whittington-Davies Chaoqun Niu John R Speakman Source Type: research
Intimate partner violence among women in Togo: a generalised structural equation modeling approach
Conclusion
IPV is a complex and multifactorial phenomenon in Togo. The Togo government as well as women’s human rights organisations should consider these factors when designing IPV programmes. (Source: BMJ Open)
Source: BMJ Open - February 19, 2024 Category: General Medicine Authors: Jean Simon, D., Kondo Tokpovi, V. C. Tags: Open access, Public health Source Type: research
Quality Assessment of Selected Essential Antimicrobial Drugs from Drug Retail Outlets of Selected Cities in Eastern Ethiopia
The objective of this study was to assess the quality of four commonly used antimicrobials marketed in the cities of Dire Dawa and Jijiga and the town of Togo-Wuchale, which have high potential for illegal drug trade activities in Ethiopia because they are located near the border with Somalia. A total of 54 brands/samples of amoxicillin, amoxicillin/clavulanic acid, ciprofloxacin, and norfloxacin formulations were collected covertly from 43 facilities using a convenience sampling strategy from March 16 to March 29, 2022. The samples were first screened using Global Pharma Health Fund (GPHF)-Minilab protocols and then analy...
Source: Am J Trop Med Hyg - February 13, 2024 Category: Infectious Diseases Authors: Hailu Anjulo Worku Birhane Ariaya Hymete Ayenew Ashenef Source Type: research
