Fight Aging! Newsletter, December 25th 2023
This study generates a comprehensive single-cell transcriptomic atlas of human atherosclerosis including 118,578 high-quality cells from atherosclerotic coronary and carotid arteries. By performing systematic benchmarking of integration methods, we mitigated data overcorrection while separating major cell lineages. Notably, we define cell subtypes that have not been previously identified from individual human atherosclerosis scRNA-seq studies.
Besides characterizing granular cell-type diversity and communication, we leverage this atlas to provide insights into smooth muscle cell (SMC) modulation. We integrate genome...
Source: Fight Aging! - December 24, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Growing Thyroid Tissue in the Spleen to Restore Function
Over the past decade or so, researchers have demonstrated that it is possible to use existing organs as bioreactors to host organoids derived from other organ tissues. Functional liver tissue can be grown in lymph nodes, as can thymus tissue. Here, researchers show that thyroid organoids can be grown in the spleen. This is intended to help patients who have undergone thyroidectomy, but will this capability also be useful in the context of the aging of the thyroid gland? Interestingly, the aging of the thyroid is poorly understood in comparison to the interaction of aging with larger organs such as liver, kidney, or heart. ...
Source: Fight Aging! - December 19, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Total thyroidectomy with fibrosis
This patient has had a total thyroidectomy for thyroid malignancy. Following extensive radiotherapy, there ' s fibrosis in the thyroid bed.Ultrasound images show empty thyroid fossa with extensive fibrosis. (Source: cochinblogs)
Source: cochinblogs - October 20, 2022 Category: Radiology Source Type: blogs
Fight Aging! Newsletter, March 29th 2021
Discussion of Systemic Inflammation and its Contribution to Dementia
Fisetin Reduces D-Galactose Induced Cognitive Loss in Mice
Reprogramming Cancer Cells into Normal Somatic Cells
Considering Longevity Medicine and the Education of Physicians
Researchers Generate Thyroid Organoids Capable of Restoring Function in Mice
In Search of Transcriptional Signatures of Aging
A Pace of Aging Biomarker Correlates with Manifestations of Aging
Targeting Tissues with Extracellular Vesicles
Calorie Restriction Slows Aging of the Gut Microbiome in Mice
Mitochondrial DNA Heteroplasmy in the Aging Heart
Evidence...
Source: Fight Aging! - March 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Researchers Generate Thyroid Organoids Capable of Restoring Function in Mice
When building functional organ tissue from the starting point of pluripotent stem cells, a different recipe is required for each different tissue type. Good progress is being made in establishing these recipes, and over the past decade the research community has steadily expanded the number of organs for which tissue engineered organoids can be constructed. An organoid is a millimeter-scale segment of functional organ tissue, only lacking the blood vessel network needed to support larger structures. Organoids are very useful in research, but in many cases can also be used to restore lost organ function when transplanted in...
Source: Fight Aging! - March 22, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Is there a role for surgery in treating Hashimoto ’s thyroiditis?
This study raises the possibility of a role for surgery for patients with Hashimoto’s thyroiditis who continue to feel poorly despite optimal treatment with thyroid hormone.
However, the study, while well done, is a relatively small one. We need longer-term follow up and confirmation with additional studies done on diverse populations.
It’s also important to consider that thyroid surgery in patients with advanced Hashimoto’s thyroiditis is difficult. Rates of complications, including injury to the laryngeal nerve (which controls voice) and the parathyroid glands (which maintain normal blood calcium levels), are incre...
Source: Harvard Health Blog - August 12, 2019 Category: Consumer Health News Authors: Jeffrey Garber, MD, FACP, FACE Tags: Health Thyroid Disorders Source Type: blogs
MKSAP: 34-year-old man with episodic palpitations
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
A 34-year-old man is evaluated for episodic palpitations of 8 months’ duration. The palpitations last 5 to 10 minutes and then resolve spontaneously. They are usually associated with sweating and anxiety. Medical history is significant for thyroidectomy for medullary thyroid carcinoma diagnosed at 12 years of age. His father has also undergone thyroidectomy for medullary thyroid cancer. His only medication is levothyroxine.
On physical examination, blood pressure is 164/92 mm Hg, pulse rate is 106/min, and...
Source: Kevin, M.D. - Medical Weblog - July 29, 2017 Category: General Medicine Authors: < a href="http://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Endocrinology Source Type: blogs
Are we practicing medical misogyny?
When it comes to cancer, I’m neither physician nor patient, nor even a policy expert. But being both a critical thinker and a feminist, I’m struck by what the juxtaposition of two seemingly unrelated new oncology studies, published in highly respected medical journals a month apart, can tell us about how gender shapes the way we perceive (or misperceive) illness, and the impact that has on patients’ well-being.
On April 14, JAMA Oncology published “Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma.” Although the title may be nearly impenetrable to the...
Source: Kevin, M.D. - Medical Weblog - May 6, 2016 Category: Journals (General) Authors: Lois Leveen, PhD Tags: Conditions Cancer Source Type: blogs
Sayer Ji: Willfully misunderstanding overdiagnosis and misdiagnosis since…forever
If there’s one lesson that I like to emphasize while laying down my near-daily dose of Insolence, both Respectful and not-so-Respectful, it’s that practicing medicine and surgery is complicated. Part of the reason that it’s complicated is that for many diseases our understanding is incomplete, meaning that physicians have to apply existing science to their… (Source: Respectful Insolence)
Source: Respectful Insolence - May 2, 2016 Category: Surgery Authors: Orac Tags: Cancer Complementary and alternative medicine Quackery Skepticism/critical thinking lobectomy misdiagnosis overdiagnosis Sayer Ji screening thyroid cancer thyroidectomy Yuri E. Nikiforov Source Type: blogs
What’s better than gluten-free? GRAIN-free!
Heather learned the hard way that thinking about food from the “gluten-free” perspective can impair health and lead you down some needless detours.
“The first picture was taken about six months ago. I have stage 3 adrenal fatigue, and had a total thyroidectomy nearly two years ago due to a multi-nodular goiter. It’s been a very long journey to wellness, and I’m fortunate enough to have a wonderful osteopathic physician helping me along. He was the one who suggested your book to me. I finally got around to reading it shortly after Christmas, and started the diet a little over two months ago.
...
Source: Wheat Belly Blog - March 27, 2015 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Success Stories gluten goiter grains Weight Loss Source Type: blogs
If It’s Not Your Heart or Your Age, It Could Be Your Thyroid
If your heart starts pounding and skipping beats what is your first thought? For Mary M., 49, it was, “Oh No! Is this a heart attack? Is it heart arrhythmia? I know my mother has an irregular heartbeat and my grandmother died from a stroke. Is it my turn?” So, off she went to the doctor. Her pounding heart had been waking her up at night and she was ready for the diagnosis and sat pretty calmly through the EKG test. Her mother took heart medication, exercised and watched her diet so she knew how to handle it. When the doctor returned to the room and told her “Your heart looks fine and your heart rate is...
Source: Disruptive Women in Health Care - January 15, 2015 Category: Consumer Health News Authors: dw at disruptivewomen.net Tags: Women's Health Source Type: blogs
Amiodarone and thyroid dysfunction
Brief Review
Amiodarone is one of the most widely used anti arrhythmic drug. It is well known that amiodarone can induce both hypothyroidism and hyperthyroidism due to the iodine content of the drug. 200 milligrams of amiodarone daily would deliver twenty to forty times the usual daily iodine intake. Amiodarone reduces 5-deiodinase activity and thereby the monodeiodination of T4 to T3. There is decreased generation of T3 and reduced clearance of rT3 (reverse T3), which accumulates. Destructive thyroiditis is due to the direct toxic effect of amiodarone and its metabolite on the thyroid follicular cells.1
It has been menti...
Source: Cardiophile MD - December 21, 2014 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: General Cardiology Source Type: blogs
Thyroid cancer and life with out a thyroid
A pop quiz: What does your thyroid do anyway?Something to do with weight.Some weird gland thing that we all have but doesn't do much.I have no idea.The master gland of metabolism and energy.If you answered #4 you get a gold star. If you answered any of the others, you are not that different from the average person.The thyroid is our master gland of metabolism and energy. Every single body function that requires oxygen and energy -- basically, everything that goes on in our bodies! -- requires thyroid hormone in proper amounts. That means we need the proper balance of thyroid hormone in order to feel and live well. We ...
Source: Caroline's Breast Cancer Blog - February 25, 2014 Category: Cancer Tags: chronic thyroid cancer Source Type: blogs
They did it again
I hate it when this happens. A medical standard protocol is decided to be not good and may cause long term harm. I find it frustrating. I go to the doctor and get the best care I can. I do my part to cooperate and take my pills or whatever is decided is best.Then they change their minds.For many years, TSH (Thyroid Stimulating Hormone) was suppressed as much as possible - to barely traceable levels - maybe 0.3 or 0.4 whatever thingys they measure by. The theory was to keep it as low as possible to prevent possible recurrence of thyroid cancer.Now they say keeping it that low doesn't provide additional benefit in preventing...
Source: Caroline's Breast Cancer Blog - October 22, 2013 Category: Cancer Tags: cancer treatment thyroid cancer osteoporosis side effects Source Type: blogs
Levoxyl Shortage for Thyroid Patients
I recently tried to refill my prescription for Levoxyl and learned I cannot due to a recall by the manufacturer Pfizer. I called Pfizer this morning and spoke to a robotic, though pleasant, customer service representative in India. She provided little useful information. Between my own research on the FDA and American Thyroid Association websites I learned the following:
* Pfizer has suspended production of Levoxyl, which is manufactured at a plant in Tennessee. Chemical contamination is the reason for suspended production. Emission of a strong odor was reported by pharmacists when opening 100 and 1000 ta...
Source: Everything Changes - May 9, 2013 Category: Cancer Authors: Kairol Rosenthal Tags: Uncategorized thyroid cancer levoxyl papillary carcinoma synthroid Source Type: blogs
