Voltammetric study of triazole antifungal agent terconazole on sp3 and sp2 carbon-based electrode materials
Publication date: Available online 10 March 2020Source: Journal of Electroanalytical ChemistryAuthor(s): Jan Fischer, Javier González-Martín, Pawel Lochyński, Hana Dejmková, Karolina Schwarzová-Pecková, Marisol Vega (Source: Journal of Electroanalytical Chemistry)
Source: Journal of Electroanalytical Chemistry - March 11, 2020 Category: Chemistry Source Type: research

Novel application of pentabromobenzyl column for simultaneous determination of eight antifungal drugs using high-performance liquid chromatography.
CONCLUSION: This proposed method was validated in term of linearity, limit of quantification ,limit of detection, accuracy, percision and selectivity. The method was successfully applied for the determination of these drugs in their pharmaceutical formulations and in human plasma samples. PMID: 32077818 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - February 19, 2020 Category: Chemistry Authors: Abou El-Alamin MM, Sultan MA, Atia MA, Aboul-Enein HY Tags: Comb Chem High Throughput Screen Source Type: research

Antifungal residues analysis in various Romanian honey samples analysis by high resolution mass spectrometry.
Abstract Given that the pesticide and fungicide residues determination in honey is not a routine analysis in Romania, information on these emerging contaminants is useful for consumer's safety. High resolution mass spectrometry technique was applied by Q-Exactive Orbitrap LC-MS/MS to identify and quantify environmental contaminants in honey. A list of 25 compounds, biocides and antifungals was selected for the method development, based on the occurrence in the Romanian environment and their potential usage in agriculture. The method was applied for 18 various honey samples collected in different geographic regions...
Source: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes - February 5, 2020 Category: Environmental Health Authors: Blaga GV, Chițescu CL, Lisă EL, Dumitru C, Vizireanu C, Borda D Tags: J Environ Sci Health B Source Type: research

Efficacy of ketoconazole gel-flakes in treatment of vaginal candidiasis: Formulation, in vitro and clinical evaluation
In conclusion, flakes in situ gel could be considered as a highly promising KTZ delivery option for treatment of vaginal candidiasis.Graphical abstract (Source: International Journal of Pharmaceutics)
Source: International Journal of Pharmaceutics - June 26, 2019 Category: Drugs & Pharmacology Source Type: research

Lecithin Microemulsion Lipogels Versus Conventional Gels for Skin Targeting of Terconazole: In Vitro, Ex Vivo, and In Vivo Investigation.
Abstract Topical treatment of fungal infections has several superiorities over oral treatment. However, the greatest challenge for dermal delivery is the stratum corneum which is considered an effective barrier for penetration of most antifungal drugs into deeper skin layers. Terconazole (Tr), which is the first marketed triazole antifungal, was reported to be one of the most active azoles against vaginal candidiasis. Nevertheless, our work group is the first to investigate the potential of Tr in the treatment of skin mycosis via integration into lecithin microemulsion-based lipogels (LMBGs). The microemulsion reg...
Source: AAPS PharmSciTech - April 10, 2019 Category: Drugs & Pharmacology Authors: Talaat SM, Elnaggar YSR, Abdalla OY Tags: AAPS PharmSciTech Source Type: research

Development of a stability-indicating UPLC method for terconazole and characterization of the acidic and oxidative degradation products by UPLC-Q-TOF/MS/MS and NMR
New J. Chem., 2018, Advance Article DOI: 10.1039/C8NJ00509E, PaperBalasaheb B. Chavan, G. Lakshmi Prasanna, P. Radhakrishnanand, Eswara Raju Kosuri, Pradipbhai D. Kalariya, M. V. N. Kumar Talluri Terconazole, a triazole antifungal drug, is used to treat infections in the form of a cream or suppositories. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - May 31, 2018 Category: Chemistry Authors: Balasaheb B. Chavan Source Type: research

Development of stability indicating UPLC method for terconazole and characterization of acidic and oxidative degradation products by UPLC-Q-TOF/MS/MS and NMR
New J. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8NJ00509E, PaperBalasaheb B. Chavan, Lakshmi Prasannaa G., P Radhakrishnanand, Eswara raju kosuri, Pradipbhai D Kalariya, M V Narendra Kumar Talluri Terconazole, a triazole antifungal drug is used to treat infections in the form of cream or suppositories. A simple, rapid, precise and accurate ultra high performance liquid chromatography method has... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - May 23, 2018 Category: Chemistry Authors: Balasaheb B. Chavan Source Type: research

Time-Kill Kinetics of Rezafungin (CD101) in Vagina-Simulative Medium for Fluconazole-Susceptible and Fluconazole-Resistant Candida albicans and Non-albicans Candida Species.
Conclusion: Rezafungin retained anti-Candida activity and fungicidal activity under in vitro conditions relevant to VVC. PMID: 29681727 [PubMed - in process] (Source: Infectious Diseases in Obstetrics and Gynecology)
Source: Infectious Diseases in Obstetrics and Gynecology - April 25, 2018 Category: OBGYN Tags: Infect Dis Obstet Gynecol Source Type: research

Reduced Antifungal Susceptibility of Vulvovaginal Candida Species at Normal Vaginal pH Levels: Clinical Implications
Conclusions Antifungals have reduced in vitro potency when tested at lower pH. Candida glabrata is more affected than C. albicans. The impact may be greatest for the antifungal terconazole and against C. glabrata isolates. (Source: Journal of Lower Genital Tract Disease)
Source: Journal of Lower Genital Tract Disease - March 24, 2018 Category: OBGYN Tags: Original Research Articles: Vagina and Vulva Source Type: research

Formulation and in vivo assessment of terconazole-loaded polymeric mixed micelles enriched with Cremophor EL as dual functioning mediator for augmenting physical stability and skin delivery.
Authors: Abd-Elsalam WH, El-Zahaby SA, Al-Mahallawi AM Abstract The aim of the current study was to formulate terconazole (TCZ) loaded polymeric mixed micelles (PMMs) incorporating Cremophor EL as a stabilizer and a penetration enhancer. A 23 full factorial design was performed using Design-Expert® software for the optimization of the PMMs which were formulated using Pluronic P123 and Pluronic F127 together with Cremophor EL. To confirm the role of Cremophor EL, PMMs formulation lacking Cremophor EL was prepared for the purpose of comparison. Results showed that the optimal PMMs formulation (F7, where the ratio...
Source: Drug Delivery - February 8, 2018 Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research

Micellar liquid chromatographic determination of sertaconazole and terconazole in bulk, pharmaceutical dosage forms and spiked human plasma
Publication date: June 2014 Source:Bulletin of Faculty of Pharmacy, Cairo University, Volume 52, Issue 1 Author(s): Mohamed Rizk , Safaa S. Toubar , Maha M.A. El-Alamin , Marwa M.M. Azab A micellar liquid chromatographic method was developed for the determination of sertaconazole and terconazole in bulk, dosage forms and human plasma using intersil cyano column and mobile phase consisting of 0.1M sodium dodecyl sulphate, 20% 1-propanol, and 0.3% triethylamine in 0.02M ortho-phosphoric acid (pH 4) at 225nm. Different chromatographic parameters were studied, e.g. types of columns, pH of mobile phase, concentration of sodiu...
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 13, 2014 Category: Drugs & Pharmacology Source Type: research

Allergic contact dermatitis of the vulva.
CONCLUSIONS: Allergic contact dermatitis is a frequent finding in patients presenting with vulvar symptoms. We identified a relevant positive result to patch testing in 39%. We found fragrances, medicaments, and preservatives to be of most relevance. PMID: 23474446 [PubMed - in process] (Source: Dermatitis)
Source: Dermatitis - March 1, 2013 Category: Dermatology Authors: O'Gorman SM, Torgerson RR Tags: Dermatitis Source Type: research