PLGA-modified Syloid < sup > ® < /sup > -based microparticles for the ocular delivery of terconazole: in-vitro and in-vivo investigations
Drug Deliv. 2022 Dec;29(1):2117-2129. doi: 10.1080/10717544.2022.2092239.ABSTRACTThe eye is an invulnerable organ with intrinsic anatomical and physiological barriers, hindering the development of a pioneer ocular formulation. The aim of this work was to develop an efficient ocular delivery system that can augment the ocular bioavailability of the antifungal drug, terconazole. Mesoporous silica microparticles, Syloid® 244 FP were utilized as the carrier system for terconazole. Preliminary studies were carried out using different drug:Syloid® weight ratios. The optimum weight ratio was mixed with various concentrations (3...
Source: Drug Delivery - July 15, 2022 Category: Drugs & Pharmacology Authors: Nada Zaghloul Azza A Mahmoud Nermeen A Elkasabgy Nada M El Hoffy Source Type: research

Development of bifunctional vaginal suppositories by joint use terconazole and probiotic for treatment and prophylaxis of vulvovaginal candidiasis
CONCLUSIONS: Due to its physicochemical, biopharmaceutical and bioadhesive properties the base Suppocire AP is preferable for manufacturing vaginal bifunctional suppositories. Lactobacilli kill C. albicans by coaggregating and direct releasing hydrogen peroxide onto target cells.PMID:34726986 | DOI:10.1080/03639045.2021.2001485 (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - November 2, 2021 Category: Drugs & Pharmacology Authors: Maria M Pashayan Hrachya G Hovhannisyan Source Type: research

Ibrexafungerp (Brexafemme) for Vulvovaginal Candidiasis
Date: September 6, 2021 Issue #:  1632Summary:  The FDA has approved ibrexafungerp (Brexafemme– Scynexis), a first-in-class triterpenoid antifungal ( " fungerp " ), for oral treatment of vulvovaginal candidiasis in postmenarchal females. (Source: The Medical Letter)
Source: The Medical Letter - August 10, 2021 Category: Drugs & Pharmacology Authors: admin Tags: Brexafemme Butoconazole Canesten Clotrimazole Diflucan Fluconazole Gynazole Gyne-Lotrimin ibrexafungerp Monistat terconazole Tioconazole Vagistat Vulvovaginal candidiasis Source Type: research

Chills, fatigue, chest distress, and an abnormal increase in WBC, neutrophil, CRP, and PCT induced by terconazole: A case report
Int J Clin Pharmacol Ther. 2021 Apr 16. doi: 10.5414/CP203916. Online ahead of print.ABSTRACTThe vaginal routes of administration of terconazole, a synthetic triazole derivative, is widely used by patients with uncomplicated vulvovaginal candidiasis (VVC). A 32-year-old woman suffered from chills, fatigue, and chest distress after receiving one 80-mg terconazole vaginal suppository for the treatment of uncomplicated VVC. Then, the symptom persisted for 10 hours until the residue of terconazole was removed, and the vagina was repeatedly washed with iodophor. In addition, white blood cell (WBC), neutrophil, C-reactive protei...
Source: Clinical Pharmacology and Therapeutics - April 16, 2021 Category: Drugs & Pharmacology Authors: Xuemei Li Xiaohong Yang Kejing Wang Lin Chen Source Type: research

Chills, fatigue, chest distress, and an abnormal increase in WBC, neutrophil, CRP, and PCT induced by terconazole: A case report
Int J Clin Pharmacol Ther. 2021 Apr 16. doi: 10.5414/CP203916. Online ahead of print.ABSTRACTThe vaginal routes of administration of terconazole, a synthetic triazole derivative, is widely used by patients with uncomplicated vulvovaginal candidiasis (VVC). A 32-year-old woman suffered from chills, fatigue, and chest distress after receiving one 80-mg terconazole vaginal suppository for the treatment of uncomplicated VVC. Then, the symptom persisted for 10 hours until the residue of terconazole was removed, and the vagina was repeatedly washed with iodophor. In addition, white blood cell (WBC), neutrophil, C-reactive protei...
Source: International Journal of Clinical Pharmacology and Therapeutics - April 16, 2021 Category: Drugs & Pharmacology Authors: Xuemei Li Xiaohong Yang Kejing Wang Lin Chen Source Type: research

Chills, fatigue, chest distress, and an abnormal increase in WBC, neutrophil, CRP, and PCT induced by terconazole: A case report
Int J Clin Pharmacol Ther. 2021 Apr 16. doi: 10.5414/CP203916. Online ahead of print.ABSTRACTThe vaginal routes of administration of terconazole, a synthetic triazole derivative, is widely used by patients with uncomplicated vulvovaginal candidiasis (VVC). A 32-year-old woman suffered from chills, fatigue, and chest distress after receiving one 80-mg terconazole vaginal suppository for the treatment of uncomplicated VVC. Then, the symptom persisted for 10 hours until the residue of terconazole was removed, and the vagina was repeatedly washed with iodophor. In addition, white blood cell (WBC), neutrophil, C-reactive protei...
Source: Clinical Pharmacology and Therapeutics - April 16, 2021 Category: Drugs & Pharmacology Authors: Xuemei Li Xiaohong Yang Kejing Wang Lin Chen Source Type: research

Chills, fatigue, chest distress, and an abnormal increase in WBC, neutrophil, CRP, and PCT induced by terconazole: A case report
Int J Clin Pharmacol Ther. 2021 Apr 16. doi: 10.5414/CP203916. Online ahead of print.ABSTRACTThe vaginal routes of administration of terconazole, a synthetic triazole derivative, is widely used by patients with uncomplicated vulvovaginal candidiasis (VVC). A 32-year-old woman suffered from chills, fatigue, and chest distress after receiving one 80-mg terconazole vaginal suppository for the treatment of uncomplicated VVC. Then, the symptom persisted for 10 hours until the residue of terconazole was removed, and the vagina was repeatedly washed with iodophor. In addition, white blood cell (WBC), neutrophil, C-reactive protei...
Source: International Journal of Clinical Pharmacology and Therapeutics - April 16, 2021 Category: Drugs & Pharmacology Authors: Xuemei Li Xiaohong Yang Kejing Wang Lin Chen Source Type: research