Analysis of a mouse germ cell tumor model establishes pluripotency-associated miRNAs as conserved serum biomarkers for germ cell cancer detection
bioRxiv. 2023 Sep 12:2023.09.09.556995. doi: 10.1101/2023.09.09.556995. Preprint.ABSTRACTMalignant testicular germ cells tumors (TGCTs) are the most common solid cancers in young men. Current TGCT diagnostics include conventional serum protein markers, but these lack the sensitivity and specificity to serve as accurate markers across all TGCT subtypes. MicroRNAs (miRNAs) are small non-coding regulatory RNAs and informative biomarkers for several diseases. In humans, miRNAs of the miR-371-373 cluster are detectable in the serum of patients with malignant TGCTs and outperform existing serum protein markers for both initial d...
Source: Cancer Control - September 25, 2023 Category: Cancer & Oncology Authors: Amanda R Loehr Dennis M Timmerman Michelle Liu Ad J M Gillis Melia Matthews Jordana C Bloom Peter K Nicholls David C Page Andrew D Miller Leendert H J Looijenga Robert S Weiss Source Type: research
Histopathologic Patterns of Ovarian Tumors in Hawassa University Comprehensive Specialized Hospital, Southern Ethiopia
CONCLUSION: In the current study, surface epithelial tumors were the most common ovarian tumors followed by germ cell tumors. Younger age at presentation was observed for malignant ovarian tumors.PMID:37744161 | PMC:PMC10513869 | DOI:10.1155/2023/2803201 (Source: Journal of Oncology)
Source: Journal of Oncology - September 25, 2023 Category: Cancer & Oncology Authors: Tibebu Amare Abena Fekade Yerakly Tesfalem Korga Source Type: research
