Fight Aging! Newsletter, January 3rd 2022
In this study, we showed that the iPaD (inducing Plagl2 and anti-Dyrk1a) lentivirus substantially rejuvenated the proliferative and neurogenic potential of NSCs in the aged brain. Clonal analysis by a sparse labeling approach as well as transcriptome analysis indicated that iPaD can rejuvenate aged NSCs (19-21 mo of age) to a level comparable with those at 1 or 2 months of age and successfully improved cognition of aged mice.
Once rejuvenated and activated by iPaD, aged dormant NSCs can generate, on average, 4.9 neurons but very few astrocytes in 3-week tracing. Furthermore, these activated NSCs were maintained for ...
Source: Fight Aging! - January 2, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Look Back at 2021: Progress Towards the Treatment of Aging as a Medical Condition
Well, here we are again, at the end of another pandemic year, a year older and - hopefully - a year wiser and more knowledgeable. I said all that really needs to be said on the topic of COVID-19 as an age-related condition at the end of last year. We might hope that, given widespread vaccination, the pandemic will become a topic of diminishing importance as the year ahead progresses, even given the present round of variants, fears, and reintroduction of restrictions.
Advocacy for Aging Research
Have we finally made significant progress in convincing the world that aging is the cause of age-related disease, th...
Source: Fight Aging! - December 31, 2021 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
Fight Aging! Newsletter, June 28th 2021
In conclusion, in our prospective community-based study, aging-related biomarkers were associated with measures of subclinical atherosclerosis cross-sectionally and with all-cause mortality prospectively, supporting the concept that these biomarkers may reflect the aging process in community-dwelling adults.
The Role of Aging Macrophages in Skin Inflammation
https://www.fightaging.org/archives/2021/06/the-role-of-aging-macrophages-in-skin-inflammation/
The immune system is complex and ages in complex ways, pressed by the lifetime burden of infection and rising levels of molecular damage that trigger man...
Source: Fight Aging! - June 27, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Senolytic Therapy Alleviates Temporomandibular Joint Degeneration in Old Mice
Senescent cell accumulation appears to be a major player in the pathology of most of the joint-related issues that occur in older individuals. Senescent cells secrete signals that provoke a state of chronic inflammation, alter nearby cell behavior, and disrupt tissue structure and maintenance. Clearance of these cells reverses numerous age-related conditions and measures of aging in mice. Hence the advent of senolytic therapies that selectively destroy senescent cells is a much anticipated development in medicine. Indeed, the first such therapies are pre-existing drugs, such as the dasatinib and quercetin combination, are ...
Source: Fight Aging! - June 21, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Podcast: There ’s More to Trauma than PTSD
Most of us are familiar with post-traumatic stress disorder. PTSD (deservedly) gets a lot of attention, largely focused on soldiers returning from service. But trauma comes in many forms, and most people have experienced it in one form or another. In this episode, learn about the differences between PTSD and other forms of trauma, how to identify it, and what can be done about it.
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About Our Guest
Robert T. Muller, Ph.D., is the author of the psychotherapy book, “Trauma & the Struggle to Open Up: From Avoidance to Recovery & Gro...
Source: World of Psychology - April 18, 2019 Category: Psychiatry & Psychology Authors: The Psych Central Show Tags: General PTSD The Psych Central Show Trauma Gabe Howard Vincent M. Wales Source Type: blogs
The Enigmatic Ganglion Cyst
Ganglion cysts are soft tissue, fluid-filled swellings most frequently found in the hand and wrist; their origin is not exactly clear. They are common, however, and can occasionally be associated with surprising morbidity despite their benign nature. The morbidity seems to be related to their tendency to localize in highly mobile and anatomically tight quarters such as the hand and wrist. Nevertheless, they can show up almost anywhere.Cysts can also have sequelae, such as sciatica from a piriformis ganglionic cyst, compression radiculopathy from a lumbar intraspinal ganglion cyst, foot drop from peroneal nerve cyst, met...
Source: M2E Too! Mellick's Multimedia EduBlog - April 1, 2019 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
Grown Cartilage Used to Fix Diseased Joints Responsible for TMJ Dysfunction
Temporomandibular joint dysfunction (TMJ) is a condition which makes it difficult to chew on food and talk, while being quite painful and unpleasant. It’s caused by the breakdown of the cartilage disc that brings together two bones of the jaw.
Researchers from University of California, Irvine, University of California, Davis, and The University of Texas School of Dentistry at Houston have now developed a way of taking tissue from a rib of one animal, separating out cartilage cells, and then used those cells to grow a new replacement cartilage that can be implanted into another animal. By the way, this is because tr...
Source: Medgadget - June 21, 2018 Category: Medical Devices Authors: Editors Tags: ENT Genetics Orthopedic Surgery Source Type: blogs
MKSAP: 82-year-old woman with left-sided headaches
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
An 82-year-old woman is evaluated for a 2-week history of left-sided headaches with pain on chewing, accompanied by achiness in the shoulders and hips. She has no other pertinent personal or family history. She takes no medications.
On physical examination, temperature is 38.1 °C (100.6 °F), blood pressure is 132/86 mm Hg, pulse rate is 88/min, and respiration rate is 18/min. BMI is 25. Eye examination is normal. There are tenderness and swelling over the left temporal area. Moderate to severe pain on range of...
Source: Kevin, M.D. - Medical Weblog - February 17, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Rheumatology Source Type: blogs
HYPERMOBILITY CARTOON: In which I come unhinged — again
I have severe Joint Hypermobility Disorder. I dislocated my jaw chewing on a piece of baguette. I walked a couple blocks to the dentist, did the new patient registration, and they advised me to go to A&E [Accident & Emergency]. So my husband picked me up, and four hours later my jaw had been clicked […] (Source: Andrea's Buzzing About:)
Source: Andrea's Buzzing About: - December 4, 2017 Category: Disability Authors: andrea Tags: Ehlers-Danlos Syndrome Hypermobility TMJ (Temporomandibular Joint Disorder) Source Type: blogs
Unlocking the lock jaw: Temporomandibular Joint (TMJ) dysfunction
The temporomandibular joint (TMJ) is one of the most heavily utilized and underappreciated joints in the human body. Mechanically, the TMJ is what allows you to open and close your mouth, and to a lesser extent, extend and move your jaw from side to side. Functionally, it facilitates eating, talking, and facial expressions. Without a TMJ, McGruff the crime dog would not be able to “Take a bite out of crime,” and Jaws would have never become a savage predatory superstar of the deep blue sea. Just kidding. We all know from “Shark Week” that sharks do not actually have a TMJ, but you get the idea.
Structurally, the ...
Source: Harvard Health Blog - February 22, 2017 Category: Consumer Health News Authors: Paul G. Mathew, MD, FAAN, FAHS Tags: Dental Health Headache Pain Management Source Type: blogs
Opioid Induced Hyperalgesia Prevented by Buprenorphine?
“Buprenorphine is a kappa receptor antagonist. For these reasons, buprenorphine might be unique in its ability to treat chronic pain and possibly OIH.”
The opioid crisis has been fueled by the use of opioids to treat chronic pain. Practice patterns have changed, but doctors are still criticized for their roles in the overuse of opioids. I’ve sat through community ‘heroin forums’ (sometimes on stage) as sheriffs, politicians, and ‘recovered addicts’ firmly pointed fingers at health professionals. I, meanwhile, kept my finger under the table, but had the thought that some of the people pointing ...
Source: Suboxone Talk Zone - February 5, 2017 Category: Addiction Authors: Jeffrey Junig MD PhD Tags: Acute Pain Buprenorphine Chronic pain Suboxone treatment buprenorphine treats chronic pain chronic pain treatment opioid induced hyperalgesia opioid pain relief pain vs. addiction Source Type: blogs
Top stories in health and medicine, April 27, 2015
From MedPage Today:
Delaying HCV Tx Reduces Likelihood of Eradication. Delaying treatment of hepatitis C virus infection markedly increased the risk of not being able to clear the virus in these patients.
Paying Residents to Keep Stroke Patients Safe. A team of resident watchdogs and a simple checklist helps one hospital system improve safety for stroke patients.
Point/Counterpoint: What’s Next for Homeopathy. The FDA held a 2-day hearing this week to gather opinion on homeopathy and the degree to which the agency should regulate it. This came after the FDA had warned consumers away from over-the-counter homeopathi...
Source: Kevin, M.D. - Medical Weblog - April 27, 2015 Category: Journals (General) Authors: MedPage Today Tags: News GI Neurology Specialist Source Type: blogs
Sue is young again following Wheat Belly!
Look at Sue’s wonderful Wheat Belly transformation, along with her description of the joint pains she reversed:
“Your book has changed my life. After one week of being wheat-free, my TMJ [temporomandibular joint pain] was gone, my sore knee was gone, and my neck and joints were no longer stiff, sore, and inflamed. My belly went away in 2 weeks. And I have been able to play tennis four days a week instead of one.
“My husband’s cholesterol went from 270 to 130. I am a true believer and have referred so many friends to read your book. I feel 20 years younger and am 40 lbs lighter.”
Doesn’t...
Source: Wheat Belly Blog - March 26, 2015 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Success Stories acid reflux cholesterol gluten grains joint pain TMJ Weight Loss william davis Source Type: blogs
Working on Bone Tissue Engineering
In the field of tissue engineering at present the work on simpler tissues and smaller tissue sections is the closest to widespread commercial realization. Most of the leading lines of research and development involve the use of decellularization, in which donor tissue, which can be from a different species, is stripped of its cells leaving behind the intricate structure of the extracellular matrix. That acts as a scaffold to guide repopulation with cells grown from a patient sample, producing functional tissue ready for transplantation. Here is a short interview with a tissue engineer working on the generation of bone sect...
Source: Fight Aging! - December 8, 2014 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Research and Reviews in the Fastlane 052
This study looked at compliance with discharge instructions. Surprisingly (or maybe not so), 39% of pediatric patients returned to play (RTP) on the day of the injury. RTP is widely recognized as a risk for recurrent and more severe concussions as well as significant morbidity. It is the duty of the Emergency Physician to stress the importance of discharge instructions as well as the importance of appropriate follow up.
Recommended by: Anand Swaminathan
PediatricsSingleton T et al. Emergency department care for patients with hemophilia and von Willebrand disease. J Emerg Med. 2010; 39(2): 158-65. PMID: 18757163
Bleeding...
Source: Life in the Fast Lane - October 9, 2014 Category: Emergency Medicine Authors: Nudrat Rashid Tags: Administration Anaesthetics Cardiology Clinical Research Education Emergency Medicine Haematology Infectious Disease Intensive Care International Emergency Medicine Microbiology Neurosurgery Obstetrics / Gynecology Ophthalmology Source Type: blogs
