Q & A on the investigational vaccine candidate M72/AS01E
M72/AS01E is a subunit vaccine comprised of an immunogenic fusion protein (M72) derived from two Mycobacterium tuberculosis (M.tb) antigens (MTB32A and MTB39A), and the GlaxoSmithKline (GSK) proprietary adjuvant AS01E. AS01E is the same adjuvant used in Shingrix GSK vaccine, as well as in the new malaria vaccine RTS,S/AS01E. The M72/AS01E vaccine candidate is being developed by the pharmaceutical company GlaxoSmithKline, in partnership with AERAS. AERAS is a not for profit organization based in the US, aimed at supporting tuberculosis vaccine research, funded by the Bill and Melinda Gates foundation, the UK Department for...
Source: WHO Feature Stories - October 10, 2018 Category: International Medicine & Public Health Tags: tuberculosis [subject], tb Source Type: news

BCG vaccine may reduce blood sugar in type-1 diabetics
Research, presented at the European Association for the Study of Diabetes conference, suggests that the bacillus Calmette-Guerin vaccine is effective at reducing blood sugar levels in people with type-1 diabetes.MedicalXpress (Source: Society for Endocrinology)
Source: Society for Endocrinology - October 5, 2018 Category: Endocrinology Source Type: news

Uganda:Ugandan Medic Develops New TB Vaccine for Adults
[Monitor] Kampala -A Ugandan medical doctor, Dr Jacqueline Akite, together with a team of other international scientists have registered landmark success by developing a new vaccine that stops the spread of pulmonary tuberculosis (TB) in adults. (Source: AllAfrica News: Tuberculosis)
Source: AllAfrica News: Tuberculosis - September 28, 2018 Category: Infectious Diseases Source Type: news

TB vaccine shows promise against diabetes
For Hodalis Gaytan, 20, living with Type 1 diabetes means depending on an assortment of expensive medicines and devices to stay healthy. Test strips. Needles. A glucose meter. Insulin. (Source: CNN.com - Health)
Source: CNN.com - Health - July 12, 2018 Category: Consumer Health News Source Type: news

Mixed Results with TB Vaccines in Trial
(MedPage Today) -- No difference for initial infection, but reduced rates of sustained QFT conversions versus placebo (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - July 11, 2018 Category: American Health Source Type: news

NEJM publishes final results from phase two study showing vaccines can reduce rate of sustained TB infections
(Burness) Aeras, a nonprofit organization dedicated to developing vaccines against tuberculosis (TB), today announced the publication of the full results from a Phase 2, randomized, controlled clinical trial of two TB vaccines-- the currently available BCG vaccine and an investigational vaccine, H4:IC31--in the New England Journal of Medicine (NEJM). (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - July 11, 2018 Category: Infectious Diseases Source Type: news

Nigeria:BCG Can Reverse Type 1 Diabetes to Almost Undetectable Levels, Eight-Year Study Shows
[Guardian] An eight-year study has shown the Bacillus Calamine Guerin (BCG) vaccine against tuberculosis can reverse Type 1 diabetes to almost undetectable levels. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - June 26, 2018 Category: African Health Source Type: news

TB Vaccine for T1D Study Stirs Controversy
(MedPage Today) -- Long-term data suggest BCG vaccine may alter immune attack (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - June 25, 2018 Category: American Health Source Type: news

Possible cure for diabetes? Generic drug can reverse type 1 diabetes long-term, study finds
Research at Massachusetts General Hospital looks increasingly like a long-term cure for type 1 diabetes, with a newly released study showing patients have normal blood sugar levels eight years after a clinical trial. In research published in journal npj Vaccines, patients who had been treated with the Bacillus Calmette-Guerin (BCG) vaccine — an inexpensive, generic vaccine used around the world to prevent tuberculosis — had normal blood sugar levels eight years after the trial ended. While… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - June 25, 2018 Category: Pharmaceuticals Authors: Jessica Bartlett Source Type: news

TB Vaccine Linked to Better Type 1 Diabetes Control
Title: TB Vaccine Linked to Better Type 1 Diabetes ControlCategory: Health NewsCreated: 6/21/2018 12:00:00 AMLast Editorial Review: 6/22/2018 12:00:00 AM (Source: MedicineNet Diabetes General)
Source: MedicineNet Diabetes General - June 22, 2018 Category: Endocrinology Source Type: news

BCG Vaccine Tied to Reduced Hyperglycemia in Type 1 Diabetes
THURSDAY, June 21, 2018 -- The Bacillus Calmette Gu érin (BCG) vaccine is associated with a reduction in hyperglycemia among patients with type 1 diabetes with long-term disease, according to a study published online June 21 in npj Vaccines. Willem... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 21, 2018 Category: Pharmaceuticals Source Type: news

There ’s Hope for a Vaccine to Prevent Type 1 Diabetes
Could a vaccine for type-1 diabetes be on the horizon? In a new study, a small group of people with type 1 diabetes who were given a vaccine showed improvement in their blood sugar levels to nearly normal levels—and the changes lasted for five to eight years. The study, published Thursday in the journal npj Vaccines by researchers at Massachusetts General Hospital, looked at nine people with type 1 diabetes who were given a vaccine to prevent tuberculosis, called bacillus Calmette-Guérin (BCG). They had two injections, four weeks apart. Levels of their hemoglobin a1c (HbA1c), which measures a person’s bl...
Source: TIME: Health - June 21, 2018 Category: Consumer Health News Authors: Alexandra Sifferlin Tags: Uncategorized diabetes healthytime Source Type: news

Generic drug shows promise as diabetes vaccine in small, years-long study
A cheap, generic tuberculosis vaccine lowered blood glucose levels in nine patients with Type I diabetes and the effects lasted for years, according to a study published this week in npj Vaccines. The study was conducted at Massachusetts General Hospital by Dr. Denise Faustman – a name that has long been saddled with controversy in the diabetes community, due in large part to a dispute with the JDRF after the organization declined to fund her work. Get the full story at our sister site, Drug Delivery Business News. The post Generic drug shows promise as diabetes vaccine in small, years-long study appeared first on M...
Source: Mass Device - June 21, 2018 Category: Medical Devices Authors: Sarah Faulkner Tags: Diabetes Pharmaceuticals Research & Development Massachusetts General Hospital Source Type: news

TB Vaccine Linked to Better Type 1 Diabetes Control
A little more than three years after getting two tuberculosis shots four weeks apart, about 50 people with type 1 diabetes saw their long-term average blood sugar levels drop significantly -- and for at least five years. (Source: WebMD Health)
Source: WebMD Health - June 21, 2018 Category: Consumer Health News Source Type: news

TB Vaccine Tied to Better Type 1 Diabetes Control
A little more than three years after getting two tuberculosis shots four weeks apart, about 50 people with type 1 diabetes saw their long-term average blood sugar levels drop significantly -- and for at least five years. (Source: WebMD Health)
Source: WebMD Health - June 21, 2018 Category: Consumer Health News Source Type: news