Secondary syphilis presenting as Syphilide psoriasiforme: lessons from the older syphilology literature.
We present herein a case of syphilide psoriasiforme, an uncommon but well recognized clinical presentation of secondary syphilis. A 46-year-old HIV-infected female patient was referred to our attention with a presumptive diagnosis of palmoplantar psoriasis. On examination, there were exuberant pinkish-red papules and plaques covered with a thick silvery scale in the palms, flexor surfaces of the wrists, and the medial longitudinal arches of the feet. Serological and histopathological analyses uncovered the diagnosis of syphilis. Clinical remission was obtained after treatment. A detailed review of the literature on syphili...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - April 4, 2020 Category: Tropical Medicine Authors: Martins CJ, Lima RB, Eyer-Silva WA, Almenara CB, Carvalho-Rangel I, Carvalho RS, Basílio-de-Oliveira RP, Araujo LF, Ferry FRA, Silva LRD Tags: Rev Inst Med Trop Sao Paulo Source Type: research

Syphilis and HIV infection in indigenous Mbya Guarani communities of Puerto Iguazu (Argentina): diagnosis, contact tracking, and follow-up.
;n JM Abstract The aim of study was to assess the prevalence of Treponema pallidum and HIV infection in Amerindian people (Mbya Guarani) over the age of 11 in Puerto Iguazu (Argentina) and to describe the contact tracking of cases. The method was a cross-sectional study in the Mbya Guarani people living in three villages of Puerto Iguazu (community A, pop. 1,146; community B, pop. 369; and community C, pop. 149). Participants were randomly invited to participate in the survey and in blood testing. Of the 551 participants, 48 were infected by T. pallidum (8.71%; 95% confidence interval [CI] 7.38-10.04). The infecti...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - April 4, 2020 Category: Tropical Medicine Authors: Marx J, Acosta L, Deschutter EJ, Bornay-Llinares FJ, Sotillo-Soler V, Ramos-Rincón JM Tags: Rev Inst Med Trop Sao Paulo Source Type: research

Retinal dysfunction of syphilitic outer retinopathy
ConclusionsSyphilitic outer retinopathy affected the retinal structures and function that can be restored by antibiotic treatments. (Source: Documenta Ophthalmologica)
Source: Documenta Ophthalmologica - April 4, 2020 Category: Opthalmology Source Type: research

Malignant Syphilis and Pruritic Papular Eruption in an HIV-Positive Man
Publication date: Available online 2 April 2020Source: Actas Dermo-Sifiliográficas (English Edition)Author(s): J. Granizo-Rubio, C. Caviedes-Vallejo, N. Chávez-Dávila, V. Pinos-León (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - April 3, 2020 Category: Dermatology Source Type: research

An efficient method for simultaneously screening for HIV, syphilis, and HCV based on one dried blood spot sample
Publication date: Available online 1 April 2020Source: Antiviral ResearchAuthor(s): Jieqiong Ma, Yanan Ren, Lin He, Xiaoxia He, Xing Wenge, Jiang Yan (Source: Antiviral Therapy)
Source: Antiviral Therapy - April 3, 2020 Category: Virology Source Type: research

Congenital infections in Hong Kong: an overview of TORCH.
Abstract Congenital infections refer to a group of perinatal infections that may have similar clinical presentations, including rash and ocular findings. TORCH is the acronym that covers these infections (toxoplasmosis, other [syphilis], rubella, cytomegalovirus, herpes simplex virus). There are, however, other important causes of intrauterine/perinatal infections, including enteroviruses, varicella zoster virus, Zika virus, and parvovirus B19. Intrauterine and perinatal infections are significant causes of fetal and neonatal mortality and important contributors to childhood morbidity. A high index of suspicion fo...
Source: Hong Kong Med J - April 2, 2020 Category: General Medicine Authors: Leung KKY, Hon KL, Yeung A, Leung AKC, Man E Tags: Hong Kong Med J Source Type: research

COVID-19, syphilis and biologic therapies for psoriasis and psoriatic arthritis: A word of caution
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - April 1, 2020 Category: Dermatology Authors: Naveen Kumar Kansal Source Type: research

Infections causing stroke or stroke-like syndromes
ConclusionsStroke or stroke-like syndrome of infectious origin can be observed in an important proportion of case presenting with sensory-motor deficit of unknown origin; their accurate diagnosis has a considerable impact in terms of treatment choices and outcome. (Source: Infection)
Source: Infection - April 1, 2020 Category: Infectious Diseases Source Type: research

Overlapping Transmission Networks of Early Syphilis and/or Newly HIV Diagnosed Gay, Bisexual and Other Men Who Have Sex with Men (MSM): Opportunities for Optimizing Public Health Interventions
AbstractSyphilis and HIV among gay, bisexual and other men who have sex with men (MSM) are syndemic suggesting current prevention strategies are not effective. Sex partner meeting places and their networks may yield effective and optimal interventions. From 2009 to 2017, 57 unique venues were reported by  >  1 MSM and 7.0% (n = 4), 21.1% (n = 12) and 71.9% (n = 41) were classified as syphilis, HIV or co-diagnosed venues, respectively. Forty-nine venues were connected in one main network component with four online, co-diagnosis venues representing 51.6% of reports a...
Source: AIDS and Behavior - April 1, 2020 Category: Infectious Diseases Source Type: research

An efficient method for simultaneously screening for HIV, syphilis, and HCV based on one dried blood spot sample.
CONCLUSION: The DBS-based ELISA method demonstrated good performance for simultaneously screening for anti-HIV, anti-HCV, and anti-TP antibodies. DBS samples are a promising method to screen for HIV, HCV, and TP infections. IMPORTANCE: DBS samples are a promising alternative to plasma samples, with the advantages of good sample stability, smaller blood volume, simpler storage, and easier transport. DBS sample testing is used for the diagnosis of a wide variety of pathogens, including HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV). The performance of DBS samples for the serological diagnosis of HIV, HCV, and...
Source: Antiviral Research - April 1, 2020 Category: Virology Authors: Ma J, Ren Y, He L, He X, Wenge X, Yan J Tags: Antiviral Res Source Type: research

Health of Special Immigrant Visa holders from Iraq and Afghanistan after arrival into the United States using Domestic Medical Examination data, 2014 –2016: A cross-sectional analysis
ConclusionIn this analysis, we observed that 14% of SIV adults had LTBI, 27% of SIVH had at least one intestinal parasite, and about half of SIV children had EBLL. Most adults were susceptible to HBV. In general, prevalence of infection was higher for most conditions among Afghan SIVH compared to Iraqi SIVH. The Centers for Disease Control and Prevention (CDC)Guidelines for the US Domestic Medical Examination for Newly Arriving Refugees can assist state public health departments and clinicians in the care of SIVH during the domestic medical examination. Future analyses can explore other aspects of health among resettled SI...
Source: PLoS Medicine - March 31, 2020 Category: Internal Medicine Authors: Gayathri S. Kumar Source Type: research

Early Syphilis: New Diagnostic Approaches in a Changing Scenario
Publication date: Available online 29 March 2020Source: Actas Dermo-Sifiliográficas (English Edition)Author(s): T. Toledo Pastrana (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - March 30, 2020 Category: Dermatology Source Type: research

A homozygote frameshift mutation in OCLN gene result in Pseudo-TORCH syndrome type I: A case report extending the phenotype with central diabetes insipidus and renal dysfunction.
Abstract Intrauterine infections with the pathogens, including toxoplasmosis, other (syphilis, varicella, mumps, parvovirus, and HIV), rubella, cytomegalovirus, and herpes simplex (TORCH) in susceptible individuals during pregnancy, result in microcephaly, white matter disease, cerebral atrophy, and calcifications in the fetus. Pseudo-TORCH syndrome is an umbrella term, consisting of several syndromes, resultant from different genetic alterations and pathogenetic mechanisms. Band-like calcification with simplified gyration and polymicrogyria (BLC-PMG) is one of these conditions, resultant from biallelic mutations ...
Source: European Journal of Medical Genetics - March 30, 2020 Category: Genetics & Stem Cells Authors: Ekinci F, Yildizdas RD, Horoz OO, Herguner O, Bisgin A Tags: Eur J Med Genet Source Type: research

[Relationship between the supply of syphilis diagnosis and treatment in primary care and incidence of gestational and congenital syphilis].
Abstract Brazil has reported an increase in the incidence of both gestational and congenital syphilis, posing a serious public health problem in the country. The study aimed to analyze the relationship between the supply of syphilis diagnosis and treatment in primary care and the incidence rates of gestational and congenital syphilis. An ecological study analyzed these incidence rates and the coverage of diagnostic and therapeutic measures in primary care. The study sample consisted of municipalities (counties) with population over 20,000, with coverage by primary care over 50%, and where the majority of the teams...
Source: Cadernos de Saude Publica - March 28, 2020 Category: International Medicine & Public Health Authors: Figueiredo DCMM, Figueiredo AM, Souza TKB, Tavares G, Vianna RPT Tags: Cad Saude Publica Source Type: research

Clinical and laboratory characteristics of ocular syphilis and neurosyphilis among individuals with and without HIV infection.
Abstract BACKGROUND/AIMS: In the era of increasing incidence of syphilis globally, ocular syphilis is re-emerging as an important cause of uveitis. The aim of this study was to determine the clinical and laboratory characteristics of ocular- and neurosyphilis among individuals with and without HIV infection. METHODS: Retrospective analysis of patients diagnosed with ocular syphilis presenting to Tygerberg Hospital, South Africa, over a 5-year period ending December 2018. RESULTS: Two-hundred and fifteen eyes of 146 patients were included. HIV coinfection was present in 52.1% of the patients, with 23.7% o...
Source: The British Journal of Ophthalmology - March 27, 2020 Category: Opthalmology Authors: Mathew D, Smit D Tags: Br J Ophthalmol Source Type: research

A patient with anti-NXP2-positive dermatomyositis and syphilis
We present a patient with active syphilis infection who developed dermatomyositis and discuss the significance of anti-NXP2 autoantibody positivity. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - March 26, 2020 Category: Dermatology Source Type: research

Technologies, strategies and approaches for testing populations at risk of sexually transmitted infections: a systematic review protocol to inform prevention and control in EU/EEA countries
DiscussionOutcomes of this study will inform policy makers, national and international programme coordinators, public health and clinical experts, and civil society organisations involved in STI prevention and control in EU/EEA countries and elsewhere. The review will provide a direction for future researchers and programmers seeking to improve STI testing services among key populations at high risk for STIs.Systematic review registrationIn accordance with guidelines outlined in the PRISMA-P methodology, this protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO) on 30 January ...
Source: Systematic Reviews - March 25, 2020 Category: International Medicine & Public Health Source Type: research

Single-Locus-Sequence-Based Typing of the mgpB Gene Reveals Transmission Dynamics in Mycoplasma genitalium [Epidemiology]
Sexually transmitted infections (STIs) by Mycoplasma genitalium are a major problem worldwide, especially given their marked and rapid propensity for developing antimicrobial resistance. Since very few treatment options exist, clinicians face an important challenge in the management of the infection. In this scenario, little is known regarding the transmission dynamics of M. genitalium and the epidemiology of antimicrobial resistance. This mgpB-based molecular typing study, conducted among 54 asymptomatically infected individuals prospectively recruited from an STI screening service, reveals two distinct epidemiological cl...
Source: Journal of Clinical Microbiology - March 25, 2020 Category: Microbiology Authors: Fernandez-Huerta, M., Serra-Pladevall, J., Esperalba, J., Moreno-Mingorance, A., Fernandez-Naval, C., Barbera, M.-J., Aparicio, D., Pich, O. Q., Pumarola, T., Jensen, J. S., Espasa, M. Tags: Epidemiology Source Type: research

The Changing Spectrum of Sexually Transmitted Infections in Europe.
Abstract As long as 400 years ago, syphilitic ulcers and gonococcal discharge were observed in connection with sexual intercourse. War, poverty, and lack of efficient therapeutic options led to a high incidence of venereal diseases, many of which had devastating outcomes. This situation continued until the beginning of the 20th century, when the microbial aetiology of venereal diseases was discovered. The infection rate dropped with the availability of antibiotic therapy after the Second World War. However, since the beginning of the 21st century, a steady increase in sexually transmitted infections (STIs) has bee...
Source: Acta Dermato-Venereologica - March 24, 2020 Category: Dermatology Authors: Stary A Tags: Acta Derm Venereol Source Type: research

Effect of anti-TP0136 antibodies on the progression of lesions in an infected rabbit model.
This study aimed to investigate the effect of anti-TP0136 antibodies on the progression of lesions in an infected rabbit model. Intramuscular injection of rTP0136 into rabbits in the immunized group (n = 4) elicited high titers of anti-TP0136 antibodies, and rabbits were then challenged with 105T. pallidum per site along their back. Lesion development was observed, and the injection sites were biopsied for tp0574 mRNA and histological analyses every week until the wound healed. The rabbits in the control group were injected with normal saline instead of rTP0136. Viable T. pallidum in the challenged rabbits was as...
Source: International Immunopharmacology - March 24, 2020 Category: Allergy & Immunology Authors: Li QL, Tong ML, Liu LL, Lin LR, Lin Y, Yang TC Tags: Int Immunopharmacol Source Type: research

Contrast-enhanced ultrasound evaluation of testicular syphilis: a case report.
Authors: Tagliati C, Macchini M, Argalia G, Giuseppetti GM, Giovagnoni A Abstract In North America and Europe, syphilis incidence has increased dramatically in the past decade among high-risk groups. Syphilis may occur in any organ, including the testis. There are not many cases of testicular syphilis assessed by means ofultrasound examination described in the literature, and in no case was the evaluation carried out using advanced ultrasound techniques. Here we present a case of testicular syphilis evaluated by contrast-enhanced ultrasound. PMID: 32190859 [PubMed - as supplied by publisher] (Source: ...
Source: Medical Ultrasonography - March 20, 2020 Category: Radiology Tags: Med Ultrason Source Type: research

Syphilis screening in pregnant women: Discordant results require careful confirmation
In the past 15 years, many high volume clinical laboratories implemented reverse sequence syphilis screening. Reverse sequence screening uses an automated treponemal immunoassay as the initial screening step, instead of the traditional rapid plasma reagin. Reverse sequence screening is economical for high volume laboratories but has led to diagnostic difficulties when the testing algorithm yields discordant results, particularly for pregnant women. In this volume of The Journal, Williams et al evaluated 35 108 reverse sequence syphilis screening events among pregnant women in Ohio from 2011-2018. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - March 20, 2020 Category: Pediatrics Authors: Rebecca Pellett Madan Tags: The Editors' Perspectives Source Type: research

Vitreous treponemal antibody as a supplementary test to serology for the confirmation of syphilitic chorioretinitis
Conclusion: Intraocular fluid analysis of nontreponemal and treponemal antibody may play an important role in ruling out suspected ocular syphilis in settings without a polymerase chain reaction facility, especially immunocompromised patients who are at risk of multiple infections. Further studies are needed to establish the sensitivity and specificity of nontreponemal and treponemal antibody test on vitreous samples. (Source: Retinal Cases and Brief Reports)
Source: Retinal Cases and Brief Reports - March 20, 2020 Category: Opthalmology Tags: Case Report Source Type: research

Spontaneous improvement of syphilis chorioretinitis: case report and review of the literature
Conclusion: Spontaneous improvement of syphilis chorioretinitis is possible. Clinicians should keep a high index of suspicion and consider syphilis chorioretinitis in diseases that affect the outer retina even with spontaneous improvement. (Source: Retinal Cases and Brief Reports)
Source: Retinal Cases and Brief Reports - March 20, 2020 Category: Opthalmology Tags: Case Report Source Type: research

Transfusion-transmitted infections in hemophilia patients who underwent surgical treatment: a study from a single center in north China.
Conclusions: Though few patients have become positive for HBsAg and HIV Ab, HCV is still the major virus of concern for hemophiliacs who have undergone orthopedic procedures. Hepatitis B vaccination should be given to the high-risk population including hemophilia patients as soon as possible. PMID: 32190141 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - March 20, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Syphilis and HIV Co-infection in Mississippi: Implications for Control and Prevention
This study aimed to determine and describe the co-infection pattern in Mississippi by using a case-controlled design to analyze cases diagnosed with syphilis or HIV from 2007 to 2016. Direct matching was employed to identify cases that were co-infected during the same calendar year, and binary logistic regression analysis was used to determine predictors of co-infection. Results showed that 1736 (34.0%) of syphilis and HIV cases were co-infected during the same calendar year. Binary logistic regression results demonstrated that race, gender, age group, and exposure category were independently associated with co-infection s...
Source: AIDS and Behavior - March 19, 2020 Category: Infectious Diseases Source Type: research

Syphilis testing performance: continuous quality improvement (CQI) works for some but not for all.
PMID: 32190935 [PubMed - as supplied by publisher] (Source: Australian and New Zealand Journal of Public Health)
Source: Australian and New Zealand Journal of Public Health - March 19, 2020 Category: International Medicine & Public Health Authors: Adily A, Matthews V, Ward JE Tags: Aust N Z J Public Health Source Type: research

425 The Great Mimicker Unveiled: A Case of Membranous Nephropathy from Syphilis
Publication date: April 2020Source: American Journal of Kidney Diseases, Volume 75, Issue 4Author(s): (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - March 18, 2020 Category: Urology & Nephrology Source Type: research

Syphilis seroprevalence among HIV-infected males in Istanbul, Turkey.
Authors: Köksal MO, Beka H, Evlice O, Çiftçi S, Keskin F, Başaran S, Akgül B, Eraksoy H, Ağaçfidan A Abstract Syphilis has become a serious issue for human immunodeficiency virus (HIV)-infected patients worldwide in recent years; however, the studies related to HIV coinfection and syphilis reinfections in Istanbul, Turkey, are limited. Our objective was to determine the seroprevalence of syphilis among HIV-infected men in the city which has one of the highest HIV prevalence rates in Turkey. Two hundred and forty four (244) HIV-positive men were evaluated at Istanbul Medical Faculty,...
Source: Revista Argentina de Microbiologia - March 18, 2020 Category: Microbiology Tags: Rev Argent Microbiol Source Type: research

IJERPH, Vol. 17, Pages 1990: Epidemiological Features and Risk Factors for Acquiring Hepatitis B, Hepatitis C, and Syphilis in HIV-Infected Patients in Shaanxi Province, Northwest China
Chang Human immunodeficiency virus (HIV)-infected patients are at a higher risk for co-infection with Hepatitis B virus (HBV), Hepatitis C virus (HCV), and Treponema pallidum (TP; the agent causing syphilis) than the general population. The prevalence of HBV, HCV, and syphilis has geographic differences and varies from region to region among HIV-positive individuals. A retrospective study was carried out on HIV-positive individuals between June 2011 and June 2016 in Shaanxi Province. Univariate and multivariate logistic regression analyses using stepwise regression analysis regarding risk factors for HIV–...
Source: International Journal of Environmental Research and Public Health - March 18, 2020 Category: Environmental Health Authors: Chao Zhang Qiang Ren Wenhui Chang Tags: Article Source Type: research

Syphilis among pregnant women in Northeast Brazil from 2008 to 2015: a trend analysis according to sociodemographic and clinical characteristics
CONCLUSIONS: Despite an increase in primary care coverage, The increase in cases of syphilis among pregnant women is still considered a challenge. (Source: Revista da Sociedade Brasileira de Medicina Tropical)
Source: Revista da Sociedade Brasileira de Medicina Tropical - March 17, 2020 Category: Tropical Medicine Source Type: research

Smittsomme sykdommer blant pasienter ved Helsesenter for papirl øse migranter i Oslo.
Smittsomme sykdommer blant pasienter ved Helsesenter for papirløse migranter i Oslo. Tidsskr Nor Laegeforen. 2020 Mar 17;140(4): Authors: Austad RH, Sandbakken E, Sandrib H, Aavitsland P, Bruun JN, Eick F, Lie AK Abstract BACKGROUND: Undocumented migrants probably fall outside the scope of public infectious disease control schemes. The article aims to describe the extent of undetected highly hazardous communicable diseases among patients at the Health Centre for Undocumented Migrants in Oslo. MATERIAL AND METHOD: We reviewed the records of all patients who attended the Health Centre for th...
Source: Tidsskrift for den Norske Laegeforening - March 17, 2020 Category: General Medicine Authors: Austad RH, Sandbakken E, Sandrib H, Aavitsland P, Bruun JN, Eick F, Lie AK Tags: Tidsskr Nor Laegeforen Source Type: research

High Interest in Syphilis Pre-exposure and Post-exposure Prophylaxis Among Gay, Bisexual and Other Men Who Have Sex With Men in Vancouver and Toronto
Conclusions There is considerable interest in syphilis PrEP/PEP in gbMSM attending Toronto/Vancouver STI clinics. (Source: Sexually Transmitted Diseases)
Source: Sexually Transmitted Diseases - March 13, 2020 Category: Sexual Medicine Tags: Original Studies Source Type: research

Partner Notification Among Persons With Early Syphilis in Shenzhen, China, 2011–2017: Implications for Practice and Policy
Conclusions There is a need to improve PN practices in China, which include developing operational guidelines of PN and to develop and evaluate novel PN ways like using Internet-based strategy. (Source: Sexually Transmitted Diseases)
Source: Sexually Transmitted Diseases - March 13, 2020 Category: Sexual Medicine Tags: Original Studies Source Type: research

A Multiregion Analysis of Shale Drilling Activity and Rates of Sexually Transmitted Infections in the United States
Conclusions Associations between shale drilling and chlamydia and gonorrhea in Texas may reflect increased risk in areas with higher drilling activity and a greater number of major metropolitan areas. Interstate differences highlight the need for local epidemiology to prioritize community health policies. (Source: Sexually Transmitted Diseases)
Source: Sexually Transmitted Diseases - March 13, 2020 Category: Sexual Medicine Tags: Original Studies Source Type: research

Mapping Geographical Patterns and High Rate Areas for Sexually Transmitted Infections in Portugal: A Retrospective Study Based on the National Epidemiological Surveillance System
Conclusions Wide spatial inequalities in STI notification rates were observed, which were predominantly concentrated in the 2 metropolitan areas of the country. Our findings can help guide more targeted interventions to reduce STIs incidence. (Source: Sexually Transmitted Diseases)
Source: Sexually Transmitted Diseases - March 13, 2020 Category: Sexual Medicine Tags: Original Studies Source Type: research

Genital Ulcers: Differential Diagnosis and Management.
Abstract Genital ulcers may be located on the vagina, penis, and anorectal or perineal areas and may be infectious or noninfectious. Herpes simplex virus is the most common cause of genital ulcers in the United States. A diagnosis of genital herpes simplex virus infection is made through physical examination and observation of genital lesions. The 2015 Centers for Disease Control and Prevention sexually transmitted disease guidelines provide strategies for the management of patients with genital ulcer disease. Specific testing includes a polymerase chain reaction test for herpes simplex virus; syphilis serology an...
Source: American Family Physician - March 13, 2020 Category: Primary Care Authors: Roett MA Tags: Am Fam Physician Source Type: research

Management of Intraocular Infections in HIV.
Conclusion: Although the treatment of intraocular infections in patients with AIDS may be challenging, prompt assessment of the clinical features and appropriate aggressive management of the underlying etiology are critical to avoid life and vision threatening. PMID: 32162992 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - March 13, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Association between head and neck cancer and sexually transmitted diseases: a nationwide, case-control study
This study determined the association between selected STDs (syphilis, gonorrhoea, and HIV) and HNC from 1978-2014 in Denmark. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 12, 2020 Category: Radiology Authors: C. Gr ønhøj, K.K. Jakobsen, C.V. Buchwald Tags: Epidemiology and Prevention Source Type: research

Factors associated with cutaneous ulcers among children in two yaws-endemic districts in Ghana
ConclusionsPoor personal hygiene, overcrowding and lack of access to improved sanitary facilities are the factors that facilitate the transmission of yaws in the Awutu Senya West and Upper West Akyem districts. Yaws was also more common among males and school-aged children. Improving living conditions, access to good sanitary facilities and encouraging good personal hygiene practices should be core features of eradication programs in endemic communities. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - March 12, 2020 Category: Infectious Diseases Source Type: research

Altered Brain Function in Young HIV Patients with Syphilis Infection: A Voxel-Wise Degree Centrality Analysis
(Source: Infection and Drug Resistance)
Source: Infection and Drug Resistance - March 11, 2020 Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research

Could “Hood’s Sarsaparilla” Root Out Uncle Sam’s Rash of Pains?
Before the onetime sassafras-based “root beer” of today, sarsaparilla (pronounced “sass-puh-RILL-uh”;Smilax sp.) reigned as America ’s vine for flavoring beverages and remedies. Originally a Native American treatment for gastrointestinal and dermatologic complaints, sarsaparilla began to be used for “blood disorders,” scurvy, scrofula, syphilis, and even leprosy. Popularizing this panacea was Vermont native Charles Ira Hoo d (1845 to 1922), who had moved to Lowell, Massachusetts, to apprentice as a pharmacist. After compounding his namesake sarsaparilla in 1876, Hood marketed it na...
Source: Anesthesiology - March 10, 2020 Category: Anesthesiology Source Type: research

Multi-syphilitic gummas in pituitary and cerebellopontine angle in a patient
ConclusionsSyphilitic gummas in pituitary and CPA are similar to benign or malignant brain tumors, easily leading to misdiagnosis. Gumma should be considered in differential diagnosis when a patient has unexplained nervous system symptoms or signs and imaging findings suggest intracranial mass in syphilis seropositive patients. (Source: Pituitary)
Source: Pituitary - March 10, 2020 Category: Endocrinology Source Type: research

Don't forget syphilis in membranous nephropathy before immunosuppressants: Latent syphilis in a patient with proteinuria.
Authors: Kaynar K, Güvercin B, Mungan S, Ulusoy Ş PMID: 32144011 [PubMed - as supplied by publisher] (Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia)
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - March 9, 2020 Category: Urology & Nephrology Tags: Nefrologia Source Type: research

The Treponema pallidum outer membrane protein Tp92 activates endothelial cells via the chemerin/CMKLR1 pathway.
In this study, we investigated the effect of Tp92 on endothelial cells activation. The data showed that Tp92 induced chemerin production in activated endothelial cells. Endothelial cell-derived chemerin upregulated the expression of TNF-α and ICAM-1 in endothelial cells via CMKLR1. In addition, endothelial cell-derived chemerin promoted THP-1-derived macrophage migration towards endothelial cells. These findings suggest that Tp92 may play an important role in mediating endothelial cell activation by inducing the secretion of chemerin. PMID: 32173267 [PubMed - as supplied by publisher] (Source: International Jour...
Source: International Journal of Medical Microbiology - March 9, 2020 Category: Microbiology Authors: Zhang RL, Wang QQ Tags: Int J Med Microbiol Source Type: research

Factors associated with exchanging sex for money in men who have sex with men in Brazil
Resumo Objetivou-se analisar a associa ção entre fatores sociodemográficos, programáticos e contextuais e ter recebido dinheiro em troca de sexo entre homens que fazem sexo com homens (HSH). Estudo multicêntrico, transversal, realizado em 10 cidades brasileiras, entre 2008 e 2009. Foram entrevistados 3.749 HSH selecionados pela téc nica amostral “ Respondent Driven-Sampling ” (RDS). “ Odds Ratio ” ponderado (ORp) foi obtido por meio de regress ão logística, permanecendo no modelo final as variáveis associadas ao evento (p
Source: Ciencia e Saude Coletiva - March 7, 2020 Category: Occupational Health Source Type: research

Syphilis: Understanding Traditional and Reverse Screening Algorithms
Interpreting syphilis screening tests can be a challenge for health care providers. Clinical laboratories primarily use the reverse algorithm to screen for syphilis; however, the Centers for Disease Control and Prevention recommend the traditional algorithm. Both algorithms require the interpretation of 2 different serologic assays for screening and confirmation. Serologic testing used in both algorithms is reviewed for nurse practitioners to correctly interpret test results to establish a timely diagnosis and provide stage-appropriate treatment. (Source: The Journal for Nurse Practitioners)
Source: The Journal for Nurse Practitioners - March 6, 2020 Category: Nursing Authors: Jacqueline F. Thomas, Shayria Catlin, Jonathan A. Stacey Tags: Featured Article Source Type: research

The P2X7 receptor mediates NLRP3-dependent IL-1 β secretion and promotes phagocytosis in the macrophage response to Treponema pallidum.
This study was conducted to investigate the role of P2X7R in modifying NLRP3-dependent IL-1β secretion and regulating phagocytosis by Treponema pallidum (T. pallidum)-induced macrophages. Macrophages derived from a human acute monocytic leukemia cell line were cultured with T. pallidum. The activation of P2X7R in T. pallidum-treated macrophages occurred in a dose- and time-dependent manner. The P2X7R silencing group showed significantly decreased NLRP3 mRNA and protein levels (vs. the Tp group, P 
Source: International Immunopharmacology - March 6, 2020 Category: Allergy & Immunology Authors: Xu SL, Lin Y, Liu W, Zhu XZ, Liu D, Tong ML, Liu LL, Lin LR Tags: Int Immunopharmacol Source Type: research

[Screening of Human Immunodeficiency Virus and Other Sexually Transmitted Infections in a Group of Sex Workers in Indoor Settings in the Porto Metropolitan Area].
CONCLUSION: The adaptation of the screening methodology performed in a clinical setting to the proximity context has shown to be an innovative response in Portugal, especially in sentinel populations. PMID: 32130095 [PubMed - as supplied by publisher] (Source: Acta Medica Portuguesa)
Source: Acta Medica Portuguesa - March 5, 2020 Category: General Medicine Tags: Acta Med Port Source Type: research

The Impact of Treatment as Prevention on the HIV Epidemic in British Columbia, Canada
This study proposes to describe the impact of a publicly funded Treatment as Prevention (TasP) strategy in British Columbia (BC), Canada, in decreasing the individual and public health impact of the HIV/AIDS Epidemic.Recent FindingsIn BC, TasP has been associated with a steady decline in HIV-related morbidity and mortality. At the same time, a demographic transition was observed among people living with HIV (PLWH), with the majority of those on antiretroviral treatment (ART) now ≥ 50 years of age, living with at least one comorbidity, and dying from age-associated comorbidities. We also documented a progress...
Source: Current HIV/AIDS Reports - March 3, 2020 Category: Infectious Diseases Source Type: research