Associated factors, incidence, and management of gestational and congenital syphilis in a Brazilian state capital: a cross-sectional study
This study aimed to describe the clinical and epidemiological profile of cases of gestational and congenital syphilis and the hospital care provided for newborns in Campo Grande municipality, Mato Grosso do Sul State, Brazil, from 2013 to 2018. This is a cross-sectional study based on data from Brazilian Notifiable Diseases Surveillance System (SINAN) and hospital medical records. Chi-square or Fisher's exact test and logistic regression analysis were used to assess the associations and relationships between the child's clinical outcome at birth and the mother's clinical-obstetric and epidemiological characteristics. Cumul...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - April 24, 2024 Category: Tropical Medicine Authors: C ássia de Paula Pires Lisany Krug Mareto M árcio José de Medeiros Everton Falc ão de Oliveira Source Type: research
Ten Years of HIV Diagnosis in a Dermatology and Venereology Department: A Retrospective Study on Demographic, Clinical, and Laboratory Characteristics
We present a large patient database on the clinical conditions associated with newly diagnosed HIV, concluding that infectious diseases were the most common conditions associated with newly diagnosed HIV.PMID:38648929 | DOI:10.1016/j.ad.2024.04.016 (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - April 22, 2024 Category: Dermatology Authors: Diogo de Sousa Pedro Garrido Daniel Nunes Carlos Lemos Jo ão Borges-Costa Source Type: research
Preventive Care for Men Who Have Sex With Men
Am Fam Physician. 2024 Apr;109(4):324-332.ABSTRACTMen who have sex with men (MSM) is an inclusive term used to refer to phenotypic males who have insertive or receptive sex (penile-anal or penile-oral) with other phenotypic males, including people who are transgender or have other gender identities. MSM may report their sexual orientation as homosexual, bisexual, heterosexual, or something else, but this stated sexual orientation may not align with their sexual attraction or behaviors. Several health conditions disproportionately affect MSM compared with age-matched heterosexual men, including HIV infection, anal cancer, s...
Source: American Family Physician - April 22, 2024 Category: Primary Care Authors: Stephen McMullan Therese Anderson Nadine Elhage Source Type: research
Communicable Disease Screening and Human Immunodeficiency Virus Prevention in the Emergency Department
Emerg Med Clin North Am. 2024 May;42(2):369-389. doi: 10.1016/j.emc.2024.02.007. Epub 2024 Mar 19.ABSTRACTEmergency departments (ED) provide care to populations with high rates of communicable diseases, like HIV, hepatitis C virus, and syphilis. For many patients, the ED is their sole entry point into the healthcare system and they do not routinely access screening and prevention services elsewhere. As such, the ED can serve an important public health role through communicable disease identification, treatment, and prevention. In this article, we examine national recommendations, peer-reviewed literature, and expert consen...
Source: The Medical Clinics of North America - April 19, 2024 Category: General Medicine Authors: Douglas A E White Rachel E Solnick Source Type: research
Application of metagenomic next-generation sequencing in the diagnosis of Bartonella neuroretinitis: a case report and literature review
ConclusionmNGS, a fast and unbiased method, can be used to detectB. henselae (if present) in intraocular fluid samples.; however, the results should be interpreted together with the clinical symptoms and other auxiliary test results. (Source: Journal of Ophthalmic Inflammation and Infection)
Source: Journal of Ophthalmic Inflammation and Infection - April 19, 2024 Category: Opthalmology Source Type: research
Case of Haemophilus influenzae urethritis in a male patient
We report a case of H. influenzae urethritis and describe a relatively novel treatment approach. A man presented to Melbourne Sexual Health Centre with a 3-day history of penile discharge and dysuria. He engaged in condomless oral and anal sex with casual male partners in preceding months. On examination, purulent urethral discharge was noted. Urethral microscopy showed Gram-positive bacilli and epithelial cells. Screening for chlamydia, gonorrhoea, Mycoplasma genitalium, Trichomonas vaginalis, HIV and syphilis was performed. He was treated for NGU with a 1-week course of doxycycline. Initial investigations were all negati...
Source: Sexually Transmitted Infections - April 18, 2024 Category: Sexual Medicine Authors: Samra, R. S., Plummer, E. L., Vodstrcil, L., Bradshaw, C. S. Tags: PostScript Source Type: research
BASHH feedback from the 2023 IUSTI-Europe conference in Malta
There is a growing relationship between BASHH and IUSTI.1 In 2023, several BASHH scholars were invited to give feedback on the IUSTI conference in Malta. Asymptomatic STI screening: Chris Kenyon, (Belgium) Despite good evidence for HIV and syphilis screening in asymptomatic patients, evidence is lacking for other STIs, for example, Neisseria gonorrhoeae and Chlamydia trachomatis. Kenyon et al2 highlighted the potential harms of widespread screening for asymptomatic STIs, particularly in HIV-pre-exposure prophylaxis (HIV-PrEP) cohorts, namely increased antimicrobial consumption and antimicrobial resistance (AMR). In Belgium...
Source: Sexually Transmitted Infections - April 18, 2024 Category: Sexual Medicine Authors: Richardson, D., Butler, M., Bull Olozabal, O., Gupta, N., Naser, F., Sultan, B., Caswell, R. J. Tags: BASHH column Source Type: research
Can laboratory HIV and infectious syphilis data inform future pre-exposure prophylaxis use in women in Ontario, Canada?
Conclusion
Although it is clinically appropriate to recommend HIV PrEP to women with syphilis, Ontario surveillance data suggest that the population-level impact of this strategy on the HIV epidemic in Ontario would have been modest during this 11-year period. Future studies should explore additional ways of prioritising women for PrEP. (Source: Sexually Transmitted Infections)
Source: Sexually Transmitted Infections - April 18, 2024 Category: Sexual Medicine Authors: Sadeghi, Y., Nelson, P., Sullivan, A., Allen, V., Hasso, M., Liu, J., Tran, V., Tan, D. H. S. Tags: Open access Short reports Source Type: research
Seroconversion in syphilis screening without positive confirmatory tests points at early infection
Conclusion
The majority of unconfirmed CLIA seroconversions represented early syphilis infections. Therefore, additional T. pallidum PCR, a follow-up consultation or early treatment is recommended. (Source: Sexually Transmitted Infections)
Source: Sexually Transmitted Infections - April 18, 2024 Category: Sexual Medicine Authors: Nieuwenburg, S. A., Jongen, V. W., Schim van der Loeff, M., de Vries, H., van Dam, A. Tags: Original research Source Type: research
Understanding dynamics and overlapping epidemiologies of HIV, HSV-2, chlamydia, gonorrhea, and syphilis in sexual networks of men who have sex with men
CONCLUSION: STI epidemiologies demonstrate substantial overlap and associations, alongside nuanced differences that shape a unique pattern for each STI. Gonorrhea exhibits an "intermediate STI epidemiology," reflected by the highest average correlation coefficient with other STIs.PMID:38628844 | PMC:PMC11018893 | DOI:10.3389/fpubh.2024.1335693 (Source: Herpes)
Source: Herpes - April 17, 2024 Category: Infectious Diseases Authors: Ryosuke Omori Hiam Chemaitelly Laith J Abu-Raddad Source Type: research
Syphilis Treatment Among People Who Are Pregnant in Six U.S. States, 2018-2021
CONCLUSION: In this surveillance cohort, people without timely prenatal care had the highest risk for syphilis treatment inadequacy; however, almost a third of people who received timely prenatal care were not adequately treated. These findings underscore gaps in syphilis screening and treatment for pregnant people, especially those experiencing substance use and homelessness, and the need for systems-based interventions, such as treatment outside of traditional prenatal care settings.PMID:38626449 | DOI:10.1097/AOG.0000000000005586 (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - April 16, 2024 Category: OBGYN Authors: Ayzsa Tannis Kathryn Miele Jeffrey M Carlson Kevin P O'Callaghan Kate R Woodworth Breanne Anderson Aisha Praag Kourtney Pulliam Nicole Coppola Teri' Willabus Deborah Mbotha Dejene Abetew Salvatore Currenti Nicole D Longcore Amanda Akosa Dana Meaney-Delman Source Type: research
Syphilis Treatment Among People Who Are Pregnant in Six U.S. States, 2018-2021
CONCLUSION: In this surveillance cohort, people without timely prenatal care had the highest risk for syphilis treatment inadequacy; however, almost a third of people who received timely prenatal care were not adequately treated. These findings underscore gaps in syphilis screening and treatment for pregnant people, especially those experiencing substance use and homelessness, and the need for systems-based interventions, such as treatment outside of traditional prenatal care settings.PMID:38626449 | DOI:10.1097/AOG.0000000000005586 (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - April 16, 2024 Category: OBGYN Authors: Ayzsa Tannis Kathryn Miele Jeffrey M Carlson Kevin P O'Callaghan Kate R Woodworth Breanne Anderson Aisha Praag Kourtney Pulliam Nicole Coppola Teri' Willabus Deborah Mbotha Dejene Abetew Salvatore Currenti Nicole D Longcore Amanda Akosa Dana Meaney-Delman Source Type: research
Syphilis Treatment Among People Who Are Pregnant in Six U.S. States, 2018-2021
CONCLUSION: In this surveillance cohort, people without timely prenatal care had the highest risk for syphilis treatment inadequacy; however, almost a third of people who received timely prenatal care were not adequately treated. These findings underscore gaps in syphilis screening and treatment for pregnant people, especially those experiencing substance use and homelessness, and the need for systems-based interventions, such as treatment outside of traditional prenatal care settings.PMID:38626449 | DOI:10.1097/AOG.0000000000005586 (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - April 16, 2024 Category: OBGYN Authors: Ayzsa Tannis Kathryn Miele Jeffrey M Carlson Kevin P O'Callaghan Kate R Woodworth Breanne Anderson Aisha Praag Kourtney Pulliam Nicole Coppola Teri' Willabus Deborah Mbotha Dejene Abetew Salvatore Currenti Nicole D Longcore Amanda Akosa Dana Meaney-Delman Source Type: research
Multicentre double-blind randomised placebo-controlled trial evaluating the efficacy of the meningococcal B vaccine, 4CMenB (Bexsero), against Neisseria gonorrhoeae infection in men who have sex with men: the GoGoVax study protocol
This study will evaluate the efficacy of 4CMenB against N. gonorrhoeae infection in men (cis and trans), transwomen and non-binary people who have sex with men (hereafter referred to as GBM+).
Methods and analysis
This is a double-blind, randomised placebo-controlled trial in GBM+, either HIV-negative on pre-exposure prophylaxis against HIV or living with HIV (CD4 count >350 cells/mm3), who have had a diagnosis of gonorrhoea or infectious syphilis in the last 18 months (a key characteristic associated with a high risk of N. gonorrhoeae infection). Participants are randomised 1:1 to receive two doses of 4CMenB or placeb...
Source: BMJ Open - April 16, 2024 Category: General Medicine Authors: Seib, K. L., Donovan, B., Thng, C., Lewis, D. A., McNulty, A., Fairley, C. K., Yeung, B., Jin, F., Fraser, D., Bavinton, B. R., Law, M., Chen, M. Y., Chow, E. P. F., Whiley, D. M., Mackie, B., Jennings, M. P., Jennison, A. V., Lahra, M. M., Grulich, A. E. Tags: Open access, Infectious diseases Source Type: research
Police Harassment and Psychiatric, Sexual, and Substance Use Risk Among Black Sexual Minority Men and Black Transgender Women in the HIV Prevention Trials 061 Cohort
ConclusionPH may influence not only mental health but also behavioral risks that contribute to HIV/STI among BSMM/BTW, highlighting the potential wide-ranging and downstream effects of PH on health. Further research is required to confirm associations and elucidate pathways through which PH may influence HIV/STI among BSMM/BTW. (Source: Journal of Racial and Ethnic Health Disparities)
Source: Journal of Racial and Ethnic Health Disparities - April 12, 2024 Category: International Medicine & Public Health Source Type: research
