Interim Estimates of 2023-2024 Seasonal Influenza Vaccine Effectiveness Among Adults in Korea
In this study, we aimed to estimate the interim vaccine effectiveness (VE) of the influenza vaccination to prevent influenza during the early season. From November 1, 2023, to December 31, 2023, we enrolled 2,632 subjects with influenza-like illness from eight hospitals participating in hospital-based influenza morbidity and mortality surveillance. A retrospective test-negative case-control study was conducted to estimate the VE. The results showed an adjusted VE of 22.5% (95% confidence interval [CI], 6.6 to 35.8) for the total population. The adjusted VE was 22.3% (95% CI, 6.1 to 35.7) for influenza A and 9.4% (95% CI, -...
Source: Journal of Korean Medical Science - April 23, 2024 Category: Biomedical Science Authors: Yu Jung Choi Jang Wook Sohn Won Suk Choi Seong-Heon Wie Jacob Lee Jin-Soo Lee Hye Won Jeong Joong Sik Eom Eliel Nham Hye Seong Jin Gu Yoon Ji Yun Noh Joon Young Song Hee Jin Cheong Woo Joo Kim Source Type: research
Interim Estimates of 2023-2024 Seasonal Influenza Vaccine Effectiveness Among Adults in Korea
In this study, we aimed to estimate the interim vaccine effectiveness (VE) of the influenza vaccination to prevent influenza during the early season. From November 1, 2023, to December 31, 2023, we enrolled 2,632 subjects with influenza-like illness from eight hospitals participating in hospital-based influenza morbidity and mortality surveillance. A retrospective test-negative case-control study was conducted to estimate the VE. The results showed an adjusted VE of 22.5% (95% confidence interval [CI], 6.6 to 35.8) for the total population. The adjusted VE was 22.3% (95% CI, 6.1 to 35.7) for influenza A and 9.4% (95% CI, -...
Source: J Korean Med Sci - April 23, 2024 Category: General Medicine Authors: Yu Jung Choi Jang Wook Sohn Won Suk Choi Seong-Heon Wie Jacob Lee Jin-Soo Lee Hye Won Jeong Joong Sik Eom Eliel Nham Hye Seong Jin Gu Yoon Ji Yun Noh Joon Young Song Hee Jin Cheong Woo Joo Kim Source Type: research
Interim Estimates of 2023-2024 Seasonal Influenza Vaccine Effectiveness Among Adults in Korea
In this study, we aimed to estimate the interim vaccine effectiveness (VE) of the influenza vaccination to prevent influenza during the early season. From November 1, 2023, to December 31, 2023, we enrolled 2,632 subjects with influenza-like illness from eight hospitals participating in hospital-based influenza morbidity and mortality surveillance. A retrospective test-negative case-control study was conducted to estimate the VE. The results showed an adjusted VE of 22.5% (95% confidence interval [CI], 6.6 to 35.8) for the total population. The adjusted VE was 22.3% (95% CI, 6.1 to 35.7) for influenza A and 9.4% (95% CI, -...
Source: Journal of Korean Medical Science - April 23, 2024 Category: Biomedical Science Authors: Yu Jung Choi Jang Wook Sohn Won Suk Choi Seong-Heon Wie Jacob Lee Jin-Soo Lee Hye Won Jeong Joong Sik Eom Eliel Nham Hye Seong Jin Gu Yoon Ji Yun Noh Joon Young Song Hee Jin Cheong Woo Joo Kim Source Type: research
Viruses, Vol. 16, Pages 626: Detection and Characterization of Influenza A Virus Endemic Circulation in Suckling and Nursery Pigs Originating from Vaccinated Farms in the Same Production System
The objective of this study was to evaluate the detection of IAV in suckling and nursery piglets from IAV-vaccinated sows from farms with endemic IAV infections. Eight nasal swab collections were obtained from 135 two-week-old suckling piglets from four farms every other week from March to September 2013. Oral fluid samples were collected from the same group of nursery piglets. IAV RNA was detected in 1.64% and 31.01% of individual nasal swabs and oral fluids, respectively. H1N2 was detected most often, with sporadic detection of H1N1 and H3N2. Whole-genome sequences of IAV isolated from suckling piglets revealed an H1 hem...
Source: Viruses - April 18, 2024 Category: Virology Authors: Alessandra Silva Dias Amy L. Vincent Baker Rodney B. Baker Jianqiang Zhang Michael A. Zeller Pravina Kitikoon Phillip C. Gauger Tags: Article Source Type: research
Pilot-scale production of a highly efficacious and stable monoglycosylated influenza split virus vaccine
In conclusion, this study provides efficacy and safety profiles of IVR-190mg for further clinical study and shows that this vaccine without a glycan shield has great potential to be safe and protective against H1N1 variants.PMID:38582606 | DOI:10.1016/j.vaccine.2023.11.038 (Source: Vaccine)
Source: Vaccine - April 6, 2024 Category: Allergy & Immunology Authors: Chia-Ying Wu Shao-En Kao Yung-Chieh Tseng Jen-Tzu Hou Li-Yang Wu Juine-Ruey Chen Source Type: research
Preparation and characterization of curdlan-chitosan conjugate nanoparticles as mucosal adjuvants for intranasal influenza H1N1 subunit vaccine
In this study, stable nanoparticles formed by curdlan-O-HTCC conjugate (CO NP) were prepared and characterized. Furthermore, the efficacy of CO NP was evaluated as a mucosal adjuvant in an intranasal influenza H1N1 subunit vaccine. The results revealed that CO NP exhibits uniform and spherical morphology, with a size of 190.53 ± 4.22 nm, and notably, it remains stable in PBS at 4 °C for up to 6 weeks. Biological evaluation demonstrated that CO NP stimulates the activation of antigen-presenting cells (APCs), including macrophages and dendritic cells (DCs), both in vitro and in vivo. Furthermore, intranasal administration ...
Source: International Journal of Biological Macromolecules - April 3, 2024 Category: Biochemistry Authors: Honglei Jiang Shu Zhang Yipan Chen Fengshan Wang Wenjie Jiang Source Type: research
Swine influenza A virus: challenges and novel vaccine strategies
Swine Influenza A Virus (IAV-S) imposes a significant impact on the pork industry and has been deemed a significant threat to global public health due to its zoonotic potential. The most effective method of preventing IAV-S is vaccination. While there are tremendous efforts to control and prevent IAV-S in vulnerable swine populations, there are considerable challenges in developing a broadly protective vaccine against IAV-S. These challenges include the consistent diversification of IAV-S, increasing the strength and breadth of adaptive immune responses elicited by vaccination, interfering maternal antibody responses, and ...
Source: Frontiers in cellular and infection microbiology - April 3, 2024 Category: Microbiology Source Type: research
Supplementation of seasonal vaccine with multi-subtype neuraminidase and M2 ectodomain virus-like particle improves protection against homologous and heterologous influenza viruses in aged mice
Antiviral Res. 2024 Mar 30:105877. doi: 10.1016/j.antiviral.2024.105877. Online ahead of print.ABSTRACTThe conventional inactivated split seasonal influenza vaccine offers low efficacy, particularly in the elderly and against antigenic variants. Here, to improve the efficacy of seasonal vaccination for the elderly population, we tested whether supplementing seasonal bivalent (H1N1 + H3N2) split (S) vaccine with M2 ectodomain repeat and multi-subtype consensus neuraminidase (NA) proteins (N1 NA + N2 NA + flu B NA) on a virus-like particle (NA-M2e) would induce enhanced cross-protection against different influenza viruses in...
Source: Antiviral Research - April 1, 2024 Category: Virology Authors: Jannatul Ruhan Raha Ki-Hye Kim Noopur Bhatnagar Rong Liu Chau Thuy Tien Le Bo Ryoung Park Phillip Grovenstein Surya Sekhar Pal Eun-Ju Ko Chong Hyun Shin Bao-Zhong Wang Sang-Moo Kang Source Type: research
Supplementation of seasonal vaccine with multi-subtype neuraminidase and M2 ectodomain virus-like particle improves protection against homologous and heterologous influenza viruses in aged mice
Antiviral Res. 2024 Mar 30:105877. doi: 10.1016/j.antiviral.2024.105877. Online ahead of print.ABSTRACTThe conventional inactivated split seasonal influenza vaccine offers low efficacy, particularly in the elderly and against antigenic variants. Here, to improve the efficacy of seasonal vaccination for the elderly population, we tested whether supplementing seasonal bivalent (H1N1 + H3N2) split (S) vaccine with M2 ectodomain repeat and multi-subtype consensus neuraminidase (NA) proteins (N1 NA + N2 NA + flu B NA) on a virus-like particle (NA-M2e) would induce enhanced cross-protection against different influenza viruses in...
Source: Cell Research - April 1, 2024 Category: Cytology Authors: Jannatul Ruhan Raha Ki-Hye Kim Noopur Bhatnagar Rong Liu Chau Thuy Tien Le Bo Ryoung Park Phillip Grovenstein Surya Sekhar Pal Eun-Ju Ko Chong Hyun Shin Bao-Zhong Wang Sang-Moo Kang Source Type: research
Supplementation of seasonal vaccine with multi-subtype neuraminidase and M2 ectodomain virus-like particle improves protection against homologous and heterologous influenza viruses in aged mice
Antiviral Res. 2024 Mar 30:105877. doi: 10.1016/j.antiviral.2024.105877. Online ahead of print.ABSTRACTThe conventional inactivated split seasonal influenza vaccine offers low efficacy, particularly in the elderly and against antigenic variants. Here, to improve the efficacy of seasonal vaccination for the elderly population, we tested whether supplementing seasonal bivalent (H1N1 + H3N2) split (S) vaccine with M2 ectodomain repeat and multi-subtype consensus neuraminidase (NA) proteins (N1 NA + N2 NA + flu B NA) on a virus-like particle (NA-M2e) would induce enhanced cross-protection against different influenza viruses in...
Source: Antiviral Research - April 1, 2024 Category: Virology Authors: Jannatul Ruhan Raha Ki-Hye Kim Noopur Bhatnagar Rong Liu Chau Thuy Tien Le Bo Ryoung Park Phillip Grovenstein Surya Sekhar Pal Eun-Ju Ko Chong Hyun Shin Bao-Zhong Wang Sang-Moo Kang Source Type: research
Supplementation of seasonal vaccine with multi-subtype neuraminidase and M2 ectodomain virus-like particle improves protection against homologous and heterologous influenza viruses in aged mice
Antiviral Res. 2024 Mar 30:105877. doi: 10.1016/j.antiviral.2024.105877. Online ahead of print.ABSTRACTThe conventional inactivated split seasonal influenza vaccine offers low efficacy, particularly in the elderly and against antigenic variants. Here, to improve the efficacy of seasonal vaccination for the elderly population, we tested whether supplementing seasonal bivalent (H1N1 + H3N2) split (S) vaccine with M2 ectodomain repeat and multi-subtype consensus neuraminidase (NA) proteins (N1 NA + N2 NA + flu B NA) on a virus-like particle (NA-M2e) would induce enhanced cross-protection against different influenza viruses in...
Source: Antiviral Research - April 1, 2024 Category: Virology Authors: Jannatul Ruhan Raha Ki-Hye Kim Noopur Bhatnagar Rong Liu Chau Thuy Tien Le Bo Ryoung Park Phillip Grovenstein Surya Sekhar Pal Eun-Ju Ko Chong Hyun Shin Bao-Zhong Wang Sang-Moo Kang Source Type: research
Supplementation of seasonal vaccine with multi-subtype neuraminidase and M2 ectodomain virus-like particle improves protection against homologous and heterologous influenza viruses in aged mice
Antiviral Res. 2024 Mar 30;225:105877. doi: 10.1016/j.antiviral.2024.105877. Online ahead of print.ABSTRACTThe conventional inactivated split seasonal influenza vaccine offers low efficacy, particularly in the elderly and against antigenic variants. Here, to improve the efficacy of seasonal vaccination for the elderly population, we tested whether supplementing seasonal bivalent (H1N1 + H3N2) split (S) vaccine with M2 ectodomain repeat and multi-subtype consensus neuraminidase (NA) proteins (N1 NA + N2 NA + flu B NA) on a virus-like particle (NA-M2e) would induce enhanced cross-protection against different influenza viruse...
Source: Antiviral Research - April 1, 2024 Category: Virology Authors: Jannatul Ruhan Raha Ki-Hye Kim Noopur Bhatnagar Rong Liu Chau Thuy Tien Le Bo Ryoung Park Phillip Grovenstein Surya Sekhar Pal Eun-Ju Ko Chong Hyun Shin Bao-Zhong Wang Sang-Moo Kang Source Type: research
Anti-NMDA Receptor Encephalitis, Human Papillomavirus, and microRNA
CONCLUSION: This finding suggests that in cases where individuals receiving HPV vaccination experience psychiatric or neurological symptoms, it should be considered to diagnose anti-NMDA receptor encephalitis, given the exclusion of other possible complications.PMID:38549528 | DOI:10.2174/0109298673264615231124072130 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Hsiuying Wang Source Type: research
Anti-NMDA Receptor Encephalitis, Human Papillomavirus, and microRNA
CONCLUSION: This finding suggests that in cases where individuals receiving HPV vaccination experience psychiatric or neurological symptoms, it should be considered to diagnose anti-NMDA receptor encephalitis, given the exclusion of other possible complications.PMID:38549528 | DOI:10.2174/0109298673264615231124072130 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Hsiuying Wang Source Type: research
Anti-NMDA Receptor Encephalitis, Human Papillomavirus, and microRNA
CONCLUSION: This finding suggests that in cases where individuals receiving HPV vaccination experience psychiatric or neurological symptoms, it should be considered to diagnose anti-NMDA receptor encephalitis, given the exclusion of other possible complications.PMID:38549528 | DOI:10.2174/0109298673264615231124072130 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Hsiuying Wang Source Type: research
