Treat the Pathway, not the Gene (from Precision Medicine and the Reinvention of Human Disease)
Treat the key pathway, not the genetic mutation (fromPrecision Medicine and the Reinvention of Human Disease)Some of the earliest and most successful Precision Medication drugs have targeted specific mutations occurring in specific subsets of diseases. One such example is ivacaftor, which targets the G551D mutation present in about 4% of individuals with cystic fibrosis [135]. It is seldom wise to argue with success, but it must be mentioned that the cost of developing a new drug is about $5 billion [136]. To provide some perspective, $5 billion exceeds the total gross national product of many countries, including Sierra L...
Source: Specified Life - February 5, 2018 Category: Information Technology Tags: clinical trials convergent pathways cost of precision medicine precision treatment Source Type: blogs

Defining the next revolution for women, work and family
During these last days of the summer, we here at Disruptive Women are reflecting on posts near when we first launched—it’s fascinating to see how far we’ve come and where we still have to go—to push—to Disrupt.  After all, a woman’s work is never done. We originally published this post on June 19, 2012. by Madeleine Kunin. Trying to “do it all” takes a toll on women’s health. And men’s health too.  Surprisingly, more men than women report feeling work life stress. It’s time to take a serious look at how we expect families to com...
Source: Disruptive Women in Health Care - August 29, 2016 Category: Consumer Health News Authors: dw at disruptivewomen.net Tags: Caregiving Children Politics Child care childcare family Family and Medical Leave Act feminism Paid leave Poverty workplace flexibility Source Type: blogs

Where Do K-1 Visa Holders Come From?
Syed Farook and Tashfeen Malik were killed last week in a gun battle with police after they committed a mass shooting in San Bernardino, California.  Malik entered the U.S. on a K-1 visa, known as the fiancé visa, accompanied by Farook.  Their attack is the first perpetrated by somebody on the K-1 visa - igniting a debate over increasing visa security.    The government issued approximately 262,162 K-1 visas from 2005 to 2013 – 3177 or 1.21 percent of the total to Pakistani citizens.  Senator Rand Paul’s (R-KY) SECURE Act identifies 34 countries as particularly terror-prone. ...
Source: Cato-at-liberty - December 7, 2015 Category: American Health Authors: Alex Nowrasteh Source Type: blogs

Heading Off The Looming Diabetes-Tuberculosis Epidemic
Tuberculosis (TB) has recently made headlines in the U.S. And news of these cases remind us once again that TB is far from conquered. This disease infects about 8.6 million people every year and kills 1.5 million, more than any other infectious disease except human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS). Increasingly, TB’s spread is fueled by rising rates of diabetes—as with HIV, diabetes weakens the immune system, making a person more vulnerable to TB infection and illness—particularly in emerging economies like India and China, which are the source for much o...
Source: Health Affairs Blog - August 19, 2015 Category: Health Management Authors: Anthony Harries Tags: Costs and Spending Equity and Disparities Featured Global Health Organization and Delivery Population Health Public Health Diabetes epidemics HIV/AIDS TB World Diabetes Foundation World Health Organization Source Type: blogs

Welcome to the American Republic, William Windsor
David Boaz The royals are coming, the royals are coming! In this case, the grandson of the Queen of England, along with his wife, who took a fairytale leap from commoner to duchess by marrying him. (Just imagine, Kate Middleton a duchess while Margaret Thatcher was only made a countess.) And once again Americans who have forgotten the American Revolution are telling us to bow and curtsy before them, and address them as “Your Royal Highness,” and stand when William enters the room. So one more time: Americans don’t bow or curtsy to foreign monarchs. (If you don’t believe me, ask Miss Manne...
Source: Cato-at-liberty - December 7, 2014 Category: American Health Authors: David Boaz Source Type: blogs

Freedom of Thought Under Siege Around the Globe: When You are Not Free to Not Believe
Doug Bandow Much of the world has just celebrated the most sacred Christian holiday, yet persecution of Christians has never been fiercer, especially in the Middle East.  Other faiths also suffer varying degrees of persecution.  Nonbelievers also often are mistreated.  The lack of religious belief is less likely to be punished by communist and former communist regimes.  But such systems penalize almost all independent thought.  Moreover, atheists and other freethinkers are at special risk in theocratic and especially aggressively Muslim states.  The International Humanist and Ethical Union re...
Source: Cato-at-liberty - December 31, 2013 Category: Health Medicine and Bioethics Commentators Authors: Doug Bandow Source Type: blogs