The Prevalence and Antimicrobial Susceptibility of Methicillin-Resistant Staphylococcus aureus Before and After the COVID-19 Pandemic in a Tertiary Saudi Hospital
CONCLUSION: It was concluded that the prevalence rates of MRSA have not increased in 2020 when compared to 2019. Vancomycin, linezolid, trimethoprim-sulfamethoxazole, and doxycycline remain susceptible to the positive collected MRSA strains. There was no significant difference between the prevalence and antimicrobial resistance rates of MRSA between 2019 and 2020. Continued research efforts are needed to address this persistent public health threat. Strategies to control the spread of MRSA should include early detection of MRSA and surveillance, even during pandemics.PMID:38529437 | PMC:PMC10962010 | DOI:10.7759/cureus.548...
Source: Cancer Control - March 26, 2024 Category: Cancer & Oncology Authors: Omar B Ahmed Fayez S Bahwerth Radi Alsafi Eman A Elsebaei Gamal T Ebid Abdulrhaman Theyab Hamza Assaggaf Source Type: research

Expression of Concern: Mechanisms and toxicity evaluation of the degradation of sulfamethoxazole by MPUV/PMS process (Chemosphere, Volume 212, December 2018, Pages 365-375)
Chemosphere. 2024 Apr;353:141601. doi: 10.1016/j.chemosphere.2024.141601. Epub 2024 Mar 2.NO ABSTRACTPMID:38528396 | DOI:10.1016/j.chemosphere.2024.141601 (Source: Chemosphere)
Source: Chemosphere - March 26, 2024 Category: Chemistry Source Type: research

Expression of Concern: Adding CuCo < sub > 2 < /sub > O < sub > 4 < /sub > -GO to inhibit bromate formation and enhance sulfamethoxazole degradation during the ozone/peroxymonosulfate process: Efficiency and mechanism (Chemosphere, Volume 286, Part 2, January 2022, 131829)
Chemosphere. 2024 Apr;353:141614. doi: 10.1016/j.chemosphere.2024.141614. Epub 2024 Mar 2.NO ABSTRACTPMID:38528407 | DOI:10.1016/j.chemosphere.2024.141614 (Source: Chemosphere)
Source: Chemosphere - March 26, 2024 Category: Chemistry Source Type: research

Expression of Concern: Mechanisms and toxicity evaluation of the degradation of sulfamethoxazole by MPUV/PMS process (Chemosphere, Volume 212, December 2018, Pages 365-375)
Chemosphere. 2024 Apr;353:141601. doi: 10.1016/j.chemosphere.2024.141601. Epub 2024 Mar 2.NO ABSTRACTPMID:38528396 | DOI:10.1016/j.chemosphere.2024.141601 (Source: Chemosphere)
Source: Chemosphere - March 26, 2024 Category: Chemistry Source Type: research

Expression of Concern: Adding CuCo(2)O(4)-GO to inhibit bromate formation and enhance sulfamethoxazole degradation during the ozone/peroxymonosulfate process: Efficiency and mechanism (Chemosphere, Volume 286, Part 2, January 2022, 131829)
Chemosphere. 2024 Apr;353:141614. doi: 10.1016/j.chemosphere.2024.141614. Epub 2024 Mar 2.NO ABSTRACTPMID:38528407 | DOI:10.1016/j.chemosphere.2024.141614 (Source: Chemosphere)
Source: Chemosphere - March 26, 2024 Category: Chemistry Source Type: research

Infection and antibiotic-associated changes in the fecal microbiota of < em > C. rodentium < /em > ϕ < em > stx2 < sub > dact < /sub > < /em > -infected C57BL/6 mice
Antimicrob Agents Chemother. 2024 Mar 25:e0005724. doi: 10.1128/aac.00057-24. Online ahead of print.ABSTRACTEnterohemorrhagic Escherichia coli causes watery to bloody diarrhea, which may progress to hemorrhagic colitis and hemolytic-uremic syndrome. While early studies suggested that antibiotic treatment may worsen the pathology of an enterohemorrhagic Escherichia coli (EHEC) infection, recent work has shown that certain non-Shiga toxin-inducing antibiotics avert disease progression. Unfortunately, both intestinal bacterial infections and antibiotic treatment are associated with dysbiosis. This can alleviate colonization r...
Source: Antimicrobial Agents and Chemotherapy - March 25, 2024 Category: Microbiology Authors: Sabrina M ühlen Ann Kathrin Heroven Bettina Elxnat Silke Kahl Dietmar H Pieper Petra Dersch Source Type: research

Infection and antibiotic-associated changes in the fecal microbiota of < em > C. rodentium < /em > ϕ < em > stx2 < sub > dact < /sub > < /em > -infected C57BL/6 mice
Antimicrob Agents Chemother. 2024 Mar 25:e0005724. doi: 10.1128/aac.00057-24. Online ahead of print.ABSTRACTEnterohemorrhagic Escherichia coli causes watery to bloody diarrhea, which may progress to hemorrhagic colitis and hemolytic-uremic syndrome. While early studies suggested that antibiotic treatment may worsen the pathology of an enterohemorrhagic Escherichia coli (EHEC) infection, recent work has shown that certain non-Shiga toxin-inducing antibiotics avert disease progression. Unfortunately, both intestinal bacterial infections and antibiotic treatment are associated with dysbiosis. This can alleviate colonization r...
Source: Antimicrobial Agents and Chemotherapy - March 25, 2024 Category: Microbiology Authors: Sabrina M ühlen Ann Kathrin Heroven Bettina Elxnat Silke Kahl Dietmar H Pieper Petra Dersch Source Type: research

Effects of antibiotics on secondary metabolism and oxidative stress in oilseed rape seeds
In this study, typical tetracycline and sulfonamide antibiotics tetracycline (TC) and sulfamethoxazole (SMZ) were used to investigate the effects of antibiotics on rapeseed quality and oxidative stress at the level of secondary metabolism on the basis of examining the effects of the two drugs on the growth of soil-cultivated rapeseed seedlings. The results showed that both plant height and biomass of rapeseed seedlings were significantly suppressed and ROS were significantly induced in rapeseed by exposure to high concentrations (2.5 mg/kg) of TC and SMZ. Carotenoids, tocopherols, and SOD enzymes were involved in the oxida...
Source: Environmental Science and Pollution Research International - March 23, 2024 Category: Environmental Health Authors: Ke Li Mengting Zhao Shanshan Zhou Lili Niu Lu Zhao Dongmei Xu Source Type: research

Effects of antibiotics on secondary metabolism and oxidative stress in oilseed rape seeds
In this study, typical tetracycline and sulfonamide antibiotics tetracycline (TC) and sulfamethoxazole (SMZ) were used to investigate the effects of antibiotics on rapeseed quality and oxidative stress at the level of secondary metabolism on the basis of examining the effects of the two drugs on the growth of soil-cultivated rapeseed seedlings. The results showed that both plant height and biomass of rapeseed seedlings were significantly suppressed and ROS were significantly induced in rapeseed by exposure to high concentrations (2.5 mg/kg) of TC and SMZ. Carotenoids, tocopherols, and SOD enzymes were involved in the oxida...
Source: Environmental Science and Pollution Research International - March 23, 2024 Category: Environmental Health Authors: Ke Li Mengting Zhao Shanshan Zhou Lili Niu Lu Zhao Dongmei Xu Source Type: research

Survey of Japanese nephrologists' use of clinical practice guidelines for rapidly progressive glomerulonephritis
ConclusionsThe survey responses revealed how Japan's new RPGN guidelines are used in actual clinical practice. Our findings will contribute to the guidelines' dissemination and implementation. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - March 22, 2024 Category: Urology & Nephrology Source Type: research

Assessing the potential for improved predictive capacity of antimicrobial resistance in outpatient Staphylococcus aureus isolates using seasonal and spatial antibiograms
ConclusionsStandard antibiograms are poor in predictingS. aureus susceptibility to antibiotics often chosen by clinicians, and seasonal and spatial antibiograms do not provide an improved tool in anticipating non-susceptibility. These findings suggest that further refinements to antibiograms may be necessary to improve their utility in informing choice of effective antibiotic therapy. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - March 22, 2024 Category: Infectious Diseases Source Type: research

Whole genome sequencing and molecular epidemiology of methicillin-resistant Staphylococcus aureus isolated from patients with bacteraemia in Slovenia
ConclusionThis study demonstrates that bacteraemia in central Slovenia is caused by diverse MRSA lineages. Identification of newly emerged lineages should be followed in the future to detect changes in the molecular epidemiology of MRSA in our country. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - March 22, 2024 Category: Microbiology Source Type: research

Myelotoxicity and kidney dysfunction related to the use of trimethoprim-sulfamethoxazole for the treatment of Pneumocystis jirovecii pneumonia: a case report of severe adverse events with a common drug
We present the case of a male patient with hypertension and a recent diagnosis of non-Hodgkin lymphoma, undergoing rituximab treatment for two months. He was admitted to the intensive care unit due to dyspnea, tachypnea, and pleuritic pain, requiring mechanical ventilation. Chest computed tomography showed bilateral and multilobed ground-glass opacities, compromising more than 80% of the lung parenchyma. Pulmonary tuberculosis and COVID-19 were ruled out. An angiotomography and Doppler ultrasound revealed an extensive pulmonary thrombus and deep venous thrombosis. Empiric treatment with TMP-SMX for PCP was initiated, but w...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 21, 2024 Category: Tropical Medicine Authors: Isabel Cristina Melo Mendes Roxana Flores Mamani David Richer Araujo Coelho Clarisse Pimentel Source Type: research

Myelotoxicity and kidney dysfunction related to the use of trimethoprim-sulfamethoxazole for the treatment of Pneumocystis jirovecii pneumonia: a case report of severe adverse events with a common drug
We present the case of a male patient with hypertension and a recent diagnosis of non-Hodgkin lymphoma, undergoing rituximab treatment for two months. He was admitted to the intensive care unit due to dyspnea, tachypnea, and pleuritic pain, requiring mechanical ventilation. Chest computed tomography showed bilateral and multilobed ground-glass opacities, compromising more than 80% of the lung parenchyma. Pulmonary tuberculosis and COVID-19 were ruled out. An angiotomography and Doppler ultrasound revealed an extensive pulmonary thrombus and deep venous thrombosis. Empiric treatment with TMP-SMX for PCP was initiated, but w...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 21, 2024 Category: Tropical Medicine Authors: Isabel Cristina Melo Mendes Roxana Flores Mamani David Richer Araujo Coelho Clarisse Pimentel Source Type: research

Myelotoxicity and kidney dysfunction related to the use of trimethoprim-sulfamethoxazole for the treatment of Pneumocystis jirovecii pneumonia: a case report of severe adverse events with a common drug
We present the case of a male patient with hypertension and a recent diagnosis of non-Hodgkin lymphoma, undergoing rituximab treatment for two months. He was admitted to the intensive care unit due to dyspnea, tachypnea, and pleuritic pain, requiring mechanical ventilation. Chest computed tomography showed bilateral and multilobed ground-glass opacities, compromising more than 80% of the lung parenchyma. Pulmonary tuberculosis and COVID-19 were ruled out. An angiotomography and Doppler ultrasound revealed an extensive pulmonary thrombus and deep venous thrombosis. Empiric treatment with TMP-SMX for PCP was initiated, but w...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - March 21, 2024 Category: Tropical Medicine Authors: Isabel Cristina Melo Mendes Roxana Flores Mamani David Richer Araujo Coelho Clarisse Pimentel Source Type: research