Nasal screening for methicillin-resistant Staphylococcus aureus does not reduce surgical site infection after primary lumbar fusion
Background Context: Preoperative methicillin-resistant Staphylococcus aureus (MRSA) testing and decolonization has demonstrated success for arthroplasty patients in surgical site infections (SSIs) prevention. Spine surgery, however, has seen varied results.
Purpose: The purpose of this study was to determine the impact of nasal MRSA testing and operative debridement rates on surgical site infection after primary lumbar fusion.
Study Design/setting: Retrospective cohort study and/or Consolidated medical enterprise PATIENT SAMPLE: Adult patients undergoing primary instrumented lumbar fusions from January 2015 to December 2...
Source: Current Awareness Service for Health (CASH) - January 17, 2022 Category: Consumer Health News Source Type: news
Efficacy of antimicrobial peptide LL-37 against biofilm forming Staphylococcus aureus strains obtained from chronic wound infections
The antimicrobial peptide LL-37 showed inhibitory effects against Staphylococcus aureus strains, which often responsible for wound infections. Understanding the molecular mechanisms of biofilm-containing wound infections is important. Thus, this study aimed to investigate both the antimicrobial and biofilm efficacy of LL-37 against biofilm-positive methicillin-susceptible S. aureus (MSSA) strains and biofilm-positive methicillin-resistant S. aureus (MRSA) strains obtained from chronic wound infections and its effect on different quorum sensing and virulence genes at suboptimal concentrations. Fifteen biofilm-forming MRSA a...
Source: Current Awareness Service for Health (CASH) - January 17, 2022 Category: Consumer Health News Source Type: news
Combined sterilization and fabrication of drug-loaded scaffolds using supercritical CO 2 technology
The access of biodegradable scaffolds to the clinical arena is constrained by the absence of a suitable sterilization technique for the processing of advanced polymeric materials. Sterilization with supercritical CO 2 (scCO 2 ) may circumvent some technological limitations (e.g., low temperature, no chemical residues on the material), although scCO 2 can plasticize the polymer depending on the processing conditions used. In this latter case, the integration of the manufacturing and sterilization processes is of particular interest to obtain sterile and customized scaffolds in a single step. In this work, scCO 2 was exploit...
Source: Current Awareness Service for Health (CASH) - January 17, 2022 Category: Consumer Health News Source Type: news
Antimicrobial effectiveness of wound matrices containing native extracellular matrix with polyhexamethylene biguanide
This study compares the antimicrobial and wound healing capabilities, both in vivo and in vitro against methicillin-resistant Staphylococcus aureus (MRSA) USA 300, for the following compounds: Collagen Wound Matrix-Anti Microbial (CWM-AM); Collagen Wound Matrix-Anti Microbial XT (CWM-AM XT); Antimicrobial Hydrofiber Wound Dressing (AHWD); Dermal Scaffold with Silver (DRSAg); Collagen Extracellular Matrix (CEM); Collagen Wound Matrix (CWM); Matrix Wound Dressing with Silver (MWDAg); Cadexomer Iodine Gel (CIG); Triple Antibiotic Ointment (TAO); and Antimicrobial Wound Gel (AWG). For the in vitro zone of inhibition assay, AWG...
Source: Current Awareness Service for Health (CASH) - January 17, 2022 Category: Consumer Health News Source Type: news
Effectiveness and real-world materials compatibility of a novel hydrogen peroxide disinfectant cleaner.
A novel 4% hydrogen peroxide disinfectant was effective against methicillin-resistant Staphylococcus aureus (MRSA), Clostridioides difficile spores, carbapenem-resistant Escherichia coli, and 2 strains of Candida auris. In laboratory testing, a sodium hypochlorite disinfectant caused fading and loss of pliability of a hospital mattress, but the hydrogen peroxide disinfectant did not. These findings suggest that the hydrogen peroxide-based disinfectant may be a useful addition to the sporicidal disinfectant products available for use in healthcare settings. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - December 14, 2021 Category: Consumer Health News Source Type: news
Pathogenicity and virulence of Staphylococcus aureus
Staphylococcus aureus is one of the most frequent worldwide causes of morbidity and mortality due to an infectious agent. This pathogen can cause a wide variety of diseases, ranging from moderately severe skin infections to fatal pneumonia and sepsis. Treatment of S. aureus infections is complicated by antibiotic resistance and a working vaccine is not available. There has been ongoing and increasing interest in the extraordinarily high number of toxins and other virulence determinants that S. aureus produces and how they impact disease. In this review, we will give an overview of how S. aureus initiates and maintains infe...
Source: Current Awareness Service for Health (CASH) - December 14, 2021 Category: Consumer Health News Source Type: news
The use of functionalized nanoparticles to treat Staphylococcus aureus-based surgical-site infections: a systematic review.
Staphylococcus aureus-based surgical site infections have become the leading cause of failure for total joint arthroplasty operations and remain a major issue across surgical specialties. Moreover, S. aureus-based infections are becoming drastically more difficult to treat due to the development of antibiotic resistant strains and due to the bacteria ' s propensity to produce biofilms. The emergence of highly resistant S. aureus infections has created the need for a novel antimicrobial treatment. Functionalized nanoparticles have recently been suggested as being a viable option to fill this void due to their strong antimic...
Source: Current Awareness Service for Health (CASH) - December 14, 2021 Category: Consumer Health News Source Type: news
Hospital- and System-Wide Interventions for Health Care-Associated Infections: A Systematic Review.
Hospitals face increasing pressure to reduce health care-associated infections (HAI) due to their costs and evidence of preventability. However, there is limited synthesis of evidence regarding interventions that can be successfully implemented hospital- or system-wide. Using Donabedian ' s structure-process-outcome model, we conducted a systematic literature review from 2008 to early 2019, identifying 96 studies with 214 outcomes examining the relationship between hospital- or system-wide interventions and HAIs. This literature ' s methodologic and reporting quality was generally poor. The most common HAIs studied were me...
Source: Current Awareness Service for Health (CASH) - December 14, 2021 Category: Consumer Health News Source Type: news
What is the Difference Between a Paronychia and a Felon?
Discussion
The hands are one of the most important parts of the body for interacting with the world. They are remarkably adapted having sensitive sensory receptors as well as feedback receptors for grasping, holding, and manipulating objects. Hands, especially with an opposable thumb, multiple joints within the hand, along with the wrist and elbow, allow the hand to move in multiple positions to manipulate the world. Hands also symbolize an emotional caring and sharing between individuals as hands are used to provide a true “human touch” in personal and social situations.
Due to their important interactions in ...
Source: PediatricEducation.org - December 6, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
Environmental Shedding of MRSA Is Far Greater than from Multidrug-Resistant Gram-Negative Bacilli
An observational cohort study revealed shedding of methicillin-resistant Staphylococcus aureus by colonized patients outside hospital rooms or during outpatient clinic visits occurred more often than in those colonized by multidrug-resistant gram-negative bacilli. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - November 12, 2021 Category: Consumer Health News Source Type: news
Risk factors for nosocomial methicillin resistant Staphylococcus aureus (MRSA) colonization in a neonatal intensive care unit: A Case-control study
Persistently circulating MRSA clone in NICU. • Risk factors for MRSA colonization, independent of length of stay& gestational age. • Colonization pressure, lower ATP pass rate are associated with acquisition of colonization. • Higher acuity of care is also associated with acquisition of colonization. • In a multivariable model, only colonization pressure was significantly associated. To determine risk factors for MRSA col onization in a Level IV Neonatal Intensive Care Unit (NICU) independent of length of stay and gestational age in the context of a persistently circulating MRSA clone. Retrospective matched case-co...
Source: Current Awareness Service for Health (CASH) - November 12, 2021 Category: Consumer Health News Source Type: news
Does high adherence to contact precautions lead to low in-hospital transmission of multidrug-resistant microorganisms in the endemic setting? "
Conclusion: High adherence coupled with continuous monitoring of CP correlated to a very low in-hospital transmission rate. These results indicate that CP is highly effective if routine monitoring of adherence is implemented. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - November 12, 2021 Category: Consumer Health News Source Type: news
Investigations of Staphylococcal contamination on environmental surfaces of a neonatal intensive care unit of a children's hospital
Viable Staphylococci were found on 54% of NICU surfaces sampled. • Mannitol-negative Staphylococci were dominant type of Staphylococci found. • MRSA was the lowest percentage of Staphylococci, found on 11% of sites. • Greatest NICU presence of Staphylococci found on floors and return air ducts. • Contamination of floors and return air ducts could serve as a pathogen reservoir. Staphylococci species are known to cause healthcare-associated infections in neonatal intensive care (NICU) unit patients. Little is known about Staphylococcal contamination of NICU environments. Swabs from 25 of 46 (54%) surfaces sampled in ...
Source: Current Awareness Service for Health (CASH) - November 12, 2021 Category: Consumer Health News Source Type: news
Does high adherence to contact precautions lead to low in-hospital transmission of multi-drug-resistant micro-organisms in the endemic setting?
Conclusion: High adherence coupled with continuous monitoring of CPs correlated with a very low in-hospital transmission rate. These results indicate that CPs are highly effective if routine monitoring of adherence is implemented. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 15, 2021 Category: Consumer Health News Source Type: news
Surveillance for Healthcare-Associated Infections: Hospital-Onset Adult Sepsis Events Versus Current Reportable Conditions
Conclusions CDC ' s HO-ASE definition detects many serious nosocomial infections missed by currently reportable HAIs. HO-ASE surveillance could increase the efficiency and clinical significance of surveillance while identifying new targets for prevention. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 8, 2021 Category: Consumer Health News Source Type: news
