Effect of experimental pulmonary arterial hypertension on renal and bone parameters of rats submitted to resistance exercise training
This study aimed to assess the impacts of stable PAH induced by monocrotaline (MCT) and RT on renal morphometry, as well as bone morphometry and biomechanical properties in male Wistar rats. Four experimental groups, untrained control (UC, n=7), trained control (TC, n=7), untrained hypertensive (UH, n=7), trained hypertensive (TH, n=7), were defined. After the first MCT or saline injection (20 mg/kg), trained rats were submitted to a RT program (i.e., Ladder climbing), 5 times/week. Seven days later the rats received the second MCT or saline dose. After euthanasia, renal and femoral histomorphometry and femoral biomechanic...
Source: An Acad Bras Cienc - April 24, 2024 Category: Science Authors: Le ôncio L Soares Luciano B Leite Ma íra O Freitas Luiz Ot ávio G Ervilha Mayra S P íccolo Alexandre M O Portes Filipe R Drummond Leonardo Mateus T DE Rezende Mariana M Neves Emily C C Reis Miguel A Carneiro-J únior Ant ônio José Natali Source Type: research
Diazoxide and moderate ‐intensity exercise improve skeletal muscle function by decreasing oxidants and enhancing antioxidant defenses in hypertensive male rats
AbstractHigh sodium intake is decisive in the incidence increase and prevalence of hypertension, which has an impact on skeletal muscle functionality. Diazoxide is an antihypertensive agent that inhibits insulin secretion and is an opener of KATP channels (adosine triphosphate sensitive potasium channels). For this reason, it is hypothesized that moderate-intensity exercise and diazoxide improve skeletal muscle function by reducing the oxidants in hypertensive rats. Male Wistar rats were assigned into eight groups: control (CTRL), diazoxide (DZX), exercise (EX), exercise + diazoxide (EX + DZX), hypertension (HTN),...
Source: Physiological Reports - April 24, 2024 Category: Physiology Authors: Estefan ía Bravo Sánchez,
César J. Nolasco Ruíz,
Mariana Gómez‐Barroso,
Christian Cortés Rojo,
Alain R. Rodríguez Orozco,
Alfredo Saavedra Molina,
Salvador Manzo Ávalos,
Rocío Montoya Pérez Tags: ORIGINAL ARTICLE Source Type: research
Urinary metabolites indicative of the administration of hypoxen monitored by liquid chromatography –high resolution/accurate mass tandem mass spectrometry
First data on suitable urinary markers indicative of the administration of the poly(dihydroxyphenylene) thiosulfonate-based drug hypoxen were generated, which can be employed to support the World Anti-Doping Agency monitoring program. AbstractHypoxen, a poly(dihydroxyphenylene) thiosulfonate-based drug, has been investigated concerning its effect on mitochondrial respiration and the utilization of lactate, especially in the context of strenuous exercise. Since 2023, patterns of use regarding hypoxen amongst the athletic population are monitored by the World Anti-Doping Agency (WADA) and its accredited anti-doping laborator...
Source: Drug Testing and Analysis - April 24, 2024 Category: Drugs & Pharmacology Authors: Christian G örgens,
Tristan Möller,
Sven Guddat,
Erkebulan Svambayev,
Hans Geyer,
Andreas Thomas,
Mario Thevis Tags: SPECIAL ISSUE ‐ SHORT COMMUNICATION Source Type: research
Trends in exposure to drugs and prohibited substances among sports: A nationwide analysis of 2008 –2022 inquiry records
This study aimed to enhance the prevention of sports-prohibited substance misuse by analyzing data collected from major nationwide service systems, enabling the identification of trends in athletes' exposure to drugs and prohibited substances. The study collected over 30,000 data points from three major national anti-doping inquiry systems, spanning from 2008 to 2022. The information of the users consulted products, prohibited substances, and sports disciplines in the data were calculated and categorized. The usage of inquiry systems has shown an increasing trend from 2008 to 2022. Athletes comprised the majority of users ...
Source: Drug Testing and Analysis - April 24, 2024 Category: Drugs & Pharmacology Authors: Cheng ‐Chia Chen,
Mei‐Chich Hsu,
Yu‐Tse Wu,
Chi‐Hua Chen,
Tzu‐Yu Lin,
Wei Ho,
William Chih‐Wei Chang Tags: RESEARCH ARTICLE Source Type: research
Professional Societies in Surgical Infection Care
Prevention of surgical site infection (SSI) is a key charge for surgeons. The use of perioperative antibiotics is based on evidence. Still, other elements of the SSI prevention bundle, such as hair clipping, have not demonstrated efficacy in prospective trials. Many surgeons have adopted wound irrigation or wound protector use, as these practices are specifically designed to reduce bacterial load at the surgical wound site, and their decontaminating and barrier effects intuitively seem to make sense as preventive measures. The World Health Organization has endorsed the use of wound protectors for intraoperative SSI prevent...
Source: JAMA Surgery - April 24, 2024 Category: Sports Medicine Source Type: research
Error in the Visual Abstract
In the Original Investigation titled “Morbidity After Mechanical Bowel Preparation and Oral Antibiotics Prior to Rectal Resection: The MOBILE2 Randomized Clinical Trial” published online on March 20, 2024, there was an error in the accompanying visual abstract title. The title should be “Morbidity After Mechanical Bowel Preparati on and Oral Antibiotics Prior to Rectal Resection.” The visual abstract was corrected online. (Source: JAMA Surgery)
Source: JAMA Surgery - April 24, 2024 Category: Sports Medicine Source Type: research
Plastic Wound Protector vs Surgical Gauze for Surgical Site Infection Reduction in Open GI Surgery
This randomized clinical trial examines whether a plastic wound protector lowers surgical site infection rates compared with surgical gauze in open gastrointestinal (GI) surgeries. (Source: JAMA Surgery)
Source: JAMA Surgery - April 24, 2024 Category: Sports Medicine Source Type: research
Total Neoadjuvant Therapy for Pancreatic Cancer —What Is Totality?
This article discusses the meaning of the word total in relation to total neoadjuvant therapy for pancreatic cancer. (Source: JAMA Surgery)
Source: JAMA Surgery - April 24, 2024 Category: Sports Medicine Source Type: research
Solution to Pollution in Surgical Wounds —Not Just Dilution
The systematic review and network meta-analysis by Groenen and colleagues published in a recent issue of JAMA Surgery on incisional wound irrigation for the prevention of surgical site infection (SSI) is a commendable effort in shedding light on a controversial topic in surgery. The key premise is that network meta-analyses can compare the impact of multiple different irrigation solutions on the development of SSI, even when they were not compared in the original studies. Although the study contributes valuable insights, it is essential to scrutinize the inherent challenges in defining and standardizing SSIs, as well as th...
Source: JAMA Surgery - April 24, 2024 Category: Sports Medicine Source Type: research
Incisional Wound Irrigation for the Prevention of Surgical Site Infection
This systematic review and network meta-analysis investigates the outcomes of using different types of prophylactic intraoperative incisional wound irrigation solutions for the prevention of surgical site infections. (Source: JAMA Surgery)
Source: JAMA Surgery - April 24, 2024 Category: Sports Medicine Source Type: research
Elective Appendectomy Following Antibiotics for Appendicitis
This Viewpoint considers which may be the better long-term approach to appendicitis —interval elective appendectomy or nonsurgical treatment with antibiotics. (Source: JAMA Surgery)
Source: JAMA Surgery - April 24, 2024 Category: Sports Medicine Source Type: research
Interval Appendectomy After Successful Antibiotic Treatment?
This Viewpoint discusses the pros and cons of performing interval appendectomy in patients who have recovered from successful antibiotic treatment of acute uncomplicated appendicitis. (Source: JAMA Surgery)
Source: JAMA Surgery - April 24, 2024 Category: Sports Medicine Source Type: research
Correction to: Maximal cardiopulmonary exercise testing in glioblastoma patients undergoing chemotherapy: assessment of feasibility, safety, and physical fitness status
(Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 24, 2024 Category: Cancer & Oncology Source Type: research
The iATTEND Trial: A Trial Comparing Hybrid versus Standard Cardiac Rehabilitation
The improving ATTENDance (iATTEND) to cardiac rehabilitation (CR) trial tested the hypotheses that hybrid cardiac rehabilitation (HYCR = combination of virtual and in-facility CR sessions) would result in greater attendance compared to traditional, facility-based only CR (FBCR) and yield equivalent improvements in exercise capacity and health status. Patients were randomized to HYCR (n=142) or FBCR (n=140), stratified by sex a nd race. Attendance was assessed as number of CR sessions completed within 6 mo (primary end-point) and % patients completing 36 CR sessions. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - April 24, 2024 Category: Cardiology Authors: Steven J. Keteyian, Crystal Grimshaw, Jonathan K. Ehrman, Dennis J. Kerrigan, Khaled Abdul-Nour, David E. Lanfear, Clinton A. Brawner Source Type: research
The effect of extracorporeal shock-wave therapy on pain in patients with various tendinopathies: a systematic review and meta-analysis of randomized control trials
ConclusionThis study suggests that ESWT can be a highly effective therapy option for relieving pain in people with tendinopathy. Nonetheless, it is encouraged to make additional recommendations based on high-quality clinical research and more accurate information in order to define the optimal therapeutic options for each type of tendinopathy. (Source: BMC Sports Science, Medicine and Rehabilitation)
Source: BMC Sports Science, Medicine and Rehabilitation - April 24, 2024 Category: Sports Medicine Source Type: research
