More Commentary on the Role of PF4 in Reducing Brain Inflammation
Platelets in the blood are not just involved in clotting. Near every aspect of our biology has evolved many different functions, and the complexity of our biochemistry is still far from fully explored. Increased platelet factor 4 (PF4) shows up as a feature in a number of different interventions known to reduce inflammation in the aging brain. Researchers are now moving in the direction of developing therapies for neurodegenerative conditions based on the upregulation of PF4 or the delivery of recombinant PF4. Platelets are a component of blood best known for their role in clotting, but research in recent years ha...
Source: Fight Aging! - March 27, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

This One Thought Will Motivate You To Exercise
If you want to run more, use this thought as motivation. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - March 26, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Motivation Source Type: blogs

Apigenin, Sleep, and Aging
For those following research into efforts to upregulate NAD+ levels to improve mitochondrial function, this paper is an interesting sidebar. Some degree of loss of NAD+ emerges from increased activity of CD38. Apigenin is a dietary supplement that can modestly influence both sleep and pace of aging, the latter in short-lived laboratory species at least. Apigenin can increase NAD+ levels by inhibiting CD38 activity. Like much of metabolism, this is all very interesting, but the effect sizes are nothing to write home about. If upregulating NAD+ levels is the goal, you'll do better by exercising. The fundamental flaw in so mu...
Source: Fight Aging! - March 26, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Predicting the Order of Arrival of the First Rejuvenation Therapies
It has been going on eight years since I last speculated on the order of arrival of the first rejuvenation therapies. Tempus fugit, and time for an updated version! Eight years is a long enough span of time for the first of those rejuvenation therapies to now exist, albeit in a prototypical form, arguably proven in principle but not concretely. The world progresses but my biases remain much the same: the first rejuvenation therapies to work well enough to merit the name will be based on the SENS vision, that aging is at root caused by a few classes of accumulated cell and tissue damage, and biotechnologies that either repa...
Source: Fight Aging! - March 25, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Pediatric Exercise Testing
Discussion on pediatric exercise testing. Pediatric exercise testing may be used for evaluation of various disorders of cardiac rhythm rather than for inducible ischemia as in adults. In a child with suspected sinus node dysfunction, chronotropic incompetence from sinus node dysfunction can be assessed by exercise testing. Evaluation of escape rates and ventricular ectopy with exercise in complete heart block is an important aspect in the evaluation of congenital complete heart block. ECG showing congenital complete heart block with ventricular rate of 47/min and atrial rate of 63/min. In stage I of Bruce protocol, the atr...
Source: Cardiophile MD - March 25, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

Redi Health Lands $14 Million Investment to Continue Improving Patient Health Outcomes by Connecting Pharma, Providers, and Patients in One Platform
Series B Funding Round Led by Blue Heron Capital, with Participation from North Coast Ventures, Refinery Ventures, Mutual Capital Partners, Rev1 Ventures, and M25 Redi Health today announced that it has closed $14 million in Series B funding. The funding round was led by Blue Heron Capital, with participation from North Coast Ventures and existing investors Refinery Ventures, Mutual Capital Partners, Rev1 Ventures, and M25. Redi Health will use the financing to foster innovation, develop and launch new products, expand its unique network, and accelerate overall growth. The funding underscores Redi Health’s success...
Source: EMR and HIPAA - March 25, 2024 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Blue Heron Capital Gordon Crenshaw Health IT Funding Health IT Fundings Health IT Investment Jim Clair Luke Buchanan M25 Mutual Capital Partners North Coast Ventures Redi.Health Refinery Ventures Source Type: blogs

Estrogen-Related Receptor Agonists as Exercise Mimetic Drugs
Just as the research community is interested in finding pharmaceutical ways to provoke some the beneficial reactions to calorie restriction, there is also considerable effort devoted to the search for drug candidates that can mimic some of the benefits of exercise. If the history of calorie restriction mimetic drug development is any guide, this will be a slow process, and the resulting compounds will produce lesser benefits than actual exercise, as they will only touch on a small subset of the processes involved. Still, there is no shortage of programs in this space, and here is one example. Exercise benefits bot...
Source: Fight Aging! - March 25, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Palpitations and presyncope in a 40-something
Discussion: Putting all of the information together this patient is most likely suffering from arrhythmogenic cardiomyopathy (AC) better known as ARVC. The medical hx is typical, with sudden onset tachydysrhythmia during physical exertion. It is not uncommon for the initial presentation to be sudden cardiac death (SCD). In fact it is one of the leading causes of SCD in people age less than 40 years. Thus it is very important to identify this disorder. AC is a disease in which myocardium is replaced by fibrofatty tissue. This usually and predominantly affects the RV free wall and apical regions, but it can affect the left v...
Source: Dr. Smith's ECG Blog - March 24, 2024 Category: Cardiology Authors: Magnus Nossen Source Type: blogs

Medical Economics
Sorry for missing a couple of days, been bizzy. Anyway, to continue with our trashing of the " discipline " of economics (which is actually more a branch of theology than a science),it should be obvious that Medicine exists in a world even less like Economics 101 than most industries. To begin with, while our basic needs for food, clothing and shelter are predictable and roughly similar for everyone, our need for medical services is largely unpredictable, and it varies radically from person to person and time to time. Some people go for decades without really needing any at all, although there are some preventive measures ...
Source: Stayin' Alive - March 23, 2024 Category: American Health Source Type: blogs

Transforming Clinical Quality & Value in Rehabilitation with Neurocognitive Technology
The following is a guest article by Jared Gillespie, Senior Director of Clinical Solutions at Academy Medtech Ventures (AMV) In the landscape of rehabilitative care, the integration of neurocognitive technology stands as a beacon of innovation, charting a course toward improved clinical quality and patient outcomes. This journey into the brain’s potential within rehabilitation not only elevates the standard of care but also underscores the role of advanced technologies in shaping the future of healthcare. Traditional rehabilitative care has predominantly focused on physical recovery, often overlooking the brain’...
Source: EMR and HIPAA - March 22, 2024 Category: Information Technology Authors: Guest Author Tags: Clinical Communication and Patient Experience Health IT Company Healthcare IT Hospital - Health System Academy Medtech Ventures AMV Clinical Quality Healthcare Transformation Jared Gillespie Neurocognitive Technology rehabilitative c Source Type: blogs

Discover The Ultimate Depression-Busting Exercises — Backed By 200+ Studies (M)
Over 200 studies confirm it: exercise is a powerful tool against major depressive disorder. But which are best, and for whom? (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - March 20, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Depression Exercise subscribers-only Source Type: blogs

Single Frame Echo Quiz
Transcript of the video: Interpreting an echo quiz just from a single frame has a lot of limitations. But, still for an academic exercise, we will try. Unlike the ECG, where a single image may be more informative, echo usually requires moving images. And moreover, even ECG requires a knowledge of the clinical background before interpretation, to avoid errors. Similarly, for echocardiogram, what we would do usually is, first we do a clinical history evaluation, then physical examination, and after that only we proceed with echocardiography in our routine work. But for an academic curiosity, we will just try to interpret an...
Source: Cardiophile MD - March 18, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

The Apple Drink That Boosts Weight Loss
The drink can boost weight loss without exercise or changing diet. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - March 16, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Weight Loss Source Type: blogs

What is the risk of ACS after PCI in a CTO related artery ?
CTOs are opened primarily for four reasons Angina which is refractory to drugs Stress test positivity with or without angina Anxiety of having a blocked coronary artery in a self educated patient Cardiologist’s clandestine pride & pursuit* * Personal experience included Some evidence based observation Most of the studies as on today do not give survival advantage of opening a CTO.(DECISION-CTO,EURO-CTO,EXPLORE,IMPACTOR) Opening a CTO, for reasons other than angina (i.e. for relief of dyspnea or improving functional capacity) is largely conjectural and based on randomly accrued data back...
Source: Dr.S.Venkatesan MD - March 16, 2024 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized cto cto hardware cto trials jcto score open artery hypothesisacc esc aha guidelines Source Type: blogs

Efforts to Produce Drugs to Slow or Reverse Sarcopenia Benefit from the Semaglutide Hype
This popular science article is a reminder that all too little in this world happens for entirely rational reasons. Drugs aimed at slowing or reversing the age-related loss of muscle mass leading to sarcopenia are presently under development by a number of companies, though none of the candidates discussed are producing effect sizes that look very favorable in comparison to the effects of resistance exercise. These efforts will likely benefit from the present manufactured hype that attends the use of antidiabetic GLP1 receptor agonists for weight loss, as one of the side-effects of this drug is modest loss of muscle mass. ...
Source: Fight Aging! - March 15, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs