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Molecules, Vol. 29, Pages 1913: Identifying the Multitarget Pharmacological Mechanism of Action of Genistein on Lung Cancer by Integrating Network Pharmacology and Molecular Dynamic Simulation
Woo Food supplements have become beneficial as adjuvant therapies for many chronic disorders, including cancer. Genistein, a natural isoflavone enriched in soybeans, has gained potential interest as an anticancer agent for various cancers, primarily by modulating apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis. However, in lung cancer, the exact impact and mechanism of action of genistein still require clarification. To provide more insight into the mechanism of action of genistein, network pharmacology was employed to identify the key targets and their roles in lung cancer pathogenesis. Based on ...
Source: Molecules - April 23, 2024 Category: Chemistry Authors: Raju Das Joohan Woo Tags: Article Source Type: research

Retraction Notice to "Genistein improves sensorimotor gating: Mechanisms related to its neuroprotective effects on the striatum" [Neuropharm. 105 (2016) 35-46]
Neuropharmacology. 2024 Apr 20:109964. doi: 10.1016/j.neuropharm.2024.109964. Online ahead of print.NO ABSTRACTPMID:38644148 | DOI:10.1016/j.neuropharm.2024.109964 (Source: Neuropharmacology)
Source: Neuropharmacology - April 21, 2024 Category: Drugs & Pharmacology Authors: Esther T Menze Ahmed Esmat Mariane G Tadros Amani E Khalifa Ashraf B Abdel-Naim Source Type: research

Molecules, Vol. 29, Pages 1712: Genistein Prevents Apoptosis and Oxidative Stress Induced by Methylglyoxal in Endothelial Cells
In this study, the effect of genistein, a natural soybean isoflavone, has been evaluated on MG-induced cytotoxicity in human endothelial cells. Our results show that genistein is able to counteract the MG-induced apoptosis by restraining ROS production, thus inhibiting the MAPK signaling pathways and caspase-3 activation. These findings identify a beneficial role for genistein, providing new insights for its potential clinical applications in preserving endothelial function in diabetic vascular complications. (Source: Molecules)
Source: Molecules - April 10, 2024 Category: Chemistry Authors: Liccardo Sapio Perrella Sirangelo Iannuzzi Tags: Article Source Type: research

Genistein alleviates dextran sulfate sodium-induced colitis in mice through modulation of intestinal microbiota and macrophage polarization
ConclusionsThese results revealed that genistein mediated macrophage polarization balance by improving intestinal microbiota and its metabolites, thereby alleviating DSS-induced colitis. (Source: European Journal of Nutrition)
Source: European Journal of Nutrition - April 9, 2024 Category: Nutrition Source Type: research

Effect of Maternal DEHP Exposure on Lipid Metabolism in Adult Male Rats and the Antagonistic Effect of Genistein
Biomed Environ Sci. 2024 Mar 20;37(3):315-319. doi: 10.3967/bes2024.034.NO ABSTRACTPMID:38582995 | DOI:10.3967/bes2024.034 (Source: Biomedical and Environmental Sciences : BES)
Source: Biomedical and Environmental Sciences : BES - April 7, 2024 Category: Biomedical Science Authors: Yun Bo Zhang Jiang Li Li Jie Tian Xiao Lin Na Source Type: research

Genistein loaded by PRF improved bone healing in obese mice
CONCLUSIONS: GEN promotes osteogenic differentiation of MC3T3-E1, and it can effectively accelerate the healing of cranial bone defects after loading with PRF in obese mice.PMID:38583019 (Source: Shanghai Journal of Stomatology)
Source: Shanghai Journal of Stomatology - April 7, 2024 Category: Dentistry Authors: Xue-Bing Zhang Qi Li Source Type: research