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Safety and Immunogenicity of VPM1002 Vaccination or BCG Revaccination Against TB in Pre-Adolescents Living With and Without HIV in South Africa
Conditions:   Tuberculosis;   HIV Infections Interventions:   Biological: VPM1002 Vaccine;   Biological: BCG Vaccine;   Drug: Placebo Sponsors:   International Maternal Pediatric Adolescent AIDS Clinical Trials Group;   National Institute of Allergy and Infectious Diseases (NIAID);   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   National Institute of Mental Health (NIMH) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 14, 2022 Category: Research Source Type: clinical trials

A protocol for monitoring fidelity of a preconception-life course intervention in a middle-income setting: the Healthy Life Trajectories Initiative (HeLTI), South Africa
DiscussionThe NIH BCC Treatment Fidelity Framework provided a solid foundation for reporting intervention fidelity across settings to improve intervention validity, ability to assess intervention effectiveness, and transparency. However, context-specific challenges to fidelity (monitoring) were identified, and transparency around such challenges and possible solutions in low- and middle-income settings could help foster solutions to improve adherence, reporting, and monitoring of intervention fidelity in this setting.Trial registrationPan African Clinical Trials RegistryPACTR201903750173871. Registered on 27 March 2019 (Source: Trials)
Source: Trials - September 6, 2022 Category: Research Source Type: clinical trials

Tuberculosis Diagnostic Trial of CAD4TB Screening Alone Compared to CAD4TB Screening Combined With a CRP Triage Test, Both Followed by Confirmatory Xpert MTB/RIF Ultra in Communities of Lesotho and South Africa
Condition:   Tuberculosis Interventions:   Diagnostic Test: CAD4TB;   Diagnostic Test: POC-CRP;   Diagnostic Test: Xpert MTB/RIF Ultra Sponsors:   Klaus Reither;   SolidarMed Lesotho;   Institute of Tropical Medicine, Antwerp, Belgium;   Radboud University Medical Center Nijmegen, Netherlands;   Charité Berlin, Germany;   Human Science Research Council, South Africa Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 2, 2022 Category: Research Source Type: clinical trials