Systems Analysis and Improvement Approach to Prevent TB
Conditions: Tuberculosis; TPT; TB - Tuberculosis Interventions: Other: Systems Analysis and Improvement Approach for TB (SAIA-TB) Sponsors: Boston College; National Institutes of Health (NIH); Boston University; University of Washington; Medical Research Council, South Africa; National Institute of Nursing Research (NINR) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 18, 2024 Category: Research Source Type: clinical trials

Brief Transdiagnostic Treatment for Anxiety Disorders and Post-traumatic Stress Disorder (PTSD) in South Africa: A Hybrid-Effectiveness Trial
Conditions: Anxiety Disorders; Post-traumatic Stress Disorder Interventions: Behavioral: False Safety Behavioral Elimination Treatment (FSET); Behavioral: Enhanced Standard Care Sponsors: Harvard Medical School (HMS and HSDM); University of Stellenbosch; Fogarty International Center of the National Institute of Health; Massachusetts General Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 4, 2024 Category: Research Source Type: clinical trials

Improved Access to Quality Care and Healthcare Use
Conditions: Health Care Utilization; Health Knowledge, Attitudes, Practice; Health, Subjective Interventions: Other: Free high-quality care; Other: Close distance; Other: Far distance Sponsors: London School of Economics and Political Science; University of Witwatersrand, South Africa Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 23, 2024 Category: Research Source Type: clinical trials

Project Phakama: Testing Support Strategies to Empower Young Women on PrEP in South Africa
Conditions: Pre-exposure Prophylaxis; HIV Infections Interventions: Behavioral: Case management; Behavioral: Food vouchers; Behavioral: PrEP support buddy; Behavioral: Community-based PrEP pickup points Sponsors: Johns Hopkins Bloomberg School of Public Health; TB/HIV Care; Unity Health Toronto; National Institute of Mental Health (NIMH) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 23, 2024 Category: Research Source Type: clinical trials

Sensing Technologies for Maternal Depression Treatment in Low-Resource Settings
Conditions: Post Partum Depression Interventions: Behavioral: Problem Management Plus (PM+) Sponsors: George Washington University; Transcultural Psychosocial Organization Nepal; University of Witwatersrand, South Africa; Yale University; Duke University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 12, 2024 Category: Research Source Type: clinical trials

ENHANCE-EvideNce Led Co-created HeAlth Systems interventioNs for MLTCs CarE
Conditions: HIV Infections; Hypertension; Diabetes Mellitus; Asthma; Depression; Myocardial Infarction; Stroke Interventions: Other: ENHANCE intervention (health systems) Sponsors: University of KwaZulu; University of Cape Town; King ' s College London; University of East Anglia; University of Oxford; Medical Research Council, South Africa Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 8, 2024 Category: Research Source Type: clinical trials

Developing Screening Clinical Breast Examination Implementation Strategies in South Africa
Conditions: Breast Cancer Sponsors: Yale University; University of Witwatersrand, South Africa Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 31, 2024 Category: Research Source Type: clinical trials

ThiPhiSA: New Pathways to Prevention From Community TB Screening in South Africa
Conditions: Tuberculosis Interventions: Drug: TB preventive therapy (TPT) Sponsors: University of Washington; Human Sciences Research Council; National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 22, 2024 Category: Research Source Type: clinical trials

Comparison of Self-collection Using Dry Compared to Wet Swabs for HPV Detection
Conditions: Human Papillomavirus Infection Interventions: Device: • COPAN Self-collection FLOQSwabs® (COPAN, Italy) Sponsors: Foundation for Innovative New Diagnostics, Switzerland; Kenya Medical Research Institute; Frere Hospital, East London, South Africa Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 19, 2024 Category: Research Source Type: clinical trials

Quabodepistat in combination with delamanid and bedaquiline in participants with drug-susceptible pulmonary tuberculosis: protocol for a multicenter, phase 2b/c, open-label, randomized, dose-finding trial to evaluate safety and efficacy
The objective of this study is to evaluate the safety, efficacy, and appropriate dosing of a 4-month regimen of QBS in combination with delamanid and bedaquiline in participants with drug-susceptible pulmonary TB in comparison with the 6-month standard treatment (i.e., rifampicin, isoniazid, ethambutol, and pyrazinamide).MethodsThis phase 2b/c, open-label, randomized, parallel group, dose-finding trial will enroll approximately 120 participants (including no more than 15% with human immunodeficiency virus [HIV] coinfection) aged ≥ 18 to ≤ 65 years at screening with newly diagnosed pulmonary drug-sensitive TB from ~8 si...
Source: Trials - January 19, 2024 Category: Research Source Type: clinical trials

Effect Of Health Extension Worker-Led Based Interventions on Improving Self-Management Behavior Among Diabetic Patients in Ethiopia
Conditions: Diabetes Mellitus, Self-management Behavior and Glycosylated Hemoglobin Levels Interventions: Behavioral: Health Extension Led club based Intervention Sponsors: Debre Berhan University; University of South Africa Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 3, 2024 Category: Research Source Type: clinical trials

YoPA - A Youth-centred Participatory Action
Conditions: Physical Activity; Health Promotion; Sleep Interventions: Other: Social and/or physical environmental interventions Sponsors: Amsterdam UMC, location VUmc; Stichting Alexander (the Netherlands); Syddansk Universitet, Denmark; Aalborg Kommune (Denmark); University of the Witwatersrand Johannesburg (South Africa); WITS Health Consortium (South Africa); Redeemer ' s University (Nigeria); Value Re-Orientation for Community Enhancement (Nigeria); Instituut voor Tropische Geneeskunde, Belgium; COFAC Cooperativa de Formacao e Animacao Cultural CRL (Portugal) Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 25, 2023 Category: Research Source Type: clinical trials

Identifying and Addressing Barriers to Retention in the Cervical Cancer Treatment Cascade Among Women With HIV in South Africa
Conditions: Cervical Cancer; Hiv Interventions: Behavioral: Retention in cervical cancer care intervention Sponsors: Boston University Charles River Campus; University of Witwatersrand, South Africa Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 25, 2023 Category: Research Source Type: clinical trials

E-cigarette Harm Reduction Among PLWHA in South Africa
Conditions: Tobacco Smoking Interventions: Other: Nicotine Replacement Therapy (NRT); Other: E-Cigarette (EC); Behavioral: Counseling Sponsors: NYU Langone Health; JOHN E FOGARTY INTERNATIONAL CENTER FOR ADVANCED STUDY IN THE HEALTH SCIENCES (FIC) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 14, 2023 Category: Research Source Type: clinical trials

Positive Deviance to Improve Retention in HIV Care HIV Care in South Africa
Conditions: Hiv Interventions: Behavioral: Connect Sponsors: RAND; National Institute of Mental Health (NIMH); University of Stellenbosch; Western Cape Department of Health and Wellness Enrolling by invitation (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 5, 2023 Category: Research Source Type: clinical trials