Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits
In this study, we investigated transcriptional dynamics in different classes of interneurons during the formation of cortical inhibitory circuits in mouse. We found that whether interneurons form synapses on the dendrites, soma, or axon initial segment of pyramidal cells is determined by synaptic molecules that are expressed in a subtype-specific manner. Thus, cell-specific molecular programs that unfold during early postnatal development underlie the connectivity patterns of cortical interneurons. (Source: ScienceNOW)
Source: ScienceNOW - January 24, 2019 Category: Science Authors: Favuzzi, E., Deogracias, R., Marques-Smith, A., Maeso, P., Jezequel, J., Exposito-Alonso, D., Balia, M., Kroon, T., Hinojosa, A. J., F. Maraver, E., Rico, B. Tags: Neuroscience reports Source Type: news

Proceedings from the Ice Hockey Summit III: action on concussion - Smith AM, Alford PA, Aubry M, Benson B, Black A, Brooks A, Burke C, D'Arcy R, Dodick D, Eaves M, Eickhoff C, Erredge K, Farrell K, Finnoff J, Fraser DD, Giza C, Greenwald RM, Hoshizaki B, Huston J, Jorgensen J, Joyner M, Krause D, LaVoi N, Leaf M, Leddy J, Margarucci K, Margulies S, Mihalik J, Munce T, Oeur A, Prideaux C, Roberts WO, Shen F, Soma D, Tabrum M, Stuart MB, Wethe J, Whitehead JR, Wiese-Bjornstal D, Stuart MJ.
The Ice Hockey Summit III provided updated scientific evidence on concussions in hockey to inform these five objectives: 1) describe sport-related concussion (SRC) epidemiology, 2) classify prevention strategies, 3) define objective, diagnostic tests, 4) i... (Source: SafetyLit)
Source: SafetyLit - January 11, 2019 Category: International Medicine & Public Health Tags: Jurisprudence, Laws, Legislation, Policies, Rules Source Type: news

Morbidity of adolescents at the Kaya Regional Hospital Center (Burkina Faso) - Sawadogo N, Garanet F, Traor é D, Somé/Béré C, Maré Z, Dabiré G.
This study aimed to determine the epidemiological and evolutionary profile of hospital-based adolescent disease in Kaya, Burkina Faso. PATIENTS AND METHODS: We conducted a cross-sectional descriptive studyall adolescents hospitalized from 2014... (Source: SafetyLit)
Source: SafetyLit - December 3, 2018 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

Analysis of soma mine disaster using causal analysis based on systems theory (CAST) - Duzgun HS, Leveson N.
Analyzing accidents of sociotechnical systems requires an understanding of the system safety structure. Among various methods proposed for accident analysis in complex sociotechnical systems the Systems-Theoretic Accident Model and Processes (STAMP) model ... (Source: SafetyLit)
Source: SafetyLit - October 8, 2018 Category: International Medicine & Public Health Tags: Disaster Preparedness Source Type: news

In Six Francophone West African Cities, Mayors Are Serious about Investing in Family Planning
Ouagadougou, Burkina Faso, is one of the cities now committing its own resources to launch new family planning and reproductive health activities. Photo by Trevor Snapp for IntraHealth International.September 24, 2018en fran çaisIn francophone West Africa, a new method of addressing family planning is taking hold as mayors become more engaged in planning for their communities ’ health and economic development goals. In the last 18 months, mayors and local officials from six cities in four countries have begun reproductive health initiatives thanks to guidance and funding fromthe Challenge Initiative (TCI).In a region wh...
Source: IntraHealth International - September 24, 2018 Category: International Medicine & Public Health Authors: mnathe Source Type: news

Tennessee nurse wrote herself prescriptions for over 10,000 opioids and muscle relaxers
Tennessee nurse Patricia Tillis, 61, had been suspended after writing herself 104 prescriptions over three years. She used a pre-signed prescription pad to give herself oxycodone and Soma. (Source: the Mail online | Health)
Source: the Mail online | Health - September 17, 2018 Category: Consumer Health News Source Type: news

Unexpected results with light-gated chloride channel GtACR2 lead to improved technique
(Baylor College of Medicine) Characterization of light-gated chloride channel GtACR2 in mouse cortical neurons revealed that GtACR2 activation inhibited the soma, but unexpectedly depolarized the presynaptic terminals resulting in neurotransmitter release. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - August 13, 2018 Category: Biology Source Type: news

Rapid effects of estradiol on aggression depend on genotype in a species with an estrogen receptor polymorphism - Merritt J, Davis M, Jalabert C, Libecap T, Williams D, Soma K, Maney D.
[Abstract unavailable] Language: en... (Source: SafetyLit)
Source: SafetyLit - December 28, 2017 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

Trends in carisoprodol abuse and misuse after regulatory scheduling: a retrospective review of California poison control calls from 2008 to 2015 - Sun C, Hollenbach KA, Cantrell FL.
BACKGROUND: In January 2012, carisoprodol was classified as a Schedule IV substance under the controlled substances act from a previously non-controlled, non-scheduled classification. Carisoprodol is marketed as a skeletal muscle relaxant and is commonly c... (Source: SafetyLit)
Source: SafetyLit - December 14, 2017 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

The promise of spatial transcriptomics for neuroscience in the era of molecular cell typing
The stereotyped spatial architecture of the brain is both beautiful and fundamentally related to its function, extending from gross morphology to individual neuron types, where soma position, dendritic architecture, and axonal projections determine their roles in functional circuitry. Our understanding of the cell types that make up the brain is rapidly accelerating, driven in particular by recent advances in single-cell transcriptomics. However, understanding brain function, development, and disease will require linking molecular cell types to morphological, physiological, and behavioral correlates. Emerging spatially res...
Source: ScienceNOW - October 5, 2017 Category: Science Authors: Lein, E., Borm, L. E., Linnarsson, S. Tags: Genetics special/review Source Type: news

FDA Issues Warning About Mixing Opioid Addiction Treatments With Other Meds
TRENTON, N.J. (AP) — The Food and Drug Administration issued new warnings Wednesday about the dangers of combining medication for opioid addiction with anti-anxiety medicines and other drugs that also slow breathing and brain activity. The FDA warned that mixing such drugs can cause difficulty breathing, coma or death, so it should be done with caution. The agency said a growing number of people fighting opioid addiction with methadone or buprenorphine also take other prescription drugs that slow action of the central nervous system. The warning lists several dozen brand-name and generic drugs that could be risky, includ...
Source: JEMS Patient Care - September 20, 2017 Category: Emergency Medicine Authors: Linda A. Johnson, Associated Press Tags: Patient Care News Source Type: news

FDA Issues Warning About Mixing Opioid Addiction Treatments With Other Meds
TRENTON, N.J. (AP) — The Food and Drug Administration issued new warnings Wednesday about the dangers of combining medication for opioid addiction with anti-anxiety medicines and other drugs that also slow breathing and brain activity. The FDA warned that mixing such drugs can cause difficulty breathing, coma or death, so it should be done with caution. The agency said a growing number of people fighting opioid addiction with methadone or buprenorphine also take other prescription drugs that slow action of the central nervous system. The warning lists several dozen brand-name and generic drugs that could be risky, includ...
Source: JEMS: Journal of Emergency Medical Services News - September 20, 2017 Category: Emergency Medicine Authors: Linda A. Johnson, Associated Press Tags: Patient Care News Source Type: news

FDA Issues Warning About Mixing Opioid Addiction Treatments With Other Meds
TRENTON, N.J. (AP) — The Food and Drug Administration issued new warnings Wednesday about the dangers of combining medication for opioid addiction with anti-anxiety medicines and other drugs that also slow breathing and brain activity. The FDA warned that mixing such drugs can cause difficulty breathing, coma or death, so it should be done with caution. The agency said a growing number of people fighting opioid addiction with methadone or buprenorphine also take other prescription drugs that slow action of the central nervous system. The warning lists several dozen brand-name and generic drugs that could be risky, includ...
Source: JEMS Patient Care - September 20, 2017 Category: Emergency Medicine Authors: Linda A. Johnson, Associated Press Tags: Patient Care News Source Type: news

UM SOM Names Deputy Director of Graduate and Postdoctoral Studies for its Graduate Program in Life Sciences
Dudley K. Strickland, PhD, Associate Dean for Graduate and Postdoctoral Studies at the University of Maryland School of Medicine (UM SOM), along with UM SOM Dean E. Albert Reece, MD, PhD, MBA, announced that Peixin Yang, PhD, Professor of Obstetrics, Gynecology and Reproductive Sciences (OB-GYN), has been named Deputy Director of Graduate and Postdoctoral Studies in UM SOM’s Graduate Program in Life Sciences (GPILS). (Source: University of Maryland School of Medicine News Headlines)
Source: University of Maryland School of Medicine News Headlines - August 9, 2017 Category: Universities & Medical Training Source Type: news