Fight Aging! Newsletter, July 4th 2022
This study showed that centenarians had very specific changes in CD4+ T cell populations, which were manifested by an elevated Th17/Treg ratio in vivo, as well as a changed secretory phenotype. Although the T cells of centenarians cannot resist the aging-related expression of proinflammatory genes, their secretory phenotype was altered, explaining the relatively low level of inflammation in centenarians. These results suggested the presence of a mechanism to ameliorate inflammaging in centenarians. This may be achieved by reversing the imbalance of Th17/Treg cells and reducing pro-inflammatory cytokines. Longevit...
Source: Fight Aging! - July 3, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

How One Type of Tumor Converts Innate Immune Cells to its Cause
We examined the cross-talk between these two populations of cells. We found that the tumor cells expressed high levels of a protein called macrophage migration inhibitory factor (MIF), and that the myeloid cells had receptors to sense the MIF proteins. This makes them switch their biology and promote, rather than block, tumor growth." The investigators believe this information could be used to create novel therapies against soft-tissue sarcoma. A medication designed to stop cancer cells from expressing MIF could be tested in combination with existing therapies, for example, to see if it improves outcomes for patients. ...
Source: Fight Aging! - June 28, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Last Month in Oncology with Dr. Bishal Gyawali: April 2019
By BISHAL GYAWALI, MD Keynote speech on the JAVELIN not going far enough to improve survival The treatment landscape for metastatic renal-cell carcinoma has changed dramatically with the introduction of immunotherapies. Unfortunately though, we are promoting combinations over single agents without having much idea of added benefit of each drug. This is an important issue because when we combine two drugs, the only thing we are certain of are the added toxicities. PD-1 inhibitor nivolumab had improved OS when given in second line, however nivolumab was tested in combination with ipilimumab (not as a nivolumab monother...
Source: The Health Care Blog - May 10, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Physicians Bishal Gyawali Clinical Trials Oncology PD-1 inhibitor Source Type: blogs

A Wee Wiggle in my Journey to Family
You're reading A Wee Wiggle in my Journey to Family, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. Many of us have faced depression, struggled with low self-esteem, and other debilitating mental health challenges. My own journey with depression was a result of growing up with a rare blood disorder and being told I could never have children of my own. This completely changed my dreams of what family and life meant. Years later I suffered with a rare soft tissue sarcoma, yet, baffling the best of doctors, I survived. I’...
Source: PickTheBrain | Motivation and Self Improvement - December 13, 2018 Category: Consumer Health News Authors: donnagrantwilcox Tags: depression featured psychology self improvement best books Donna Grant Wilcox faith family mental health pickthebrain Source Type: blogs

Mice don ’ t vomit
The fact that mice don’t vomit is one of the many things that I learned while reading an extraordinary May 16 Boston Globe article about an experimental cancer treatment that cured, yes, cured a dog, a golden retriever, from soft tissue sarcoma. This cancer treatment, immunotherapy, might possibly (someday) help human patients, too. Anyway, have a look here: goo.gl/DyBnJZ Really quite amazing. Incidentally, many thanks to Cynthia for posting the link to this article on Facebook… Quick update: our 8.5 month old kittens, Pandora and Pixie, were sterilized on Monday and are doing well, phew… Tomorrow I̵...
Source: Margaret's Corner - May 23, 2018 Category: Cancer & Oncology Authors: Margaret Tags: Blogroll golden retriever immunotherapy sarcoma Source Type: blogs

An Interview with Orthopaedic Oncologist Dr. Vincent Ng
Dr. Vincent Ng is an orthopaedic oncologist with the University of Maryland Greenebaum Comprehensive Cancer Center and an Assistant Professor or Orthopaedics with the University of Maryland School of Medicine.  Dr. Ng specializes in treating bone cancer and soft tissue sarcoma.  Below he answers common questions about orthopaedic oncology. What is an orthopaedic oncologist? How do they differ from surgical oncologists? “An orthopaedic oncologist specializes in bone and soft tissue tumors.  I treat any adult or pediatric patient with any bone or soft tissue tumor/lesion/mass, whether benign or malignant, whether it is...
Source: Life in a Medical Center - June 2, 2017 Category: Universities & Medical Training Authors: UMMC Tags: Cancer Doctors bone cancer oncology orthopedics Source Type: blogs

Fight Aging! Newsletter, July 25th 2016
This study builds on preliminary findings from the first phase of the INTERSTROKE study, which identified ten modifiable risk factors for stroke in 6,000 participants from 22 countries. The full-scale INTERSTROKE study included an additional 20,000 individuals from 32 countries in Europe, Asia, America, Africa and Australia, and sought to identify the main causes of stroke in diverse populations, young and old, men and women, and within subtypes of stroke. To estimate the proportion of strokes caused by specific risk factors, the investigators calculated the population attributable risk for each factor (PAR; an esti...
Source: Fight Aging! - July 24, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Chemistry Technique Concentrates Chemo at Sarcoma Tumor Sites
Today’s chemotherapy delivery is poorly targeted, leading to lots of systemic side effects  while often doing too little to attack the cancer itself. Researchers at State University of New York at Albany have now developed a way of encapsulating chemo agents within special shells that concentrate and open up around a special pre-positioned material next to a tumor. The technique, dubbed “local drug activation,” relies on so-called “bioorthogonal chemistry” to gather near an implanted complementary biomaterial and have it trigger the shells to open up. In a proof of concept, the researchers t...
Source: Medgadget - July 20, 2016 Category: Medical Equipment Authors: Editors Tags: Nanomedicine Oncology Source Type: blogs

Matching Fund Donors Sought for SENS Universal Cancer Therapy Crowdfunding
There is a month left to go in the SENS crowdfunding campaign that aims to accelerate development of an important component of a universal cancer therapy, a way to block the mechanisms of telomere lengthening that every type of cancer depends upon. The SENS Research Foundation and Lifespan.io volunteers are looking for donors to put up matching funds of a few thousand dollars or more, in order to take that news and that inducement to a number of conferences and other events over the next few weeks. More than 150 people have donated to the campaign to date, and we'd like to triple that number in the next 30 days. To ...
Source: Fight Aging! - July 18, 2016 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs

Intro to Class Blending
I thought I'd devote the next few blogs to a concept that has gotten much less attention than it deserves: blended classes. Class blending lurks behind much of the irreproducibility in "Big Science" research, including clinical trials. It also is responsible for impeding progress in various disciplines of science, particularly the natural sciences, where classification is of utmost importance. We'll see that the scientific literature is rife with research of dubious quality, based on poorly designed classifications and blended classes. For today, let's start with a definition and one example. We'll discuss many more spe...
Source: Specified Life - March 26, 2016 Category: Information Technology Tags: classification complexity data science irreproducible results ontologies ontology Source Type: blogs

Sarcoma – Signs, Histology, and Treatment
Pathophysiology of Soft Tissue Sarcoma 1) sarcomas of the soft tissue are a family of neoplasms affecting the soft tissue of the body Causes 2) previous radiation 3) HIV 4) genetic predisposition such as L-Fraumeni syndrome 5) asbestosis 6) congenital immunodeficiences 7) dioxin exposure 8) Herpes virus Signs and Symptoms 1) most common presentation is an enlarging mass 2) pain 3) neuralgia and neurologic deficits, if the tumor encases a nerve structure 4) metastases are usually via the blood system and most commonly go to the lungs Characteristic Test Findings Radiology – mass on MRI Histology/Gross Pathology 1) m...
Source: Inside Surgery - January 27, 2013 Category: Surgeons Authors: Editor Tags: Oncology angiosarcoma leimyosarcoma malignant fibrous histiocytosis p53 Schwannoma tumor suppressor Source Type: blogs