Vigeo attenuates cartilage and bone destruction in a collagen ‑induced arthritis mouse model by reducing production of pro‑inflammatory cytokines
Exp Ther Med. 2024 Mar 19;27(5):208. doi: 10.3892/etm.2024.12496. eCollection 2024 May.ABSTRACTRheumatoid arthritis (RA) is an autoimmune and chronic inflammatory disease characterized by articular cartilage destruction, bone destruction and synovial hyperplasia. It has been suggested that Vigeo, a mixture of Eleutherococcus senticosus, Achyranthes japonica and Atractylodes japonica fermented with Korean nuruk, has an anti-osteoporotic effect in a mouse model of inflammation-mediated bone loss. The present study evaluated the therapeutic effects of Vigeo in RA using a collagen-induced arthritis (CIA) mouse model. DBA/1J mi...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Yoon-Hee Cheon Chang Hoon Lee So Young Eun Gyeong Do Park Chong Hyuk Chung Ju-Young Kim Myeung Su Lee Source Type: research
Molecules, Vol. 29, Pages 866: Anti-Neuroinflammatory Effects of Adaptogens: A Mini-Review
ak
Introduction: Adaptogens are a group of plants that exhibit complex, nonspecific effects on the human body, increasing its ability to adapt, develop resilience, and survive in stress conditions. They are found in many traditional medicinal systems and play a key role in restoring the body’s strength and stamina. Research in recent years has attempted to elucidate the mechanisms behind their pharmacological effects, but it appears that these effects are difficult to define precisely and involve multiple molecular pathways. Neuroinflammation: In recent years, chronic inflammation has been recognized as o...
Source: Molecules - February 15, 2024 Category: Chemistry Authors: Dagmara Wr óbel-Biedrawa Irma Podolak Tags: Review Source Type: research
Harder, better, faster, stronger? Retrospective chart review of adverse events of interactions between adaptogens and antidepressant drugs
Conclusion: Clinicians should monitor the adverse events associated with the concomitant use of adaptogens and antidepressant drugs in patients with mental disorders. Aggregation of side effects and pharmacokinetic interactions (inhibition of CYP and p-glycoprotein) between those medicines may result in clinically significant adverse events. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - September 27, 2023 Category: Drugs & Pharmacology Source Type: research
Genome-wide identification of MBD gene family members in Eleutherococcus senticosus with their expression motifs under drought stress and DNA demethylation
Methyl-binding domain (MBD) is a class of methyl-CpG-binding domain proteins that affects the regulation of gene expression through epigenetic modifications. MBD genes are not only inseparable from DNA methylatio... (Source: BMC Genomics)
Source: BMC Genomics - February 22, 2023 Category: Genetics & Stem Cells Authors: Shuo Wang, Jing Dong, Xue-Lei Zhao, Xin Song, Yue-Hong Long and Zhao-Bin Xing Tags: Research Source Type: research
Screening of anti-fatigue active ingredients of < em > Eleutherococcus senticosus < /em > via spectrum-effect relationship based on factor analysis and LC-MS/MS
This study attempts to establish the spectrum-effect relationship of ES antifatigue activity to screen the effective components. The results showed that the similarity of 15 ES fingerprints obtained by LC-MS/MS was 0.533-0.992, and the chemical structures of 22 common peaks were identified. The anti-fatigue activity of 15 batches of ES was characterized by forced swimming test of mice and quantified by CAFI, among which S4, S1 and S5 had better activity. 9 components (caffeic acid, 5-(4-O-β-D-glucosylferoyl)-quinic acid, (±)13-HODE, isofraxidin, eleutheroside E, syringin, pinoresinol diglucoside or its isomer, 7,8-dihydr...
Source: Natural Product Research - January 31, 2023 Category: Biochemistry Authors: Jiabo Cheng Lequn Qiu Naveed Ahmad Jie Liu Mengfei Tian Chunying Li Chunjian Zhao Source Type: research
Screening of anti-fatigue active ingredients of < em > Eleutherococcus senticosus < /em > via spectrum-effect relationship based on factor analysis and LC-MS/MS
This study attempts to establish the spectrum-effect relationship of ES antifatigue activity to screen the effective components. The results showed that the similarity of 15 ES fingerprints obtained by LC-MS/MS was 0.533-0.992, and the chemical structures of 22 common peaks were identified. The anti-fatigue activity of 15 batches of ES was characterized by forced swimming test of mice and quantified by CAFI, among which S4, S1 and S5 had better activity. 9 components (caffeic acid, 5-(4-O-β-D-glucosylferoyl)-quinic acid, (±)13-HODE, isofraxidin, eleutheroside E, syringin, pinoresinol diglucoside or its isomer, 7,8-dihydr...
Source: Natural Product Research - January 31, 2023 Category: Biochemistry Authors: Jiabo Cheng Lequn Qiu Naveed Ahmad Jie Liu Mengfei Tian Chunying Li Chunjian Zhao Source Type: research
Evaluation of the pharmacological effects and exploration of the mechanism of traditional Chinese medicine preparation Ciwujia tablets in treating insomnia based on ethology, energy metabolism, and urine metabolomic approaches
Ciwujia Tablets (CWT) are produced by concentrating and drying the extract solution of the dried rhizome of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim [Araliaceae; E. senticosus radix et rhizoma]. Besides, CWT is included in the 2020 edition of Chinese Pharmacopoeia and is widely used in the treatment of insomnia. It mainly contains eleutheroside B, eleutheroside E, isofraxidin, eleutheroside C, ciwujiatone, and chlorogenic acid, as well as other chemical components. Although the clinical efficacy of CWT in treating insomnia has been confirmed, its functions and pharmacological effects have not been systematical...
Source: Frontiers in Pharmacology - December 5, 2022 Category: Drugs & Pharmacology Source Type: research
Molecules, Vol. 27, Pages 5579: Phenolic Profile, Antioxidant, Anti-Enzymatic and Cytotoxic Activity of the Fruits and Roots of Eleutherococcus senticosus (Rupr. et Maxim.) Maxim
el Załuski
Eleutherococcus senticosus (Rupr. et Maxim.) Maxim. is well-known for its adaptogenic properties in traditional Eastern medicine. It has been categorized as an endangered species due to the over-exploitation of the roots. As a result, alternatives must be found, including the usage of renewable aerial parts such as fruits. The goal of this research was to determine the phenolic compounds and the enzymatic, antioxidant, and cytotoxic activities of the intractum gained from the E. senticosus fruits and the mixture of chloroform-methanol roots extract with naringenin (3:7:5). The obtained results showed, that ...
Source: Molecules - August 30, 2022 Category: Chemistry Authors: Filip Graczyk Jakub G ębalski Anna Makuch-Kocka Dorota Gawenda-Kempczy ńska Aneta A. Ptaszy ńska Sebastian Grzyb Anna Bogucka-Kocka Daniel Za łuski Tags: Article Source Type: research
Tea saponin additive to extract eleutheroside B and E from Eleutherococcus senticosus by ultrasonic mediation and its application in a semi-pilot scale
Ultrason Sonochem. 2022 May 18;86:106039. doi: 10.1016/j.ultsonch.2022.106039. Online ahead of print.ABSTRACTThe safety of ethanol in operations and its effects on human health are gradually being questioned. Under this premise, we attempted to use the natural surfactant tea saponin, which originates from the processing residues of camellia oil, as the additive of the extraction solvent and to extract eleutheroside B and eleutheroside E in the roots and rhizomes of E. senticosus by ultrasonic mediation. After a single-factor experiment, extraction kinetics at different powers and reaction temperatures, and Box-Behnken desi...
Source: Ultrasonics Sonochemistry - May 22, 2022 Category: Chemistry Authors: Xinyu Yang Tingting Liu Shuwen Qi Huiyan Gu Jialei Li Lei Yang Source Type: research
Tea saponin additive to extract eleutheroside B and E from Eleutherococcus senticosus by ultrasonic mediation and its application in a semi-pilot scale
Ultrason Sonochem. 2022 May 18;86:106039. doi: 10.1016/j.ultsonch.2022.106039. Online ahead of print.ABSTRACTThe safety of ethanol in operations and its effects on human health are gradually being questioned. Under this premise, we attempted to use the natural surfactant tea saponin, which originates from the processing residues of camellia oil, as the additive of the extraction solvent and to extract eleutheroside B and eleutheroside E in the roots and rhizomes of E. senticosus by ultrasonic mediation. After a single-factor experiment, extraction kinetics at different powers and reaction temperatures, and Box-Behnken desi...
Source: Ultrasonics Sonochemistry - May 22, 2022 Category: Chemistry Authors: Xinyu Yang Tingting Liu Shuwen Qi Huiyan Gu Jialei Li Lei Yang Source Type: research
Comprehensive Analysis of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. Leaves Based on UPLC-MS/MS: Separation and Rapid Qualitative and Quantitative Analysis
This study was first carried out to comprehensively analyze the phenols and saponins in ESL, including phytochemical, qualitative, quantitative, and bioactivity analysis. The results showed that 30 compounds, including 20 phenolic compounds and 7 saponins, were identified. Twelve of them were isolated from Eleutherococcus Maxim. for the first time. In the qualitative analysis, 30 phenolic compounds and 28 saponins were accurately detected. Their characteristic cleavage processes were described by UPLC-QTOF-MS/MS. Ten representative ingredients were quantitated in 29 different regions via a 4000 QTRAP triple quadrupole tand...
Source: Frontiers in Pharmacology - May 17, 2022 Category: Drugs & Pharmacology Source Type: research
Mechanism of Action of Shenerjiangzhi Formulation on Hyperlipidemia Induced by Consumption of a High-Fat Diet in Rats Using Network Pharmacology and Analyses of the Gut Microbiota
Shenerjiangzhi formulation (SEJZ) is a new traditional Chinese medicine formulation (patent number: CN110680850A). SEJZ contains Eleutherococcus senticosus (Rupr. and Maxim.), Maxim (Araliaceae; E. senticosus radix and rhizome), Lonicera japonica Thunb (Caprifoliaceae; Lonicera japonica branch, stem), Crataegus pinnatifida Bunge (Rosaceae; Crataegus pinnatifida fruit), and Auricularia auricula. SEJZ has been designed to treat hyperlipidemia. Despite the therapeutic benefits of SEJZ, its underlying mechanism of action is not known. We explored the efficacy of SEJZ against hyperlipidemia by integrating network pharmacology a...
Source: Frontiers in Pharmacology - April 5, 2022 Category: Drugs & Pharmacology Source Type: research
Deer Velvet and Eleutherococcus senticosus Mixture Regulated Immune Function in C57BL/6N Mice with Immunosuppression Induced by Forced Swimming
Journal of Medicinal Food,Volume 24, Issue 11, Page 1213-1221, November 2021. (Source: Journal of Medicinal Food)
Source: Journal of Medicinal Food - November 17, 2021 Category: Nutrition Authors: Soo-Jeung Park Minhee Lee Jeong-Moon Yun Dakyung Kim Dong Hwan Oh Jinkyung Kim Myeongkuk Shim Hee-Jin Oh Jeongmin Lee Source Type: research
Advances in the Extraction, Purification, Structural Characteristics and Biological Activities of Eleutherococcus senticosus Polysaccharides: A Promising Medicinal and Edible Resource With Development Value
In recent years, natural polysaccharides have received growing attention and interest in view of their values in food, medical, cosmetics and other fields. Eleutherococcus senticosus (E. senticosus) is a medicine and food homologous plant that possess anti-tumor, anti-inflammatory, central nervous system and cardiovascular protection, anti-radiation, enhancement of human microcirculation, improvement of physical fatigue effects, mainly based on lignans, flavonoids and coumarin types. E. senticosus polysaccharides (ESPS), act as a kind of polysaccharide extracted and isolated from the root and rhizome of E. senticosus, have...
Source: Frontiers in Pharmacology - November 1, 2021 Category: Drugs & Pharmacology Source Type: research
Aidi injection as adjunctive treatment to gemcitabine-based chemotherapy for advanced non-small cell lung cancer: a systematic review and meta-analysis
CONCLUSIONS: Current moderate evidence revealed that Aidi injection as an adjunctive treatment to GBC was associated with superior benefits in patients with advanced NSCLC and alleviate toxicities. High-quality RCTs are needed to further confirm the results.PMID:34541998 | PMC:PMC8451693 | DOI:10.1080/13880209.2021.1973038 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - September 20, 2021 Category: Drugs & Pharmacology Authors: Sitong Guo Yan Li Henghai Su Mingyu Meng Jiaxi Xi Guangyan Mo Xiaoyu Chen Source Type: research
