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A high-throughput screening system targeting the nuclear export pathway via the third nuclear export signal of influenza A virus nucleoprotein.
Abstract Two classes of antiviral drugs, M2 channel inhibitors and neuraminidase (NA) inhibitors, are currently approved for the treatment of influenza; however, the development of resistance against these agents limits their efficacy. Therefore, the identification of new targets and the development of new antiviral drugs against influenza are urgently needed. The third nuclear export signal (NES3) of nucleoprotein (NP) is the most important for viral replication among seven NESs encoded by four viral proteins, NP, M1, NS1, and NS2. NP-NES3 is critical for the nuclear export of NP, and targeting NP-NES3 is therefo...
Source: Virus Research - March 3, 2016 Category: Virology Authors: Kakisaka M, Mano T, Aida Y Tags: Virus Res Source Type: research

KevinMD online presence biopsy: May 4, 2016
x I recently did a Facebook Live video where I analyzed various physician online presences and gave tips on how to improve them. If you’re interested in having me look at your presence, leave your name in the comments, and I’ll get to it in future installments. Join my Facebook page get notified about future live chats. Thanks to all those who participated! Your patients are rating you online: How to respond. Manage your online reputation: A social media guide. Find out how.
Source: Kevin, M.D. - Medical Weblog - May 5, 2016 Category: Journals (General) Authors: Tags: Kevin's Take Facebook Live Online reputation Source Type: blogs

Ask KevinMD! May 1, 2016
x You ask questions.  I answer them on Facebook Live. Join my Facebook page get notified about future live chats. Thanks to all those who participated! Your patients are rating you online: How to respond. Manage your online reputation: A social media guide. Find out how.
Source: Kevin, M.D. - Medical Weblog - May 2, 2016 Category: Journals (General) Authors: Tags: Kevin's Take Facebook Live Source Type: blogs

KevinMD online presence biopsy: May 12, 2016
x Another episode of the KevinMD online presence biopsy.  Click the video above and hear what I have to say as I Google physicians’ online presences. If you’re interested in having me look at your presence, leave your name in the comments, and I’ll get to it in future installments. Join my Facebook page get notified about future live chats. Thanks to all those who participated! Your patients are rating you online: How to respond. Manage your online reputation: A social media guide. Find out how.
Source: Kevin, M.D. - Medical Weblog - May 12, 2016 Category: Journals (General) Authors: Tags: Kevin's Take Online reputation Source Type: blogs

#AskKevinMD Live! Episode 4
x You ask questions.  I answer them on Facebook Live.  Click on the video above for a replay. Send your questions @KevinMD on Twitter with the hashtag #AskKevinMD. Join my Facebook page get notified about future live chats. Your patients are rating you online: How to respond. Manage your online reputation: A social media guide. Find out how.
Source: Kevin, M.D. - Medical Weblog - May 12, 2016 Category: Journals (General) Authors: Tags: Kevin's Take #AskKevinMD Source Type: blogs

What keeps doctors up at night - the human side of medicine
The panel discussion on " First, Do No Harm: featured the medical legends, Dr Farokh Udwadia, Dr Yeshwant Amdekar and Dr Sunil Pandya. It gives a rare glimpse into the heart and soul of a doctor - and you can see what makes them keep awake at night worrying about their patients. The book, Patient Safety - Protect yourself from Medical Errors is now online at www.safetyforpatients.in You can also download it free at http://www.slideshare.net/malpani/patient-safety-protect-yourself-from-medical-errors
Source: Dr.Malpani's Blog - July 24, 2016 Category: Reproduction Medicine Source Type: blogs

Researching the Cost of Stellara, a Drug Used to Treat Plaque Psoriasis
Everyone understands that the cost of many drugs has risen to atmospheric levels. The & #0160;current levels have the potential to & #0160;bankrupt our healthcare system in short order (see: How Do We Deal With Rising Drug Costs? ). Here is a quote from an & #0160;article proposing & #0160;some ways for addressing this problem: According to a recent report by federal health officials, prescription-drug spending rose 12.6% in 2014, the latest year for which data are available, and it is expected to rise 7.3% a year through 2018. & #0160; Big drug-price increases have triggered congressional investigations, criticism from ...
Source: Lab Soft News - July 26, 2016 Category: Laboratory Medicine Authors: Bruce Friedman Tags: Cost of Healthcare Health Economics Health Insurance Medical Consumerism Pharmaceutical Industry Source Type: blogs

Divorcing Reimbursement From Real-World Prices: Medicare Still Uses 2003 AWPs For Some Drugs
Average wholesale prices (AWPs) have long been recognized as a flawed payment benchmark because they are list prices that do not reflect the real-world prices available in the marketplace. For that reason, a common joke in the drug pricing world panned AWP as “Ain’t What’s Paid.” After years of reports from the Office of Inspector General (OIG), analysis from the Government Accountability Office (GAO), and litigation that highlighted the flaws in AWPs, Congress required in 2003 that reimbursement of Part B drugs be set 106 percent of their average sales price (ASP). ASPs are calculated based on the prices at which ...
Source: Health Affairs Blog - November 21, 2016 Category: Health Management Authors: David Tawes and Marta Wosinska Tags: Costs and Spending Drugs and Medical Innovation Medicare Payment Policy Average wholesale prices durable medical equipment Medicare Part B Office of Inspector General Source Type: blogs

Webinar: Preparing Biomedical Information Professionals to Understand and Teach Research Data Management
As part of the NIH BD2K training initiative, two curricula were created to prepare medical librarians to understand and teach research data management to researchers. The first curricula is web-based and uses interactive educational technologies to provide librarians with a better understanding of research data management, as well as the practice and culture of biomedical research. A second curriculum was developed as a toolkit to be used by librarians for in-person teaching of researchers and consists of slides, scripts, evaluation tools, and instructions. Several modules in the toolkit allow for guided customization on t...
Source: NN/LM Middle Atlantic Region Blog - May 30, 2017 Category: Databases & Libraries Authors: Hannah Sinemus Tags: Data Science News from NLM/NIH Source Type: news

4-Year-Old Boy Killed While Riding Bike In Manchester, NH Identified
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Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - November 13, 2020 Category: Consumer Health News Authors: CBS Boston Tags: Boston News Seen On WBZ-TV Syndicated CBSN Boston Syndicated Local Jacoby Adamtzikis Manchester NH News Source Type: news

Don ’ t Rely On A Negative Coronavirus Test To See Family For Thanksgiving
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Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - November 16, 2020 Category: Consumer Health News Authors: CBS Boston Tags: Boston News Health CNN Coronavirus Thanksgiving Source Type: news

Sudbury Police Officer Al Hutchinson Hosts ‘ QuaranStory Time ’ For Kids In Town
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Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - November 18, 2020 Category: Consumer Health News Authors: CBS Boston Tags: Boston News Covid-19 Boston, MA Syndicated Local Al Hutchinson Sudbury News Source Type: news

Walpole Teen Builds Christmas Trees, Raises $13,000 For Friend Injured In Accident
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Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - December 3, 2020 Category: Consumer Health News Authors: CBS Boston Tags: Boston News Syndicated CBSN Boston Syndicated Local Evan McGrew Greyson Beauregard Rachel Holt Walpole news Source Type: news

Potential inhibitors of the main protease of SARS-CoV-2 and modulators of arachidonic acid pathway: Non-steroidal anti-inflammatory drugs against COVID-19
This study highlights the new application of NSAIDs as anti-viral drugs used against COVID-19. NSAIDs may also attenuate the cytokine storm through the downregulation of inflammatory mediators in the arachidonic acid pathway.PMID:34340125 | DOI:10.1016/j.compbiomed.2021.104686
Source: Molecular Medicine - August 2, 2021 Category: Molecular Biology Authors: Mohsen Sisakht Aida Solhjoo Amir Mahmoodzadeh Mohammad Fathalipour Maryam Kabiri Amirhossein Sakhteman Source Type: research

Blog: Get set for a Queen ’ s Speech that delivers nothing
In last week’s local elections, the Tories took a hammering at the ballot box. Losing nearly 500 council seats is anything but a ringing endorsement of the party in power, and losing flagship councils in the capital is a bad look for a former London mayor. At UNISON, it was just as we expected, because we know our members’ biggest concern – just like many voters across the UK – is the cost of living crisis. It’s a crisis that deepens with every day the Tories remain in power in Westminster. There’s no sign of it abating and news coverage tells us every day about how much people are struggling. As the results we...
Source: UNISON Health care news - May 10, 2022 Category: UK Health Authors: Christina McAnea Tags: General secretary's blog News cost of living Queen's Speech TUC march Source Type: news