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Total 52396 results found since Jan 2013.

Design and evaluation of an augmented reality-based exergame system to reduce fall risk in the elderly - Chen M, Tang Q, Xu S, Leng P, Pan Z.
Falls are a major public health concern in today's aging society. Virtual reality (VR) technology is a promising method for reducing fall risk. However, the absence of representations of the user's body in a VR environment lessens the spatial sense of pres...
Source: SafetyLit - October 10, 2020 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news

Educational needs and disaster response readiness: a cross-sectional study of clinical nurses - Jang I, Kim JS, Lee J, Seo Y.
AIM: To analyse clinical nurses' educational needs and disaster response readiness and the factors influencing their disaster response readiness. DESIGN: This was a cross-sectional study. METHODS: A convenience sample comprising 260 nurses with mor...
Source: SafetyLit - October 10, 2020 Category: International Medicine & Public Health Tags: Disaster Preparedness Source Type: news

IDS 2021: Innovative hygiene concepts in the dental practice: This is precisely why IDS 2021 is so important
 #idscologne Innovative hygiene concepts in the dental practice: This is precisely why IDS 2021 is so important Established and innovative surgery hygiene for hands, surfaces, instruments, special sections – tips and intelligent, additional protection measures – IDS demonstrates Corona prevention in its entire spectrum Dental surgeries are considered to be one of the most Corona-secure places in the country. After all, " hygiene and infection control " is a core competence of the dental and dentist technician teams as well as of their dental industry partners. The International Dental Show (IDS)&nbs...
Source: Dental Technology Blog - October 9, 2020 Category: Dentistry Source Type: news

Scaling Up SDG4 in Crises
Yasmine Sherif, Director of Education Cannot WaitBy Yasmine SherifNEW YORK, Oct 9 2020 (IPS) Out of global crises spring opportunities for change. In crisis, change is not an option. It is a necessity. And, as Plato famously noted: “Necessity is the mother of invention.” Education Cannot Wait (ECW) is an invention that sprang out of crisis and was borne of necessity. Yasmine SherifEducation Cannot Wait was conceived as a direct response to the lack of financial resources and crisis-sensitive approaches needed to address the learning crisis for 75 million vulnerable children and adolescents impacted by armed conflicts,...
Source: IPS Inter Press Service - Health - October 9, 2020 Category: International Medicine & Public Health Authors: Yasmine Sherif Tags: Armed Conflicts Climate Change Economy & Trade Education Education Cannot Wait. Future of Education is here Financial Crisis Global Headlines Health Human Rights Humanitarian Emergencies Migration & Refugees Poverty & SDGs TerraV Source Type: news

Implementing a quick Sequential (Sepsis-Related) Organ Failure Assessment sepsis screening tool: an interrupted times series study
Conclusion(s): The implementation of the qSOFA-based SS tool resulted in early, but not significantly improved, provision of 6-h bundle care. Screening procedures were regularly conducted, but sepsis alerts rarely activated. Further research is needed to better understand the implementation of sepsis care in developing settings.
Source: Current Awareness Service for Health (CASH) - October 9, 2020 Category: Consumer Health News Source Type: news

Effect of IV Push Antibiotic Administration on Antibiotic Therapy Delays in Sepsis
Conclusion(s): Use of an IV push strategy may safely facilitate more rapid administration of beta-lactam antibiotics and may allow for better compliance with sepsis management guidelines.
Source: Current Awareness Service for Health (CASH) - October 9, 2020 Category: Consumer Health News Source Type: news

Alcohol use disorders and associated factors among adults in rural communities in Enugu State, Nigeria: a cross-sectional survey - Ani PN, Ngwu EK, Ani BU.
Evidence has shown increasing rate of alcohol abuse among rural dwellers. At the same time little is known about the association between alcohol use disorders (AUD) and factors peculiar to this group of people. A cross-sectional study design was adopted to...
Source: SafetyLit - October 9, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Environmental factors are associated with hospital admissions for sepsis-related pneumonia: A bidirectional case-crossover design
Conclusion(s): Short-term exposure to environmental factors (temperature, relative humidity, NO2, SO2, O3, CO, and PM10) was associated with a higher risk of hospital admissions for sepsis-related pneumonia. Our findings support the role of environmental factors in monitoring the risk of hospital admissions for sepsis-related pneumonia and can help plan and prepare public health resources.
Source: Current Awareness Service for Health (CASH) - October 9, 2020 Category: Consumer Health News Source Type: news

Normothermia in patients with sepsis who present to emergency departments is associated with low compliance with sepsis bundles and increased in-hospital mortality rate
Objectives: To investigate the impact of normothermia on compliance with sepsis bundles and in-hospital mortality in patients with sepsis who present to emergency departments. Design(s): Retrospective multicenter observational study. Patient(s): Nineteen university-affiliated hospitals of the Korean Sepsis Alliance participated in this study. Data were collected regarding patients who visited emergency departments for sepsis during the 1-month period. The patients were divided into three groups based on their body temperature at the time of triage in the emergency department (i.e., hypothermia [ 38degreeC]). Intervention(s...
Source: Current Awareness Service for Health (CASH) - October 9, 2020 Category: Consumer Health News Source Type: news

Sepsis and the Obesity Paradox: Size Matters in More Than One Way
Objectives: Multiple studies have demonstrated an obesity paradox such that obese ICU patients have lower mortality and better outcomes. We conducted this study to determine if the mortality benefit conferred by obesity is affected by baseline serum lactate and mean arterial pressure. Design(s): Retrospective analysis of prospectively collected clinical data. Setting(s): Five community-based and one academic medical center in the Omaha, NE. Patient(s): 7,967 adults hospitalized with sepsis. Intervention(s): None. Measurements and Main Results: Patients were categorized by body mass index as underweight, normal weight, over...
Source: Current Awareness Service for Health (CASH) - October 9, 2020 Category: Consumer Health News Source Type: news

Utilization of the signature method to identify the early onset of sepsis from multivariate physiological time series in critical care monitoring
This study focuses on the development and validation of a new signature-based regression model, augmented with a particular choice of the handcrafted features, to identify a patient ' s risk of sepsis based on physiologic data streams. The model makes a positive or negative prediction of sepsis for every time interval since admission to the ICU. Design(s): The data were sourced from the PhysioNet/Computing in Cardiology Challenge 2019 on the " Early Prediction of Sepsis from Clinical Data. " It consisted of ICU patient data from three separate hospital systems. Algorithms were scored against a specially designed utility fu...
Source: Current Awareness Service for Health (CASH) - October 9, 2020 Category: Consumer Health News Source Type: news

A time-phased machine learning model for real-time prediction of sepsis in critical care
Conclusion(s): The proposed Time-phAsed machine learning model for Sepsis Prediction model is accurate and interpretable for real-time prediction of sepsis onset in critical care, which holds great potential for further evaluation in prospective studies.
Source: Current Awareness Service for Health (CASH) - October 9, 2020 Category: Consumer Health News Source Type: news

Development, Validation, and Clinical Utility Assessment of a Prognostic Score for 1-Year Unplanned Rehospitalization or Death of Adult Sepsis Survivors
Conclusions and Relevance: The prognostic score reported in this study uses 8 internationally feasible predictors measured during the index sepsis admission and provides clinically useful information on sepsis survivors ' risk of unplanned rehospitalization or death in the first year after hospital discharge.
Source: Current Awareness Service for Health (CASH) - October 9, 2020 Category: Consumer Health News Source Type: news

Are Early-Onset Sepsis Evaluations and Empiric Antibiotics Mandatory for All Neonates Admitted with Respiratory Distress?
The objective of this study was to evaluate the success and safety of an antimicrobial stewardship protocol for neonates admitted with respiratory distress at birth. Study Design a A retrospective cohort analysis of all infants admitted to the neonatal intensive care unit (NICU) with respiratory distress from January 2013 to February 2018 was conducted. In April 2016, an antimicrobial stewardship protocol was implemented, dividing neonates into two groups: maternal indications for delivery (no infectious risk factors for early-onset sepsis [EOS]) and fetal indications (risk factors present) for delivery. Neonates with risk...
Source: Current Awareness Service for Health (CASH) - October 9, 2020 Category: Consumer Health News Source Type: news

The self-other divergence effect for doping likelihood: mediation by guilt and moderation by moral agency and values - Ring C, Kavussanu M, Walters B.
OBJECTIVES: Self-other divergence refers to individuals judging themselves to be different from others. DESIGN: The authors used a quasi-experimental repeated-measures design to compare the effects of an independent variable (perspective: self, other) ...
Source: SafetyLit - October 8, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Research challenges in evaluating gender-based violence response services in a refugee camp - McAlpine A, Bacchus LJ, Muuo SW, Muthuri SK, Bangha M, Izugbara C, Franchi G, Hess T, Spangaro J, Pearson R, Hossain M.
This article presents a case study of research in Dadaab, Kenya to highlight some of the relevant challenges encountered while conducting gender-based violence research in humanitarian settings. A longitudinal mixed-methods design was used to evaluate a co...
Source: SafetyLit - October 8, 2020 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

The Brain Injury Functional Outcome Measure (BI-FOM): a single instrument capturing the range of recovery in moderate-severe traumatic brain injury - Whyte J, Giacino JT, Heinemann AW, Bodien Y, Hart T, Sherer M, Whiteneck GG, Mellick D, Hammond FM, Semik P, Rosenbaum A, Richardson RN.
OBJECTIVE: To develop a measure of global functioning after moderate-severe TBI with similar measurement precision but a longer measurement range than the FIM. DESIGN: Phase 1: Retrospective analysis of 5 data sets containing FIM, DRS, and other assessme...
Source: SafetyLit - October 8, 2020 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Modeling operating speed using continuous speed profiles on two-lane rural highways in India - Malaghan V, Pawar DS, Dia H.
The geometric elements of the road, such as tangents and curves, play a vital role in road safety because significant crashes are reported on the horizontal curves and tangent-to-curve transitions. Literature reveals that inconsistent geometric design of r...
Source: SafetyLit - October 8, 2020 Category: International Medicine & Public Health Tags: Engineering, Physics, Structural Soundness and Failure Source Type: news

‘ Be proud of our union ’
“I could not be prouder of this union and the way that you, our activists – and UNISON staff – have stepped up,” general secretary Dave Prentis told the union’s national executive council (NEC). In a time of crisis, insecurity and anxiety, the courage and dedication of UNISON members was what kept the country going, he said. “Our members have been through so much during the pandemic, and the union has to be there for them.” He told how, “back in March, we had 24 hours to close our buildings and relocate every function of the union so we could still be there for our members. Six months on and I could not be ...
Source: UNISON Health care news - October 8, 2020 Category: UK Health Authors: Martin Cullen Tags: Article News dave prentis NEC Source Type: news

New drug carrier systems
(University of Delaware) A UD research team has devised tiny cargo-carrying systems many times smaller than a human hair, made from molecules called peptides that help provide structure for cells and tissues. The team has reported advances in the nanoparticle design that allow them to control the shape of the nanoparticles to allow them to better bind to tissue in the body and stay in a particular location.
Source: EurekAlert! - Medicine and Health - October 8, 2020 Category: International Medicine & Public Health Source Type: news

ideas42 and University of Chicago Crime Lab challenge assumptions about missed court dates
(ideas42) Behavioral design nonprofit ideas42 and the University of Chicago Crime Lab announced the publication of their new joint paper, Using Behavioral Nudges to Reduce Failure to Appear in Court in Science Magazine. The paper's results demonstrate that redesigning New York City's summons form to make it simpler and clearer reduced failure to appear rates by 13%, and sending text message reminders reduced failure to appear rates by 21%.
Source: EurekAlert! - Social and Behavioral Science - October 8, 2020 Category: International Medicine & Public Health Source Type: news

Design Partners adds health care design studio
While Design Partners is more known for its work designing for the military, government, hospitality, education, commercial and residential high-rise projects, the firm has done some health care work, primarily for the military.
Source: bizjournals.com Health Care:Biotechnology headlines - October 7, 2020 Category: Biotechnology Authors: Janis L. Magin Source Type: news

Examining the effects of neighbourhood design on walking in growing megacity - Zhao P, Wan J.
It is widely believed that neighbourhood design can play a role in promoting walking. However, when personal attitudes and preferences as well as different types of walking are taken into account, research conclusions are still mixed. This paper provides n...
Source: SafetyLit - October 3, 2020 Category: International Medicine & Public Health Tags: Engineering, Physics, Structural Soundness and Failure Source Type: news

Rise of the mutants: New uOttawa-led research to improve enzyme design methodologies
(University of Ottawa) A group of researchers at the University of Ottawa has been looking for ways to improve enzyme design methodologies. They developed a novel computational procedure for enzyme design that is more accurate than previous methods because it allows to approximate the intrinsic flexibility of the protein scaffold used as a template for design.
Source: EurekAlert! - Biology - October 1, 2020 Category: Biology Source Type: news

High-resolution structures of the SARS-CoV-2 2'-O-methyltransferase reveal strategies for structure-based inhibitor design
There are currently no antiviral therapies specific for SARS-CoV-2, the virus responsible for the global pandemic disease COVID-19. To facilitate structure-based drug design, we conducted an x-ray crystallographic study of the SARS-CoV-2 nsp16-nsp10 2'-O-methyltransferase complex, which methylates Cap-0 viral mRNAs to improve viral protein translation and to avoid host immune detection. We determined the structures for nsp16-nsp10 heterodimers bound to the methyl donor S-adenosylmethionine (SAM), the reaction product S-adenosylhomocysteine (SAH), or the SAH analog sinefungin (SFG). We also solved structures for nsp16-nsp10...
Source: Signal Transduction Knowledge Environment - September 28, 2020 Category: Science Authors: Rosas-Lemus, M., Minasov, G., Shuvalova, L., Inniss, N. L., Kiryukhina, O., Brunzelle, J., Satchell, K. J. F. Tags: STKE Research Articles Source Type: news

Understanding the experiences of self-injurious behavior in autism spectrum disorder: implications for monitoring technology design - Cantin-Garside KD, Nussbaum MA, White SW, Kim S, Kim CD, Fortes DMG, Valdez RS.
OBJECTIVE: Monitoring technology may assist in managing self-injurious behavior (SIB), a pervasive concern in autism spectrum disorder (ASD). Affiliated stakeholder perspectives should be considered to design effective and accepted SIB monitoring methods. ...
Source: SafetyLit - September 28, 2020 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

Covid-19 skin rash website criticised for lack of BAME examples
Only two out of 400 Covid images on British Association of Dermatologists ’ website feature black or brown skinCoronavirus – latest updatesSee all our coronavirus coverageA website dedicated to sharing images of Covid-19-related skin rashes to help doctors and patients identify whether an unusual rash might be a sign of coronavirus infection has been criticised for containing just two images of black or brown skin.The British Association of Dermatologists ’ (BAD)Covid-19 Skin Patternswebsite features 400 images of Covid-associated rashes, from prickly heat and chickenpox-type rashes to raised itchy hives and chilblai...
Source: Guardian Unlimited Science - September 28, 2020 Category: Science Authors: Linda Geddes Tags: Coronavirus outbreak Race Science UK news Source Type: news

Dialogical research design: practising ethical, useful and safe(r) research - Poopuu B.
This article explores the potential merits of a dialogical research design and practice, and how this might alleviate the harmful effects of doing research in vulnerable contexts. A dialogical approach suggests that the study of social phenomena should fol...
Source: SafetyLit - September 24, 2020 Category: International Medicine & Public Health Tags: Research Methods, Surveillance and Codes, Models Source Type: news

South Africa: TLC2020 - Design Thinking During a Pandemic
[UCT] If you've signed up for a course at the University of Cape Town's (UCT) Hasso Plattner School of Design Thinking (d-school), then you're familiar with the classroom set-up. White boards line the walls and the conventional in-class seating arrangement has been replaced with high tables and chairs. Teamwork is the norm, and the energy in the room is palpable.
Source: AllAfrica News: Health and Medicine - September 24, 2020 Category: African Health Source Type: news

Engenious Design solves its employees' challenge: remote learning for kids
As local school districts mulled hybrid and remote learning formats, plenty of uncertainty remained for parents.   "During the summer, everyone's going, 'Well, I'm hopeful they're going to go back to school,' and I heard a speaker say once, 'Hope is not a strategy for success,'" Melissa Nickel, operations director for Engenious Design, told the Kansas City Business Journal. Nickel, who has a second- and fif th-grader, decided to find a solution for herself and her co-workers. She pitched the on-site…
Source: bizjournals.com Health Care:Biotechnology headlines - September 21, 2020 Category: Biotechnology Authors: Leslie Collins Source Type: news

Guidance for design and implementation of queue jump lane with presignal for a heterogeneous traffic environment - Bhattacharyya K, Maitra B, Boltze M.
In mixed traffic streams, especially near intersections, bus priority treatments are necessary to prevent buses from significant travel time losses. This paper aims to assist practitioners and field engineers to identify the design parameters and potential...
Source: SafetyLit - September 21, 2020 Category: International Medicine & Public Health Tags: Engineering, Physics, Structural Soundness and Failure Source Type: news

Accelerating Drug Development Timelines – Evolution in Trial Design...
In this free webinar, the featured speakers will discuss Complex Innovative Design (CID) for clinical trial program development including master protocols, phase-less trial designs and other...(PRWeb September 21, 2020)Read the full story at https://www.prweb.com/releases/accelerating_drug_development_timelines_evolution_in_trial_design_approaches_in_oncology_upcoming_webinar_hosted_by_xtalks/prweb17408611.htm
Source: PRWeb: Medical Pharmaceuticals - September 21, 2020 Category: Pharmaceuticals Source Type: news

Conceptual design and evaluation of a novel bilateral pretension seatbelt: a computational study - Du X, Deng Y, Zhang G, Cao L, Zhu F.
The aim of this study is to design a novel, high-efficiency and low-cost Bilateral Pretensioner (BLP) and evaluate it using a computational approach, i.e. coupling of FEA and multibody dynamics. The BLP system was designed by changing the rotation axle of ...
Source: SafetyLit - September 15, 2020 Category: International Medicine & Public Health Tags: Engineering, Physics, Structural Soundness and Failure Source Type: news

Effective communication in the context of safe design decision making - Pirzadeh P, Lingard H, Blismas N.
The proactive practice of anticipating and 'designing out' health and safety (H&S) risks at the early stage of a construction project, known as safety in design, is a legislative requirement in Australia, as in many other countries. Effective communication...
Source: SafetyLit - September 15, 2020 Category: International Medicine & Public Health Tags: Engineering, Physics, Structural Soundness and Failure Source Type: news

Multi-material design of a vehicle body considering crashworthiness safety and social effects - Chen Y, Cheng X, Fu K.
This study develops and performs a multi-material design for a...
Source: SafetyLit - September 15, 2020 Category: International Medicine & Public Health Tags: Engineering, Physics, Structural Soundness and Failure Source Type: news

Revisiting Lorent and Szymberski: evaluating how research in prevention through design is interpreted and cited - Tymvios N, Hardison D, Behm M, Hallowell M, Gambatese J.
This paper examines the evidence behind two widely accepted theories in Prevention through Design (PtD) research. The concept of mitigating/removing construction hazards during design, is relatively new considering the history of construction work. Within ...
Source: SafetyLit - September 15, 2020 Category: International Medicine & Public Health Tags: Commentary Source Type: news

Exploring community security interventions using design thinking approach - Bonsu GA, Abaitey AK, Chisin AV.
This study uses design thinking to explore the creation and usage of community security intervention tools. Four communities in the Asokore Mampong Municipality in Ghana were selected purposively for the study. Data were gathered through focus group discus...
Source: SafetyLit - September 15, 2020 Category: International Medicine & Public Health Tags: Community-Based Prevention Source Type: news

Calibrating design guidelines using mental workload and reliability analysis - Habib K, Gouda M, El-Basyouny K.
The generic nature of road design is indiscriminate to age, race, or gender, as it is implicitly assumed that there are few behavioral differences between drivers while traversing various alignment elements (e.g., horizontal curves, tangential segments, et...
Source: SafetyLit - September 15, 2020 Category: International Medicine & Public Health Tags: Distraction, Fatigue, Chronobiology, Vigilance, Workload Source Type: news

Dersch Design & Engineering Milestones Include Best Company...
Dersch Design & Engineering achieved a variety of industry milestones over the last year, with receiving the SD METRO “Best Companies with Under 50 Employees to Work For” recognition a highlight.(PRWeb September 15, 2020)Read the full story at https://www.prweb.com/releases/dersch_design_engineering_milestones_include_best_company_recognition_by_sd_metro_magazine/prweb17390001.htm
Source: PRWeb: Medical Pharmaceuticals - September 15, 2020 Category: Pharmaceuticals Source Type: news

Call for Award Applicants: Johnson & Johnson Seeks Female Researchers Working in Science, Technology, Engineering, Math, Manufacturing and Design
NEW BRUNSWICK, N.J. (September 14, 2020) – Johnson & Johnson today announced that it is accepting applications for its 2021 Women in STEM2D (WiSTEM2D) Scholars Award, aimed at supporting assistant or associate academic professors in the disciplines of Science, Technology, Engineering, Math, Manufacturing and Design. For three years, each recipient will receive mentorship from leaders at Johnson & Johnson and a total $150,000 ($50,000 each year). The deadline for applications is Oct. 15, 2020 at 9 a.m. HST, and guidelines and additional details are available here: https://www.jnj.com/wistem2d-university-scholars.L...
Source: Johnson and Johnson - September 14, 2020 Category: Pharmaceuticals Tags: Our Company Source Type: news

Convergent set-based design for complex resilient systems - Wade Z, Parnell GS, Goerger S, Pohl E, Specking E.
The Department of Defense Engineered Resilient Systems (ERS) goes beyond the concept of resilience as a response to a disruption. The ERS project focuses on improving design agility and cost-effectiveness leading to improvements in systems analysis, develo...
Source: SafetyLit - September 14, 2020 Category: International Medicine & Public Health Tags: Disaster Preparedness Source Type: news

Integrating set-based design into cost analysis - Buchanan RK, Richards JE, Rinaudo CH, Goerger SR.
The Department of Defense science and technology communities seek to improve decision-making capability in analysis of alternatives through implementing model-based engineering early in the design process. Point-based design has been the traditional design...
Source: SafetyLit - September 14, 2020 Category: International Medicine & Public Health Tags: Disaster Preparedness Source Type: news

New method to design diamond lattices and other crystals from microscopic building blocks
(Arizona State University) In a new study appearing in the journal Physical Review Letters, researchers describe a technique for using LEGO ® -like elements at the scale of a few billionths of a meter. Further, they are able to cajole these design elements to self-assemble, with each LEGO ® piece identifying its proper mate and linking up in a precise sequence to complete the desired nanostructure.
Source: EurekAlert! - Biology - September 14, 2020 Category: Biology Source Type: news

DHS Expands COVID Connect Test Registration Website to Include Spanish, Hmong, and Somali Languages
Today, Governor Tony Evers announced that COVID Connect, the Department of Health Services (DHS) COVID-19 test registration website, is now available in Spanish and soon will be available in Hmong and Somali. Since COVID Connect launched in July, more than 180,000 test registrations have been logged on the site. In order to increase access to COVID Connect for all Wisconsinites, DHS will continue to translate this registration tool into more...(see release)
Source: Wisconsin DHFS Press Releases - September 10, 2020 Category: Hospital Management Authors: goodsesjfs Source Type: news

2021 Breakthrough Prize Winners Announced: Researcher Who Developed Protein Design Technology Awarded $3 Million
David Baker, whose protein design technology is being used to develop therapies for Covid-19 and cancer, received one of several awards to scientists from the Breakthrough Prize Foundation that add up to a combined total of $21.75 million.
Source: Forbes.com Healthcare News - September 10, 2020 Category: Pharmaceuticals Authors: Alex Knapp, Forbes Staff Tags: Science /science Innovation /innovation Healthcare /healthcare Billionaires /worlds-billionaires Editors' Pick editors-pick Coronavirus technology alexknappblog Source Type: news

Biopharma Leaders Unite To Stand With Science
NEW YORK, September 8, 2020 — The CEOs of AstraZeneca (LSE/STO/NYSE: AZN), BioNTech (NASDAQ: BNTX), GlaxoSmithKline plc (LSE/NYSE: GSK), Johnson & Johnson (NYSE: JNJ), Merck (NYSE: MRK), known as MSD outside the United States and Canada, Moderna, Inc. (Nasdaq: MRNA), Novavax, Inc. (Nasdaq: NVAX), Pfizer Inc. (NYSE: PFE), and Sanofi (NASDAQ: SNY), today announced a historic pledge, outlining a united commitment to uphold the integrity of the scientific process as they work towards potential global regulatory filings and approvals of the first COVID-19 vaccines. All nine CEOs signed the following pledge: We, the unders...
Source: Johnson and Johnson - September 8, 2020 Category: Pharmaceuticals Tags: Our Company Source Type: news

A defined structural unit enables de novo design of small-molecule-binding proteins
The de novo design of proteins that bind highly functionalized small molecules represents a great challenge. To enable computational design of binders, we developed a unit of protein structure—a van der Mer (vdM)—that maps the backbone of each amino acid to statistically preferred positions of interacting chemical groups. Using vdMs, we designed six de novo proteins to bind the drug apixaban; two bound with low and submicromolar affinity. X-ray crystallography and mutagenesis confirmed a structure with a precisely designed cavity that forms favorable interactions in the drug–protein complex. vdMs may enab...
Source: ScienceNOW - September 2, 2020 Category: Science Authors: Polizzi, N. F., DeGrado, W. F. Tags: Biochemistry, Chemistry r-articles Source Type: news

Do inclined sleeping surfaces impact infants' muscle activity and movement? A safe sleep product design perspective - Wang J, Siddicky SF, Carroll JL, Rabenhorst BM, Bumpass DB, Whitaker BN, Mannen EM.
The design of inclined sleep products may be associated with an increased risk of suffocation when an infant finds themselves prone in the product. It is important to understand how different inclined sleep surface angles impact infants' muscle activity wh...
Source: SafetyLit - September 2, 2020 Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news