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Hepatitis C virus-associated pruritus: Etiopathogenesis and therapeutic strategies.
Abstract In addition to its contributing role in the development of chronic liver diseases, chronic hepatitis C virus (HCV) infection is associated with extrahepatic manifestations, particularly, cutaneous-based disorders including those with pruritus as a symptom. Pruritus is frequently associated with the development of chronic liver diseases such as cholestasis and chronic viral infection, and the accumulation of bile acids in patients' sera and tissues as a consequence of liver damage is considered the main cause of pruritus. In addition to their role in dietary lipid absorption, bile acids can trigger the act...
Source: World Journal of Gastroenterology : WJG - February 7, 2017 Category: Gastroenterology Authors: Alhmada Y, Selimovic D, Murad F, Hassan SL, Haikel Y, Megahed M, Hannig M, Hassan M Tags: World J Gastroenterol Source Type: research

Is endoscopic ultrasound examination necessary in the management of esophageal cancer?
Abstract Despite substantial efforts at early diagnosis, accurate staging and advanced treatments, esophageal cancer (EC) continues to be an ominous disease worldwide. Risk factors for esophageal carcinomas include obesity, gastroesophageal reflux disease, hard-alcohol use and tobacco smoking. Five-year survival rates have improved from 5% to 20% since the 1970s, the result of advances in diagnostic staging and treatment. As the most sensitive test for locoregional staging of EC, endoscopic ultrasound (EUS) influences the development of an optimal oncologic treatment plan for a significant minority of patients wit...
Source: World Journal of Gastroenterology : WJG - February 7, 2017 Category: Gastroenterology Authors: DaVee T, Ajani JA, Lee JH Tags: World J Gastroenterol Source Type: research

Current and future therapies for inherited cholestatic liver diseases.
Abstract Familial intrahepatic cholestasis (FIC) comprises a group of rare cholestatic liver diseases associated with canalicular transport defects resulting predominantly from mutations in ATP8B1, ABCB11 and ABCB4. Phenotypes range from benign recurrent intrahepatic cholestasis (BRIC), associated with recurrent cholestatic attacks, to progressive FIC (PFIC). Patients often suffer from severe pruritus and eventually progressive cholestasis results in liver failure. Currently, first-line treatment includes ursodeoxycholic acid in patients with ABCB4 deficiency (PFIC3) and partial biliary diversion in patients with ...
Source: World Journal of Gastroenterology : WJG - February 7, 2017 Category: Gastroenterology Authors: van der Woerd WL, Houwen RH, van de Graaf SF Tags: World J Gastroenterol Source Type: research

To screen or not to screen? Celiac antibodies in liver diseases.
Abstract Celiac disease (CD) is a systemic immune-mediated disorder triggered by dietary gluten in genetically predisposed individuals. The typical symptoms are anemia, diarrhea, fatigue, weight loss, and abdominal pain. CD has been reported in patients with primary sclerosing cholangitis, primary biliary cholangitis, autoimmune hepatitis, aminotransferase elevations, nonalcoholic fatty liver disease, hepatitis B, hepatitis C, portal hypertension and liver cirrhosis. We evaluate recommendations for active screening for CD in patients with liver diseases, and the effect of a gluten-free diet in these different sett...
Source: World Journal of Gastroenterology : WJG - February 7, 2017 Category: Gastroenterology Authors: Narciso-Schiavon JL, Schiavon LL Tags: World J Gastroenterol Source Type: research

Sinusoidal endotheliitis as a histological parameter for diagnosing acute liver allograft rejection.
CONCLUSION: Our data suggest that SE scoring could be a reliable and reproducible supplemental parameter to the existing Banff schema for diagnosing acute liver allograft rejection. PMID: 28223723 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 7, 2017 Category: Gastroenterology Authors: Shi Y, Dong K, Zhang YG, Michel RP, Marcus V, Wang YY, Chen Y, Gao ZH Tags: World J Gastroenterol Source Type: research

Genomic variability of Helicobacter pylori isolates of gastric regions from two Colombian populations.
CONCLUSION: In Túquerres, high risk of GC there was a greater probability of multiple colonization by H. pylori. From the analysis of the results of the PCR-RAPD, it was found higher genetic variability in the isolates of H. pylori in the population of high risk for the development of GC. PMID: 28223724 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 7, 2017 Category: Gastroenterology Authors: Matta AJ, Pazos AJ, Bustamante-Rengifo JA, Bravo LE Tags: World J Gastroenterol Source Type: research

Gut microbial diversity analysis using Illumina sequencing for functional dyspepsia with liver depression-spleen deficiency syndrome and the interventional Xiaoyaosan in a rat model.
CONCLUSION: The microbiome relative abundance of FD rats with liver depression-spleen deficiency syndrome was significantly different from the normal cohort. XYS intervention may effectively adjust the gut dysbacteriosis in FD. PMID: 28223725 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 7, 2017 Category: Gastroenterology Authors: Qiu JJ, Liu Z, Zhao P, Wang XJ, Li YC, Sui H, Owusu L, Guo HS, Cai ZX Tags: World J Gastroenterol Source Type: research

Dendritic cells engineered to secrete anti-DcR3 antibody augment cytotoxic T lymphocyte response against pancreatic cancer in vitro.
CONCLUSION: DCs engineered to secrete anti-DcR3 antibody can augment CTL responses against PC in vitro, and the immune-enhancing effects may be partly due to their capability of down-regulating DC apoptosis and adjusting the Th1/Th2 cytokine network. PMID: 28223726 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 7, 2017 Category: Gastroenterology Authors: Chen J, Guo XZ, Li HY, Zhao JJ, Xu WD Tags: World J Gastroenterol Source Type: research

Remote ischemic perconditioning prevents liver transplantation-induced ischemia/reperfusion injury in rats: Role of ROS/RNS and eNOS.
CONCLUSION: Liver graft protection by RIPerC is similar to or better than that of IPostC, and involves inhibition of oxidative stress and up-regulation of the PI3K/Akt/eNOS/NO pathway. PMID: 28223727 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 7, 2017 Category: Gastroenterology Authors: He N, Jia JJ, Li JH, Zhou YF, Lin BY, Peng YF, Chen JJ, Chen TC, Tong RL, Jiang L, Xie HY, Zhou L, Zheng SS Tags: World J Gastroenterol Source Type: research

Levothyroxine therapy and impaired clearance are the strongest contributors to small intestinal bacterial overgrowth: Results of a retrospective cohort study.
CONCLUSION: The most important contributors for the development of SIBO in ascending order are immunosuppression, impairment of intestinal clearance and levothyroxine use, but they do not sufficiently explain its emergence. PMID: 28223728 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 7, 2017 Category: Gastroenterology Authors: Brechmann T, Sperlbaum A, Schmiegel W Tags: World J Gastroenterol Source Type: research

Preoperative albumin level is a marker of alveolar echinococcosis recurrence after hepatectomy.
CONCLUSION: Low preoperative albumin level was associated with AE recurrence in the present cohort. Thus, preoperative albumin may be a useful biomarker to guide follow-up. PMID: 28223729 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 7, 2017 Category: Gastroenterology Authors: Joliat GR, Labgaa I, Demartines N, Halkic N Tags: World J Gastroenterol Source Type: research

Magnetic resonance elastography is accurate in detecting advanced fibrosis in autoimmune hepatitis.
CONCLUSION: MRE is a promising modality for detection of advanced fibrosis and cirrhosis in patients with AIH with superior diagnostic accuracy compared to laboratory assessment and MRI. PMID: 28223730 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 7, 2017 Category: Gastroenterology Authors: Wang J, Malik N, Yin M, Smyrk TC, Czaja AJ, Ehman RL, Venkatesh SK Tags: World J Gastroenterol Source Type: research

Risk of alcohol use relapse after liver transplantation for alcoholic liver disease.
CONCLUSION: Patients with ALD referred for LT require comprehensive evaluation, including evaluation of psychosocial criteria, to prevent alcoholic recidivism. PMID: 28223731 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 7, 2017 Category: Gastroenterology Authors: Onishi Y, Kimura H, Hori T, Kishi S, Kamei H, Kurata N, Tsuboi C, Yamaguchi N, Takahashi M, Sunada S, Hirano M, Fujishiro H, Okada T, Ishigami M, Goto H, Ozaki N, Ogura Y Tags: World J Gastroenterol Source Type: research

Effects of sex and generation on hepatitis B viral load in families with hepatocellular carcinoma.
CONCLUSION: Sex and generation play important roles on HBV viral load. Maternal birth age and nutritional changes could be the reasons of viral load difference between generations. PMID: 28223732 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 7, 2017 Category: Gastroenterology Authors: Hsieh AR, Fann CS, Yeh CT, Lin HC, Wan SY, Chen YC, Hsu CL, Tai J, Lin SM, Tai DI Tags: World J Gastroenterol Source Type: research

Impact of humic acids on the colonic microbiome in healthy volunteers.
CONCLUSION: Humic acids have a profound effect on healthy colonic microbiome and may be potentially interesting substances for the development of drugs that control the innate colonic microbiome. PMID: 28223733 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 7, 2017 Category: Gastroenterology Authors: Swidsinski A, Dörffel Y, Loening-Baucke V, Gille C, Reißhauer A, Göktas O, Krüger M, Neuhaus J, Schrödl W Tags: World J Gastroenterol Source Type: research

Early thrombomodulin- α administration outcome for acute disseminated intravascular coagulopathy in gastrointestinal surgery.
CONCLUSION: Early administration of TM-α and improvements in each parameter were essential for treatment of DIC. The diagnosis of patients with mild symptoms requires further study. PMID: 28223734 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 7, 2017 Category: Gastroenterology Authors: Konishi H, Okamoto K, Shoda K, Arita T, Kosuga T, Morimura R, Komatsu S, Murayama Y, Shiozaki A, Kuriu Y, Ikoma H, Nakanishi M, Ichikawa D, Fujiwara H, Otsuji E Tags: World J Gastroenterol Source Type: research

Frailty is independently associated with increased hospitalisation days in patients on the liver transplant waitlist.
CONCLUSION: In cirrhotics on the liver transplant waitlist, physical frailty is a significant predictor of hospitalisation and total hospitalised days per year, independent of liver disease severity. PMID: 28223735 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 7, 2017 Category: Gastroenterology Authors: Sinclair M, Poltavskiy E, Dodge JL, Lai JC Tags: World J Gastroenterol Source Type: research

Percutaneous electrochemotherapy in the treatment of portal vein tumor thrombosis at hepatic hilum in patients with hepatocellular carcinoma in cirrhosis: A feasibility study.
CONCLUSION: In patients with cirrhosis, ECT seems effective and safe for curative treatment of Vp3-Vp4 PVTT from HCC. PMID: 28223736 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 7, 2017 Category: Gastroenterology Authors: Tarantino L, Busto G, Nasto A, Fristachi R, Cacace L, Talamo M, Accardo C, Bortone S, Gallo P, Tarantino P, Nasto RA, Di Minno MN, Ambrosino P Tags: World J Gastroenterol Source Type: research

Pancreaticoduodenectomy: Secondary stenting of the celiac trunk after inefficient median arcuate ligament release and reoperation as an alternative to simultaneous hepatic artery reconstruction.
Abstract In patients undergoing pancreaticoduodenectomy (PD), unrecognized hemodynamically significant celiac axis (CA) stenosis impairs hepatic arterial flow by suppressing the collateral pathways supplying arterial flow from the superior mesenteric artery and leads to serious hepatobiliary complications due to liver and biliary ischemia, with a high rate of mortality. CA stenosis is usually due to an extrinsic compression by a previously asymptomatic median arcuate ligament (MAL). MAL is diagnosed by computerized tomography in about 10% of the candidates for PD, but only half are found to be hemodynamically sign...
Source: World Journal of Gastroenterology : WJG - February 7, 2017 Category: Gastroenterology Authors: Guilbaud T, Ewald J, Turrini O, Delpero JR Tags: World J Gastroenterol Source Type: research

Peroral endoscopic myotomy for treatment of Guillain-Barre syndrome-associated achalasia: A rare case.
We report the case of a patient diagnosed with GBS-associated type I achalasia who was successfully treated with peroral endoscopic myotomy (POEM). A 30-year-old man who was diagnosed with GBS 3 mo before was referred to our department with dysphagia and meal-related regurgitation. The results of esophagography, endoscopy, and high-resolution manometry (HRM) revealed type I achalasia. POEM that utilized a submucosal tunneling technique was performed to treat the GBS-associated type I achalasia. After POEM, smooth passage of a contrast agent into the stomach was shown in follow-up esophagography, and follow-up HRM revealed ...
Source: World Journal of Gastroenterology : WJG - February 7, 2017 Category: Gastroenterology Authors: Shin SK, Kim KO, Kim EJ, Kim SY, Kim JH, Kim YJ, Chung JW, Kwon KA, Park DK Tags: World J Gastroenterol Source Type: research

Micronutrient deficiencies in patients with chronic atrophic autoimmune gastritis: A review.
Abstract Chronic atrophic autoimmune gastritis (CAAG) is an organ-specific autoimmune disease characterized by an immune response, which is directed towards the parietal cells and intrinsic factor of the gastric body and fundus and leads to hypochlorhydria, hypergastrinemia and inadequate production of the intrinsic factor. As a result, the stomach's secretion of essential substances, such as hydrochloric acid and intrinsic factor, is reduced, leading to digestive impairments. The most common is vitamin B12 deficiency, which results in a megaloblastic anemia and iron malabsorption, leading to iron deficiency anemi...
Source: World Journal of Gastroenterology : WJG - January 28, 2017 Category: Gastroenterology Authors: Cavalcoli F, Zilli A, Conte D, Massironi S Tags: World J Gastroenterol Source Type: research

Intraepithelial lymphocytes, scores, mimickers and challenges in diagnosing gluten-sensitive enteropathy (celiac disease).
Abstract The upper digestive tract is routinely scoped for several causes of malabsorption, and the number of duodenal biopsy specimens has increased notably in the last 10 years. Gluten-sensitive enteropathy (GSE) is an autoimmune disease, which shows an increasing prevalence worldwide and requires a joint clinico-pathological approach. The classical histopathology of GSE with partial or total villous blunting is well recognized, but the classification of GSE is not straightforward. Moreover, several mimickers of GSE with intraepithelial lymphocytosis have been identified in the last 20 years, with drug interacti...
Source: World Journal of Gastroenterology : WJG - January 28, 2017 Category: Gastroenterology Authors: Sergi C, Shen F, Bouma G Tags: World J Gastroenterol Source Type: research

Mutational analysis of hepatitis E virus ORF1 "Y-domain": Effects on RNA replication and virion infectivity.
CONCLUSION: This is the first demonstration of the critical role of Y-domain sequences in HEV life cycle, which may involve gene regulation and/or membrane binding in intracellular replication complexes. PMID: 28216965 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 28, 2017 Category: Gastroenterology Authors: Parvez MK Tags: World J Gastroenterol Source Type: research

Suppression of colorectal tumorigenesis by recombinant Bacteroides fragilis enterotoxin-2 in vivo.
CONCLUSION: Oral administration with lower-dose biologically active recombinant BFT-2 inhibited colorectal tumorigenesis in mice. PMID: 28216966 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 28, 2017 Category: Gastroenterology Authors: Lv Y, Ye T, Wang HP, Zhao JY, Chen WJ, Wang X, Shen CX, Wu YB, Cai YK Tags: World J Gastroenterol Source Type: research

Assessment of multi-modality evaluations of obscure gastrointestinal bleeding.
CONCLUSION: DBE is a safe and well-tolerated procedure for the diagnosis and treatment of OGIB, with a diagnostic yield that may be increased after obtaining a preceding VCE or MPCTE. However, inpatients with active ongoing bleeding may benefit from proceeding directly to antegrade DBE. PMID: 28216967 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 28, 2017 Category: Gastroenterology Authors: Law R, Varayil JE, WongKeeSong LM, Fidler J, Fletcher JG, Barlow J, Alexander J, Rajan E, Hansel S, Becker B, Larson JJ, Enders FT, Bruining DH, Coelho-Prabhu N Tags: World J Gastroenterol Source Type: research

Complications and management of forgotten long-term biliary stents.
CONCLUSION: The most common complication of retained long-term plastic biliary stents was acute cholangitis associated with CBD stones. Endoscopic management was successfully performed in most cases. PMID: 28216968 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 28, 2017 Category: Gastroenterology Authors: Sohn SH, Park JH, Kim KH, Kim TN Tags: World J Gastroenterol Source Type: research

Validation of prognostic indices in Egyptian Budd-Chiari syndrome patients: A single-center study.
CONCLUSION: The New Clichy score could independently predict the one-year survival in Egyptian BCS patients. PMID: 28216969 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 28, 2017 Category: Gastroenterology Authors: Sakr M, Abdelhakam SM, Elsayed SA, Allam EH, Farid AM, Abdelmoaty W, Hassan AM, Shaker M, El-Gharib M, Eldorry A Tags: World J Gastroenterol Source Type: research

Predictors of vitamin D deficiency in inflammatory bowel disease and health: A Mississippi perspective.
CONCLUSION: BMI > 30 kg/m(2) and AA race are predictive of vitamin D deficiency. Gender, age and diagnosis of IBD are not predictive of vitamin D deficiency. PMID: 28216970 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 28, 2017 Category: Gastroenterology Authors: Pallav K, Riche D, May WL, Sanchez P, Gupta NK Tags: World J Gastroenterol Source Type: research

Prediction of esophageal and gastric histology by macroscopic diagnosis during upper endoscopy in pediatric celiac disease.
CONCLUSION: In the absence of macroscopic abnormalities, routine esophageal and gastric biopsy during endoscopy for pediatric CD does not identify major pathologies. These findings have cost and time saving implications for clinical practice. PMID: 28216971 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 28, 2017 Category: Gastroenterology Authors: Boschee ED, Yap JY, Turner JM Tags: World J Gastroenterol Source Type: research

Laparoscopic resection vs laparoscopic radiofrequency ablation for the treatment of small hepatocellular carcinomas: A single-center analysis.
CONCLUSION: Our preliminary results confirm the superiority of hepatic resection on thermoablation in the treatment of small HCC in selected patients, when both approaches are made laparoscopically. LLR showed better results compared to LRFA in terms of OS. These data need to be confirmed by further studies on a larger number of patients. PMID: 28216972 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 28, 2017 Category: Gastroenterology Authors: Casaccia M, Santori G, Bottino G, Diviacco P, Andorno E Tags: World J Gastroenterol Source Type: research

Endoscopic ultrasound-guided gallbladder drainage for acute cholecystitis: Long-term outcomes after removal of a self-expandable metal stent.
CONCLUSION: EUS-GBD with a SEMS is a possible alternative treatment for acute cholecystitis. Long-term outcomes after removal of the SEMS were excellent. Removal of the SEMS at 4-wk after SEMS placement and improvement of symptoms might avoid migration of the stent and recurrence of cholecystitis due to food impaction. PMID: 28216973 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 28, 2017 Category: Gastroenterology Authors: Kamata K, Takenaka M, Kitano M, Omoto S, Miyata T, Minaga K, Yamao K, Imai H, Sakurai T, Watanabe T, Nishida N, Kudo M Tags: World J Gastroenterol Source Type: research

Comparative study: Vonoprazan and proton pump inhibitors in Helicobacter pylori eradication therapy.
CONCLUSION: Vonoprazan might be superior to PPIs in first-line H. pylori therapy, particularly for smokers. However, caution is required due to possible adverse events. PMID: 28216974 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 28, 2017 Category: Gastroenterology Authors: Sakurai K, Suda H, Ido Y, Takeichi T, Okuda A, Hasuda K, Hattori M Tags: World J Gastroenterol Source Type: research

Negative oncologic impact of poor postoperative pain control in left-sided pancreatic cancer.
CONCLUSION: Adequate postoperative pain relief during the early postoperative period has important clinical implications for oncologic outcomes after resection of left-sided pancreatic cancer. PMID: 28216975 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 28, 2017 Category: Gastroenterology Authors: Min EK, Chong JU, Hwang HK, Pae SJ, Kang CM, Lee WJ Tags: World J Gastroenterol Source Type: research

Correlation of transient elastography with hepatic venous pressure gradient in patients with cirrhotic portal hypertension: A study of 326 patients from India.
CONCLUSION: TE has a fair positive correlation with HVPG; thus, TE can be used as a non-invasive modality to assess the degree of portal hypertension. A cut-off TE value of 21.6 kPa identifies CSPH with a PPV of 93%. PMID: 28216976 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 28, 2017 Category: Gastroenterology Authors: Kumar A, Khan NM, Anikhindi SA, Sharma P, Bansal N, Singla V, Arora A Tags: World J Gastroenterol Source Type: research

Implications of small-bowel transit time in the detection rate of capsule endoscopy: A multivariable multicenter study of patients with obscure gastrointestinal bleeding.
CONCLUSION: In this selected, prospectively collected cohort of small-bowel capsule endoscopy performed for obscure gastrointestinal bleeding, a longer small-bowel transit time was associated with a higher detection rate of significant lesions, along with age and a low center volume, with age serving as an independent predictor. PMID: 28216977 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 28, 2017 Category: Gastroenterology Authors: Girelli CM, Soncini M, Rondonotti E Tags: World J Gastroenterol Source Type: research

Association between endotoxemia and histological features of nonalcoholic fatty liver disease.
CONCLUSION: LBP/EndoCab IgG were not correlated with lobular inflammation or fibrosis. More accurate LPS biomarkers are required to stringently assess the contribution of endotoxemia to conventional NASH. PMID: 28216979 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 28, 2017 Category: Gastroenterology Authors: Kitabatake H, Tanaka N, Fujimori N, Komatsu M, Okubo A, Kakegawa K, Kimura T, Sugiura A, Yamazaki T, Shibata S, Ichikawa Y, Joshita S, Umemura T, Matsumoto A, Koinuma M, Sano K, Aoyama T, Tanaka E Tags: World J Gastroenterol Source Type: research

Long-term prognosis in patients continuing taking antithrombotics after peptic ulcer bleeding.
CONCLUSION: After the occurrence of peptic ulcer bleeding, continuing antithrombotics increases the risk of recurrent bleeding events, while discontinuing antithrombotics would increase the risk of death and developing cardiovascular disease. This suggests that clinicians should comprehensively consider the use of antithrombotics after peptic ulcer bleeding. PMID: 28216980 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 28, 2017 Category: Gastroenterology Authors: Wang XX, Dong B, Hong B, Gong YQ, Wang W, Wang J, Zhou ZY, Jiang WJ Tags: World J Gastroenterol Source Type: research

Real case of primitive embryonal duodenal carcinoma in a young man.
We report here the case of a young man suffering from a rare germ cell tumour. The patient was a 25-year-old man who was referred to our centre for asthenia, stinging epigastric pain, and an iron deficiency anaemia. Gastroscopy revealed a circumferential vegetating lesion on the second portion of the duodenum. The lesion was indurated at the third portion of the duodenum, responsible for a tight stenosis. A computerized tomography-scan of the chest, abdomen and pelvis, and a pancreatic MRI showed a circumferential lesion with a bi-ductal dilatation (i.e., of the common bile duct and Wirsung's duct) without metastatic local...
Source: World Journal of Gastroenterology : WJG - January 28, 2017 Category: Gastroenterology Authors: Barbieux J, Memeo R, De Blasi V, Suciu S, Faucher V, Averous G, Roy C, Marescaux J, Mutter D, Pessaux P Tags: World J Gastroenterol Source Type: research

Late-onset severe biliary bleeding after endoscopic pigtail plastic stent insertion.
Abstract Here, we report our experience with a case of severe biliary bleeding due to a hepatic arterial pseudoaneurysm that had developed 1 year after endoscopic biliary plastic stent insertion. The patient, a 78-year-old woman, presented with hematemesis and obstructive jaundice. Ruptured hepatic arterial pseudoaneurysm was diagnosed, which was suspected to have been caused by long-term placement of an endoscopic retrograde biliary drainage (ERBD) stent. This episode of biliary bleeding was successfully treated by transarterial embolization (TAE). Pseudoaneurysm leading to hemobilia is a rare but potentially fat...
Source: World Journal of Gastroenterology : WJG - January 28, 2017 Category: Gastroenterology Authors: Yasuda M, Sato H, Koyama Y, Sakakida T, Kawakami T, Nishimura T, Fujii H, Nakatsugawa Y, Yamada S, Tomatsuri N, Okuyama Y, Kimura H, Ito T, Morishita H, Yoshida N Tags: World J Gastroenterol Source Type: research

Correcting for non-compliance when determining colonic transit time with radio-opaque markers.
This report proposes a series of alternatives based on possible scenarios for deviations from the intended intake of radio-opaque markers. The proposed method to correct for missed or delayed consumption of radio-opaque markers can help to increase the accuracy of the CTT measurements in clinical trials. PMID: 28216983 [PubMed - indexed for MEDLINE] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 28, 2017 Category: Gastroenterology Authors: Ibarra A, Olli K, Ouwehand AC Tags: World J Gastroenterol Source Type: research

Second-look surgery plus hyperthermic intraperitoneal chemotherapy for patients with colorectal cancer at high risk of peritoneal carcinomatosis: Does it really save lives?
Abstract The treatment of peritoneal carcinomatosis (PC) of colorectal origin with cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) has a 5-year recurrence-free or cure rate of at least 16%, so it is no longer labeled as a fatal disease, and offers prolonged survival for patients with a low peritoneal carcinomatosis index. Metachronous PC of colorectal origin is so predictable that there is a model which has been used to successfully determine the individual risk of each patient. Patients at risk are clearly identified; those with the highest risk have small peritoneal nodules pre...
Source: World Journal of Gastroenterology : WJG - January 21, 2017 Category: Gastroenterology Authors: Cortes-Guiral D, Elias D, Cascales-Campos PA, Badía Yébenes A, Guijo Castellano I, León Carbonero AI, Martín Valadés JI, Garcia-Foncillas J, Garcia-Olmo D Tags: World J Gastroenterol Source Type: research

Pancreatic stellate cell: Pandora's box for pancreatic disease biology.
Abstract Pancreatic stellate cells (PSCs) were identified in the early 1980s, but received much attention after 1998 when the methods to isolate and culture them from murine and human sources were developed. PSCs contribute to a small proportion of all pancreatic cells under physiological condition, but are essential for maintaining the normal pancreatic architecture. Quiescent PSCs are characterized by the presence of vitamin A laden lipid droplets. Upon PSC activation, these perinuclear lipid droplets disappear from the cytosol, attain a myofibroblast like phenotype and expresses the activation marker, alpha smo...
Source: World Journal of Gastroenterology : WJG - January 21, 2017 Category: Gastroenterology Authors: Bynigeri RR, Jakkampudi A, Jangala R, Subramanyam C, Sasikala M, Rao GV, Reddy DN, Talukdar R Tags: World J Gastroenterol Source Type: research

Potential role of the gut microbiota in synthetic torpor and therapeutic hypothermia.
Abstract Therapeutic hypothermia is today used in several clinical settings, among them the gut related diseases that are influenced by ischemia/reperfusion injury. This perspective paved the way to the study of hibernation physiology, in natural hibernators, highlighting an unexpected importance of the gut microbial ecosystem in hibernation and torpor. In natural hibernators, intestinal microbes adaptively reorganize their structural configuration during torpor, and maintain a mutualistic configuration regardless of long periods of fasting and cold temperatures. This allows the gut microbiome to provide the host ...
Source: World Journal of Gastroenterology : WJG - January 21, 2017 Category: Gastroenterology Authors: Sisa C, Turroni S, Amici R, Brigidi P, Candela M, Cerri M Tags: World J Gastroenterol Source Type: research

Clinical impact of immunomonitoring in the treatment of inflammatory bowel disease.
Abstract Despite improvement in outcomes, loss of response (LOR) to tumor necrosis factor-alpha (TNFα) therapies is a big concern in the management of inflammatory bowel disease. LOR is associated with flares of disease, increased hospitalisation rates, need for surgical interventions, and decline in quality of life. LOR may be multifactorial, but immunogenicity makes a significant contribution. Traditionally doses of anti-TNFα have been adjusted based on clinical response, using a standard approach. Immunomonitoring involves the measurement of anti-TNFα trough and antibody levels. It takes into account the und...
Source: World Journal of Gastroenterology : WJG - January 21, 2017 Category: Gastroenterology Authors: Tighe D, McNamara D Tags: World J Gastroenterol Source Type: research

Sex differences and effects of oestrogen in rat gastric mucosal defence.
CONCLUSION: Gastric mucosal blood flow is higher in male than in female rats and is reduced in male rats by oestrogen administration. PMID: 28210078 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 21, 2017 Category: Gastroenterology Authors: Shore R, Björne H, Omoto Y, Siemiatkowska A, Gustafsson JÅ, Lindblad M, Holm L Tags: World J Gastroenterol Source Type: research

α2-Heremans-schmid glycoprotein (fetuin A) downregulation and its utility in inflammatory bowel disease.
CONCLUSION: AHSG can be used to distinguish between IBD and IBS patients or HC while at the same time "predicting" complicated disease behavior, need for therapy escalation and surgery. Moreover, AHSG may offer new insights into the pathogenesis of IBD, since it is involved in key processes. PMID: 28210079 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 21, 2017 Category: Gastroenterology Authors: Manolakis AC, Christodoulidis G, Kapsoritakis AN, Georgoulias P, Tiaka EK, Oikonomou K, Valotassiou VJ, Potamianos SP Tags: World J Gastroenterol Source Type: research

IL23R single nucleotide polymorphisms could be either beneficial or harmful in ulcerative colitis.
CONCLUSION: We demonstrated susceptible or protective character of the investigated IL23R SNPs on the phenotype of UC, confirming the genetic association. PMID: 28210080 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 21, 2017 Category: Gastroenterology Authors: Fischer S, Kövesdi E, Magyari L, Csöngei V, Hadzsiev K, Melegh B, Hegyi P, Sarlós P Tags: World J Gastroenterol Source Type: research

Role of LAP(+)CD4(+) T cells in the tumor microenvironment of colorectal cancer.
CONCLUSION: LAP(+)CD4(+) T cells accumulated in the tumor microenvironment of CRC patients and were involved in immune evasion mediated by IL-10 and TGF-β. PMID: 28210081 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 21, 2017 Category: Gastroenterology Authors: Zhong W, Jiang ZY, Zhang L, Huang JH, Wang SJ, Liao C, Cai B, Chen LS, Zhang S, Guo Y, Cao YF, Gao F Tags: World J Gastroenterol Source Type: research

Multitarget stool DNA tests increases colorectal cancer screening among previously noncompliant Medicare patients.
CONCLUSION: Mt-sDNA provided medical benefit to screening noncompliant Medicare population. High compliance with mt-sDNA and subsequent follow-up diagnostic colonoscopy identified patients with clinically critical advanced colorectal neoplasia. PMID: 28210082 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 21, 2017 Category: Gastroenterology Authors: Prince M, Lester L, Chiniwala R, Berger B Tags: World J Gastroenterol Source Type: research

Incidental adenocarcinoma in patients undergoing surgery for stricturing Crohn's disease.
CONCLUSION: The frequency of incidental colorectal cancer in patients, who undergo surgery for stenotic CD, is low but associated with poor prognosis. However, surgeons need to be aware about the possibility of malignancy in stricturing CD, especially if localized in the rectum. PMID: 28210083 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - January 21, 2017 Category: Gastroenterology Authors: Kristo I, Riss S, Argeny S, Maschke S, Chitsabesan P, Stift A Tags: World J Gastroenterol Source Type: research