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This page shows you the latest research publications in this category.

[Metabolic syndrome and bipolar disorder: Is sleep the missing link?]
CONCLUSIONS: Circadian and sleeping disorder may have a role in the prevalence of metabolic syndrome in BP. Hormones like leptin and ghrelin could be the link between these perturbations. Prevention and treatment of circadian disorder in BP may greatly reduce the occurrence of MetS in these patients. Being aware of this statement and taking care of these troubles should be a big step forward for treatment of BP. PMID: 27663044 [PubMed - as supplied by publisher] (Source: L Encephale)
Source: L Encephale - September 26, 2016 Category: Psychiatry Tags: Encephale Source Type: research

Resistin as an inflammatory marker in patients with schizophrenia treated with clozapine.
CONCLUSIONS: Resistin is a biomarker of systemic inflammation associated with smoking among patients with schizophrenia on clozapine treatment. Resistin might have a role as a marker of cardiovascular comorbidity. PMID: 27658459 [PubMed - as supplied by publisher] (Source: Nordic Journal of Psychiatry)
Source: Nordic Journal of Psychiatry - September 25, 2016 Category: Psychiatry Tags: Nord J Psychiatry Source Type: research

The role of irisin in the relationship between psoriasis and insulin resistance.
CONCLUSION: In conclusion, we observed that serum irisin levels were significantly lower in patients with psoriasis, and associated with serum lipid levels and disease activity in our study. These results can be interpreted that irisin is involved in the disease pathogenesis of patients with psoriasis in relation to metabolic dysregulation. PMID: 27652568 [PubMed - as supplied by publisher] (Source: Giornale Italiano di Dermatologia e Venereologia)
Source: Giornale Italiano di Dermatologia e Venereologia - September 24, 2016 Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research

The microbial epigenome in metabolic syndrome
Publication date: Available online 23 September 2016 Source:Molecular Aspects of Medicine Author(s): Marlene Remely, Alexander G. Haslberger Dietary habits, lifestyle, medication, and food additives affect the composition and functions of the GI microbiota. Metabolic syndrome is already known to be associated with an aberrant gut microbiota affecting systemic low-grade inflammation, which is also outlined by differing epigenetic patterns. Thus, structural changes and compositional evaluation of gut microbial differences affecting epigenetic patterns in metabolic syndrome are of research interest. In the present review we ...
Source: Molecular Aspects of Medicine - September 24, 2016 Category: Molecular Biology Source Type: research

Metabolic syndrome and the hepatorenal reflex.
Authors: Wider MD Abstract Insufficient hepatic O2 in animal and human studies has been shown to elicit a hepatorenal reflex in response to increased hepatic adenosine, resulting in stimulation of renal as well as muscle sympathetic nerve activity and activating the renin angiotensin system. Low hepatic ATP, hyperuricemia, and hepatic lipid accumulation reported in metabolic syndrome (MetS) patients may reflect insufficient hepatic O2 delivery, potentially accounting for the sympathetic overdrive associated with MetS. This theoretical concept is supported by experimental results in animals fed a high fructose diet ...
Source: Surgical Neurology International - September 23, 2016 Category: Neurosurgery Tags: Surg Neurol Int Source Type: research

Effects of Short-Term Free-Weight and Semiblock Periodization Resistance Training on Metabolic Syndrome
Abstract: South, MA, Layne, AS, Stuart, CA, Triplett, NT, Ramsey, MW, Howell, ME, Sands, WA, Mizuguchi, S, Hornsby, WG, Kavanaugh, AA, and Stone, MH. Effects of short-term free-weight and semiblock periodization resistance training on metabolic syndrome. J Strength Cond Res 30(10): 2682–2696, 2016—The effects of short-term resistance training on performance and health variables associated with prolonged sedentary lifestyle and metabolic syndrome (MS) were investigated. Resistance training may alter a number of health-related, physiological, and performance variables. As a result, resistance training can be used as a va...
Source: Journal of Strength and Conditioning Research - September 23, 2016 Category: Sports Medicine Tags: Original Research Source Type: research

One month of omega-3 fatty acid supplementation improves lipid profiles, glucose levels and blood pressure in overweight schoolchildren with metabolic syndrome
Journal Name: Journal of Pediatric Endocrinology and Metabolism Issue: Ahead of print (Source: Journal of Pediatric Endocrinology and Metabolism)
Source: Journal of Pediatric Endocrinology and Metabolism - September 23, 2016 Category: Endocrinology Source Type: research

Body ‐mass index is associated with fibrosis regression during long‐term nucleoside analogue therapy in chronic hepatitis B
ConclusionAn increased BMI hindered fibrosis regression in patients with chronic hepatitis B during nucleoside analogue treatment, suggesting that control of metabolic risk factors, in addition to virologic suppression via antiviral therapy, might be needed to halt the fibrogenic process in chronic hepatitis B. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - September 23, 2016 Category: Drugs & Pharmacology Authors: W. ‐K. Seto, J. Fung, K.‐S. Cheung, L.‐Y. Mak, R. W. H. Hui, K. S. H. Liu, C.‐L. Lai, M.‐F. Yuen Tags: Original Article Source Type: research

Association of metabolic syndrome with various anthropometric and atherogenic parameters in the Kazakh population in China
This study aimed to evaluate the association of the metabolic syndrome (MetS) with various anthropometric and atherogenic parameters in adult Kazakh population in China. (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - September 23, 2016 Category: Lipidology Authors: Xiaocui Chen, Chunhui He, Yitong Ma, Yining Yang, Fen Liu, Xiang Ma, Xiaomei Li, Xiang Xie and Bangdang Chen Source Type: research

Circadian clock control of hepatic lipid metabolism: role of small heterodimer partner (Shp)
Hepatic steatosis, the accumulation of triglyceride droplets in the hepatocytes, is a common hepatic pathology seen in subjects with obesity/metabolic syndrome and those with excessive alcohol use. The pathogenesis underlying hepatic steatosis is complex. Recent studies have shown the specific role played by the molecular clock mechanism in the control of lipid metabolism and that the disruption of these tissue clocks may lead to the disturbances in lipid homeostasis. This review reports a novel role of small heterodimer partner in maintaining triglyceride and lipoprotein homeostasis through neuronal PAS domain protein 2. ...
Source: Journal of Investigative Medicine - September 23, 2016 Category: Research Authors: Wang, L., Liangpunsakul, S. Tags: Experimental biology symposia Source Type: research

Predictors of adherence in a prevention program for patients with metabolic syndrome
The study objectives were (1) comparison of baseline characteristics between individuals with metabolic syndrome, adhering/not adhering to a primary prevention program modificacão do estilo de vida e risco cardiovascular; and (2) determination of risk factors for program adherence. The sample included 127 participants with mean age (±standard deviation) of 49.58 (±7.77) years, participating in the modificacão do estilo de vida e risco cardiovascular between 2010 and 2012. Results show that program adherence predictors were age (odds ratio: 1.134, 95% confidence interval: 1.106–1.833); prac...
Source: Journal of Health Psychology - September 23, 2016 Category: Psychiatry & Psychology Authors: Susin, N., de Melo Boff, R., Ludwig, M. W. B., Feoli, A. M. P., da Silva, A. G., Macagnan, F. E., da Silva Oliveira, M. Tags: Articles Source Type: research

Association of IGFBP-6 Expression with Metabolic Syndrome and Adiponectin and IGF-IR Receptor Levels in Colorectal Cancer.
CONCLUSIONS: The IGFBP-6 mRNA level and protein level were found to be associated with presence of the metabolic syndrome. Positive correlations indicated probable cross-talk between the IGF-IR-mediated and adiponectin-mediated signaling pathways in colorectal carcinomas. IGFBP-6 may be considered as a potential biomarker associated with lymphogenous metastasis and the metabolic syndrome in colorectal cancer. PMID: 27644646 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - September 22, 2016 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

The regulatory Roles of O-GlcNAcylation in mitochondrial Homeostasis and metabolic Syndrome.
Authors: Zhao L, Feng Z, Yang X, Liu J Abstract Nutrients excess is one of the leading causes of metabolic syndrome globally. Protein post-translational O-GlcNAc modification has been recognized as an essential nutrient sensor of the cell. Emerging studies suggest that O-GlcNAcylation lies at the core linking nutritional stress to insulin resistance. Mitochondria are the major site for ATP production in most eukaryotes. Mitochondrial dysfunction and oxidative stress have long been considered as an important mechanism underlying insulin resistance. The metabolic process is under the influence of environmental and nu...
Source: Free Radical Research - September 22, 2016 Category: Research Tags: Free Radic Res Source Type: research

Protodioscin ameliorates fructose-induced renal injury via inhibition of the mitogen activated protein kinase pathway
Conclusion Taken together, protodioscin is a potential drug candidate for high dietary fructose-induced metabolic syndrome and renal injury. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - September 22, 2016 Category: Drugs & Pharmacology Source Type: research

The awareness to metabolic syndrome among hospital health providers
Conclusion Though hospital workers showed high level of awareness to the existence of MetS, they failed to differentiate correctly MetS cases from non-MetS ones. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - September 22, 2016 Category: Endocrinology Source Type: research

Impulsivity is associated with blood pressure and waist circumference among adolescents with bipolar disorder
Conclusion BP and waist circumference are associated with impulsivity in BD adolescents, but not in HC adolescents. Future studies are warranted to determine temporality and to evaluate whether optimizing CVRFs improves impulsivity among BD adolescents. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - September 22, 2016 Category: Psychiatry Source Type: research

Antioxidant Enzyme Activity and Cognition in Obese Individuals with or without Metabolic Risk Factors
Conclusion: There is a significant mild cognitive impairment and increased oxidative stress activity in the metabolically unhealthy obese. Whether treatment with anti-oxidants improves cognitive dysfunction remains to be determined. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - September 22, 2016 Category: Endocrinology Authors: Farah, R. Gilbey, P. Asli, H. Khamisy-Farah, R. Assy, N. Tags: Article Source Type: research

High Intensity Interval Training Reduces the Levels of Serum Inflammatory Cytokine on Women with Metabolic Syndrome
Conclusions: The HIIT program used here positively affected inflammatory profile and other parameters, as glucose, HbA1cand NOx, on postmenopausal women with MS. Moreover, 2 weeks of detraining can reverse the beneficial effects of HIIT program. Our results point out the necessity to aply acontinuous HITT program, in order maintain the benefits detected, to post menopausal women with MS. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)
Source: Experimental and Clinical Endocrinology and Diabetes - September 22, 2016 Category: Endocrinology Authors: Steckling, F. M. Farinha, J. B. Santos, D. L. D. Bresciani, G. Mortari, J. A. Stefanello, S. T. Courtes, A. A. Duarte, T. Duarte, M. M. M. F. Moresco, R. N. Cardoso, M. S. Soares, F. A.A. Tags: Article Source Type: research

Rice bran protein hydrolysates reduce arterial stiffening, vascular remodeling and oxidative stress in rats fed a high-carbohydrate and high-fat diet
ConclusionRBPH mitigate the deleterious effects of HCHF through potential mechanisms involving enhanced NO bioavailability, anti-ACE, anti-inflammatory and antioxidant properties. RBPH could be used as dietary supplements to minimize oxidative stress and vascular alterations triggered by MetS. (Source: European Journal of Nutrition)
Source: European Journal of Nutrition - September 22, 2016 Category: Nutrition Source Type: research

Time-restricted feeding improves insulin resistance and hepatic steatosis in a mouse model of postmenopausal obesity
Menopause is associated with significant hormonal changes that result in increased total body fat and abdominal fat, amplifying the risk for metabolic syndrome and diseases such as diabetes, cardiovascular disease and cancer in postmenopausal women. Intermittent fasting regimens hold significant health benefit promise for obese humans, however, regimens that include extreme daytime calorie restriction or daytime fasting are generally associated with hunger and irritability, hampering long-term compliance and adoption in the clinical setting. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - September 22, 2016 Category: Biomedical Science Authors: Heekyung Chung, Winjet Chou, Dorothy D. Sears, Ruth E. Patterson, Nicholas Webster, Lesley G. Ellies Source Type: research

Glycine prevents metabolic steatohepatitis in diabetic KK-Ay mice through modulation of hepatic innate immunity.
Abstract Strategies for prevention and treatment of nonalcoholic steatohepatitis (NASH) remain to be established. Here, we evaluated the effect of glycine on metabolic steatohepatitis in genetically obese, diabetic KK-A(y) mice. Male KK-A(y) mice were fed a diet containing 5% glycine for 4 weeks, and liver pathology was evaluated. Hepatic mRNA levels for lipid-regulating molecules, cytokines/chemokines, and macrophage M1/M2 markers were determined by real time RT-PCR. Hepatic expression of natural killer (NK) T cells was analyzed by flow cytometry. Dietary glycine blunted body weight gain significantly, and preven...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - September 22, 2016 Category: Physiology Authors: Takashima S, Ikejima K, Arai K, Yokokawa J, Kon K, Yamashina S, Watanabe S Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

Bilirubin as an important physiological modulator of oxidative stress and chronic inflammation in metabolic syndrome and diabetes: a new aspect on old molecule
(Source: Diabetology International)
Source: Diabetology International - September 21, 2016 Category: Endocrinology Source Type: research

Molecules, Vol. 21, Pages 1264: Cyanidin-3-O-glucoside: Physical-Chemistry, Foodomics and Health Effects
Anthocyanins (ACNs) are plant secondary metabolites from the flavonoid family. Red to blue fruits are major dietary sources of ACNs (up to 1 g/100 g FW), being cyanidin-3-O-glucoside (Cy3G) one of the most widely distributed. Cy3G confers a red hue to fruits, but its content in raspberries and strawberries is low. It has a good radical scavenging capacity (RSC) against superoxide but not hydroxyl radicals, and its oxidative potential is pH-dependent (58 mV/pH unit). After intake, Cy3G can be metabolized (phases I, II) by oral epithelial cells, absorbed by the gastric epithelium (1% –10%) and it is gut-transformed (phase ...
Source: Molecules - September 21, 2016 Category: Chemistry Authors: Francisco Olivas-Aguirre Joaqu ín Rodrigo-García Nina Mart ínez-Ruiz Arely C árdenas-Robles Sandra Mendoza-D íaz Emilio Álvarez-Parrilla Gustavo Gonz ález-Aguilar Laura de la Rosa Arnulfo Ramos-Jim énez Abraham Wall-Medrano Tags: Review Source Type: research

Arterial stiffness in metabolic syndrome
Conclusion Transthoracic echocardiographic determination of AVP is a simple practical method and correlates well with FMD in patients with MS. (Source: Journal of the Saudi Heart Association)
Source: Journal of the Saudi Heart Association - September 21, 2016 Category: Cardiology Source Type: research

SES Gradients Among Mexicans in the United States and in Mexico: A New Twist to the Hispanic Paradox?
AbstractRecent empirical findings have suggested the existence of a twist in the Hispanic paradox, in which Mexican and other Hispanic foreign-born migrants living in the United States experience shallower socioeconomic status (SES) health disparities than those in the U.S. population. In this article, we seek to replicate this finding and test conjectures that could explain this new observed phenomenon using objective indicators of adult health by educational attainment in several groups: (1) Mexican-born individuals living in Mexico and in the United States, (2) U.S.-born Mexican Americans, and (3) non-Hispanic American ...
Source: Demography - September 21, 2016 Category: Global & Universal Source Type: research

Sedentary Lifestyle and High-Carbohydrate Intake are Associated with Low-Grade Chronic Inflammation in Post-Menopause: A Cross-sectional Study
Conclusions sedentary lifestyle and high-carbohydrate intake were associated with low-grade chronic inflammation and cardiovascular risk in postmenopause.Resumo Introdu ção A doença cardiovascular é a principal causa de morte em mulheres na pós-menpausa e inflamação está envolvida com o processo de aterosclerose. Objetivo avaliar se o padrão alimentar, o perfilmetabólico, a composição corporal e a atividade física estão associados à inflamação c rônica de baixo grau, de acordo com os níveis de proteína C-reativa (PCR-us), em mulheres na pós-menopausa. Métodos noventa e cinco participantes pós-menopá...
Source: Revista Brasileira de Ginecologia e Obstetricia - September 20, 2016 Category: OBGYN Source Type: research

Obese dogs with and without obesity-related metabolic dysfunction – a proteomic approach
Approximately 20  % of obese dogs have metabolic disturbances similar to those observed in human metabolic syndrome, a condition known as obesity-related metabolic dysfunction. This condition is associated with... (Source: BMC Veterinary Research)
Source: BMC Veterinary Research - September 20, 2016 Category: Veterinary Research Authors: Asta Tvarijonaviciute, Jose J. Ceron, Carlos de Torre, Blanka B. Ljubi ć, Shelley L. Holden, Yann Queau, Penelope J. Morris, Josep Pastor and Alexander J. German Source Type: research

CYP450-mediated Fatty Acid and Eicosanoids in Metabolic Syndrome and Vascular Diseases
Publication date: September 2016 Source:Prostaglandins & Other Lipid Mediators, Volume 125 Author(s): Nader G. Abraham (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - September 20, 2016 Category: Lipidology Source Type: research

Hepatic steatosis, detected by hepatorenal index in ultrasonography, as a predictor of insulin resistance in obese subjects
ConclusionDetection and quantification of hepatic steatosis by ultrasound and the hepatorenal index is a feasible screening tool for identifying patients with low risk of having insulin resistance (IR, HRI<1.17), patients at risk of having IR (HRI 1.17-1.41) and patients with likely IR (HRI ≥1.42), especially in obese individuals. (Source: BMC Obesity)
Source: BMC Obesity - September 20, 2016 Category: Eating Disorders and Weight Management Source Type: research

Impact of metabolic syndrome on the incidence of type 2 diabetes in middle-aged Japanese individuals with impaired insulin secretion: the Saku study
ConclusionsThe prevention of MetS is important, particularly in individuals with low insulin secretion. (Source: Diabetology International)
Source: Diabetology International - September 20, 2016 Category: Endocrinology Source Type: research

Associations of Vitamin D with Insulin Resistance, Obesity, Type 2 Diabetes, and Metabolic Syndrome
Publication date: Available online 20 September 2016 Source:The Journal of Steroid Biochemistry and Molecular Biology Author(s): Sunil J. Wimalawansa The aim of this study to determine the relationships of vitamin D with diabetes, insulin resistance obesity, and metabolic syndrome. Intra cellular vitamin D receptors and the 1-α hydroxylase enzyme are distributed ubiquitously in all tissues suggesting a multitude of functions of vitamin D. It plays an indirect but an important role in carbohydrate and lipid metabolism as reflected by its association with type 2 diabetes (T2D), metabolic syndrome, insulin secretion, insuli...
Source: The Journal of Steroid Biochemistry and Molecular Biology - September 20, 2016 Category: Biochemistry Source Type: research

The highly neglected burden of resistant hypertension in Africa: a systematic review and meta-analysis
Conclusions There is a huge dearth of research on the epidemiology of RH in Africa. Thereby, an extensive study of RH prevalence and risk factors is still largely warranted to curtail the high and continuously increasing burden of hypertension across Africa. (Source: BMJ Open)
Source: BMJ Open - September 20, 2016 Category: Journals (General) Authors: Nansseu, J. R. N., Noubiap, J. J. N., Mengnjo, M. K., Aminde, L. N., Essouma, M., Jingi, A. M., Bigna, J. J. R. Tags: Open access, Cardiovascular medicine, Epidemiology, Public health Research Source Type: research

Association between serum zinc and later development of metabolic syndrome in middle - aged and older men: the Kuopio Ischaemic Heart Disease Risk Factor Study
The aim of this study was to investigate associations of serum zinc with incident metabolic syndrome and its components in middle-aged and older Finnish men. (Source: Nutrition)
Source: Nutrition - September 20, 2016 Category: Nutrition Authors: Teymoor Yary, Jyrki K. Virtanen, Anu Ruusunen, Tomi-Pekka Tuomainen, Sari Voutilainen Source Type: research

New PPARα/γ/δ Optimal Activator Rationally Designed by Computational Methods
In this study, we proposed new PPAR γ agonists using PharmaGist Server for pharmacophore prediction, the molecular docking was performed by GOLD (genetic optimization for ligand docking) v2.2, AutoDock 4.2 and AutoDock Vina 1.1 and QikProp v4.0 and Derek for absorption, distribution, metabolism, excretion and toxicity (ADMET) assessment. One molecule showed high predicted affinity to PPAR γ and favorable pharmacokinetic and toxicity properties. It was then evaluated against PPAR α and PPAR δ and showed greater affinity to these receptors than the controls. Therefore this molecule is a promising drug lead for the develo...
Source: Journal of the Brazilian Chemical Society - September 19, 2016 Category: Chemistry Source Type: research

Influence of Post-disaster Evacuation on Incidence of Metabolic Syndrome.
CONCLUSION: This is the first study to demonstrate that evacuation after a disaster is associated with increased incidence of METS. PMID: 27629253 [PubMed - as supplied by publisher] (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - September 19, 2016 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Venous and Arterial Thrombosis: Is There a Link?
Authors: Prandoni P Abstract An increasing body of evidence suggests the likelihood of a link between venous and arterial thrombosis. The two vascular complications share several risk factors, such as age, obesity, smoking, diabetes mellitus, blood hypertension, hypertriglyceridemia, and metabolic syndrome. Moreover, there are many examples of conditions accounting for both venous and arterial thrombosis, such as the antiphospholipid antibody syndrome, hyperhomocysteinemia, malignancies, infections, and the use of hormonal treatment. Finally, several recent studies have consistently shown that patients with venous ...
Source: Advances in Experimental Medicine and Biology - September 19, 2016 Category: Research Tags: Adv Exp Med Biol Source Type: research

Timing and Type of Alcohol Consumption and the Metabolic Syndrome - ELSA-Brasil
In conclusion, the alcohol—metabolic syndrome association differs markedly depending on the relationship of intake to meals . Beverage preference—wine or beer—appears to underlie at least part of this difference. Notably, most alcohol was consumed in metabolically unfavorable type and timing. If further investigations extend these findings to clinically relevant endpoints, public policies should recommend that alcoho l, when taken, should be preferably consumed with meals. (Source: PLoS One)
Source: PLoS One - September 19, 2016 Category: Biomedical Science Authors: Bruna Angelo Vieira Source Type: research

Molecules, Vol. 21, Pages 1222: Molecular Modeling Studies of 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors through Receptor-Based 3D-QSAR and Molecular Dynamics Simulations
11 β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a potential target for the treatment of numerous human disorders, such as diabetes, obesity, and metabolic syndrome. In this work, molecular modeling studies combining molecular docking, 3D-QSAR, MESP, MD simulations and free energy calculations were performed on pyridine amides and 1,2,4-triazolopyridines as 11β-HSD1 inhibitors to explore structure-activity relationships and structural requirement for the inhibitory activity. 3D-QSAR models, including CoMFA and CoMSIA, were developed from the conformations obtained by docking strategy. Th e derived pharmacophoric f...
Source: Molecules - September 19, 2016 Category: Chemistry Authors: Haiyan Qian Jiongjiong Chen Youlu Pan Jianzhong Chen Tags: Article Source Type: research

A Comparison of the Abdominal Fat Distribution and Coronary Risk Markers in Body Mass Index-matched Subjects with and without Fatty Liver.
Conclusion Both males and females with fatty liver had lower insulin sensitivity, lower plasma levels of HDL-C and adiponectin, and higher triglyceride and LDL-C levels. However, the plasma levels of apolipoprotein B, RLP-C, and oxidized LDL were only higher and closely associated with fatty liver in men. Men with fatty liver had a higher risk of coronary disease than women with fatty liver. PMID: 27629946 [PubMed - in process] (Source: Internal Medicine)
Source: Internal Medicine - September 18, 2016 Category: Internal Medicine Tags: Intern Med Source Type: research

A Study on the Relationship between Reflux Esophagitis and Periodontitis.
Conclusion We did not find an association between periodontitis and reflux esophagitis in the present study. On the other hand, the presence of periodontitis was found to correlate with hypertension and dyslipidemia. PMID: 27629943 [PubMed - in process] (Source: Internal Medicine)
Source: Internal Medicine - September 18, 2016 Category: Internal Medicine Tags: Intern Med Source Type: research

Psoriasis and cardiovascular disorders.
Authors: Frieder J, Ryan C Abstract Psoriasis is associated with an increased risk of cardiovascular disease and related comorbidities such as diabetes mellitus, metabolic syndrome, dyslipidemia, and obesity. The precise mechanistic links underlying the association between psoriasis and cardiovascular disease remain unknown, however, multiple pathologic mechanisms have been proposed. Shared inflammatory pathways between psoriasis and atherosclerosis are likely involved. Other possible mechanisms include endothelial dysfunction, cytokine dysregulation, platelet upregulation, and dyslipidemia. Additional studies are ...
Source: Giornale Italiano di Dermatologia e Venereologia - September 18, 2016 Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research

Comparison of Plasma Glucose and Gut Hormone Levels Between Drinking Enteral Formula Over a Period of 5 and 20 Minutes in Japanese Patients With Type 2 Diabetes: A Pilot Study.
CONCLUSIONS: Eating quickly per se probably does not affect postprandial glucose excursions, but the increased energy intake resulting from eating quickly may increase the body weight and increase insulin resistance. Eating quickly may increase energy intake and worsen long-term metabolic parameters. PMID: 27635181 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - September 18, 2016 Category: Research Authors: Kamiko K, Aoki K, Kamiyama H, Taguri M, Terauchi Y Tags: J Clin Med Res Source Type: research

Insulin lispro low mixture twice daily vs basal insulin glargine once daily and prandial insulin lispro once daily as insulin intensification strategies in patients with type 2 diabetes: Latin American subpopulation analysis of a randomized trial
This post hoc analysis examined the efficacy and safety of twice-daily insulin lispro low mixture (LM25) and once-daily basal insulin glargine plus once-daily prandial insulin lispro (IGL) in a Latin American ... (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - September 17, 2016 Category: Endocrinology Authors: Arturo Rojas, Georgina Sposetti, Jorge L. Gross, Douglas Eugenio Barbieri, Ran Duan, Bruno Linetzky, Janaina Martins De Lana, Oded Stempa and Angel Rodriguez Source Type: research

Maternal fat-soluble vitamins, brain development and regulation of feeding behavior: an overview of research
Recent research shows a link between vitamin intake during pregnancy and offspring health. Inadequate intakes of water soluble vitamins during pregnancy lead to obesity and characteristics of the metabolic syndrome, concurrent with altered developments in food intake regulatory pathways. Few studies, however, have reported on the effects of fat-soluble vitamins (A, D, E and K) on the development of food intake regulatory pathways. The majority of studies to date have focused on associations between inadequate and high intakes of folic acid and vitamin D and neurocognitive development of the offspring. (Source: Nutrition Research)
Source: Nutrition Research - September 17, 2016 Category: Nutrition Authors: Diana S ánchez-Hernández, G. Harvey Anderson, Abraham N. Poon, Emanuela Pannia, Clara E. Cho, Pedro S.P. Huot, Ruslan Kubant Tags: Review Source Type: research

A unified Hyperglycemia and Diabetic ketoacidosis (DKA) insulin infusion protocol based on an Excel algorithm and implemented via Electronic Medical Record (EMR) in Intensive Care Units
Conclusions This IIP maintained ATR without hypoglycemia for patients in the ICU setting without requiring complex nursing calculations. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - September 17, 2016 Category: Endocrinology Source Type: research

Advances in the non-invasive assessment of vascular dysfunction in metabolic syndrome and diabetes: focus on endothelium, carotid mechanics and renal vessels
Conclusions Vascular dysfunction represents a major mechanism for the development of cardiovascular disease in patients with abnormal glucose metabolism. Hence, the currently available non-invasive techniques to assess early structural and vascular abnormalities merit recommendation in this population, although their predictive value and sensitivity to monitor treatment-induced changes have not yet been established and are still under investigation. (Source: Nutrition, Metabolism and Cardiovascular Diseases)
Source: Nutrition, Metabolism and Cardiovascular Diseases - September 17, 2016 Category: Nutrition Source Type: research

Glucagon like peptide-1 and its receptor agonists: Their roles in management of Type 2 Diabetes Mellitus
This study summarizes the major work done to investigate the roles of glucagon like peptide-1 (GLP) and its receptor (GLP-1R); the use of GLP-R agonists and dipeptidyl peptidase 4 inhibitor in the management of type 2 diabetes mellitus. It focuses on the recent therapeutic development which have occurred in this field, and also discussing the evolvement of the potential treatments which can be discovered and implemented in the near future to design an effective therapy for type 2 diabetes mellitus. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - September 17, 2016 Category: Endocrinology Source Type: research

Guest Editorial: How stress changes the brain and causes a cluster of uniquely human diseases
The goal of this manuscript is to explain how stress is critically involved in the pathophysiology of a cluster of uniquely human diseases which include migraine headaches, hypertension, metabolic syndrome (obesity), stroke, deep vein thrombosis (DVT)/pulmonary emboli (PE), auto-immune diseases, schizophrenia, post-traumatic stress disorder, Alzheimer ’s disease, and atherosclerosis. As is familiar to clinicians, some people have several of these diagnoses while other people are apparently healthy and have not a single one—the diseases tend to come as a “package deal”. (Source: Medical Hypotheses)
Source: Medical Hypotheses - September 17, 2016 Category: Biomedical Science Authors: Arnold E. Eggers Tags: Editorial$Author's introduction Source Type: research

The 10-Year trend of adult diabetes, prediabetes and associated risk factors in Tehran: Phases 1 and 4 of Tehran Lipid and Glucose Study
Conclusion We observed an increasing trend in the prevalence of diabetes over a 10-year period in TLGS. This is an accordance with estimates ​​in this field and highlights the need for education, prevention, treatment and control of diabetes. We also found increased rates of central and general obesity, smoking and divorce along with decreased marriage rates, which should be considered by the healthcare policymakers and state health officials as significant risk factors of diabetes. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - September 17, 2016 Category: Endocrinology Source Type: research

All cause mortality and body mass index in a young Asian occupational cohort without baseline metabolic syndrome components
The aim was to investigate associations between underweight, overweight and obesity and all cause, cancer and cardiovascular disease (CVD) mortality, excluding subjects with known CVD), diabetes, hypertension and components of the metabolic syndrome (MetS) at baseline. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - September 17, 2016 Category: Cardiology Authors: Ki-Chul Sung, Seungho Ryu, Jong-Young Lee, SungHo Lee, EunSun Cheong, Jang-Young Kim, Sarah H Wild, Christopher D Byrne Source Type: research