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[Etiopathogenic factors of the different types of urinary litiasis.]
Authors: Arrabal-Martín M, Cano-García MC, Arrabal-Polo MÁ, Domínguez-Amillo A, Canales-Casco N, de la Torre-Trillo J, Cózar-Olmo JM Abstract In this review, we analyze the etiopathogenic principles of urinary lithiasis formation. In the kidney, calcifications that may cause renal lithiasis are produced as a consequence of processes that injury the urothelium at the papilla and Bellini's ducts. With the improvement of imaging techniques, mainly micro CT scan, it is possible to detect them and we may be able to anticipate to the formation of lithiasis. As we well know, there are different factors that influence...
Source: Archivos Espanoles de Urologia - February 23, 2017 Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research

[Urinary lithiasis as a systemic disease.]
Authors: Leanez Jiménez M, Candau Vargas-Zúñiga F, Reina Ruiz C Abstract Urinary lithiasis is a prevalent disorder of uncertain origin which provokes health problems through potential harm to the urinary system, renal parenchyma or the body as a whole, with a frequent trend to relapse. Historically urinary calculi have been studied and treated as an isolated disease but nowadays we know more about their connection with other pathological entities. In a small percentage of patients, diseases like primary hyperparathyroidism, tubular renal acidosis, inflammatory bowel disease or bariatric surgery have a fairly wel...
Source: Archivos Espanoles de Urologia - February 23, 2017 Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research

Early life linear growth but not weight gain, impacts adult human capital
The general consensus in the child development literature, originating from growth restricted infants, is that the earlier the infants move onto a positive growth trajectory, the better their growth and developmental outcome will be (Semin Perinatol 2010;34:207-10; Early Hum Dev 2015;91:491-7). Nevertheless, rapid catch-up growth, in terms of weight, has been linked with adult risk of obesity, metabolic syndrome, and cardiovascular disease (J Pediatr 2000;137:36-41; Curr Opin Clin Nutr Metab Care 2010;13:294 –9). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - February 23, 2017 Category: Pediatrics Authors: Julia Steinberger Tags: The Editors' Perspectives Source Type: research

What's in the Literature?
Abstract: In this edition of this column, we review new studies concerning the pathophysiology, treatment, and outcomes of patients with necrotizing myopathy, genetic testing in congenital myopathies, and limb girdle muscular dystrophies, and the incidence of polyneuropathy in the myotonic dystrophies. Various studies in myasthenia gravis, including those concerning antibody testing, clinical features, and quality of life are also reviewed as are recent findings in congenital myasthenic syndromes. Finally, 2 studies concerning polyneuropathy are discussed, including one on the association of polyneuropathy in patients with...
Source: Journal of Clinical Neuromuscular Disease - February 23, 2017 Category: Neurology Tags: Literature Review Source Type: research

Epigenetic modification by dietary factors: Implications in metabolic syndrome
Publication date: Available online 17 February 2017 Source:Molecular Aspects of Medicine Author(s): Jae-Ho Park, Soon-Hee Kim, Myeong Soo Lee, Myung-Sunny Kim Dietary factors play a role in normal biological processes and are involved in the regulation of pathological progression over a lifetime. Evidence has emerged indicating that dietary factor-dependent epigenetic modifications can significantly affect genome stability and the expression of mRNA and proteins, which are involved in metabolic dysfunction. Since metabolic syndrome is a progressive phenotype characterized by insulin resistance, obesity, hypertension, dysl...
Source: Molecular Aspects of Medicine - February 23, 2017 Category: Molecular Biology Source Type: research

Sensitivity of various body indices and visceral adiposity index in predicting metabolic syndrome among Chinese patients with adult growth hormone deficiency
ConclusionIn conclusion, our study showed all adiposity measures of interest present themselves as easy and practical tools for use in population studies and clinical practice for evaluating MetS in AGDH and VAI was identified as the best in Chinese AGHD patients among them. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - February 23, 2017 Category: Endocrinology Source Type: research

Liver dendritic cells and NAFLD evolution: a remaining open issue
Due to the growing diffusion of metabolic syndrome Non-Alcoholic Fatty Liver Disease (NAFLD), is expected to become a major cause of cirrhosis and HCC worldwide within the next decade. However, the mechanisms responsible for NAFLD progression to nonalcoholic steatohepatitis (NASH) and fibrosis/cirrhosis are still largely unclear and this hampers the development of diagnostic tools to identify NAFLD patient at risk of progressive disease [1]. In the attempt of unravelling the complex network responsible to sustain lobular inflammation in NASH, growing attention has been given to liver myeloid cells including hepatic dendrit...
Source: Journal of Hepatology - February 23, 2017 Category: Gastroenterology Authors: Christine Bernsmeier, Emanuele Albano Source Type: research

Depression is Associated with Increased Risk for Metabolic Syndrome in Latinos with Type 2 Diabetes
This study sought to examine the links between depression and MetS, as well as clinically significant elevations in cardiovascular disease (CVD) risk markers of MetS in a sample of community-dwelling older Latinos with type 2 diabetes. (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - February 23, 2017 Category: Geriatrics Authors: Veronica Cardenas, Brent T. Mausbach, David Sommerfeld, Daniel Jimenez, Roland von K änel, Jennifer S. Ho, Piedad Garcia, Greg Aarons Tags: Regular Research Articles Source Type: research

Quality Criteria in Bariatric Surgery: Consensus Review and Recommendations of the Spanish Association of Surgeons and the Spanish Society of Bariatric Surgery
We describe the main indicators based on the published literature as well as the criteria for referral of the main comorbidities according to the evidence found and grades of recommendation. (Source: Cirugia Espanola)
Source: Cirugia Espanola - February 23, 2017 Category: Surgery Source Type: research

Adipokine Concentrations and Adiposity in Hematopoietic Cell Transplant (HCT) Survivors
Background: Adult survivors of acute leukemia in childhood have a higher than expected frequency of obesity, an increased risk for metabolic syndrome and early mortality from cardiovascular (CV) disease. Adipose tissue has been recognized as an endocrine and paracrine organ that produces adipokines (leptin and adiponectin) that are associated with obesity, insulin secretion, and insulin resistance as well as endothelial function, vascular homeostasis and atherogenesis. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - February 22, 2017 Category: Hematology Authors: Tyler G. Ketterl, Eric J. Chow, Wendy M. Leisenring, Pam Goodman, Ildi H. Koves, Anna Petryk, Julia Steinberger, K. Scott Baker Source Type: research

Clinical Risk Factor Modeling for Late Coronary Artery Disease —An NHLBI Allogeneic Stem Cell Transplant Survivorship Cohort Study
Introduction: Premature coronary artery disease (CAD) is a lethal late effect in allogeneic hematopoietic cell transplant (HCT) survivors. Most conventional cardiac risk factors (e.g. dyslipidemia, metabolic syndrome, hypertension and diabetes) have been strongly implicated in the cardiac events seen in allo-HCT survivors. The Framingham risk score (FRS) is typically used in the normal population to estimate CAD risk as a screening strategy. We have studied Cardiac CT-Angiography (CCTA) to unequivocally identify CAD in asymptomatic HCT survivors and found that 10-year Framingham risk score (FRS) is specific but quite insen...
Source: Biology of Blood and Marrow Transplantation - February 22, 2017 Category: Hematology Authors: Kimberley Doucette, Upneet Chawla, Tian Xin, Natasha A. Jain, Marcus Y. Chen, Sawa Ito, Pawel Muranski, Eleftheria Koklanaris, A. John Barrett, Minoo Battiwalla Source Type: research

Psoriasis and Obesity
Psoriasis is a common chronic inflammatory skin disease with a complex pathogenesis consisting of a genetic component, immune dysfunction, and environmental factors. It is associated with numerous comorbidities including psoriatic arthritis, cardiovascular disease, metabolic syndrome, and obesity. Evidence suggests that obesity is a risk factor for incident psoriasis, aggravates existing psoriasis, and that weight reduction may improve the severity of psoriasis in overweight individuals. Excess body weight may interfere with the medical treatment used in psoriasis and adds to the cardiovascular risk profile in these patien...
Source: Dermatology - February 22, 2017 Category: Dermatology Source Type: research

Tissue-specific methylation profile in obese patients with type 2 diabetes before and after Roux-en-Y gastric bypass
Eating habits, lifestyles, and exposure to specific environmental factors can greatly impact the risk of developing type 2 diabetes (T2D), influence the genome epigenetically, and affect the expression of gene... (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - February 22, 2017 Category: Endocrinology Authors: Priscila Sala, Raquel Susana Matos de Miranda Torrinhas, Danielle Cristina Fonseca, Graziela Rosa Ravacci, Dan Linetzky Waitzberg and Daniel Giannella-Neto Source Type: research

A targeted approach toward more accurate assessment of hypertension
Publication date: Available online 21 February 2017 Source:Egyptian Journal of Chest Diseases and Tuberculosis Author(s): Dina Johar, Larry Bernstein There is neither a unifying concept nor a sufficient multivariable approach to apply the use of laboratory markers to clinical practice with respect to the metabolic syndrome. The relationship of metabolic syndrome to the development of hypertension and the concurrent development of chronic renal disease has become evident. We have shown biomarkers to have significant value in combination for assessing heart failure and pulmonary hypertension. The pathogenesis of hypertensio...
Source: Egyptian Journal of Chest Diseases and Tuberculosis - February 22, 2017 Category: Respiratory Medicine Source Type: research

Alanine Aminotransferase Is a Marker of Lipotoxicity Consequences and Hyperandrogenemia in Women with Polycystic Ovary Syndrome
Metabolic Syndrome and Related Disorders , Vol. 0, No. 0. (Source: Metabolic Syndrome and Related Disorders)
Source: Metabolic Syndrome and Related Disorders - February 22, 2017 Category: Endocrinology Source Type: research

The Correlation of Arterial Stiffness with Biophysical Parameters and Blood Biochemistry
Metabolic Syndrome and Related Disorders , Vol. 0, No. 0. (Source: Metabolic Syndrome and Related Disorders)
Source: Metabolic Syndrome and Related Disorders - February 22, 2017 Category: Endocrinology Source Type: research

Non-alcoholic fatty liver disease and colorectal cancer
As a significant cause of cancer death worldwide, colorectal cancer (CRC) is still one of the most common cancers in the world. The most efficient strategies to reduce CRC incidence include identifying risk factors for CRC and performing a preventive colonoscopy in high-risk populations. Some well-established risk factors for CRC development include hereditary syndromes and inflammatory bowel disease. Of note, in recent years, attention has been given to new evidence indicating that more than 75%–95% of CRC occurs in individuals with little or no genetic risk. For these individuals, the risk for CRC is associated wit...
Source: Postgraduate Medical Journal - February 22, 2017 Category: Journals (General) Authors: Mikolasevic, I., Orlic, L., Stimac, D., Hrstic, I., Jakopcic, I., Milic, S. Tags: Reviews Source Type: research

The role of oxidative stress on the pathophysiology of metabolic syndrome
Summary Metabolic syndrome (MetS) has a high prevalence around the world. Considering the components used to classify MetS, it is clear that it is closely related to obesity. These two conditions begin with an increase in abdominal adipose tissue, which is metabolically more active, containing a greater amount of resident macrophages compared to other fat deposits. Abdominal adiposity promotes inflammation and oxidative stress, which are precursors of various complications involving MetS components, namely insulin resistance, hypertension and hyperlipidemia. One way to block the effects of oxidative stress would be through...
Source: Revista da Associacao Medica Brasileira - February 21, 2017 Category: Journals (General) Source Type: research

Erratum
Summary Metabolic syndrome (MetS) has a high prevalence around the world. Considering the components used to classify MetS, it is clear that it is closely related to obesity. These two conditions begin with an increase in abdominal adipose tissue, which is metabolically more active, containing a greater amount of resident macrophages compared to other fat deposits. Abdominal adiposity promotes inflammation and oxidative stress, which are precursors of various complications involving MetS components, namely insulin resistance, hypertension and hyperlipidemia. One way to block the effects of oxidative stress would be through...
Source: Revista da Associacao Medica Brasileira - February 21, 2017 Category: Journals (General) Source Type: research

Prevalence of metabolic syndrome in patients with psoriasis: a hospital-based cross-sectional study
CONCLUSION: A higher prevalence of metabolic syndrome and its components in patients with psoriasis than in controls, regardless of disease severity, emphasizes the need for early treatment and follow-up of all psoriatic patients with respect to metabolic diseases. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - February 21, 2017 Category: Dermatology Source Type: research

Leukocyte telomere length in Hispanic schizophrenia patients under treatment with olanzapine
Publication date: July 2017 Source:Journal of Psychiatric Research, Volume 90 Author(s): Nancy Monroy-Jaramillo, Yaneth Rodríguez-Agudelo, Luis Carlos Aviña-Cervantes, David L. Roberts, Dawn I. Velligan, Consuelo Walss-Bass Different lines of evidence indicate that patients with schizophrenia (SZ) exhibit accelerated aging. Leukocyte telomere length (TL), an aging marker, is associated with age-related and chronic pathologies, including schizophrenia. We analyzed leukocyte TL in 170 SZ patients of Hispanic ancestry grouped based on antipsychotic treatment, compared to 126 matched controls. The group under treatment with...
Source: Journal of Psychiatric Research - February 21, 2017 Category: Psychiatry Source Type: research

Meta-analysis of metabolic syndrome and prostate cancer
amp; S Serni (Source: Prostate Cancer and Prostatic Diseases)
Source: Prostate Cancer and Prostatic Diseases - February 21, 2017 Category: Urology & Nephrology Authors: M Gacci G I Russo C De Nunzio A Sebastianelli M Salvi L Vignozzi A Tubaro G Morgia S Serni Source Type: research

Associations of PPAR- γ, APM1 and APOC1 gene polymorphisms with metabolic syndrome in children: A case-control study
Conclusion The results showed that the genetic variants of the APM1 and the APOC1 were associated with MS in children. (Source: Meta Gene)
Source: Meta Gene - February 21, 2017 Category: Genetics & Stem Cells Source Type: research

Epicardial fat in patients with metabolic syndrome
Conclusion EPF as measured by echocardiography reflects visceral fat and severe MS. Echocardiography is an easy and reliable imaging technique to classify patients with high risk. (Source: Journal of Indian College of Cardiology)
Source: Journal of Indian College of Cardiology - February 21, 2017 Category: Cardiology Source Type: research

Branched Chain Amino Acids Are Associated with Insulin Resistance Independent of Leptin and Adiponectin in Subjects with Varying Degrees of Glucose Tolerance
Metabolic Syndrome and Related Disorders , Vol. 0, No. 0. (Source: Metabolic Syndrome and Related Disorders)
Source: Metabolic Syndrome and Related Disorders - February 21, 2017 Category: Endocrinology Source Type: research

Management of Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes: A Call to Action
Traditionally a disease of hepatologists, nonalcoholic fatty liver disease (NAFLD) has recently become a major concern for a broad spectrum of health care providers. Endocrinologists and those caring for patients with type 2 diabetes mellitus (T2DM) are at center stage, as T2DM appears to worsen the course of NAFLD and the liver disease makes diabetes management more challenging. However, the nature of this relationship remains incompletely understood. Although the increasing prevalence of NAFLD is frequently attributed to the epidemic of obesity and is often oversimplified as the "hepatic manifestation of the metabolic sy...
Source: Diabetes Care - February 21, 2017 Category: Endocrinology Authors: Bril, F.; Cusi, K. Tags: Review Source Type: research

Energy metabolism drives myeloid-derived suppressor cell differentiation and functions in pathology.
Abstract Over the last decade, a heterogeneous population of immature myeloid cells with major regulatory functions has been described in cancer and other pathologic conditions and ultimately defined as MDSCs. Most of the early work on the origins and functions of MDSCs has been in murine and human tumor bearers in which MDSCs are known to be immunosuppressive and to result in both reduced immune surveillance and antitumor cytotoxicity. More recent studies, however, suggest that expansion of these immature myeloid cells may be linked to most, if not all, chronic and acute inflammatory processes. The universal expa...
Source: Journal of Leukocyte Biology - February 21, 2017 Category: Hematology Authors: Sica A, Strauss L Tags: J Leukoc Biol Source Type: research

Validation of the French Version of the DSM-5 Yale Food Addiction Scale in a Nonclinical Sample.
CONCLUSIONS: We validated a psychometrically sound French version of the YFAS 2.0 in a nonclinical population, in both its symptom count and diagnostic versions. Future studies should investigate psychometric properties of this questionnaire in clinical populations potentially at risk for FA (that is, patients with obesity, diabetes, hypertension, or other metabolic syndrome risk factors). PMID: 28212499 [PubMed - in process] (Source: Canadian Journal of Psychiatry)
Source: Canadian Journal of Psychiatry - February 20, 2017 Category: Psychiatry Authors: Brunault P, Courtois R, Gearhardt AN, Gaillard P, Journiac K, Cathelain S, Réveillère C, Ballon N Tags: Can J Psychiatry Source Type: research

Clinical utility of metabolic syndrome severity scores: considerations for practitioners
(Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - February 20, 2017 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research

Increased static and decreased capacity oxidation-reduction potentials in plasma are predictive of metabolic syndrome
Publication date: August 2017 Source:Redox Biology, Volume 12 Author(s): Gerd Bobe, Tora J. Cobb, Scott W. Leonard, Savinda Aponso, Christopher B. Bahro, Dipankar Koley, Eunice Mah, Richard S. Bruno, Maret G. Traber Electric conductivity in plasma is the balance between oxidized and reduced molecules (static Oxidation-Reduction Potential, sORP) and the amount of readily oxidizable molecules (capacity ORP, cORP). Adults with metabolic syndrome (MetS) have increased inflammation, dyslipidemia and oxidative stress; therefore, participants with MetS were hypothesized to have higher plasma sORP and lower cORP than those measur...
Source: Redox Biology - February 20, 2017 Category: Biology Source Type: research

Dietary Fiber Gap and Host Gut Microbiota.
Abstract Accumulating evidence are dramatically increasing access to the facts that the gut microbiota plays a pivotal role in host metabolism and health, which revealed the possibility of a plethora of associations between gut bacteria and human diseases. Several functional roles carried out by a major class of host's diet, such as fiber. Fiber is the main source of microbiota-accessible carbohydrate in the diet of humans. In modern diet, it is difficult to intake dietary fiber as enough as recommended standard. The low-fiber diet in the modern life, known as fiber gap, can trigger to a substantial depletion of t...
Source: Protein and Peptide Letters - February 20, 2017 Category: Biochemistry Authors: Han M, Liu P, Li D, Li Y, Ma X Tags: Protein Pept Lett Source Type: research

The association between macronutrient intake and the metabolic syndrome and its components in type 1 diabetes.
Abstract Diet is a major modifiable lifestyle factor that may affect the components of the metabolic syndrome. We aimed to investigate the association between relative proportions of macronutrients and the components of the metabolic syndrome in a population of individuals with type 1 diabetes. In all, 791 individuals without nephropathy, with plausible energy intake and known metabolic syndrome status, taking part in the Finnish Diabetic Nephropathy Study were included in the analyses. Dietary data were collected with a diet record. The association between the relative macronutrient intake and the outcome variabl...
Source: The British Journal of Nutrition - February 20, 2017 Category: Nutrition Authors: Ahola AJ, Harjutsalo V, Thorn LM, Freese R, Forsblom C, Mäkimattila S, Groop PH Tags: Br J Nutr Source Type: research

Daily Intake of Trehalose Is Effective in the Prevention of Lifestyle-Related Diseases in Individuals with Risk Factors for Metabolic Syndrome.
Authors: Mizote A, Yamada M, Yoshizane C, Arai N, Maruta K, Arai S, Endo S, Ogawa R, Mitsuzumi H, Ariyasu T, Fukuda S Abstract We previously performed animal studies that suggested that trehalose potentially prevents the development of metabolic syndrome in humans. To evaluate this possibility, we examined whether trehalose suppressed the progression of insulin resistance in a placebo-controlled, double-blind trial in 34 subjects with a body mass index (BMI) ≥23. The subjects were divided into two groups and were assigned to ingest either 10 g/d of trehalose or sucrose with meals for 12 wk. During the study, body...
Source: Journal of Nutritional Science and Vitaminology - February 19, 2017 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Fatty Liver Index and Lipid Accumulation Product Can Predict Metabolic Syndrome in Subjects without Fatty Liver Disease.
Conclusion. Metabolic syndrome increases the cardiovascular disease risk. The FLI and LAP could be used to recognize the syndrome in both subjects with and without fatty liver disease who require lifestyle modifications and counseling. PMID: 28194177 [PubMed - in process] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - February 19, 2017 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Visfatin correlates with hot flashes in postmenopausal women with metabolic syndrome: effects of genistein
AbstractDuring menopause, an increased prevalence of metabolic syndrome (MetS) and central obesity seems to increase hot flashes (HFs). Visfatin is an inflammatory adipokine secreted by visceral fat. We investigated visfatin levels and its relationship with hot flash number and BMI, in postmenopausal women with MetS. We also evaluated the effect of genistein, an isoflavone effective in reducing HFs, on visfatin levels and HFs after 1  year of treatment. This was a randomized, double-blind, placebo-controlled trial. Postmenopausal women with MetS were randomly assigned to receive placebo (n = 60) or 54 mg genistein (n ...
Source: Endocrine - February 19, 2017 Category: Endocrinology Source Type: research

Effect of Resistance Training and Caloric Restriction on the Metabolic Syndrome
Conclusion: RT + CR is an effective strategy for improving some of the metabolic abnormalities associated with MetS among older overweight and obese adults. (Source: Medicine and Science in Sports and Exercise)
Source: Medicine and Science in Sports and Exercise - February 18, 2017 Category: Sports Medicine Tags: Clinical Sciences Source Type: research

Cardiovascular Drift during Training for Fitness in Patients with Metabolic Syndrome
Purpose: The health benefits of a training program are largely influenced by the exercise dose and intensity. We sought to determine whether during a training bout of continuous versus interval exercise the workload needs to be reduced to maintain the prescribed target heart rate (HR). Methods: Fourteen obese (31 ± 4 kg·m−2) middle-age (57 ± 8 yr) individuals with metabolic syndrome, underwent two exercise training bouts matched by energy expenditure (i.e., 70 ± 5 min of continuous exercise [CE] or 45 min of interval exercise, high-intensity interval training [HIIT]). All subjects completed both trials in a randomiz...
Source: Medicine and Science in Sports and Exercise - February 18, 2017 Category: Sports Medicine Tags: Applied Sciences Source Type: research

Metabolic Syndrome and Diabetes Mellitus in Mexico: the Role of PET/CT in Endothelial Dysfunction and Cardiovascular Disease Detection
AbstractPurpose of ReviewMetabolic syndrome (MetS) and diabetes mellitus (DM) have become over the past years a global burden of disease. They are one of the main risk factors for cardiovascular disease among others. CVDs represent the number one cause of death globally. Diabetes Mellitus ’ prevalence, especially type 2, has increased dramatically in a short period increasing health care costs and mortality worldwide. Detecting coronary artery disease in diabetic patients with a myocardial perfusion imaging method such as PET/CT is the primary concern for this review.Recent FindingsThe most recent survey in Mexico done i...
Source: Current Cardiovascular Imaging Reports - February 18, 2017 Category: Radiology Source Type: research

Metabolic syndrome causes rec ognition memory impairments and reduced the hippocampal neuronal plasticity in rats
In this study, we evaluate the MS effect on the neuronal morphology of the hippocampus by a regional segregation approach. Our results demonstrate that 90days of a high-calorie diet altered metabolic energy markers and caused memory impairments, as evaluated by the recognition of novel objects test (NORT). In addition, MS animals showed significant differences in dendritic order, total dendritic length and density of dendritic spines in CA1, CA3 and dentate gyrus (DG) of the hippocampal area compared to control fed rats. Furthermore, the immunoreactivity to synaptophysin (Syp) decreased in the hippocampus of MS animals com...
Source: Journal of Chemical Neuroanatomy - February 18, 2017 Category: Neuroscience Source Type: research

Nutritional Anti-Inflammatories in the Treatment and Prevention of Type 2 Diabetes Mellitus and the Metabolic Syndrome
Overweight and obesity is epidemic across the developed world and prevalence in Australia is amongst the highest, with obesity alone costing the health system an estimated $837million[1]. Approximately 40% of Australians are overweight, undoubtedly adding to these costs and burden on the healthcare system[1]. Obesity and overweight comprise some of the key features of the Metabolic Syndrome (MetS), which is defined as central obesity plus any two of the following: raised triglycerides>1.7mmol/L, decreased high density lipoprotein cholesterol (HDL)5.6mmol/L or diagnosis of type 2 diabetes mellitus (T2DM). (Source: Diabetes ...
Source: Diabetes Research and Clinical Practice - February 18, 2017 Category: Endocrinology Authors: Lea Merone Tags: Review Source Type: research

Peptide YY (PYY) Gene Polymorphisms in the 3'-Untranslated Region and Proximal Promoter Regions Regulate Cellular Gene Expression and PYY Secretion and Metabolic Syndrome Traits in Vivo.
Authors: Shih PB, Wang L, Chiron S, Wen G, Nievergelt C, Mahata M, Khandrika S, Rao F, Fung MM, Mahata SK, Hamilton BA, O'Connor DT PMID: 28199513 [PubMed] (Source: Endocrine Reviews)
Source: Endocrine Reviews - February 17, 2017 Category: Endocrinology Tags: Endocr Rev Source Type: research

Association between obesity and heart rate variability indices: an intuition toward cardiac autonomic alteration & ndash; a risk of CVD
(Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - February 17, 2017 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research

Evaluation of clinical and laboratory markers of cardiometabolic risk in overweight and obese children and adolescents
CONCLUSIONS: The high frequency of changes in clinical, laboratory and adipokine markers indicates the need for early interventions aimed at preventing cardiometabolic complications in adulthood. (Source: Clinics)
Source: Clinics - February 17, 2017 Category: Journals (General) Source Type: research

Association of ACACB gene polymorphism (rs2268388, G & gt;A) with type 2 diabetes and end stage renal disease in Pakistani Punjabi population
Publication date: Available online 16 February 2017 Source:Meta Gene Author(s): Maryam Zain, Fazli Rabbi Awan, Syeda Sadia Najam, Mehboob Islam, Abdul Rehman Khan, Ahmed Bilal, Naima Bellili, Michel Marre, Ronan Roussel, Frederic Fumeron The Acetyl-CoA Carboxylase Beta (ACACB) is a regulator of fatty acid metabolism. A SNP (rs2268388, G>A) in this gene has been recently associated with diabetes, diabetic nephropathy, obesity as well as metabolic syndrome in some populations. Therefore, the aim of present study was to test this SNP for its association with diabetes and end stage renal disease (ESRD) in Pakistani Pun...
Source: Meta Gene - February 17, 2017 Category: Genetics & Stem Cells Source Type: research

Infulence of IL1B, IL6 and IL10 gene variants and plasma fatty acid interaction on metabolic syndrome risk in a cross-sectional population-based study
Metabolic syndrome (MetS) is a cluster of interrelated risk factors for type 2 diabetes mellitus, and cardiovascular disease, with underlying inflammatory pathophysiology. Genetic variations and diet are well-known risk factor for MetS, but the interaction between these two factors is less explored. The aim of the study was to evaluate the influence of interaction between SNP of inflammatory genes (encoding interleukin (IL)-6, IL-1 β and IL-10) and plasma fatty acids on the odds of MetS, in a population-based cross-sectional study. (Source: Clinical Nutrition)
Source: Clinical Nutrition - February 17, 2017 Category: Nutrition Authors: Marina Maintinguer Norde, Erica Oki, Antonio Augusto Ferreira Carioca, N ágila Raquel Teixeira Damasceno, Regina Mara Fisberg, Dirce Maria Lobo Marchioni, Marcelo Macedo Rogero Tags: Original article Source Type: research

Influence of IL1B, IL6 and IL10 gene variants and plasma fatty acid interaction on metabolic syndrome risk in a cross-sectional population-based study
Metabolic syndrome (MetS) is a cluster of interrelated risk factors for type 2 diabetes mellitus, and cardiovascular disease, with underlying inflammatory pathophysiology. Genetic variations and diet are well-known risk factor for MetS, but the interaction between these two factors is less explored. The aim of the study was to evaluate the influence of interaction between SNP of inflammatory genes (encoding interleukin (IL)-6, IL-1 β and IL-10) and plasma fatty acids on the odds of MetS, in a population-based cross-sectional study. (Source: Clinical Nutrition)
Source: Clinical Nutrition - February 17, 2017 Category: Nutrition Authors: Marina Maintinguer Norde, Erica Oki, Antonio Augusto Ferreira Carioca, N ágila Raquel Teixeira Damasceno, Regina Mara Fisberg, Dirce Maria Lobo Marchioni, Marcelo Macedo Rogero Tags: Original article Source Type: research

Interethnic Variation in Lipid Profiles: Implications for Underidentification of African-Americans at risk for Metabolic Disorders.
Authors: Bentley AR, Rotimi CN Abstract Interethnic differences exist in the distribution of serum lipids, with African Americans (AA) generally having a healthier lipid profile than other US ethnic groups. Similar lipid distributions are observed among other African ancestry groups with distinct lifestyle characteristics, suggesting the importance of inherited factors. Despite healthier serum lipids, AA experience a disproportionate burden of Type 2 Diabetes and Cardiovascular Disease. As evidence of a different relationship between serum lipids and disease exists, the characterization of metabolic risk using lipi...
Source: Expert Review of Endocrinology and Metabolism - February 16, 2017 Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research

Metabolically healthy versus unhealthy obesity and risk for diabetes mellitus and cardiovascular diseases
Obesity presents one of the biggest issues of modern-day life for a wide variety of medical specialties, starting with the cardiologist and ending with the diabetologist or the bariatric surgeon. However, in the last few years a new entity has emerged, the metabolically healthy obese (MHO) individual. This category encompasses obese individuals without the presence of metabolic diseases such as type 2 diabetes mellitus, dyslipidemia, or hypertension. Several studies have thus been undertaken to determine the risk of these MHO individuals for diabetes mellitus or cardiovascular diseases compared with the ‘unhealthy’ obe...
Source: Cardiovascular Endocrinology - February 16, 2017 Category: Cardiology Tags: Review Articles Source Type: research

Hypertension in diabetes and the risk of cardiovascular disease
Hypertension (HTN) is an important risk factor for cardiovascular disease and its many manifestations. It shares pathogenic pathways with diabetes and is part of a common metabolic entity, the metabolic syndrome. When combined with diabetes, HTN has been shown to predict and promote increased risk for cardiovascular disease events over and above each risk factor alone. Of the components of this metabolic syndrome, HTN is relatively easy to diagnose and thereby more accessible for implementing preventive and treatment strategies. The recent release of Joint National Committee-8 guidelines for the treatment of HTN has fueled...
Source: Cardiovascular Endocrinology - February 16, 2017 Category: Cardiology Tags: Review Articles Source Type: research

Erratum to: Diagnostic performance analysis for diabetic cardiovascular autonomic neuropathy based on short-term heart rate variability using Bayesian methods: preliminary analysis
(Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - February 16, 2017 Category: Endocrinology Authors: Jun Chen, Shuang-Bin Yang, Juanmei Liu and Zi-Hui Tang Source Type: research