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Current evidence on the health-beneficial effects of berry fruits in the prevention and treatment of metabolic syndrome
Purpose of review: Berries belong to the best dietary sources of bioactive compounds, which exert a synergistic and cumulative effect on promotion of human health and prevention of diseases. The present review presents the most recent findings of animal and human studies regarding the health benefits of berries in terms of prevention and treatment of obesity, hypertension, type 2 diabetes, dyslipidemia, and nonalcoholic fatty liver disease. Recent findings: In the last years, there was a growing number of evidence from human epidemiological and interventional studies, which emphasized the role of berries in the management...
Source: Current Opinion in Clinical Nutrition and Metabolic Care - October 7, 2016 Category: Nutrition Tags: FUNCTIONAL FOODS AND DIETARY SUPPLEMENTS: Edited by Nathalie M. Delzenne and Gerard E. Mullin Source Type: research

Natural Products for the Treatment of Obesity, Metabolic Syndrome, and Type 2 Diabetes 2016.
Authors: Thounaojam MC, Nammi S, Jadeja R PMID: 27703490 [PubMed - in process] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - October 7, 2016 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

A huge ovarian mucinous cystadenoma associated with contralateral teratoma and polycystic ovary syndrome in an obese adolescent girl.
We report an obese, perimenarchal girl with bilateral ovarian tumours coexistent with a polycystic ovary and the metabolic syndrome. PMID: 27702736 [PubMed - in process] (Source: Asia Pacific Journal of Clinical Nutrition)
Source: Asia Pacific Journal of Clinical Nutrition - October 7, 2016 Category: Nutrition Authors: Thaweekul P, Thaweekul Y, Mairiang K Tags: Asia Pac J Clin Nutr Source Type: research

Truncal and leg fat associations with metabolic risk factors among Chinese adults.
CONCLUSION: TF and LF showed opposite effects on metabolic risk factors among Chinese adults. Abdominal VAT, but not abdominal SAT, was positively associated with serum triglyceride and risk of MetS. Future studies are warranted to examine the potential mechanism of the opposite effects between TF and LF on metabolic risk factors among Chinese. PMID: 27702723 [PubMed - in process] (Source: Asia Pacific Journal of Clinical Nutrition)
Source: Asia Pacific Journal of Clinical Nutrition - October 7, 2016 Category: Nutrition Authors: Yang M, Lin J, Ma X, Zhu C, Wei C, Wang L, Jiao J, Zhu S Tags: Asia Pac J Clin Nutr Source Type: research

Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease
Publication date: Available online 6 October 2016 Source:Cell Author(s): Brian Finan, Christoffer Clemmensen, Zhimeng Zhu, Kerstin Stemmer, Karine Gauthier, Luisa Müller, Meri De Angelis, Kristin Moreth, Frauke Neff, Diego Perez-Tilve, Katrin Fischer, Dominik Lutter, Miguel A. Sánchez-Garrido, Peng Liu, Jan Tuckermann, Mohsen Malehmir, Marc E. Healy, Achim Weber, Mathias Heikenwalder, Martin Jastroch, Maximilian Kleinert, Sigrid Jall, Sara Brandt, Frédéric Flamant, Karl-Werner Schramm, Heike Biebermann, Yvonne Döring, Christian Weber, Kirk M. Habegger, Michaela Keuper, Vasily Gelfanov, Fa Liu, Josef Köhrle, Jan ...
Source: Cell - October 7, 2016 Category: Cytology Source Type: research

Clinical significance of noninvasive coronary flow reserve assessment in patients with ischemic heart disease
Purpose of review: The importance of physiologic assessments in ischemic heart disease is well recognized. Coronary flow reserve (CFR) is a novel physiologic imaging biomarker that complements both anatomic and semiquantitative perfusion assessments of coronary artery disease (CAD) severity. Recent findings: Beyond this, assessment of CFR may provide clinical insights useful for refining diagnosis, prognosis, and eventually, management of patients along the full range of ischemic heart disease phenotypes, from multivessel obstructive CAD to diffuse coronary microvascular dysfunction. Summary: We begin by defining the con...
Source: Current Opinion in Cardiology - October 6, 2016 Category: Cardiology Tags: ISCHEMIC HEART DISEASE: Edited by Peter H. Stone Source Type: research

Treating Obesity and Metabolic Syndrome with Fecal Microbiota Transplantation.
Authors: Marotz CA, Zarrinpar A Abstract The worldwide prevalence of metabolic syndrome, which includes obesity and its associated diseases, is rising rapidly. The human gut microbiome is recognized as an independent environmental modulator of host metabolic health and disease. Research in animal models has demonstrated that the gut microbiome has the functional capacity to induce or relieve metabolic syndrome. One way to modify the human gut microbiome is by transplanting fecal matter, which contains an abundance of live microorganisms, from a healthy individual to a diseased one in the hopes of alleviating illnes...
Source: The Yale Journal of Biology and Medicine - October 6, 2016 Category: Universities & Medical Training Tags: Yale J Biol Med Source Type: research

Vitamin D modifies the associations between circulating betatrophin and cardiometabolic risk factors among youths at risk for metabolic syndrome
Betatrophin has been recently reported to play a role in glucose homeostasis by inducing beta-cell proliferation in mice. However, studies in human are inconsistent. As a nutritionally-regulated liver-enriched... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 6, 2016 Category: Cardiology Authors: Junling Fu, Cong Hou, Lujiao Li, Dan Feng, Ge Li, Mingyao Li, Changhong Li, Shan Gao and Ming Li Source Type: research

Mediterranean diet and physical activity impact on metabolic syndrome among children and adolescents from Southern Italy: Contribution from the Calabrian Sierras Community Study (CSCS)
The aim of this study was to assess the impact of Mediterranean diet (MD) and physical activity on metabolic syndrome (MS) prevalence in children and adolescents. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - October 6, 2016 Category: Cardiology Authors: Francesco Martino, Paolo Emilio Puddu, Feliciana Lamacchia, Chiara Colantoni, Cristina Zanoni, Francesco Barill à, Eliana Martino, Francesco Angelico Source Type: research

Metabolic syndrome in adolescents: definition based on regression of IDF adult cut-off points
The objective of this study was to derive a sex- and age-specific definition of the metabolic syndrome (MetS) and its abnormalities for adolescents. (Source: Public Health)
Source: Public Health - October 6, 2016 Category: Global & Universal Authors: K. Benmohammed, P. Valensi, B. Balkau, A. Lezzar Tags: Original Research Source Type: research

Cardiovascular Risk Reduction in Patients with Nonalcoholic Fatty Liver Disease: The Potential Role of Ezetimibe
AbstractNonalcoholic fatty liver disease (NAFLD) is widely considered to be the hepatic manifestation of the metabolic syndrome and is closely linked to dyslipidemia, obesity, and insulin resistance. Patients with NAFLD have increased mortality when compared to the general population, primarily related to cardiovascular disease or malignancy. The biologic mechanisms that link NAFLD to cardiovascular disease include expansion of visceral adipose tissue, atherogenic dyslipidemia, impaired insulin signaling, systemic inflammation, and endothelial dysfunction. Currently, there are no approved therapies for NAFLD. It has recent...
Source: Digestive Diseases and Sciences - October 6, 2016 Category: Gastroenterology Source Type: research

Sex Difference in the Association Between Metabolic Syndrome and Left Ventricular Diastolic Dysfunction
Metabolic Syndrome and Related Disorders , Vol. 0, No. 0. (Source: Metabolic Syndrome and Related Disorders)
Source: Metabolic Syndrome and Related Disorders - October 6, 2016 Category: Endocrinology Authors: Hack-Lyoung Kim Myung-A Kim Sohee Oh Mina Kim Seong Mi Park Hyun Ju Yoon Mi Seung Shin Kyung-Soon Hong Gil Ja Shin Wan-Joo Shim Source Type: research

Treatment of Nonalcoholic Fatty Liver Disease with Long-Chain n-3 Polyunsaturated Fatty Acids in Humans
Metabolic Syndrome and Related Disorders , Vol. 0, No. 0. (Source: Metabolic Syndrome and Related Disorders)
Source: Metabolic Syndrome and Related Disorders - October 6, 2016 Category: Endocrinology Authors: Nirvair S. Kelley Source Type: research

Unique effect for fructose on lipoprotein risk factors for cardiovascular disease in children is not demonstrated
A recent article by Gugliucci et al. [1] in Atherosclerosis concluded that isocaloric restriction of fructose for 9 days uniquely improved lipoprotein markers of cardiovascular disease risk in children with obesity and metabolic syndrome, implying that fructose alone is responsible for the lipoprotein changes. However, careful analysis of limitations in the protocol and data interpretation fundamentally weakens the authors' conclusion. (Source: Atherosclerosis)
Source: Atherosclerosis - October 6, 2016 Category: Cardiology Authors: John S. White, Kristine L. Clark, Mark W. Empie, John P. Foreyt, Arthur Frank Tags: Correspondence Source Type: research

Changes in Weight and Metabolic Syndrome are Associated with Prostate Growth Rate Over a 5 Year Period
To evaluate the relationship between changes in weight, waist circumference (WC), metabolic syndrome (MetS), and prostate growth over 5 years in adult population. (Source: Urology)
Source: Urology - October 6, 2016 Category: Urology & Nephrology Authors: Yoon Soo Kyung, Dalsan You, In Gab Jeong, Seungbong Han, Hong-Kyu Kim, Choung-Soo Kim Tags: Prostatic Diseases and Male Voiding Dysfunction Source Type: research

Correlation of the leucocyte count with traditional and non-traditional components of metabolic syndrome.
CONCLUSION: Aminotransferases, fibrinogen and uric acid all significantly increase with increased WBC count in a dose-dependent manner. Increased counts of the total WBC and its subtypes are positively associated with presence of metabolic syndrome. PMID: 27690724 [PubMed - as supplied by publisher] (Source: Postgraduate Medicine)
Source: Postgraduate Medicine - October 5, 2016 Category: Internal Medicine Tags: Postgrad Med Source Type: research

Erratum to: Proprotein convertase subtilisin/kexin type 9 (PCSK9) and metabolic syndrome: insights on insulin resistance, inflammation, and atherogenic dyslipidemia
(Source: Endocrine)
Source: Endocrine - October 5, 2016 Category: Endocrinology Source Type: research

Targeting Postprandial Blood Sugar over Fasting Blood Sugar: A Clinic Based Comparative Study
Conclusion Monitoring of PPBS is a safe and effective alternative to FBS to optimize glycemic control in managing patients with T2DM attending outpatient clinics. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - October 5, 2016 Category: Endocrinology Source Type: research

Microvascular Function in Aging Among Women Living with HIV
AbstractCombined antiretroviral therapy (CART) has turned HIV-infection to a treatable chronic disease during which many patients survive to middle and older age. However, they prematurely develop non-AIDS comorbidities such as cardiovascular disease, metabolic syndrome, diabetes, and HIV-associated neurocognitive disorders (HAND). Microcirculatory changes and endothelial dysfunction occur early both in HIV-infected and in aging patients, in whom they usually precede cardiovascular and neurocognitive impairments. Also, mild cognitive involvement has been reported in women during the menopausal transition. Disruption of the...
Source: Current HIV/AIDS Reports - October 5, 2016 Category: Infectious Diseases Source Type: research

Effects of deep sea water and Lactobacillus paracasei subsp. paracasei NTU 101 on hypercholesterolemia hamsters gut microbiota.
Abstract Hypercholesterolemia is a common metabolic syndrome in modern human society. Despite that the alteration of host gut microbiota has been linked to hypercholesterolemia in previous studies, the key host-microbiota interaction of hypercholesterolemia remains elusive. Lactobacillus paracasei subsp. paracasei NTU 101 (NTU 101) and deep sea water (DSW) were known for cholesterol-lowering potential. The impact of NTU 101 and DSW on hamster gut microbiota was investigated side-by-side using denaturing gradient gel electrophoresis (DGGE) and metagenomic analysis in this study. These two cholesterol-lowering subst...
Source: Applied Microbiology and Biotechnology - October 5, 2016 Category: Microbiology Authors: Lin CH, Chen YH, Tsai TY, Pan TM Tags: Appl Microbiol Biotechnol Source Type: research

Structural exploration of PPAR γ modulators through pharmacophore mapping, fragment-based design, docking, and molecular dynamics simulation analyses
AbstractPeroxisome proliferator-activated gamma receptor is an attractive therapeutic target involving various types of metabolic syndrome. Viewing the importance of peroxisome proliferator-activated gamma receptor modulators, ligand and energetically optimized pharmacophores (e-pharmacophore), hologram-based quantitative structural activity relationships, and classification-based Bayesian models were developed, followed by molecular docking, mechanics, and dynamic analyses to search for essential structural requirements in the molecules for potent and selective peroxisome proliferator-activated gamma receptor modulation. ...
Source: Medicinal Chemistry Research - October 5, 2016 Category: Chemistry Source Type: research

Identification of a nutrient-sensing transcriptional network in monocytes by using inbred rat models on a cafeteria diet [RESOURCE ARTICLE]
ABSTRACT Obesity has reached pandemic levels worldwide. The current models of diet-induced obesity in rodents use predominantly high-fat based diets that do not take into account the consumption of variety of highly palatable, energy-dense foods that are prevalent in Western society. We and others have shown that the cafeteria (CAF) diet is a robust and reproducible model of human metabolic syndrome with tissue inflammation in the rat. We have previously shown that inbred rat strains such as Wistar Kyoto (WKY) and Lewis (LEW) show different susceptibilities to CAF diets with distinct metabolic and morphometric profiles. He...
Source: DMM Disease Models and Mechanisms - October 5, 2016 Category: Biomedical Science Authors: Martinez-Micaelo, N., Gonzalez-Abuin, N., Terra, X., Ardevol, A., Pinent, M., Petretto, E., Behmoaras, J., Blay, M. Tags: Rat as a Disease Model, Metabolic Disorders RESOURCE ARTICLE Source Type: research

Type 2 diabetes and metabolic syndrome – adipokine levels and effect of drugs
. (Source: Gynecological Endocrinology)
Source: Gynecological Endocrinology - October 5, 2016 Category: Endocrinology Authors: Rabia Farooq Shajrul Amin M. Hayat Bhat Rawoof Malik Hilal Ahmad Wani Sabhiya Majid Source Type: research

Office Workers Risk of Metabolic Syndrome-Related Indicators: A 10-Year Cohort Study
The purpose of the study is to assess the relationship between the prevalence of metabolic syndrome–related risk factors and work tenure among office workers. A 10-year cohort analysis was conducted using employees’ health examinations given to new employees within 1 or 2 years of joining the firm and every 5 years thereafter. Age-adjusted odds ratios (95% confidence interval [CI], p < .05) were calculated based on a contrast test with general estimating equations. Specifically, the age-adjusted odds ratios and CIs of those with 20 ± 1 years of work, compared with those with 1 to 2 years of work, were...
Source: Western Journal of Nursing Research - October 5, 2016 Category: Nursing Authors: Ryu, H., Kim, Y., Lee, J., Yoon, S.-j., Cho, J.-h., Wong, E., Jung, J. Tags: Research Reports Source Type: research

Inflammatory and Metabolic Syndrome Biomarker Analysis of Vascular Outcomes in End-stage Renal Disease
Int J Angiol DOI: 10.1055/s-0036-1593409End-stage renal disease (ESRD) presents a complex syndrome in which inflammatory and metabolic processes contribute to disease progression and development of comorbid conditions. Over $1 trillion is spent globally on ESRD care.Plasma samples collected from 83 ESRD patients prior to hemodialysis were profiled for metabolic and inflammatory biomarker concentrations. Concentrations were compared between groups with and without history of stroke, acute coronary syndrome (ACS), congestive heart failure (CHF), and coronary artery disease (CAD).The 25 patients (30.1%) with history of stroke...
Source: International Journal of Angiology - October 5, 2016 Category: Cardiology Authors: Sweigert, Patrick J. Bansal, Vinod K. Hoppensteadt, Debra A. Saluk, Jennifer L. Syed, Daneyal A. Fareed, Jawed Tags: Original Article Source Type: research

Obstructive sleep apnea predicts risk of metabolic syndrome independently of obesity: a meta-analysis.
CONCLUSIONS: Our findings demonstrated a significant association between OSA and increased MS risk independent of BMI, and further indicated a role of nocturnal IH in this association. PMID: 27695500 [PubMed - in process] (Source: Archives of Medical Science)
Source: Archives of Medical Science - October 4, 2016 Category: Journals (General) Tags: Arch Med Sci Source Type: research

Animal models of metabolic syndrome: a review
Metabolic syndrome (MetS) consists of several medical conditions that collectively predict the risk for cardiovascular disease better than the sum of individual conditions. The risk of developing MetS in human... (Source: Nutrition and Metabolism)
Source: Nutrition and Metabolism - October 4, 2016 Category: Nutrition Authors: Sok Kuan Wong, Kok-Yong Chin, Farihah Hj Suhaimi, Ahmad Fairus and Soelaiman Ima-Nirwana Source Type: research

Development of Metabolic Syndrome Associated to Cancer Therapy: Review
AbstractLong-term childhood cancer survivors are at great risk of developing late adverse effects after treatment, such as, reduced growth, obesity, decreased fertility, high blood pressure, cardiovascular diseases, impaired glucose, another form of cancer, among others organ dysfunctions, some of them are part of the metabolic syndrome. Metabolic syndrome and cancer connection is still not entirely understood, but there are some notions about it. Metabolic alterations produced during childhood cancer are more likely determined by treatments like radiotherapy, chemotherapy, glucocorticoids therapy, and surgery. Cancer trea...
Source: Hormones and Cancer - October 4, 2016 Category: Cancer & Oncology Source Type: research

Hepatitis C in nonobese nondiabetic patients: Insulin resistance and the metabolic syndrome make a difference
(Source: Journal of Viral Hepatitis)
Source: Journal of Viral Hepatitis - October 4, 2016 Category: Infectious Diseases Authors: D. Crisan, C. Radu, A. Suciu, N. Leach, H. Stefanescu, L. Avram, N. Crisan, M. Grigorescu Tags: Letter to the Editor Source Type: research

High intake of regular-fat cheese compared with reduced-fat cheese does not affect LDL cholesterol or risk markers of the metabolic syndrome: a randomized controlled trial [Cardiovascular disease risk]
Conclusion: A high daily intake of regular-fat cheese for 12 wk did not alter LDL cholesterol or MetS risk factors differently than an equal intake of reduced-fat cheese or an isocaloric amount of carbohydrate-rich foods. This trial was registered at www.clinicaltrials.gov as NCT02616471. (Source: American Journal of Clinical Nutrition)
Source: American Journal of Clinical Nutrition - October 3, 2016 Category: Nutrition Authors: Raziani, F., Tholstrup, T., Kristensen, M. D., Svanegaard, M. L., Ritz, C., Astrup, A., Raben, A. Tags: Obesity and Metabolism Research Articles Cardiovascular disease risk Source Type: research

Plasma Alkylresorcinols Reflect Gluten Intake and Distinguish between Gluten-Rich and Gluten-Poor Diets in a Population at Risk of Metabolic Syndrome [Nutrition and Disease]
Conclusion: We propose the use of plasma alkylresorcinols to monitor compliance to a gluten-free diet as well as to help investigations into the possible effects of gluten in the wider population. This trial was registered at www.clinicaltrials.gov as NCT017119913 and NCT01731366. (Source: Journal of Nutrition)
Source: Journal of Nutrition - October 3, 2016 Category: Nutrition Authors: Lind, M. V., Madsen, M. L., Rumessen, J. J., Vestergaard, H., Gobel, R. J., Hansen, T., Lauritzen, L., Pedersen, O. B., Kristensen, M., Ross, A. B. Tags: Research Need: Role of Nutrition in Medical Management Nutrition and Disease Source Type: research

Diet Quality and Its Association with Cardiometabolic Risk Factors Vary by Hispanic and Latino Ethnic Background in the Hispanic Community Health Study/Study of Latinos [Nutritional Epidemiology]
Conclusions: Diet quality differed by Hispanic or Latino background. Although healthier diet quality was associated with lower odds of MetS in the overall Hispanic and Latino cohort, the association of AHEI and cardiometabolic factors varied by ethnic background. Nutrition-related research and interventions among ethnically diverse groups should consider individual ethnic backgrounds to optimally address diet quality and cardiometabolic health. This trial was registered at clinicaltrials.gov as NCT02060344. (Source: Journal of Nutrition)
Source: Journal of Nutrition - October 3, 2016 Category: Nutrition Authors: Mattei, J., Sotres-Alvarez, D., Daviglus, M. L., Gallo, L. C., Gellman, M., Hu, F. B., Tucker, K. L., Willett, W. C., Siega-Riz, A. M., Van Horn, L., Kaplan, R. C. Tags: Nutritional Epidemiology Research Articles Source Type: research

Evaluation of the Japanese Metabolic Syndrome Risk Score (JAMRISC): a newly developed questionnaire used as a screening tool for diagnosing metabolic syndrome and insulin resistance in Japan
ConclusionsJAMRISC questionnaire is a useful instrument for the detection of early risk of not only MetS and type 2 diabetes but also insulin resistance. (Source: Environmental Health and Preventive Medicine)
Source: Environmental Health and Preventive Medicine - October 3, 2016 Category: Environmental Health Source Type: research

Number of branch points in α-limit dextrins impact glucose generation rates by mammalian mucosal α-glucosidases
This study shows the possibility of producing slowly digestible oligosaccharides that may decrease postprandial glycemic response and control glucose delivery to the body, to address metabolic syndrome-associated diseases. (Source: Carbohydrate Polymers)
Source: Carbohydrate Polymers - October 2, 2016 Category: Biomedical Science Source Type: research

Inositols in the Treatment of Insulin-Mediated Diseases.
Authors: Muscogiuri G, Palomba S, Laganà AS, Orio F Abstract A growing body of research is currently focused on the role of inositol isomers and in particular myo-inositol (MYO-INS) and D-chiroinositol (DCI) in the treatment of insulin resistance states. Both isomers have been shown to exert insulin-mimetic action and to lower postprandial glucose. Further, insulin resistance-related diseases were associated to derangements in inositol metabolism. Thus, the aim of this review is to provide current evidence on the potential benefits of inositol isomers (MYO-INS and DCI) in the treatment of disease associated to ins...
Source: International Journal of Endocrinology - October 1, 2016 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Anoxic Brain Injury Secondary to Metabolic Encephalopathy
Conclusions: The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is a metabolic syndrome that causes hyponatremia and, in severe cases, encephalopathy and anoxic brain injury. Damage to the visual pathways can produce visual field, ocular motility, and binocular vision deficits. Comprehensive treatment including rehabilitative vision therapy bolstering the natural neuroplasticity process can provide improvements in patients’ quality of life. (Source: Optometry and Vision Science)
Source: Optometry and Vision Science - October 1, 2016 Category: Opthalmology Tags: CLINICAL COMMUNICATIONS: Clinical Cases Source Type: research

The expanding role of the bile acid receptor farnesoid X in the intestine and its potential clinical implications.
Authors: Ceulemans LJ, Canovai E, Verbeke L, Pirenne J, Farré R Abstract Knowledge about the role of farnesoid X receptor (FXR) in the intestine is rapidly expanding. In pre-clinical animal models of inflammatory bowel disease and bile duct ligation, FXR activation has proven to directly target the three pillars of intestinal homeostasis: intestinal permeability, inflammation and bacterial translocation. The protective role of FXR-ligands on this homeostasis has implications for many intestinal pathologies like inflammatory bowel disease, ischemia reperfusion injury, the metabolic syndrome, colon cancer and even d...
Source: Acta Chirurgica Belgica - October 1, 2016 Category: Surgery Tags: Acta Chir Belg Source Type: research

GSE67808 Profiling gene expression of HeLa cells transfected with FOXK1
Contributors : Hirokazu Nakatsumi ; Masaki Matsumoto ; Keiichi I NakayamaSeries Type : Expression profiling by arrayOrganism : Homo sapiensExcessive nutrition gives rise to non-infectious inflammation that constitutes the major symptoms of metabolic syndrome, but the molecular mechanism how nutrient signal links to inflammation has been poorly understood. Mammalian target of rapamycin complex 1 (mTORC1) kinase is the master regulator of cellular response to nutrient signal such as insulin and amino acids. Inhibitor of mTORC1 rapamycin is effective to various diseases such as tumour, restenosis, and obesity, which are often...
Source: GEO: Gene Expression Omnibus - October 1, 2016 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE67810 Gene expression alterations by the mTORC1-FOXK1 pathway
Contributors : Hirokazu Nakatsumi ; Masaki Matsumoto ; Keiichi I NakayamaSeries Type : Expression profiling by arrayOrganism : Homo sapiensExcessive nutrition gives rise to non-infectious inflammation that constitutes the major symptoms of metabolic syndrome, but the molecular mechanism how nutrient signal links to inflammation has been poorly understood. Mammalian target of rapamycin complex 1 (mTORC1) kinase is the master regulator of cellular response to nutrient signal such as insulin and amino acids. Inhibitor of mTORC1 rapamycin is effective to various diseases such as tumour, restenosis, and obesity, which are often...
Source: GEO: Gene Expression Omnibus - October 1, 2016 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Left ventricular pressure-volume measurements and myocardial gene expression profile in type 2 diabetic Goto-Kakizaki rats
In conclusion, while systolic dysfunction, myocardial inflammation, and abnormal electrical conduction remain absent, short-term and mild T2DM induce the alteration of cardiac TNF-α at both the mRNA and protein levels. Further assessments are required to reveal if TNF-α plays a role in the early stage of diabetic cardiomyopathy development. (Source: AJP: Heart and Circulatory Physiology)
Source: AJP: Heart and Circulatory Physiology - October 1, 2016 Category: Cardiology Authors: Korkmaz-Icöz, S., Lehner, A., Li, S., Vater, A., Radovits, T., Brune, M., Ruppert, M., Sun, X., Brlecic, P., Zorn, M., Karck, M., Szabo, G. Tags: Call for Papers: Mechanisms of Diastolic Dysfunction in Cardiovascular Disease Source Type: research

Transcriptional regulation of inflammasome-associated pattern recognition receptors, and the relevance to disease pathogenesis
Publication date: Available online 30 September 2016 Source:Molecular Immunology Author(s): Virginie Deswaerte, Saleela M. Ruwanpura, Brendan J. Jenkins Over the last decade it has emerged that inflammasome complexes provide a pivotal platform for the host innate immune system to respond to exogenous infectious microbes (viruses, bacteria, fungi) and non-infectious environmental agents (cigarette smoke, pollution), as well as endogenous “danger” signals. Upon the canonical activation of inflammasomes, a key effector function is to catalyze, via caspase-1, the maturation of the potent pro-inflammatory cytokines interle...
Source: Molecular Immunology - October 1, 2016 Category: Allergy & Immunology Source Type: research

High serum oxytocin is associated with metabolic syndrome in older men - the MINOS study
Oxytocin (OT) is a nonapeptide synthesized by supraoptic and paraventricular hypothalamic nuclei and secreted by the posterior lobe of the pituitary gland. It stimulates milk ejection and uterine contractility, regulates responses to stressors and modulates social interactions [1]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - October 1, 2016 Category: Endocrinology Authors: Pawel Szulc, Ez Zoubir Amri, Annie Varennes, Patricia Panaia-Ferrari, Eric Fontas, Jo ëlle Goudable, Roland Chapurlat, Véronique Breuil Source Type: research

Dietary protein from different food sources, incident metabolic syndrome and changes in its components: an 11-year longitudinal study in healthy community-dwelling adults
Limited data are available on the relationship of protein from different food sources with metabolic syndrome or changes in its components. We aimed to prospectively examine the relationships of protein intakes from animal, plant and major food groups with incident metabolic syndrome (MetS) and changes in its components. (Source: Clinical Nutrition)
Source: Clinical Nutrition - October 1, 2016 Category: Nutrition Authors: Xianwen Shang, David Scott, Allison Hodge, Dallas R. English, Graham G. Giles, Peter R. Ebeling, Kerrie M. Sanders Source Type: research

Impact of anthropometric cut ‐off values in determining the prevalence of metabolic alterations
ConclusionMethods to quantify adiposity that are useful in clinical practice should be developed to better classify individuals and to reflect metabolic risk more appropriately. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - October 1, 2016 Category: Journals (General) Authors: Paloma Almeda ‐Valdes, Carlos A. Aguilar‐Salinas, Misael Uribe, Samuel Canizales‐Quinteros, Nahum Méndez‐Sánchez Tags: Review Source Type: research

The rs2274911 polymorphism in GPRC6A gene is associated with insulin resistance in normal weight and obese subjects
ConclusionIn a cohort of normal weight and obese subjects, we found that the non‐rare polymorphism rs2274911 in the GPRC6A gene was associated with insulin resistance features, independently of the metabolic phenotype and OC levels.This article is protected by copyright. All rights reserved. (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - October 1, 2016 Category: Endocrinology Authors: Andrea Di Nisio, Maria Santa Rocca, Gian Paolo Fadini, Luca DeToni, Giorgio Marcuzzo, Maria Cristina Marescotti, Marta Sanna, Mario Plebani, Roberto Vettor, Angelo Avogaro, Carlo Foresta Tags: Original Article Source Type: research

Metabolic syndrome increases cardiovascular events but not hepatic events and death in patients with chronic hepatitis B
Conclusions: Metabolic syndrome increased the risk of cardiovascular events but not hepatic events and death; LSM was the important risk factor of hepatic events and death in CHB patients. (Hepatology 2016). (Source: Hepatology)
Source: Hepatology - October 1, 2016 Category: Internal Medicine Authors: Jenny Yeuk ‐Ki Cheng, Vincent Wai‐Sun Wong, Yee‐Kit Tse, Angel Mei‐Ling Chim, Henry Lik‐Yuen Chan, Grace Lai‐Hung Wong Tags: Viral Hepatitis Source Type: research

Male Lower Urinary Tract Symptoms and Cardiovascular Events: A Systematic Review and Meta-analysis
Conclusions Men with moderate to severe LUTS seem to have an increased risk of MACE. A holistic approach in considering the morbidities of aging men should be strongly encouraged and represents an important role for the practicing urologist. Patient summary We evaluated whether the severity of lower urinary tract symptoms could be considered as a significant risk factor for major adverse cardiac events (MACE) in the male population. We demonstrated that men with moderate to severe LUTS have an increased risk of MACE. The correlation among metabolic syndrome, lower urinary tract symptoms (LUTS), and cardiovascular disease i...
Source: European Urology - October 1, 2016 Category: Urology & Nephrology Source Type: research

Effects of resveratrol on crosstalk between canonical β-catenin/Wnt and FOXO pathways in ...
Background: Coronary artery disease (CAD) is the major cause of mortality and morbidity worldwide. The aim of this study was to explore the effect of resveratrol (RES) on Canonicalβ-catenin/Wnt and forkhead box O (FOXO) pathways in CAD patients.Method: We performed this study on 10 metabolic syndrome patients with three-vessel CAD and 10 sex-aged matched healthy subjects. The effects of RES onβ-Catenin, manganese superoxide dismutase (MnSOD), and peroxisome proliferator-activated receptor delta (PPAR-δ) expression were evaluated in peripheral blood mononuclear cells (PBMCs) of participants. Results: RES cou...
Source: Iranian Journal of Pharmaceutical Research - September 30, 2016 Category: Drugs & Pharmacology Source Type: research

Gene Expression Patterns Are Altered in Athymic Mice and Metabolic Syndrome Factors Are Reduced in C57BL/6J Mice Fed High-Fat Diets Supplemented with Soy Isoflavones
Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.6b03401 (Source: Journal of Agricultural and Food Chemistry)
Source: Journal of Agricultural and Food Chemistry - September 30, 2016 Category: Food Science Authors: Ting Luo, Sarah M. Snyder, Bingxin Zhao, Debra K. Sullivan, Jill Hamilton-Reeves, Gregory Guthrie, Marie-Louise Ricketts, Kathleen T. Shiverick and Neil Shay Source Type: research

Metabolic health profile in young adults with Prader ‐Willi syndrome: Results of a 2‐year randomised, placebo‐controlled, cross‐over GH trial
ConclusionsGH treatment has no adverse effects on metabolic health profile. Thus, GH‐treated young adults with PWS who have attained AH benefit from continuation of GH treatment without safety concerns regarding metabolic health.This article is protected by copyright. All rights reserved. (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - September 30, 2016 Category: Endocrinology Authors: R.J. Kuppens, N.E. Bakker, E. P. C. Siemensma, S.H. Donze, T. Stijnen, A.C.S. Hokken ‐Koelega Tags: Original Article Source Type: research