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In vitro experiment to elucidate the mechanism of the 'soft shell technique for preventing subretinal migration of perfluoro-octane
Conclusions The interfacial tension between HA and PFO is higher than that between aqueous and PFO. This is a plausible physical explanation of how the ‘soft shell’ technique might work to prevent subretinal migration of PFCL. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 22, 2017 Category: Opthalmology Authors: Chan, Y. K., Lu, Y., Czanner, G., Wu, J., Cheng, H. C., Hussain, R., Sakamoto, T., Shum, H. C., Wong, D. Tags: Original articles - Laboratory science Source Type: research

T-shaped macular buckling combined with 25G pars plana vitrectomy for macular hole, macular schisis, and macular detachment in highly myopic eyes
Conclusions MB combined with PPV should be considered as the preferred surgical approach both in primary and recurrent retinal detachment secondary to MH in high myopic eyes. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 22, 2017 Category: Opthalmology Authors: Mura, M., Iannetta, D., Buschini, E., de Smet, M. D. Tags: Original articles - Clinical science Source Type: research

Internal limiting membrane translocation for refractory macular holes
Conclusion The ILM translocation technique seems to facilitate persistent idiopathic macular hole closure, where primary surgery with PPV and ILM peeling failed. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 22, 2017 Category: Opthalmology Authors: Pires, J., Nadal, J., Gomes, N. L. Tags: Original articles - Clinical science Source Type: research

Prevalence and risk factors for epiretinal membrane: the Singapore Epidemiology of Eye Disease study
Conclusions ERM is common in Asians, particularly among Chinese. Older age is the most consistent risk factor for any ERM, and previous cataract surgery and diabetic retinopathy are the strongest risk factors for secondary ERM. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 22, 2017 Category: Opthalmology Authors: Cheung, N., Tan, S.-P., Lee, S. Y., Cheung, G. C. M., Tan, G., Kumar, N., Cheng, C.-Y., Wong, T. Y. Tags: Original articles - Clinical science Source Type: research

Treatment of type I ROP with intravitreal bevacizumab or laser photocoagulation according to retinal zone
Conclusions IVB leads to faster regression of active ROP in infants with posterior ROP compared with laser photocoagulation. Spherical equivalent after 12 months was comparable in those treated with IVB and laser photocoagulation, but it was significantly lower in posterior ROP than in peripheral zone II. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 22, 2017 Category: Opthalmology Authors: Mueller, B., Salchow, D. J., Waffenschmidt, E., Joussen, A. M., Schmalisch, G., Czernik, C., Bührer, C., Schunk, K. U., Girschick, H. J., Winterhalter, S. Tags: Original articles - Clinical science Source Type: research

Diurnal variations in luminal and stromal areas of choroid in normal eyes
Conclusions The changes in the luminal area are most likely responsible for the diurnal change in the CCT and subfoveal choroidal area. Trial registration number UMIN000019060, Pre-results. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 22, 2017 Category: Opthalmology Authors: Kinoshita, T., Mitamura, Y., Shinomiya, K., Egawa, M., Iwata, A., Fujihara, A., Ogushi, Y., Semba, K., Akaiwa, K., Uchino, E., Sonoda, S., Sakamoto, T. Tags: Open access Original articles - Clinical science Source Type: research

Five-year visual acuity outcomes and injection patterns in patients with pro-re-nata treatments for AMD, DME, RVO and myopic CNV
Conclusions In AMD, the initial VA gain was not maintained long term despite higher injection numbers compared with DME, RVO and myopic CNV. The presented real-world data provide a peer-group-based estimate of VA developments and injection frequencies for counselling patients undergoing long-term anti-VEGF therapy. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 22, 2017 Category: Opthalmology Authors: Wecker, T., Ehlken, C., Bühler, A., Lange, C., Agostini, H., Böhringer, D., Stahl, A. Tags: Open access Original articles - Clinical science Source Type: research

Choroidal structure in eyes with drusen and reticular pseudodrusen determined by binarisation of optical coherence tomographic images
Conclusions Mean total choroidal, luminal and stromal area decreased over 24 months similarly in eyes with drusen and RPD. Mean total choroidal, luminal and stromal area were more reduced in eyes with RPD, as compared with eyes with drusen and controls; however, stromal area was more represented in eyes with RPD suggesting a possible role of choroidal vascular depletion and fibrotic replacement in the pathogenesis and disease progression. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 22, 2017 Category: Opthalmology Authors: Corvi, F., Souied, E. H., Capuano, V., Costanzo, E., Benatti, L., Querques, L., Bandello, F., Querques, G. Tags: Original articles - Clinical science Source Type: research

Age-related macular degeneration in patients with uveitis
Conclusions Large drusen prevalence among patients with uveitis ≥55 years of age appears less than the prevalence in the general US population after accounting for differences in age distribution, especially for non-Hispanic whites. Although the racial and gender distribution in this study population is not directly representative of the general US population, results of this study suggest possible sparing of patients with uveitis from AMD. A larger systematic study with greater power would be needed to confirm these findings. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 22, 2017 Category: Opthalmology Authors: Fox, A. R., Chew, E. Y., Meyerle, C., Vitale, S., Ferris, F. L., Nussenblatt, R. B., Sen, H. N. Tags: Original articles - Clinical science Source Type: research

Effectiveness and safety of dexamethasone implants for postsurgical macular oedema including Irvine-Gass syndrome: the EPISODIC-2 study
Conclusions The significant gain in BCVA from baseline achieved at month 6 was maintained at month 12 after intravitreal injection of dexamethasone implant. Naïve status seems to be a good predictive factor of treatment response. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 22, 2017 Category: Opthalmology Authors: Bellocq, D., Pierre-Kahn, V., Matonti, F., Burillon, C., Voirin, N., Dot, C., Akesbi, J., Milazzo, S., Baillif, S., Soler, V., Wolff, B., Scemama, C., Malcles, A., Weber, M., Kodjikian, L. Tags: Original articles - Clinical science Source Type: research

Dexamethasone intravitreal implant in serpiginous choroiditis
Conclusions Dexamethasone intravitreal implant may be an effective treatment option to control active serpiginous lesions in patients in whom increased systemic corticosteroid therapy is contraindicated. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 22, 2017 Category: Opthalmology Authors: Miserocchi, E., Berchicci, L., Iuliano, L., Modorati, G., Bandello, F. Tags: Original articles - Clinical science Source Type: research

Treatment of severe chronic ocular graft-versus-host disease using 100% autologous serum eye drops from a sealed manufacturing system: a retrospective cohort study
Conclusions 100% autologous serum eye drops using a sealed manufacturing system were efficient in improving the ocular surface, patient symptoms and visual acuity without side effects. It seems to be safe to use 100% autologous serum despite earlier suspicions regarding immune complex accumulations and exacerbation of ocular surface inflammation. The potential effects of serum levels of systemic immunosuppressives through readministration onto the ocular surface need to be elucidated. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 22, 2017 Category: Opthalmology Authors: Tahmaz, V., Gehlsen, U., Sauerbier, L., Holtick, U., Engel, L., Radojska, S., Petrescu-Jipa, V.-M., Scheid, C., Hallek, M., Gathof, B., Cursiefen, C., Steven, P. Tags: Original articles - Clinical science Source Type: research

New appraisals of Kyrieleis plaques: a multimodal imaging study
Conclusions These imaging modalities provide in vivo, quasi-histologic images demonstrating that Kyrieleis plaques are characterised by an inflammatory involvement within the vessels' endothelium. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 22, 2017 Category: Opthalmology Authors: Pichi, F., Veronese, C., Lembo, A., Invernizzi, A., Mantovani, A., Herbort, C. P., Cunningham, E. T., Morara, M., Ricci, F., Neri, P., Nucci, P., Ciardella, A. P., Staurenghi, G., Lowder, C. Y., Srivastava, S. K. Tags: Original articles - Clinical science Source Type: research

Correlation in retinal nerve fibre layer thickness in uveitis and healthy eyes using scanning laser polarimetry and optical coherence tomography
Conclusions RNFL thickness was significantly greater when measured using SD-OCT in active uveitis as compared with GDx. There was no correlation between the RNFL thickness measurements obtained using the two techniques in uveitic eyes. The discrepancies between the results suggest that for these patients both techniques should be used in conjunction to obtain an accurate measurement of RNFL. Trial registration number IRB 00008855 Société Francaise d'Ophtalmologie IRB#1 (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 22, 2017 Category: Opthalmology Authors: Bellocq, D., Maucort-Boulch, D., Kodjikian, L., Denis, P. Tags: Original articles - Clinical science Source Type: research

Baseline retrobulbar blood flow is associated with both functional and structural glaucomatous progression after 4 years
Conclusions In this study population, lower baseline ophthalmic artery blood flow velocities were associated with simultaneous structural and functional glaucoma progression after 4 years. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 22, 2017 Category: Opthalmology Authors: Moore, N. A., Harris, A., Wentz, S., Verticchio Vercellin, A. C., Parekh, P., Gross, J., Hussain, R. M., Thieme, C., Siesky, B. Tags: Original articles - Clinical science Source Type: research

Comparison of swept-source and enhanced depth imaging spectral-domain optical coherence tomography in quantitative characterisation of the optic nerve head
Conclusions LCDH, LCDV and thinnest BMO-MRW measurements are not interchangeable between SS-OCT and EDI-OCT, but show good intrareader and inter-reader reproducibility and interdevice agreement for quantitative characterisation of the ONH, particularly among patients with glaucoma. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 22, 2017 Category: Opthalmology Authors: Li, D., Taniguchi, E. V., Cai, S., Paschalis, E. I., Wang, H., Miller, J. B., Turalba, A. V., Greenstein, S. H., Brauner, S., Pasquale, L. R., Shen, L. Q. Tags: Original articles - Clinical science Source Type: research

Efficacy of automated computer-aided diagnosis of retinal nerve fibre layer defects in healthcare screening
Conclusions The new CAD system successfully detected RNFL defects during mass screening of fundus photographs in a large population who visited a healthcare centre. The proposed algorithm can be useful for clinicians in screening RNFL defects in healthcare centres. The false-positive rate is still unsatisfactory, although improved compared with the previous study. Further studies are needed to enhance the speed and specificity of image analysis using the CAD system. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 22, 2017 Category: Opthalmology Authors: Han, S. B., Yang, H. K., Oh, J. E., Kim, K. G., Hwang, J.-M. Tags: Original articles - Clinical science Source Type: research

Relationship between corneal hysteresis and lamina cribrosa displacement after medical reduction of intraocular pressure
Conclusions A significant increase in LC thickness and a reduction in the posterior displacement of LC but not in the prelaminar tissue were demonstrated after IOP reduction with medical treatment. The factors most related with LC displacement were age and CH. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 22, 2017 Category: Opthalmology Authors: Lanzagorta-Aresti, A., Perez-Lopez, M., Palacios-Pozo, E., Davo-Cabrera, J. Tags: Open access Original articles - Clinical science Source Type: research

Predictors of intraocular pressure change after phacoemulsification in patients with pseudoexfoliation syndrome
Conclusions Non-glaucomatous patients with PXS experience moderate IOP reduction following phacoemulsification, and this effect is correlated with preoperative IOP, aspiration time and infusion fluid used intraoperatively. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 22, 2017 Category: Opthalmology Authors: Moghimi, S., Johari, M., Mahmoudi, A., Chen, R., Mazloumi, M., He, M., Lin, S. C. Tags: Original articles - Clinical science Source Type: research

Longitudinal comparison of femtosecond-assisted sub-Bowman keratomileusis versus photorefractive keratectomy for high myopia
Conclusions Our study showed that femtosecond-assisted SBK and PRK with mitomycin C have comparable safety and efficacy for correction of high myopia. However, better predictability of postoperative refraction was noted after PRK compared with SBK. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 22, 2017 Category: Opthalmology Authors: Chan, T. C. Y., Yu, M. C. Y., Mak, S., Jhanji, V. Tags: Original articles - Clinical science Source Type: research

In vivo confocal microscopy evaluation of ocular and cutaneous alterations in patients with rosacea
Conclusions IVCM could be a safe, effective and reliable tool to quantify alterations of the cornea, MG and cheek glands in patients with rosacea combined with quantification of Demodex infections. As a valuable tool for investigating the pathophysiology of the disease, it could be used to assess the effectiveness of therapy. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 22, 2017 Category: Opthalmology Authors: Liang, H., Randon, M., Michee, S., Tahiri, R., Labbe, A., Baudouin, C. Tags: Original articles - Clinical science Source Type: research

Incidence of optic canal fracture in the traumatic optic neuropathy and its effect on the visual outcome
Conclusions Among patients with OCF, 20.9% were not detected by HRCT. Patients with OCF had a worse initial visual acuity than those without OCF. There was no significant difference in final visual acuity after ETOCD. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 22, 2017 Category: Opthalmology Authors: Yan, W., Chen, Y., Qian, Z., Selva, D., Pelaez, D., Tu, Y., Wu, W. Tags: Editor's choice Original articles - Clinical science Source Type: research

Clinical implications of serum IgG4 levels in patients with IgG4-related ophthalmic disease
Conclusions Serum IgG4 level can be considered an adjunctive marker for treatment response in IgG4-ROD. Patients with serum IgG4 levels that remain elevated after steroid treatment should be carefully observed for relapse. A continuing maintenance dose of oral steroid is recommended to prevent relapse, even when clinical remission is achieved. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 22, 2017 Category: Opthalmology Authors: Woo, Y. J., Kim, J. W., Yoon, J. S. Tags: Original articles - Clinical science Source Type: research

Intermittent exotropia with a positive Bielschowsky head-tilt test
Conclusions A positive BHTT was seen in patients with IXT with larger angle exodeviations, longer elapsed time periods since the onset of IXT and worse stereoacuity. The positive BHTT could be eliminated using horizontal muscle surgery only, without complementary inferior oblique muscle weakening surgery. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 22, 2017 Category: Opthalmology Authors: Lee, T. H., Ji, Y. S., Park, S. W., Yoon, K. C., Heo, H. Tags: Original articles - Clinical science Source Type: research

Do visually impaired children and their parents agree on the child's vision-related quality of life and functional vision?
Conclusions Visually impaired children and their parents perceive the broader impact of living with VI very differently. There is value in routine capture of information independently from children and their parents for comprehensively gauging the impact of childhood VI and tailoring appropriate interventions. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 22, 2017 Category: Opthalmology Authors: Tadic, V., Cumberland, P. M., Lewando-Hundt, G., Rahi, J. S., on behalf of the vision-related quality of life group, Dale, Khaw, Moore, Salt, Taylor, Brown, Craig, Ennals, Keeley, Thompson, Osborne, Sobti, Thomas, Thompson Tags: Open access Original articles - Clinical science Source Type: research

Integrating a novel concept of sentence optotypes into the RADNER Reading Charts
Conclusion The 24 new sentence optotypes can be integrated into the existing set of 38 original sentences. Since all the statistical results obtained were similar to those of the original sentences, the best possible reliability had apparently already been achieved with the original sentence optotypes. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - February 22, 2017 Category: Opthalmology Authors: Radner, W., Radner, S., Diendorfer, G. Tags: Innovations Source Type: research

Highlights from this issue
Rahi et al (see page 244) The authors report the discordance between visually impaired children's own and their parents' reports of the child's vision-related quality of life and functional vision using two novel questionnaires designed specifically for this population. Heo et al (see page 251) The duration of elapsed time since the onset of IXT, the angle of distance exodeviation, and stereoacuity were risk factors for BHTT in IXT, and the BHTT could be resolved by horizontal muscle surgery alone. Yoon et al (see page 251) In a retrsospective study of 31 patients, the authors observed Serum IgG4 level to be a marker of tr...
Source: British Journal of Ophthalmology - February 22, 2017 Category: Opthalmology Authors: Barton, K., Chodosh, J., Jonas, J. Tags: At a glance Source Type: research

The association between skin autofluorescence and mean deviation in patients with open-angle glaucoma
Conclusions We found that the relationship between systemic oxidative stress and visual field loss was strongest in relatively young patients with OAG, suggesting that the potential benefit of antioxidant therapies to combat systemic oxidative stress might be dependent on the age of the patient. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2017 Category: Opthalmology Authors: Himori, N., Kunikata, H., Kawasaki, R., Shiga, Y., Omodaka, K., Takahashi, H., Miyata, T., Nakazawa, T. Tags: Original articles - Laboratory science Source Type: research

Patients with more severe symptoms of neuropathic ocular pain report more frequent and severe chronic overlapping pain conditions and psychiatric disease
Conclusions Consistent with a chronic overlapping pain condition, patients with DE disease with more severe NOP symptoms report more frequent and severe non-ocular functional comorbid pain disorders. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2017 Category: Opthalmology Authors: Crane, A. M., Levitt, R. C., Felix, E. R., Sarantopoulos, K. D., McClellan, A. L., Galor, A. Tags: Neurology, Epidemiology Original articles - Clinical science Source Type: research

Presbyopia compensation: looking for cortical predictors
Conclusions While our findings do not permit decisions regarding the superiority of one type of compensation over another, these preliminary results support using the P100 latency evoked by binocular patterns as a predictor of postcompensation stereoacuity. Trial registration number NCT02444130, Pre-results. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2017 Category: Opthalmology Authors: Imbeau, L., Majzoub, S., Thillay, A., Bonnet-Brilhault, F., Pisella, P.-J., Batty, M. Tags: Optic nerve, Optics and refraction Original articles - Clinical science Source Type: research

Does endogenous serum oestrogen play a role in meibomian gland dysfunction in postmenopausal women with dry eye?
Conclusion Serum oestrogen appears to be a key factor in MG signs. Although serum hormone levels did not contribute significantly to dry eye symptoms in this study, it is possible that oestrogen plays a role through its effect on meibum secretion. These findings suggest that MG dysfunction underpins dry eye symptoms in non-Sjögren's dry eye in postmenopausal women. Trial registration number ACTRN12612000281897. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2017 Category: Opthalmology Authors: Golebiowski, B., Badarudin, N., Eden, J., You, J., Hampel, U., Stapleton, F. Tags: Original articles - Clinical science Source Type: research

Immunopathology and histopathology of conjunctival biopsies in patients with presumed idiopathic punctal stenosis
Conclusions Conjunctiva appears to be an excellent proxy in evaluating patients with presumed idiopathic punctal stenosis. The biopsy is safe and provides ample tissue. Clinically, abnormal tissue should be targeted, if available. 11 of the 23 patients in this study demonstrated findings consistent with underlying immunological disorders, suggesting that conjunctival biopsy may play a role in identifying underlying aetiologies of punctal stenosis. Knowledge of these underlying conditions impacted treatments for several patients. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2017 Category: Opthalmology Authors: Reddy, A. K., Baker, M. S., Maltry, A. C., Syed, N. A., Allen, R. C. Tags: Original articles - Clinical science Source Type: research

Incidence of eyelid basal cell carcinoma in England: 2000-2010
Conclusions The findings provide the current frequency and distribution of eyelid BCCs in England, highlighting opportunities for health education and improving reporting and registration of events, and for informing service planning. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2017 Category: Opthalmology Authors: Saleh, G. M., Desai, P., Collin, J. R. O., Ives, A., Jones, T., Hussain, B. Tags: Public health Original articles - Clinical science Source Type: research

Endoresection of large uveal melanomas: clinical results in a consecutive series of 200 cases
Conclusions Eyes with a large uveal melanoma can be preserved by stereotactic radiotherapy followed by endoresection with the chance to obtain useful vision in approximately half of the cases. Adjuvant brachytherapy has no beneficial effect except a reduction of the frequency for major revision surgery. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2017 Category: Opthalmology Authors: Biewald, E., Lautner, H., Gök, M., Horstmann, G. A., Sauerwein, W., Flühs, D., Bornfeld, N. Tags: Eye (globe) Original articles - Clinical science Source Type: research

Drusen volume development over time and its relevance to the course of age-related macular degeneration
Conclusions Drusen volume increase over time can be described by a cubic function. Spontaneous regression appears to precede conversion to advanced AMD. OCT might be a promising tool for predicting the individual risk of progression of AMD. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2017 Category: Opthalmology Authors: Schlanitz, F. G., Baumann, B., Kundi, M., Sacu, S., Baratsits, M., Scheschy, U., Shahlaee, A., Mittermüller, T. J., Montuoro, A., Roberts, P., Pircher, M., Hitzenberger, C. K., Schmidt-Erfurth, U. Tags: Choroid, Retina, Open access Original articles - Clinical science Source Type: research

Relationship between macular pigment and visual function in subjects with early age-related macular degeneration
Conclusions MP relates positively to many measures of visual function in unsupplemented subjects with early AMD. The CREST trial will investigate whether enrichment of MP influences visual function among those afflicted with this condition. Trial registration number ISRCTN13894787. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2017 Category: Opthalmology Authors: Akuffo, K. O., Nolan, J. M., Peto, T., Stack, J., Leung, I., Corcoran, L., Beatty, S. Tags: Lens and zonules, Retina, Open access Original articles - Clinical science Source Type: research

The role of enhanced depth imaging optical coherence tomography in chronic Vogt-Koyanagi-Harada disease
Conclusions The positive correlation of SFCT measurements with ICGA score suggests that it may be used to monitor disease activity in chronic VKH in addition to ICGA, possibly reducing the number of ICGAs required. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2017 Category: Opthalmology Authors: Jap, A., Chee, S.-P. Tags: Choroid, Neurology Original articles - Clinical science Source Type: research

Functional-morphological parameters, aqueous flare and cytokines in macular oedema with branch retinal vein occlusion after ranibizumab
Conclusions These findings suggest that the aqueous flare is associated with inflammatory factors/cytokines, and that the change of the aqueous flare value may influence the long-term prognosis in patients with BRVO receiving IRI therapy for macular oedema. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2017 Category: Opthalmology Authors: Noma, H., Mimura, T., Yasuda, K., Shimura, M. Tags: Retina Original articles - Clinical science Source Type: research

Quantitative analysis of vitreous inflammation using optical coherence tomography in patients receiving sub-Tenon's triamcinolone acetonide for uveitic cystoid macular oedema
Conclusions This study provides evidence that the OCT-derived VIT/RPE-relative intensity may be useful as a quantitative and objective marker of disease activity and treatment response in uveitis complicated by CMO. This first longitudinal study of this novel OCT parameter is an encouraging step in the development of sensitive objective OCT-based endpoints for trials of efficacy in uveitis. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2017 Category: Opthalmology Authors: Sreekantam, S., Macdonald, T., Keane, P. A., Sim, D. A., Murray, P. I., Denniston, A. K. Tags: Retina, Epidemiology Original articles - Clinical science Source Type: research

Indocyanine-green-guided targeted laser photocoagulation of capillary macroaneurysms in macular oedema: a pilot study
Conclusions During macular oedema with severe hard exsudates due to DME or RVO, systematic detection of capillary macroaneurysms by ICGA followed by their OCT-controlled photocoagulation may be of interest. These results may contribute to re-evaluate the role of photocoagulation in the management of longstanding macular oedema. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2017 Category: Opthalmology Authors: Paques, M., Philippakis, E., Bonnet, C., Falah, S., Ayello-Scheer, S., Zwillinger, S., Girmens, J.-F., Dupas, B. Tags: Ophthalmologic surgical procedures, Retina Original articles - Clinical science Source Type: research

Three-month outcome of intravitreal ziv-aflibercept in eyes with diabetic macular oedema
Conclusions Off-label use of intravitreal ziv-aflibercept improves visual acuity, without detectable ocular toxicity or systemic side effects in DME. It offers a less expensive alternative to the approved intravitreal aflibercept (Eylea), especially in the low/middle-income countries and in countries where Eylea is not available. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2017 Category: Opthalmology Authors: Mansour, A. M., Dedhia, C., Chhablani, J. Tags: Lens and zonules Original articles - Clinical science Source Type: research

Quantification of retinal layer thickness changes in acute macular neuroretinopathy
Conclusions AMN presents with characteristic quantitative retinal changes and the extent of the lesion may be more extensive than initially presumed from NIR image lesions. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2017 Category: Opthalmology Authors: Munk, M. R., Beck, M., Kolb, S., Larsen, M., Hamann, S., Valmaggia, C., Zinkernagel, M. S. Tags: Open access Original articles - Clinical science Source Type: research

Associations between obstructive sleep apnoea, primary open angle glaucoma and age-related macular degeneration: record linkage study
Conclusions Although plausible mechanisms exist to consider a link between OSA and POAG, the two conditions are not positively associated. This holds true in either temporal direction. By contrast, OSA is positively associated with AMD. While potential confounding factors may contribute, obesity does not appear sufficient to explain this association. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2017 Category: Opthalmology Authors: Keenan, T. D. L., Goldacre, R., Goldacre, M. J. Tags: Public health, Angle, Intraocular pressure, Retina, Neurology, Glaucoma Original articles - Clinical science Source Type: research

Comparison of structure-function relationship between corresponding retinal nerve fibre layer thickness and Octopus visual field cluster defect values determined by normal and tendency-oriented strategies
Conclusions Octopus normal and TOP strategies provide similar, moderate-to-strong negative correlation between the corresponding cluster defect and sector RNFLT values for all 10 manufacturer-provided clusters. For corrected clusters the relationship is poor, which suggests that by correcting for diffuse sensitivity loss some local glaucomatous defect is removed. For structure-function based clinical decisions, use of TOP is possible but use of corrected clusters is not recommended. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2017 Category: Opthalmology Authors: Hollo, G. Tags: Angle, Intraocular pressure, Glaucoma Original articles - Clinical science Source Type: research

Bruch's membrane opening changes and lamina cribrosa displacement in non-arteritic anterior ischaemic optic neuropathy
Conclusions At onset, a significant PT thickening, backward LC movement and BMO enlargement occurred in NAION eyes compared with unaffected eyes, and these changes significantly reversed during follow-up. PTT and RNFL changes were significantly correlated. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2017 Category: Opthalmology Authors: Rebolleda, G., Garcia-Montesinos, J., De Dompablo, E., Oblanca, N., Munoz-Negrete, F. J., Gonzalez-Lopez, J. J. Tags: Optic nerve, Neurology, Epidemiology Original articles - Clinical science Source Type: research

Neuroretinal rim in non-glaucomatous large optic nerve heads: a comparison of confocal scanning laser tomography and spectral domain optical coherence tomography
Conclusions In large optic discs, BMO-MRW is thinner compared with normal-sized discs and correlates better than CSLT parameters with the RNFLT. An age-depended loss of BMO-MRW needs to be taken into account in evaluation of the neuroretinal rim. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2017 Category: Opthalmology Authors: Enders, P., Schaub, F., Hermann, M. M., Cursiefen, C., Heindl, L. M. Tags: Original articles - Clinical science Source Type: research

Preoperative characteristics and compliance with follow-up after trabeculectomy surgery in rural southern China
Conclusions Follow-up after 2 weeks was inadequate to provide optimal clinical care, and surgery is being applied too late to avoid blindness in the majority of patients. Earlier surgery, support for return visits and better explanations of the importance of follow-up are needed. Directing all patients to return for possible scleral flap suture removal may be a valid strategy to improve follow-up. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2017 Category: Opthalmology Authors: Yang, K., Jin, L., Li, L., Zeng, S., Dan, A., Chen, T., Wang, X., Li, G., Congdon, N. Tags: Ophthalmologic surgical procedures, Angle, Intraocular pressure, Vision, Neurology, Glaucoma Original articles - Clinical science Source Type: research

Outcomes of surgical interventions for primary childhood glaucoma in Northern Tanzania
Conclusions Based on the success rates of this retrospective analysis, goniotomy or trabeculotomy for younger and trabeculectomy for older children can be recommended in our setting to reduce IOP. Late presentation in combination with advanced glaucomatous damage as well as erratic postoperative follow-up and treatment were likely factors that compromised overall success rates. More efforts are necessary to detect the blinding disease earlier and improve adherence to follow-up. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2017 Category: Opthalmology Authors: Fiess, A., Furahini, G., Bowman, R., Bauer, J., Dithmar, S., Philippin, H. Tags: Ophthalmologic surgical procedures, Angle, Choroid, Eye (globe), Intraocular pressure, Glaucoma Original articles - Clinical science Source Type: research

The impact of chronic use of prostaglandin analogues on the biomechanical properties of the cornea in patients with primary open-angle glaucoma
Conclusion Topical PGAs induce reversible reduction in CH, CRF and CCT in patients with POAG. These changes contribute to underestimation of the IOP measured by Goldmann applanation tonometry and warrant caution when assessing response to treatment. Trial registration number NCT02388360, Results. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2017 Category: Opthalmology Authors: Meda, R., Wang, Q., Paoloni, D., Harasymowycz, P., Brunette, I. Tags: Angle, Intraocular pressure, Open access, Glaucoma, Epidemiology Original articles - Clinical science Source Type: research

The effect of topical application of 0.15% ganciclovir gel on cytomegalovirus corneal endotheliitis
Conclusions Clinical improvement and reduced CMV copy numbers in the aqueous humour were confirmed in the CMV corneal endotheliitis cases. Although the case numbers are limited and long-term follow-up is necessary, the topical application of 0.15% GCV gel appears to be a useful treatment option for CMV endotheliitis. Trial registration number UMIN000012435. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - January 20, 2017 Category: Opthalmology Authors: Koizumi, N., Miyazaki, D., Inoue, T., Ohtani, F., Kandori-Inoue, M., Inatomi, T., Sotozono, C., Nakagawa, H., Horikiri, T., Ueta, M., Nakamura, T., Inoue, Y., Ohashi, Y., Kinoshita, S. Tags: Cornea, Ocular surface Original articles - Clinical science Source Type: research