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The “Silver Star” Initiative: Proactively Protecting Our Older Adult Population
Topic Significance& Study Purpose/Background/Rationale: BMT recipients aged 65 years or older comprise 30% of patients at this large academic health system. BMT protocols commonly use medications at standardized doses often bringing about the need for aggressive symptom management. Lorazepam, prochlorperazine, promethazine and diphenhydramine are frequently used to treat the nausea, vomiting and diarrhea which often follow BMT conditioning regimens. Literature indicates that geriatric individuals are at a greater risk for medication-related adverse events as described per BEERS and STOP/START criteria. (Source: Biology of ...
Source: Biology of Blood and Marrow Transplantation - February 22, 2017 Category: Hematology Authors: Jeanne Verrecchio Source Type: research

A phase 2 safety study of accelerated elotuzumab infusion, over less than 1 hour, in combination with lenalidomide and dexamethasone, in patients with multiple myeloma
This article is protected by copyright. All rights reserved. (Source: American Journal of Hematology)
Source: American Journal of Hematology - February 18, 2017 Category: Hematology Authors: James Berenson, Robert Manges, Suprith Badarinath, Alan Cartmell, Kristi McIntyre, Roger Lyons, Wael Harb, Hesham Mohamed, Ali Nourbakhsh, Robert Rifkin Tags: Research Article Source Type: research

Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice Guideline
Introduction:The purpose of this guideline is to establish clinical practice recommendations for the pharmacologic treatment of chronic insomnia in adults, when such treatment is clinically indicated. Unlike previous meta-analyses, which focused on broad classes of drugs, this guideline focuses on individual drugs commonly used to treat insomnia. It includes drugs that are FDA-approved for the treatment of insomnia, as well as several drugs commonly used to treat insomnia without an FDA indication for this condition. This guideline should be used in conjunction with other AASM guidelines on the evaluation and treatment of ...
Source: Journal of Clinical Sleep Medicine : JCSM - February 15, 2017 Category: Sleep Medicine Source Type: research

Quantitative prediction of histamine H1 receptor occupancy by the sedative and non-sedative antagonists in the human central nervous system based on systemic exposure and preclinical data.
Authors: Kanamitsu K, Nozaki Y, Nagaya Y, Sugiyama Y, Kusuhara H Abstract Significant histamine H1 receptor occupation in the central nervous system (CNS) is associated with sedation. Here we examined the time profiles of the H1 receptor occupancy (RO) in the CNS using sedative (diphenhydramine and ketotifen) and non-sedative (bepotastine and olopatadine) antagonists at their therapeutic doses by integrating in vitro and animal data. A pharmacokinetic model was constructed to associate plasma concentrations and receptor binding in the brain. Dissociation and association rate constants with the H1 receptor and plas...
Source: Drug Metabolism and Pharmacokinetics - February 14, 2017 Category: Drugs & Pharmacology Tags: Drug Metab Pharmacokinet Source Type: research

Suppression in Bitterness Intensity of Bitter Basic Drug by Chlorogenic Acid.
This study showed that the bitterness intensity of DPH was suppressed by QNA and CGA through a direct electrostatic interaction with DPH as confirmed in (1)H-NMR spectroscopic analysis. CGA and QNA may therefore be useful bitterness-masking agents for the basic drug DPH. PMID: 28154308 [PubMed - in process] (Source: Chemical and Pharmaceutical Bulletin)
Source: Chemical and Pharmaceutical Bulletin - February 7, 2017 Category: Drugs & Pharmacology Authors: Shiraishi S, Haraguchi T, Nakamura S, Kojima H, Kawasaki I, Yoshida M, Uchida T Tags: Chem Pharm Bull (Tokyo) Source Type: research

Taste-Masking Effect of Chlorogenic Acid (CGA) on Bitter Drugs Evaluated by Taste Sensor and Surface Plasmon Resonance on the Basis of CGA-Drug Interactions.
Abstract The purpose of this study was to evaluate the taste-masking effects of chlorogenic acid (CGA) on bitter drugs using taste sensor measurements and surface plasmon resonance (SPR) analysis of CGA-drug interactions. Six different bitter drugs were used: amlodipine besylate (AMD), diphenhydramine hydrochloride (DPH), donepezil hydrochloride (DNP), rebamipide (RBM), diclofenac sodium (DCF) and etodolac (ETD). Taste sensor outputs were significantly inhibited by the addition of CGA to all drugs. The inhibition ratio of the taste sensor output decreased in the following order DPH>DNP>AMD≈DCF≈RBM≈ETD....
Source: Chemical and Pharmaceutical Bulletin - February 7, 2017 Category: Drugs & Pharmacology Authors: Shiraishi S, Haraguchi T, Nakamura S, Li D, Kojima H, Yoshida M, Uchida T Tags: Chem Pharm Bull (Tokyo) Source Type: research

Face and Neck Swelling Hint at a Daunting Diagnosis
​BY MOHAMMED HASSAN-ALI, MSC, & AHMED RAZIUDDIN, MDA 56-year-old black man presented to the ED complaining of face and neck swelling. An initial history was difficult to obtain because the patient did not speak English fluently and had slurred speech. Symptoms started approximately a week earlier when the patient was at his nursing home. He denied dysphagia or odynophagia, he had no rashes, pruritus, dyspnea, or peripheral edema, his face was flushed, and he had visibly engorged neck veins. He noticed that his tongue was mildly swollen, so he took Benadryl for a week with no relief. The patient said he believed that ...
Source: The Case Files - February 2, 2017 Category: Emergency Medicine Tags: Blog Posts Source Type: research

Intravenous Ferric Carboxymaltose for Iron Deficiency Anemia
Researchers from multiple institutions in Texas conducted a retrospective study of children with iron deficiency anemia (IDA) who received intravenous (IV) ferric carboxymaltose (FCM) at Children’s Medical Center in Dallas. A query of pharmacy records was used to identify study patients who received FCM over a 1-year period. The medical records of study patients were reviewed to assess hematologic response to FCM treatment and adverse events related to therapy. For patients weighing >50 kg, 2 doses (each up to 750 mg) were given at least 7 days apart. Children weighing <50 kg received 1 to 2 doses of FCM at 15 ...
Source: AAP Grand Rounds - February 1, 2017 Category: Pediatrics Authors: Hogan, M.-J. S. Tags: Hematology-Oncology Source Type: research

Diphenhydramine for Acute Extrapyramidal Symptoms After Propofol Administration
Extrapyramidal symptoms are an uncommon but well-recognized side effect after the administration of general anesthesia in patients without a significant neurologic history. Several case reports implicate propofol as the likely causative agent producing these symptoms, which include ballismus, dystonia, choreoathetosis, and opisthotonus. Currently, there is no clear consensus on first-line treatment of these symptoms. In each of the published cases, anticholinergic medications and benzodiazepines were central to initial management, although the speed and extent of symptom resolution were variable. Here we present a case of ...
Source: PEDIATRICS - February 1, 2017 Category: Pediatrics Authors: Sherer, J., Salazar, T., Schesing, K. B., McPartland, S., Kornitzer, J. Tags: Neurology, Neurologic Disorders, Anesthesiology/Pain Medicine Case Report Source Type: research

Continued midazolam versus diphenhydramine in difficult-to-sedate patients: a randomized double-blind trial
Current guidelines recommend diphenhydramine in patients undergoing endoscopy who are not adequately sedated with a benzodiazepine and opioid combination. Because this practice has not been adequately assessed, we performed a randomized, double-blind trial comparing diphenhydramine to continued midazolam in such patients. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - January 31, 2017 Category: Gastroenterology Authors: Hamita Sachar, Nipaporn Pichetshote, Kavitha Nandigam, Keta Vaidya, Loren Laine Source Type: research

Machine learning-based prediction of adverse drug effects: an example of seizure-inducing compounds
Publication date: Available online 28 January 2017 Source:Journal of Pharmacological Sciences Author(s): Mengxuan Gao, Hideyoshi Igata, Aoi Takeuchi, Kaoru Sato, Yuji Ikegaya Various biological factors have been implicated in convulsive seizures, involving side effects of drugs. For the preclinical safety assessment of drug development, it is difficult to predict seizure-inducing side effects. Here, we introduced a machine learning-based in vitro system designed to detect seizure-inducing side effects. We recorded local field potentials from the CA1 alveus in acute mouse neocortico-hippocampal slices, while 14 drugs were ...
Source: Journal of Pharmacological Sciences - January 29, 2017 Category: Drugs & Pharmacology Source Type: research

New Treatment for Soft Tissue Sarcoma
* Olaratumab (Lartruvo) is the first new drug approved in more than 40 years for the treatment of soft tissue sarcoma. It is administered as an IV infusion in combination with doxorubicin. * There is a risk of serious infusion-related reactions with olaratumab use. Grade 3 or 4 reactions require that the infusion be stopped immediately and not restarted. Embryo-fetal toxicity can occur if olaratumab is given to pregnant women. * Nurses should premedicate patients with diphenhydramine and dexamethasone prior to the first dose of olaratumab to help minimize the risk of infusion reactions. Patients require close monitorin...
Source: AJN - January 27, 2017 Category: Nursing Tags: Drug Watch Source Type: research

Inhibitory effects of antihistamines, diphenhydramine and chlorpheniramine, on proton currents in BV2 microglial cells.
We examined the effects of the H1 antihistamines, diphenhydramine and chlorpheniramine, on proton currents in BV2 microglial cells recorded using the whole-cell patch clamp technique. Diphenhydramine and chlorpheniramine reduced the proton currents with almost the same potency, yielding IC50 values of 42 and 43μM, respectively. Histamine did not affect proton currents, excluding the involvement of histamine receptors in their action. Neither drug shifted the voltage-dependence of activation or the reversal potential of the proton currents, even though diphenhydramine slowed the activation and deactivation kinetics. The in...
Source: European Journal of Pharmacology - January 25, 2017 Category: Drugs & Pharmacology Authors: Kim J, Song JH Tags: Eur J Pharmacol Source Type: research

Diphenhydramine as a cause of visual hallucinations in older adults
(Source: Geriatrics and Gerontology International)
Source: Geriatrics and Gerontology International - January 23, 2017 Category: Geriatrics Authors: Supakanya Wongrakpanich, Marvin Louis Roy Lu, Andrew Rosenzweig Tags: CASE REPORT Source Type: research

pH/thermo-responsive poly(N-isopropylacrylamide-co-maleic acid) hydrogel with a sensor and an actuator for biomedical applications
Publication date: 10 February 2017 Source:Polymer, Volume 110 Author(s): Gheorghe Fundueanu, Marieta Constantin, Sanda Bucatariu, Paolo Ascenzi Poly(N-isopropylacrylamide-co-maleic acid) (poly(NIPAAm-co-MAc)) with an appropriate comonomer ratio was designed and synthesized as an appealing pH/thermo-responsive copolymer. In simulated physiological fluids (phosphate buffer solution (PBS) at pH = 7.4 and T = 36 °C), both carboxylic groups of MAc in copolymer (pKa1 = 3.45, pKa2 = 6.09) are in the ionized form, more hydrophilic and consequently the copolymer loses the thermosensitive properties. However, when the car...
Source: Polymer - January 17, 2017 Category: Chemistry Source Type: research

Rococo study: a real-world evaluation of an over-the-counter medicine in acute cough (a multicentre, randomised, controlled study)
Conclusions Although the primary end point was not achieved, CS1002 was associated with greater reductions in cough frequency, sleep disruption and improved health status compared with SL. Trial registration number EudraCT number 2014-004255-31. (Source: BMJ Open)
Source: BMJ Open - January 16, 2017 Category: Journals (General) Authors: Birring, S. S., Brew, J., Kilbourn, A., Edwards, V., Wilson, R., Morice, A. H. Tags: Open access, General practice / Family practice, Respiratory medicine Research Source Type: research

Hot and Cold Drugs: National Park Service Medication Stability at the Extremes of Temperature.
CONCLUSIONS: We recommend that EMS providers replace atropine, naloxone, diphenhydramine, fentanyl, and midazolam frequently if they are practicing in low call volume or high-temperature environments. Further studies will be needed to determine if re-dosing midazolam, naloxone, and atropine is the appropriate clinical strategy in this setting if adequate clinical effect is not reached with a single dose. PMID: 28059581 [PubMed - as supplied by publisher] (Source: Prehospital Emergency Care)
Source: Prehospital Emergency Care - January 7, 2017 Category: Endocrinology Tags: Prehosp Emerg Care Source Type: research

Combination of ofatumumab and reduced-dose CHOP for diffuse large B-cell lymphomas in patients aged 80 years or older: an open-label, multicentre, single-arm, phase 2 trial from the LYSA group
This study was registered with ClinicalTrials.gov, number NCT01195714. Findings Between June 2, 2010, and Nov 4, 2011, we enrolled 120 patients. Age-adjusted International Prognostic Index was 2–3 in 68 (57%) of them. The median follow-up time was 26·8 months (IQR 24·5–30·1). The 2-year overall survival was 64·7% (95% CI 55·3–72·7) and median overall survival was not reached (95% CI 30·2–not reached). 45 patients died during the treatment, of whom 28 (62%) died due to lymphoma. The most common side-effect was haematological toxicity. Among the 120 patients, grade 3–4 neutropenia was reported in 24 (21%) pa...
Source: The Lancet Haematology - December 30, 2016 Category: Hematology Source Type: research

Premedication Use Before Infliximab Administration: A Cross-sectional Analysis
Conclusions: There is high interpractice and intrapractice variability for premedication use before infliximab administration. Clinician rationale for premedicating patients seems to be driven by individual preference or group practice habit. Improved knowledge of the evidence may assist in decreasing overuse of premedications, particularly diphenhydramine. (Source: Inflammatory Bowel Diseases)
Source: Inflammatory Bowel Diseases - December 24, 2016 Category: Gastroenterology Tags: Original Clinical Articles Source Type: research

Knowledge and Attitude Towards Pharmacological Management of Acute Agitation: A Survey of Psychiatrists, Psychiatry Residents, and Psychiatric Nurses.
CONCLUSION: Knowledge of evidence-based psychopharmacological management of agitation differs among attending psychiatrists, psychiatry residents and psychiatric nurses. Although the management of agitation should be individualized and context specific, monotherapy should be considered first where applicable. PMID: 27943131 [PubMed - as supplied by publisher] (Source: The Journal of American Association of Directors of Psychiatric Residency Training)
Source: The Journal of American Association of Directors of Psychiatric Residency Training - December 15, 2016 Category: Psychiatry Tags: Acad Psychiatry Source Type: research

Knowledge and Attitude Towards Pharmacological Management of Acute Agitation: A Survey of Psychiatrists, Psychiatry Residents, and Psychiatric Nurses
ConclusionKnowledge of evidence-based psychopharmacological management of agitation differs among attending psychiatrists, psychiatry residents and psychiatric nurses. Although the management of agitation should be individualized and context specific, monotherapy should be considered first where applicable. (Source: Academic Psychiatry)
Source: Academic Psychiatry - December 9, 2016 Category: Psychiatry Source Type: research

Pharmacodynamic response profiles of anxiolytic and sedative drugs
ConclusionsCompared with the antihistaminergic sedative diphenhydramine, alprazolam and pregabalin caused larger SPV‐reduction, which was correlated with simultaneous improvement of subjective calmness, during a study day in which anxiety was stimulated repeatedly. The different effect profiles of the three drugs are in line with their pharmacological distinctions. These findings corroborate the profiling of CNS effects to demonstrate pharmacological selectivity, and further support SPV as biomarker for anxiolysis involving GABA‐ergic neurons. The study also supports the use of prolonged mild threat to demonstrate anxi...
Source: British Journal of Clinical Pharmacology - December 1, 2016 Category: Drugs & Pharmacology Authors: Xia Chen, Freerk Broeyer, Marieke Kam, Joke Baas, Adam Cohen, Joop Gerven Tags: CLINICAL TRIALS Source Type: research

Regenerated cellulose capsules for controlled drug delivery: Part IV. In-vitro evaluation of novel self-pore forming regenerated cellulose capsules.
Abstract In the present work, the release mechanisms of active pharmaceutical ingredients (APIs) enclosed in self-pore forming regenerated cellulose (RC) two-piece hard shell capsules are described. The RC capsules were fabricated using a modified dip-coating approach, which yielded an assembled dosage form that was equivalent in size and shape to a conventional gelatin two-piece hard shell capsule. Drug release characteristics from RC capsules were evaluated using potassium chloride, diphenhydramine hydrochloride, tramadol hydrochloride, niacinamide, acetaminophen and ketoprofen as model APIs. The RC capsules act...
Source: European Journal of Pharmaceutical Sciences - December 1, 2016 Category: Drugs & Pharmacology Authors: Bhatt B, Kumar V Tags: Eur J Pharm Sci Source Type: research

Refractory Cutaneous IgA Vasculitis Treated with Omega-3 Fatty Acids
Conclusions: O3FA can be useful to control cutaneous IgAV.Case Rep Dermatol 2016;8:333 –340 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - November 29, 2016 Category: Dermatology Source Type: research

Presence of an H + /Quinidine Antiport System in Madin –Darby Canine Kidney Cells
ConclusionsThe present findings suggested that the renal new antiport system is involved in the bidirectional membrane transport of quinidine in MDCK cells. (Source: European Journal of Drug Metabolism and Pharmacokinetics)
Source: European Journal of Drug Metabolism and Pharmacokinetics - November 25, 2016 Category: Drugs & Pharmacology Source Type: research

A multi-omic approach to elucidate low-dose effects of xenobiotics in zebrafish (Danio rerio) larvae
Publication date: Available online 18 November 2016 Source:Aquatic Toxicology Author(s): Susie S.Y. Huang, Jonathan P. Benskin, Nik Veldhoen, Bharat Chandramouli, Heather Butler, Caren C. Helbing, John R. Cosgrove Regulatory-approved toxicity assays such as the OECD Fish Embryo Toxicity Assay (TG236) allow correlation of chemical exposure to adverse morphological phenotypes. However, these assays are ineffective in assessing sub-lethal (i.e. low-dose) effects, or differentiating between similar phenotypes induced by different chemicals. Inclusion of multi-omic analyses in studies investigating xenobiotic action provides i...
Source: Aquatic Toxicology - November 18, 2016 Category: Toxicology Source Type: research

A multi-omic approach to elucidate low-dose effects of xenobiotics in zebrafish (Danio rerio) larvae.
Abstract Regulatory-approved toxicity assays such as the OECD Fish Embryo Toxicity Assay (TG236) allow correlation of chemical exposure to adverse morphological phenotypes. However, these assays are ineffective in assessing sub-lethal (i.e. low-dose) effects, or differentiating between similar phenotypes induced by different chemicals. Inclusion of multi-omic analyses in studies investigating xenobiotic action provides improved characterization of biological response, thereby enhancing prediction of toxicological outcomes in whole animals in the absence of morphological effects. In the current study, we assessed p...
Source: Aquatic Toxicology - November 18, 2016 Category: Toxicology Authors: Huang SS, Benskin JP, Veldhoen N, Chandramouli B, Butler H, Helbing CC, Cosgrove JR Tags: Aquat Toxicol Source Type: research

Antagonistic Effects of Gingko biloba and Sophora japonica on Cerebral Vasoconstriction in Response to Histamine, 5-Hydroxytryptamine, U46619 and Bradykinin.
Abstract The aim of this study was to evaluate, for the first time, the antagonistic effects of Gingko biloba leaf (GB) and Sophora japonica L. flower bud (SJ) extracts on cerebral vasoconstriction in response to KCl, extracellular Ca[Formula: see text], histamine, 5-hydroxytryptamine (5-HT), 9,11-dideoxy-9[Formula: see text],11[Formula: see text]-methanoepoxy prostaglandin (PG) F[Formula: see text](U46619) and bradykinin (BK), in order to explain their traditional application for diseases associated with cerebral vasospasm. Isolated porcine basilar arteries (PBA) and endothelial cells from them were used as the s...
Source: The American Journal of Chinese Medicine - November 16, 2016 Category: Complementary Medicine Authors: Nguyen HT, Nguyen HT, Islam MZ, Obi T, Pothinuch P, Nguyen TV, Nguyen TM, Dao CV, Shiraishi M, Miyamoto A Tags: Am J Chin Med Source Type: research

Biodistribution of diphenhydramine in reproductive organs in an overdose case
In conclusion , DPH, dyphylline, diphenidol, and caffeine levels were higher in reproductive organs such as the prostate and testes than in the central nervous system and heart. As we determined in this case, motion sickness medications might accumulate in reproductive organs. Thus, further examination of tissue biodistribution of DPH, dyphylline, diphenidol, and caffeine is necessary to assess their potential long-term effects in these sites. (Source: Human Cell)
Source: Human Cell - November 12, 2016 Category: Cytology Source Type: research

Potential drug-drug interactions in the pediatric intensive care unit of a pulmonary teaching hospital
Conclusions: Life-threatening drug interactions may develop in pediatric patients hospitalized in the PICU. Clinical managements such as avoiding combination, close monitoring, and considering related risk factors could prevent the consequences of these interactions. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 8, 2016 Category: Respiratory Medicine Authors: Baniasadi, S., Hassanzad, M., Alehashem, M. Tags: 7.5 Neonatology and Paediatric Intensive Care Source Type: research

Actr-03. safety and feasibility of rapid rituximab infusions in patients with primary cns lymphoma
CONCLUSION:Rapid administration of rituximab was safe and feasible for patients with primary CNS lymphoma. (Source: Neuro-Oncology)
Source: Neuro-Oncology - November 7, 2016 Category: Cancer & Oncology Authors: Modelevsky, L., Tizon, R., Garonce, R., Reiss, S., Kaley, T. Tags: ADULT Clinical Trials (NON-IMMUNOLOGICAL) Source Type: research

Effect of Surfactants and Thickeners on the Stability of Menthol-Diphenhydramine Cream Identified by Magnetic Resonance Imaging.
In conclusion, we successfully established a stable formulation of menthol-diphenhydramine cream. PMID: 27803472 [PubMed - in process] (Source: Chemical and Pharmaceutical Bulletin)
Source: Chemical and Pharmaceutical Bulletin - November 4, 2016 Category: Drugs & Pharmacology Authors: Onuki Y, Yokokawa M, Utsumi S, Obata Y, Machida Y, Seike C, Hayashi Y, Takayama K Tags: Chem Pharm Bull (Tokyo) Source Type: research

Treatments affecting dog behaviour: something to be aware of
ALTHOUGH dog behaviour problems are a leading cause of relinquishment and euthanasia (Salman and others 1998), only 11 per cent of veterinarians surveyed in a USA study strongly agreed that dog behaviour is their responsibility, initiating a discussion regarding behaviour problems in dogs (Patronek and Dodman 1999). Aside from specific treatments for behaviour problems, several medical and surgical treatments that are routinely prescribed by general veterinary practitioners can affect the behaviour of dogs. Phenylpropanolamine, commonly used for the treatment of urinary sphincter hypotonus in dogs, can cause restlessness a...
Source: Veterinary Record - November 3, 2016 Category: Veterinary Research Authors: Siracusa, C. Tags: Research Source Type: research

[News] 58th ASTRO annual meeting
Rick C Miller (Mayo Clinic, Jacksonville, FL, USA) and colleagues reported the results of their randomised phase 3 trial (NCT02229539) comparing doxepin mouthwash or so-called magic mouthwash (consisting of a diphenhydramine, lidocaine, and antacid solution) with placebo, to treat pain from oral mucositis in patients receiving radiotherapy to the head and neck. The primary endpoint was the reduction in pain from oral mucositis relative to baseline pain scores. Miller reported that both doxepin and magic mouthwash improved pain relative to placebo (mean area under the curve [AUC] reduction for doxepin was 11 ·9 vs placebo ...
Source: The Lancet Oncology - October 6, 2016 Category: Cancer & Oncology Authors: Isabel Lokody Tags: News Source Type: research

Resolution of Allergic Rhinitis and Reactive Bronchospasm With Supplements and Food-specific Immunoglobulin G Elimination: A Case Report.
Conclusions • The case demonstrates the effectiveness of natural supplements and a diet eliminating IgG-reactive foods in the treatment and management of pediatric allergic rhinitis and reactive bronchospasm. PMID: 27866183 [PubMed - in process] (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - October 1, 2016 Category: Complementary Medicine Authors: Kwiatkowski L, Mitchell J, Langland J Tags: Altern Ther Health Med Source Type: research

Incidence of infusion reactions to anti-neoplastic agents in early phase clinical trials: The MD Anderson Cancer Center experience
AbstractInfusion reactions (IRs) to anti-neoplastic agents require prompt recognition and immediate treatment to avert significant complications. We conducted a retrospective review of the medical records of consecutive patients who received anti-neoplastic therapy in the outpatient treatment center of the Department of Investigational Cancer Therapeutics from January 1, 2013 to November 30, 2013. Of the 597 patients who received treatment, 9 (1.5  %) had IRs (all ≤ grade 2). The most common IRs observed on first occurrence were chills (n = 5), itching, rash, and facial flushing (n = 3 each). There were no IR-relate...
Source: Investigational New Drugs - September 29, 2016 Category: Drugs & Pharmacology Source Type: research

Valerian: an underestimated anxiolytic in the community pharmacy?
The objective of the current study was to assess pharmacists’ perception and knowledge of valerian pharmacology, explore their dispensing practice of sedatives/hypnotics and to investigate the Jordanian customers’ behaviour and preferences towards sedative/hypnotics. Data from 568 community pharmacists surveyed in Jordan was analysed. Almost one-third of the pharmacists admitted that they were unaware of the anxiolytic mechanism of valerian and half of them described valerian as a “hypnotic” instead of an “anxiolytic”. None knew that it could be hazardous to co-administer valerian with benzodiazepines. Addition...
Source: Journal of Herbal Medicine - September 13, 2016 Category: Complementary Medicine Source Type: research

Safe Use of Subcutaneous Diphenhydramine in the Inpatient Hospice Unit.
CONCLUSIONS: This retrospective review demonstrates that subcutaneous diphenhydramine injection is a safe alternative to oral and other parenteral routes, and may be particularly valuable in terminally ill patients, who are often unable to swallow and are without IV access. PMID: 27625354 [PubMed - as supplied by publisher] (Source: The American Journal of Hospice and Palliative Care)
Source: The American Journal of Hospice and Palliative Care - September 13, 2016 Category: Palliative Care Authors: Chen A, Loquias EJ, Roshan R, Levene R, Zelhof R, Hickey T, Cooney GA, Gonzalez F Tags: Am J Hosp Palliat Care Source Type: research

Screening determination of pharmaceutical pollutants in different water matrices using dual-channel capillary electrophoresis coupled with contactless conductivity detection.
In this study, the employment of purpose-made dual-channel compact capillary electrophoresis (CE) instrument with capacitively coupled contactless conductivity detection (C(4)D) as a simple and inexpensive solution for screening determination of various pharmaceutical pollutants frequently occurring in surface water and hospital wastewater in Hanoi, Vietnam is reported. Five negatively charged pharmaceutically active compounds, namely ibuprofen, diclofenac, bezafibrate, ketoprofen and mefenamic acid were determined using the first channel whereas three positively charged ones, namely diphenhydramine, metoprolol and atenolo...
Source: Talanta - September 5, 2016 Category: Chemistry Authors: Le MD, Duong HA, Nguyen MH, Sáiz J, Pham HV, Mai TD Tags: Talanta Source Type: research

Psychogenic Itch Management.
Authors: Szepietowski JC, Reszke R Abstract Pruritus is a bothersome and prevalent symptom reported by patients suffering from both cutaneous and extracutaneous diseases. Psychogenic pruritus, also referred to as functional itch disorder, is a distinct clinical entity. According to the definition proposed by the French Psychodermatology Group (FPDG) in 2007, the disorder is characterized by pruritus which is the chief complaint and psychologic factors that contribute to eliciting, worsening, and sustaining the symptoms. Specific diagnostic criteria were proposed, including 3 compulsory and 7 optional, of which 3 ha...
Source: Current Problems in Dermatology - September 2, 2016 Category: Dermatology Tags: Curr Probl Dermatol Source Type: research

Pharmacological evidence of specific acetylcholine transport in rat cerebral cortex and other brain regions
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - September 1, 2016 Category: Neuroscience Authors: Ikunobu Muramatsu, Hatsumi Yoshiki, Junsuke Uwada, Takayoshi Masuoka, Kiyonao Sada, Takanobu Taniguchi, Matomo Nishio Tags: Original Article Source Type: research

A Novel Approach to the Treatment of Orolingual Angioedema After Tissue Plasminogen Activator  Administration
Publication date: September 2016 Source:Annals of Emergency Medicine, Volume 68, Issue 3 Author(s): Lesley Pahs, Chris Droege, Hilary Kneale, Arthur Pancioli Orolingual angioedema is a rare adverse effect of tissue plasminogen activator (tPA), with an incidence of 1% to 5%. There are currently no published reports describing resolution of tPA-induced orolingual angioedema with complement inhibitor therapy. A 72-year-old man receiving home angiotensin-converting enzyme inhibitor therapy presented to the emergency department with newly developed orolingual angioedema after treatment with tPA for acute ischemic stroke. Thera...
Source: Annals of Emergency Medicine - August 25, 2016 Category: Emergency Medicine Source Type: research

Postmortem computed tomography and magnetic resonance imaging facilitates forensic autopsy in a fatal case of poisoning with formic acid, diphenhydramine, and ethanol
Abstract A case of fatal poisoning by ingesting formic acid, diphenhydramine, and ethanol by a 25-year-old woman who committed suicide is presented. Prior to autopsy, postmortem computed tomography and postmortem magnetic resonance tomography were performed and revealed severe damage to the stomach, the left thoracic wall, and parts of the liver. Imaging detected acid-induced fluid–fluid level within the thoracic cavity (fat-equivalent fluid and necrotic pleural effusion). This case report illustrates that postmortem cross-sectional imaging may facilitate dissection of severely damaged or complex regions, and ma...
Source: Forensic Science, Medicine, and Pathology - July 18, 2016 Category: Forensic Medicine Source Type: research

Intravenous lipid-emulsion therapy in a patient with cardiac arrest after overdose of diphenhydramine
Publication date: Available online 12 July 2016 Source:Journal of the Formosan Medical Association Author(s): Jiun-Hao Yu, Dong-Yi Chen, Hsien-Yi Chen, Kuo-Hua Lee (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - July 14, 2016 Category: Journals (General) Source Type: research

Intravenous lipid-emulsion therapy in a patient with cardiac arrest after overdose of diphenhydramine.
PMID: 27421174 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - July 12, 2016 Category: Journals (General) Authors: Yu JH, Chen DY, Chen HY, Lee KH Tags: J Formos Med Assoc Source Type: research

Prasugrel hypersensitivity with respiratory distress and rash.
CONCLUSION: A patient who had undergone PCI with stenting developed shortness of breath and rash associated with prasugrel therapy. Symptoms abated after supportive therapy and discontinuation of prasugrel, the probable offending agent. Treatment was safely switched to ticagrelor. PMID: 27385702 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - July 8, 2016 Category: Drugs & Pharmacology Authors: Kaufman MB, Pham T, Parameswaran L, Choy M Tags: Am J Health Syst Pharm Source Type: research

Unusual stacking with electrokinetic injection of cationic analytes from micellar solutions in capillary zone electrophoresis.
Abstract Electrokinetic injection (EKI) in capillary zone electrophoresis (CZE) of charged analytes is by the electroosmotic flow (EOF) and electrophoretic mobility of analytes. In most forms of stacking with EKI, the sample ions were introduced via electrophoretic mobility and concentrated in a stacking boundary inside the capillary. In this work, we describe the unusual stacking of cationic analytes via EKI of sodium dodecyl sulfate (SDS) micelles into a fused silica capillary filled with acidic background solution (BGS) with 40-50 % acetonitrile. The analytes prepared with SDS micelles were injected because of...
Source: Analytical and Bioanalytical Chemistry - July 2, 2016 Category: Chemistry Authors: Wuethrich A, Quirino JP Tags: Anal Bioanal Chem Source Type: research

The Use of a Pediatric Migraine Practice Guideline in an Emergency Department Setting
Conclusions: Our MCPG was clinically safe and effective in treating children with acute migraine headaches. Our data add to the dearth of existing published literature on migraine treatment protocols in the ED setting. We recommend additional prospective and comparative studies to further evaluate the effectiveness of our protocol in this patient population. (Source: Pediatric Emergency Care)
Source: Pediatric Emergency Care - July 1, 2016 Category: Emergency Medicine Tags: Original Articles Source Type: research

The Hydroalcoholic Extract of Leaves of Mandevilla moricandiana Induces NO-Mediated Vascular Relaxation
Planta MedDOI: 10.1055/s-0042-108203Natural products extracted from plants represent a valuable source of new bioactive substances. Many studies describe the potential of plant products for the treatment of cardiovascular diseases. Species of the Mandevilla genus have been studied for their biological activities, mainly as antioxidant, anti-inflammatory, and vasorelaxant. However, the phytochemical and pharmacological profiles of Mandevilla moricandiana have not been investigated yet. The aim of this study was to evaluate the vasodilator effect of the hydroalcoholic extract of the leaves of M. moricandiana, as well as its...
Source: Planta Medica - June 10, 2016 Category: Drugs & Pharmacology Authors: Ferreira, Letícia Lima Dias MoreiraGomes, Márcio ViníciusPaes, Bruno Meirellesdo Carmo, Paula LimaKonno, Tatiana Ungaretti PaleoEsteves, Francisco de AssisLopes, Norberto PeporineTomaz, José CarlosLeal, Ivana Correa RamosGuimarães, Denise OliveiraMuz Tags: Original Papers Source Type: research

Anaphylaxis and Intravenous Iron Products
In Reply In response to Dr DeLoughery’s concern about diphenhydramine, provided is a sensitivity analysis that excluded all anaphylaxis cases with the claim of “injection of diphenhydramine” (Table 1). Results are consistent with the primary analysis. (Source: JAMA)
Source: JAMA - May 24, 2016 Category: Journals (General) Source Type: research