Log in to search using one of your social media accounts:

This page shows you the latest research publications in this category.

Anti-inflammatory choline based ionic liquids: Insights into their lipophilicity, solubility and toxicity parameters
Publication date: April 2017 Source:Journal of Molecular Liquids, Volume 232 Author(s): Ana M.O. Azevedo, Susana P.F. Costa, Ana F.V. Dias, Alexandre H.O. Marques, Paula C.A.G. Pinto, Katharina Bica, Anna K. Ressmann, Marieta L.C. Passos, André R.T.S. Araújo, Salette Reis, M. Lúcia M.F.S. Saraiva The impact on in vivo efficacy and safety of two novel ionic liquids based on the association of choline with non-steroidal anti-inflammatory drugs, ketoprofen and naproxen forming IL-APIs, was evaluated. Their lipophilicity, solubility and toxicity were assessed aiming the illustration of the pharmaceutical profile and potent...
Source: Journal of Molecular Liquids - February 24, 2017 Category: Molecular Biology Source Type: research

COX-2-dependent and independent effects of COX-2 inhibitors and NSAIDs on proatherogenic changes in human monocytes/macrophages
It is the second decade of controversy regarding the cardiovascular effects of cyclo-oxygenase-2 (COX-2) inhibitors. At this time, celecoxib is the only available COX-2-specific inhibitor for treatment of pain and inflammation. Therefore, the present study was designed primarily to determine the impact of celecoxib on cholesterol handling (uptake via scavenger receptors and efflux from the cells) and foam cell formation in human THP-1 macrophages, followed by comparison to rofecoxib and other non-steroidal anti-inflammatory drugs (NSAIDs). THP-1 human macrophages and peripheral blood mononuclear cells were incubated with: ...
Source: Journal of Investigative Medicine - February 23, 2017 Category: Research Authors: Voloshyna, I., Kasselman, L. J., Carsons, S. E., Littlefield, M. J., Gomolin, I. H., De Leon, J., Reiss, A. B. Tags: Original research Source Type: research

Evaluation of para-aminosalicylic acid (PAS) as a substrate of multiple solute carrier (SLC) uptake transporters and possible drug-interactions with NSAIDs, in vitro.
In this study, PAS was found to be a novel substrate of several transporters, and drugs that inhibit these transporters can reduce PAS elimination. PMID: 28223391 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - February 21, 2017 Category: Microbiology Authors: Parvez MM, Shin HJ, Jung JA, Shin JG Tags: Antimicrob Agents Chemother Source Type: research

Characterization and regulated naproxen release of hydroxypropyl cyclosophoraose-pullulan microspheres
Publication date: 25 April 2017 Source:Journal of Industrial and Engineering Chemistry, Volume 48 Author(s): Jae Min Choi, Benel Lee, Daham Jeong, Kyeong Hui Park, Eun-Ji Choi, Yong-Joon Jeon, Someshwar D. Dindulkar, Eunae Cho, Sun Hee Do, Kyungho Lee, Im-Soon Lee, Seyeon Park, Bong-Hyun Jun, Jae-Hyuk Yu, Seunho Jung Hydroxypropyl cyclosophoraose-pullulan (HPCys-Pul) microspheres were designed as a novel hybrid system of biocompatible pullulan matrice and pendant hydroxypropyl cyclosophoraoses with drug complexing ability. The HPCys-Pul microspheres were prepared by emulsion crosslinking method, and characterized using th...
Source: Journal of Industrial and Engineering Chemistry - February 20, 2017 Category: Chemistry Source Type: research

Pharmaceutical biological degradation, sorption and mass balance determination in a conventional activated-sludge wastewater treatment plant from Murcia, Spain
Publication date: 15 May 2017 Source:Chemical Engineering Journal, Volume 316 Author(s): Isabel Martínez-Alcalá, José Manuel Guillén-Navarro, Carmen Fernández-López Pharmaceutical compounds are being detected widely in the aquatic environment due to their global consumption. Some ecotoxicological studies have revealed their implication in different toxic effects and the only mechanism available nowadays to combat with this problem are the wastewater treatment plants, which in function of the system employed seem to be more successful in the pharmaceuticals degradation. The contribution of adsorption and bio-degradat...
Source: Chemical Engineering Journal - February 11, 2017 Category: Chemistry Source Type: research

Reactive Melt Extrusion To Improve the Dissolution Performance and Physical Stability of Naproxen Amorphous Solid Dispersions
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.6b00960 (Source: Molecular Pharmaceutics)
Source: Molecular Pharmaceutics - February 10, 2017 Category: Drugs & Pharmacology Authors: Xu Liu, Lin Zhou and Feng Zhang Source Type: research

Diazepam Is No Better Than Placebo When Added to Naproxen for Acute Low Back Pain
Conclusion Among ED patients with acute, nontraumatic, nonradicular low back pain, naproxen+diazepam did not improve functional outcomes or pain compared with naproxen+placebo 1 week and 3 months after ED discharge. (Source: Annals of Emergency Medicine)
Source: Annals of Emergency Medicine - February 8, 2017 Category: Emergency Medicine Source Type: research

Improved tolerance to transplanting injury and chilling stress in rice seedlings treated with orysastrobin
Publication date: Available online 7 February 2017 Source:Plant Physiology and Biochemistry Author(s): Naoto Takahashi, Yukari Sunohara, Masami Fujiwara, Hiroshi Matsumoto In addition to their fungicidal activity, strobilurin-type fungicides are reported to show enhancing effects on crop growth and yield. Previous studies suggested that the fungicide has a mitigating effect on abiotic stresses. However, there are few reports about growth enhancement through abiotic stress alleviation by strobilurin-type fungicides, but the mechanism of action of the growth enhancement is still not clear. The present study revealed that or...
Source: Plant Physiology and Biochemistry - February 8, 2017 Category: Biochemistry Source Type: research

Eudragit( ®) RL as a stabilizer for supersaturation and a substrate for nanocrystal formation.
Eudragit(®) RL as a stabilizer for supersaturation and a substrate for nanocrystal formation. Eur J Pharm Biopharm. 2017 Feb 08;: Authors: Dereymaker A, Cinghia G, Van den Mooter G Abstract In order to optimize supersaturation levels and avoid early drug precipitation, Eudragit(®) RL was tested as a carrier in solid dispersions, either alone or in combination with a hydrophilic polymer (PVP K25). In vitro dissolution performance of the spray dried solid dispersions was tested. The phase behavior of the produced solid dispersions was analyzed as well as dissolution precipitates. In case of weak acid ...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 8, 2017 Category: Drugs & Pharmacology Authors: Dereymaker A, Cinghia G, Van den Mooter G Tags: Eur J Pharm Biopharm Source Type: research

Structure and physicochemical characterization of a naproxen – picolinamide cocrystal
Naproxen (NPX) is a nonsteroidal anti-inflammatory drug with pain- and fever-relieving properties, currently marketed in the sodium salt form to overcome solubility problems; however, alternative solutions for improving its solubility across all pH values are desirable. NPX is suitable for cocrystal formation, with hydrogen-bonding possibilities via the COOH group. The crystal structure is presented of a 1:1 cocrystal of NPX with picolinamide as a coformer [systematic name: (S)-2-(6-methoxynaphthalen-2-yl)propanoic acid – pyridine-2-carboxamide (1/1), C14H14O3 · C6H6N2O]. The pharmaceutically relevant physical propertie...
Source: Acta Crystallographica Section C - February 6, 2017 Category: Chemistry Authors: Kerr, H.E. Softley, L.K. Suresh, K. Hodgkinson, P. Evans, I.R. Tags: naproxen picolinamide cocrystal NMR crystallography DFT analysis hydrogen bonding crystal structure pharmaceuticals dimers computational chemistry research papers Source Type: research

Sorption and desorption of selected non-steroidal anti-inflammatory drugs in an agricultural loam-textured soil.
This study suggests that cooperative adsorption plays a role in the interaction of NSAIDs when present as mixtures rather than as individual compounds. PMID: 28199939 [PubMed - as supplied by publisher] (Source: Chemosphere)
Source: Chemosphere - February 6, 2017 Category: Chemistry Authors: Zhang Y, Price GW, Jamieson R, Burton D, Khosravi K Tags: Chemosphere Source Type: research

Mass spectrometry based in  vitro assay investigations on the transformation of pharmaceutical compounds by oxidative enzymes.
In conclusion, the enzymatic treatment approach worked selectively and efficiently for a few pharmaceuticals. However, for application the investigation and possibly immobilization of multiplex enzymes being able to transform diverse chemical structures is recommended. PMID: 28189026 [PubMed - as supplied by publisher] (Source: Chemosphere)
Source: Chemosphere - February 2, 2017 Category: Chemistry Authors: Stadlmair LF, Letzel T, Drewes JE, Graßmann J Tags: Chemosphere Source Type: research

Abstract A25: Inhibition or delay of microadenoma development by atorvastatin, naproxen and ED-71 in mice genetically predisposed to colorectal adenomas
Previous studies by this group demonstrate the ability of chemopreventive agents to differentially inhibit morphological subtypes (flat and polypoid) of colorectal adenomas. Recent efforts have focused on the response of microadenomas, a lesion not routinely evaluated by others, to therapeutic intervention. Microadenomas, or dysplastic aberrant crypt foci (ACFs), are direct precursors of colorectal adenomas and represent the earliest microscopic aberration that can be detected prior to colon tumor formation. The goal of the present study was to: 1) characterize the incidence and multiplicity of microadenomas (≤4 crypts) ...
Source: Cancer Research - January 31, 2017 Category: Cancer & Oncology Authors: Wen-Chi L. Chang, Harry S. Cooper, Harvey Hensley, Tianyu Li, Karthik Devarajan, Margie L. Clapper Tags: Prevention Source Type: research

Comparison of rectal indomethacin, diclofenac, and naproxen for the prevention of post endoscopic retrograde cholangiopancreatography pancreatitis
Conclusion: Diclofenac and indomethacin patient groups had a lower incidence of PEP than the naproxen group. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - January 28, 2017 Category: Gastroenterology Tags: Original Articles: Endoscopy Source Type: research

Therapy: Cardiovascular safety of celecoxib, naproxen and ibuprofen
Nature Reviews Rheumatology 13, 136 (2017). doi:10.1038/nrrheum.2017.4 Author: Michael T. Nurmohamed The PRECISION trial demonstrates that celecoxib is noninferior to ibuprofen and naproxen in regard to cardiovascular safety. Do these findings mark the end of the debate on this issue, or do aspects of the trial mean the implications for clinical practice are not clear-cut? (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - January 27, 2017 Category: Rheumatology Authors: Michael T. Nurmohamed Tags: News and Views Source Type: research

Nonsteroidal anti-inflammatory drugs for pain in women with endometriosis.
CONCLUSIONS: Owing to lack of high-quality evidence and lack of reporting of outcomes of interest for this review, we can make no judgement as to whether NSAIDs (naproxen) are effective in managing pain caused by endometriosis. No evidence shows whether any individual NSAID is more effective than another. As shown in other Cochrane reviews, women taking NSAIDs must be aware that these drugs may cause unintended effects. PMID: 28114727 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - January 23, 2017 Category: Journals (General) Authors: Brown J, Crawford TJ, Allen C, Hopewell S, Prentice A Tags: Cochrane Database Syst Rev Source Type: research

Molecules, Vol. 22, Pages 185: Alkylglycerol Derivatives, a New Class of Skin Penetration Modulators
The absorption modulating activity of two alkylglycerol derivatives (batyl and chimyl alcohol) on skin barrier properties was evaluated. Biophysical tests such as transepidermal water loss (TEWL) and attenuated total reflectance –Fourier transform infrared (ATR-FTIR) spectroscopy, as well as in vitro skin permeation studies, were performed in order to determine the effect of these compounds as chemical absorption modulators. Four drugs were used as models: three NSAIDS (diclofenac, naproxen, and piroxicam) and glycyrrhizi c acid. The results showed that treatment of the skin with alkylglycerols caused (i) a reduction on ...
Source: Molecules - January 22, 2017 Category: Chemistry Authors: Sergio Bernal-Ch ávez Lilia P érez-Carreto Mar ía Nava-Arzaluz Adriana Ganem-Rondero Tags: Article Source Type: research

Synthesis and anti-inflammatory effects of a series of novel 9- O -substituted berberine derivatives
AbstractBerberine owns multiple pharmacological activities, especially anti-inflammatory activity. To enhance the anti-inflammatory therapeutic efficiency of berberine, a series of novel 9-O-substituted berberine derivatives (5a–5d) were synthesized and their anti-inflammatory activities were evaluated.13C-NMR,1H-NMR, IR and high resolution mass spectrum (HRMS) results indicated that these derivatives were successfully synthesized. The xylene-induced inflammatory mice model demonstrated that these derivatives showed dose-dependent inhibition of ear inflammatory swelling. Comparing to berberine, ibuprofen and naproxen-mod...
Source: Medicinal Chemistry Research - January 20, 2017 Category: Chemistry Source Type: research

Sub-chronic toxicological studies of transition metal complexes of naproxen on sprague-dawley rats
Conclusion In the present investigation, there were no significant alterations in histopathological studies and physical parameters though some signs of abnormalities had been found but hematological and hormonal data did not suggest any inflammatory or toxicological activity. However, we observed that naproxen showed more side effects than metal complexes which indicated that carboxylic group (COOH) of naproxen may be responsible for showing those most of the side effects. (Source: Alexandria Journal of Medicine)
Source: Alexandria Journal of Medicine - January 19, 2017 Category: Journals (General) Source Type: research

Surface-mounted MOF templated fabrication of homochiral polymer thin film for enantioselective adsorption of drugs.
This study opened a SURMOF-templated approach for preparing porous polymer thin films. PMID: 28093585 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - January 17, 2017 Category: Chemistry Authors: Gu ZG, Fu WQ, Liu M, Zhang J Tags: Chem Commun (Camb) Source Type: research

Bar adsorptive microextraction technique - application for the determination of pharmaceuticals in real matrices.
Abstract In the present work, bar adsorptive microextraction using miniaturized devices (7.5 × 3.0 mm) coated with suitable sorbent phases, combined with microliquid desorption (100 μL) followed by high-performance liquid chromatography with diode array detection (BAμE-μLD/HPLC-DAD), is proposed for the determination of trace level of six pharmaceuticals (furosemide, mebeverine, ketoprofen, naproxen, diclofenac and mefenamic acid) in environmental water and urine matrices. By comparing ten distinct sorbent materials (five polymeric and five activated carbons), the polymer P5 proved to be the most suitabl...
Source: Analytical and Bioanalytical Chemistry - January 16, 2017 Category: Chemistry Authors: Almeida C, Ahmad SM, Nogueira JM Tags: Anal Bioanal Chem Source Type: research

Solvatochromism of antiinflammatory drug – naproxen sodium
Publication date: March 2017 Source:Journal of Molecular Liquids, Volume 230 Author(s): Marta M. Miotke, Marek Józefowicz The influence of non-specific and specific solute-solvent interactions on the popular nonsteroidal antiinflammatory drug – naproxen sodium (NAP) – solvatochromism has been studied using steady-state spectroscopic technique combined with quantum-chemical modeling. To interpret the microenvironment (solvent) effects, the established linear solvation energy relationships of Kamlet-Taft and the improved Catalán scales are used. This analysis reveals that NAP solvation is mainly determined by dipolar ...
Source: Journal of Molecular Liquids - January 15, 2017 Category: Molecular Biology Source Type: research

Evaluation of Pharmacokinetic Interactions Between Lesinurad, a New Selective Urate Reabsorption Inhibitor, and Commonly Used Drugs for Gout Treatment
Abstract Lesinurad is a novel selective uric acid reabsorption inhibitor approved for treatment of hyperuricemia associated with gout in combination with xanthine oxidase inhibitors (XOIs). Open‐label pharmacokinetic studies were performed in volunteers or subjects with hyperuricemia (serum uric acid ≥ 8 mg/dL) to investigate interactions of lesinurad (with and without concurrent XOIs) with colchicine and 2 nonsteroidal anti‐inflammatory drugs: naproxen and indomethacin. Colchicine studies included consecutive 7‐day treatment periods of (1) allopurinol 300 mg, allopurinol 300 mg plus lesinurad 400 or 600 mg, and co...
Source: Clinical Pharmacology in Drug Development - January 11, 2017 Category: Drugs & Pharmacology Authors: Zancong Shen, Kathy Tieu, David Wilson, Gail Bucci, Michael Gillen, Caroline Lee, Bradley Kerr Tags: Original Manuscript Source Type: research

Bioconversion of non-steroidal anti-inflammatory drugs diclofenac and naproxen by chloroperoxidase
We report a rapid and efficient conversion of diclofenac and naproxen by chloroperoxidase-catalyzed H2O2-oxidation, a heme protein isolated from Caldarimyces fumago. Complete conversion of diclofenac and naproxen was achieved in only 9 and 7min respectively with 0.1mmolL−1 H2O2 and nanomolar enzyme concentration at pH 3.0. The converted products were identified by HPLC–MS and NMR, suggesting involvement of multiple steps in CPO catalyzed conversion. Our work demonstrated that CPO treatment (with COD removal of 4.9%, 9.1% for diclofenac and naproxen, respectively) followed by existing bioremediation technologies (activa...
Source: Biochemical Engineering Journal - January 8, 2017 Category: Biochemistry Source Type: research

Development and evaluation of naproxen sodium gel using Piper cubeba for enhanced transdermal drug delivery and therapeutic facilitation.
CONCLUSION: It suggests P. cubeba as effective and safer tool for transdermal delivery and acts as therapeutic facilitator for naproxen. GC-MS analysis indicates lignans amp; terpenes in NHE to which this permeation enhancement activity may be attributed. PMID: 28056749 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - January 7, 2017 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Rates of Nonsteroidal Anti-Inflammatory Drug Use in Patients with Established Cardiovascular Disease: A Retrospective, Cross-Sectional Study from NHANES 2009 –2010
ConclusionsOur results indicate that there is still a large proportion of CVD patients using NSAIDs. It is now crucial to determine the reasons why prescribers are still prescribing NSAIDs despite the FDA warning. (Source: American Journal of Cardiovascular Drugs)
Source: American Journal of Cardiovascular Drugs - January 6, 2017 Category: Cardiology Source Type: research

Epiisopiloturine hydrochloride, an imidazole alkaloid isolated from Pilocarpus microphyllus leaves, protects against naproxen-induced gastrointestinal damage in rats
Conclusion Our data show that EPI protects against NAP-induced gastric and intestinal damage by reducing pro-inflammatory cytokines, reducing oxidative stress, and increasing GMBF. Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - January 3, 2017 Category: Drugs & Pharmacology Source Type: research

Epiisopiloturine hydrochloride, an imidazole alkaloid isolated from Pilocarpus microphyllus leaves, protects against naproxen-induced gastrointestinal damage in rats.
CONCLUSION: Our data show that EPI protects against NAP-induced gastric and intestinal damage by reducing pro-inflammatory cytokines, reducing oxidative stress, and increasing GMBF. PMID: 28056423 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 2, 2017 Category: Drugs & Pharmacology Authors: Nicolau LA, Carvalho NS, Pacífico DM, Lucetti LT, Aragão KS, Véras LM, Souza MH, Leite JR, Medeiros JV Tags: Biomed Pharmacother Source Type: research

Simultaneous enantiomeric analysis of pharmacologically active compounds in environmental samples by chiral LC ‐MS/MS with a macrocyclic antibiotic stationary phase
This paper presents a multi‐residue method for direct enantioselective separation of chiral pharmacologically active compounds in environmental matrices. The method is based on chiral liquid chromatography and tandem mass spectrometry detection. Simultaneous chiral discrimination was achieved with a macrocyclic glycopeptide‐based column with antibiotic teicoplanin as a chiral selector working under reverse phase mode. For the first time, enantioresolution was reported for metabolites of ibuprofen: carboxyibuprofen and 2‐hydroxyibuprofen with this chiral stationary phase. Moreover, enantiomers of chloramphenicol, ibup...
Source: Journal of Mass Spectrometry - January 1, 2017 Category: Chemistry Authors: D. Camacho ‐Muñoz, B. Kasprzyk‐Hordern Tags: Research article Source Type: research

Studying of crystal growth and overall crystallization of naproxen from binary mixtures.
Abstract Broadband dielectric spectroscopy (BDS) and differential scanning calorimetry (DSC) were applied to investigate the molecular dynamics and phase transitions in binary mixtures composed of naproxen (NAP) and acetylated saccharides: maltose (acMAL) and sucrose (acSUC). Moreover, the application of BDS method and optical microscopy enabled us to study both crystallization kinetics and crystal growth of naproxen from the solid dispersions with the highest content of modified carbohydrates (1:5 weight ratio). It was found that the activation barriers of crystallization estimated from dielectric measurements ar...
Source: European Journal of Pharmaceutics and Biopharmaceutics - December 26, 2016 Category: Drugs & Pharmacology Authors: Kaminska E, Madejczyk O, Tarnacka M, Jurkiewicz K, Kaminski K, Paluch M Tags: Eur J Pharm Biopharm Source Type: research

Herb-drug interaction of Andrographis paniculata (Nees) extract and andrographolide on pharmacokinetic and pharmacodynamic of naproxen in rats
Conclusion The results obtained from this study suggested that NP, APE and pure AN existed pharmacokinetic herb–drug interactions in rat which is correlated with anti-arthritic study. The knowledge regarding possible herb–drug interaction of NP might be helpful for physicians as well as patients using AP. So further studies should be done to understand the effect of other herbal ingredients of APE on NP as well as to predict the herb–drug interaction in humans. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - December 25, 2016 Category: Drugs & Pharmacology Source Type: research

Characterization and optimization of low cost microfluidic thread based electroanalytical device for micro flow injection analysis.
Abstract The micro flow injection analysis (μFIA) is a powerful technique that uses the principles of traditional flow analysis in a microfluidic device and brings a number of improvements related to the consumption of reagents and samples, speed of analysis and portability. However, the complexity and cost of manufacturing processes, difficulty in integrating micropumps and the limited performance of systems employing passive pumps are challenges that must be overcome. Here, we present the characterization and optimization of a low cost device based on cotton threads as microfluidic channel to perform μFIA base...
Source: Analytica Chimica Acta - December 23, 2016 Category: Chemistry Authors: Agustini D, Bergamini MF, Marcolino-Junior LH Tags: Anal Chim Acta Source Type: research

Synthesis, characterization and pharmacological evaluation of certain enzymatically cleavable NSAIDs amide prodrugs.
Abstract The presence of free carboxylic acid group in majority of non-steroidal anti-inflammatory drug (NSAIDs) is responsible from GI irritation. Coupling of the appropriate NSAIDs (diclofenac, naproxen, dexibuprofen and meclofenamic acid) 1-4, respectively with the appropriate amino acid ester 5 using dicyclohexylcarbodiimide afforded prodrugs 6-13. The structures of the prodrugs were verified based on spectral data. Chemical hydrolysis studies performed in three different non enzymatic buffer solutions at pH 1.2, 5.5 and 7.4, as well as in 80% human plasma and 10% rat liver homogenate using HPLC indicate no co...
Source: Bioorganic Chemistry - December 23, 2016 Category: Chemistry Authors: Elsaman T, Aldeeb OA, Aboul-Fadl T, Hamedelneil EI Tags: Bioorg Chem Source Type: research

Online Spectroscopic Monitoring of Drug Release Kinetics from Nanostructured Dual-Stimuli-Responsive Conducting Polymer
ConclusionThe electronic properties of the conducting polymer has an important role in release kinetics, there might be a single mechanism with the same limiting step. In addition, it was demonstrated the rate of drug release from DDPPy dramatically depends on the amounts as well as modes of applying potential which provides enhanced control of drug-release kinetics which can be accelerated or even sustained. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - December 22, 2016 Category: Drugs & Pharmacology Source Type: research

Central nervous system toxicity of mefenamic acid overdose compared with other NSAIDs: an analysis of cases reported to the United Kingdom National Poisons Information Service
ConclusionsMefenamic acid overdose is associated with a much larger and dose‐related risk of CNS toxicity, especially convulsions, compared with overdose of other NSAIDs. The benefit–risk profile of mefenamic acid should now be re‐evaluated in light of effective and less toxic alternatives. (Source: British Journal of Clinical Pharmacology)
Source: British Journal of Clinical Pharmacology - December 22, 2016 Category: Drugs & Pharmacology Authors: Ashraf Kamour, Siobhan Crichton, Gill Cooper, David J. Lupton, Michael Eddleston, J. Allister Vale, John P. Thompson, Simon H. L. Thomas Tags: HUMAN TOXICOLOGY Source Type: research

Naproxen Microparticulate Systems Prepared Using In Situ Crystallisation and Freeze-Drying Techniques.
Abstract Poor drug solubility and dissolution rate remain to be one of the major problems facing pharmaceutical scientists, with approximately 40% of drugs in the industry categorised as practically insoluble or poorly water soluble. This in turn can lead to serious delivery challenges and poor bioavailability. The aim of this research was to investigate the effects of the surfactants, poloxamer 407 (P407) and caprol® PGE 860 (CAP), at various concentrations (0.1, 0.5, 1 and 3% w/v) on the enhancement of the dissolution properties of poorly water-soluble drug, naproxen, using in situ micronisation by solvent chan...
Source: AAPS PharmSciTech - December 21, 2016 Category: Drugs & Pharmacology Authors: Solaiman A, Tatari AK, Elkordy AA Tags: AAPS PharmSciTech Source Type: research

Preconception use of pain-relievers and time-to-pregnancy: a prospective cohort study
This study was supported through funds provided by National Institute of Child Health and Human Development, National Institute of Health (R21 HD072326, T32 HD052458). The authors have no conflicts of interest to disclose. TRIAL REGISTRATION NUMBER Not applicable. (Source: Human Reproduction)
Source: Human Reproduction - December 18, 2016 Category: Reproduction Medicine Authors: McInerney, K. A., Hatch, E. E., Wesselink, A. K., Rothman, K. J., Mikkelsen, E. M., Wise, L. A. Tags: Infertility Source Type: research

In vitro antiglioma action of indomethacin is mediated via AMP-activated protein kinase/mTOR complex 1 signalling pathway.
Abstract We investigated the role of the intracellular energy-sensing AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) pathway in the in vitro antiglioma effect of the cyclooxygenase (COX) inhibitor indomethacin. Indomethacin was more potent than COX inhibitors diclofenac, naproxen, and ketoprofen in reducing the viability of U251 human glioma cells. Antiglioma effect of the drug was associated with p21 increase and G2M cell cycle arrest, as well as with oxidative stress, mitochondrial depolarization, caspase activation, and the induction of apoptosis. Indomethacin increased the phosphoryla...
Source: The International Journal of Biochemistry and Cell Biology - December 14, 2016 Category: Biochemistry Authors: Pantovic A, Bosnjak M, Arsikin K, Kosic M, Mandic M, Ristic B, Tosic J, Grujicic D, Isakovic A, Micic N, Trajkovic V, Harhaji-Trajkovic L Tags: Int J Biochem Cell Biol Source Type: research

Efficacy of naproxen with or without esomeprazole for pain and inflammation in patients after bilateral third molar extractions: A double blinded crossover study.
CONCLUSIONS: In conclusion, throughout the entire study, pain was mild after using either drug in both men and women with pain scores on average well below 40mm (VAS), although in women naproxen improved acute postoperative pain management when compared to NE. PMID: 27918744 [PubMed - as supplied by publisher] (Source: Medicina Oral, Patologia Oral y Cirugia Bucal)
Source: Medicina Oral, Patologia Oral y Cirugia Bucal - December 7, 2016 Category: ENT & OMF Tags: Med Oral Patol Oral Cir Bucal Source Type: research

Calculated Resonance Vibrational Raman Optical Activity Spectra of Naproxen and Ibuprofen
The Journal of Physical Chemistry ADOI: 10.1021/acs.jpca.6b09975 (Source: Journal of Physical Chemistry A)
Source: Journal of Physical Chemistry A - December 5, 2016 Category: Chemistry Authors: Florian Krausbeck, Jochen Autschbach and Markus Reiher Source Type: research

Zeolite catalyzed highly selective synthesis of 2-methoxy-6-acetylnaphthalene by Friedel-Crafts acylation of 2-methoxynaphthalene in acetic acid reaction media
Publication date: January 2017 Source:Journal of Molecular Catalysis A: Chemical, Volume 426, Part A Author(s): Tomoyoshi Yamazaki, Makoto Makihara, Kenichi Komura Zeolite catalyzed Friedel-Crafts acetylation of 2-methoxynaphthalene to produce 2-methoxy-6-acetylnaphthalene with high selectivity and conversion has been a challenging task, because the obtained compound is a key intermediate for an anti-inflammatory agent, Naproxen. However, no satisfactory results have been obtained with zeolite catalysts, and harmful solvents have been used to gain a high selectivity together with a high conversion. Here, we report the syn...
Source: Journal of Molecular Catalysis A: Chemical - December 3, 2016 Category: Chemistry Source Type: research

Menstrual Migraine and Treatment Options: Review
ConclusionMM can be very difficult to treat. For acute treatments, rizatriptan has the best overall evidence. For short‐term prevention, frovatriptan, zolmitriptan, or naratriptan, as well as magnesium, estrogen, naproxen sodium, or dihydroergotamine may be useful. (Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - December 2, 2016 Category: Neurology Authors: Kasra Maasumi, Stewart J. Tepper, Jennifer S. Kriegler Tags: Review Article Source Type: research

Menstrual Migraine and Treatment Options: Review.
CONCLUSION: MM can be very difficult to treat. For acute treatments, rizatriptan has the best overall evidence. For short-term prevention, frovatriptan, zolmitriptan, or naratriptan, as well as magnesium, estrogen, naproxen sodium, or dihydroergotamine may be useful. PMID: 27910087 [PubMed - as supplied by publisher] (Source: Headache)
Source: Headache - December 2, 2016 Category: Neurology Authors: Maasumi K, Tepper SJ, Kriegler JS Tags: Headache Source Type: research

Fatty Acid Binding to the Allosteric Subunit of Cyclooxygenase-2 Relieves a Tonic Inhibition of the Catalytic Subunit [Enzymology]
We report here that movement of helical residues 120–122 and loop residues 123–129 of Eallo underlies the allosteric effects of FAs and allosteric COX-2 inhibitors, including naproxen and flurbiprofen. An S121P substitution in both PGHS-2 monomers yields a variant (S121P/S121P PGHS-2) that has 1.7–1.8 times the Vmax of native PGHS-2 and is relatively insensitive to activation by FAs or inhibition by allosteric inhibitors. The S121P substitution in Eallo is primarily responsible for these effects. In X-ray crystal structures, the Cα atoms of helical residues 119–122 of S121P/S121P PGHS-2 are displaced from their no...
Source: Journal of Biological Chemistry - December 2, 2016 Category: Chemistry Authors: Liang Dong, Chong Yuan, Benjamin J. Orlando, Michael G. Malkowski, William L. Smith Tags: Lipids Source Type: research

A review of the occurrence of pharmaceuticals and personal care products in Indian water bodies.
Abstract Little information exists on the occurrence and the ultimate fate of pharmaceuticals in the water bodies in India despite being one of the world leaders in pharmaceutical production and consumption. This paper has reviewed 19 published reports of pharmaceutical occurrence in the aquatic environment in India [conventional activated sludge wastewater treatment plants (WTPs), hospital WTPs, rivers, and groundwater]. Carbamazepine (antipsychoactive), atenolol (antihypertensive), triclocarban and triclosan (antimicrobials), trimethoprim and sulfamethoxazole (antibacterials), ibuprofen and acetaminophen (analge...
Source: Ecotoxicology and Environmental Safety - December 1, 2016 Category: Environmental Health Authors: Balakrishna K, Rath A, Praveenkumarreddy Y, Guruge KS, Subedi B Tags: Ecotoxicol Environ Saf Source Type: research

Non ‐steroidal anti‐inflammatory drug‐induced cardiovascular adverse events: a meta‐analysis
Summary What is known and objectiveAlthough non‐steroidal anti‐inflammatory drugs (NSAIDs) have been studied in randomized, controlled trials and meta‐analyses in an effort to determine their cardiovascular (CV) risks, no consensus has been reached. These studies continue to raise questions, including whether cyclooxygenase‐2 (COX‐2) selectivity plays a role in conferring CV risk. We performed a meta‐analysis of current literature to determine whether COX‐2 selectivity leads to an increased CV risk. MethodsWe utilized randomized, controlled trials and prospective cohort studies. We selected eight NSAIDs based...
Source: Journal of Clinical Pharmacy and Therapeutics - December 1, 2016 Category: Drugs & Pharmacology Authors: B. R. Gunter, K. A. Butler, R. L. Wallace, S. M. Smith, S. Harirforoosh Tags: Review Article Source Type: research

Celecoxib Safety Revisited
Date: December 19, 2016 Issue #:  1510Summary:  The results of a clinical trial (PRECISION) comparing the cardiovascular safety of the COX-2 selective NSAID celecoxib (Celebrex, and generics) with that of ibuprofen and naproxen, which are nonselective, have been described in the lay press in terms that may overestimate the safety of celecoxib. (Source: The Medical Letter)
Source: The Medical Letter - November 30, 2016 Category: Drugs & Pharmacology Authors: admin Source Type: research

Enantiomeric Resolution of (RS)-Naproxen and application of (S)-Naproxen in the direct and indirect enantioseparation of racemic compounds by liquid chromatography: A review.
Abstract (S)-Naproxen (Npx), an α-aryl propionic acid derivative, belongs to class of Non-Steroidal Anti-Inflammatory Drugs and is easily available in pure (S)-form. (S)-Npx has been used as a chiral selector for chromatographic separation of a variety of racemates, using both direct and indirect methods, and has been found to be useful and successful as a basic chiral moiety. This review article describes methods for enantioseparation of (RS)-Npx, development of chiral stationary phases based on (S)-Npx and preparation of novel chiral derivatizing reagents synthesized from (S)-Npx along with their application fo...
Source: Current Medicinal Chemistry - November 28, 2016 Category: Chemistry Authors: Batra S, Bhushan R Tags: Curr Med Chem Source Type: research

Estimating population size in wastewater-based epidemiology. Valencia metropolitan area as a case study
Publication date: 5 February 2017 Source:Journal of Hazardous Materials, Volume 323, Part A Author(s): María Rico, María Jesús Andrés-Costa, Yolanda Picó Wastewater can provide a wealth of epidemiologic data on common drugs consumed and on health and nutritional problems based on the biomarkers excreted into community sewage systems. One of the biggest uncertainties of these studies is the estimation of the number of inhabitants served by the treatment plants. Twelve human urine biomarkers —5-hydroxyindoleacetic acid (5-HIAA), acesulfame, atenolol, caffeine, carbamazepine, codeine, cotinine, creatinine, hydrochloro...
Source: Journal of Hazardous Materials - November 26, 2016 Category: Environmental Health Source Type: research

Environmental fate of non-steroidal anti-inflammatory drugs in river water/sediment systems
Publication date: 5 February 2017 Source:Journal of Hazardous Materials, Volume 323, Part A Author(s): Elena Koumaki, Daniel Mamais, Constantinos Noutsopoulos Laboratory tests were conducted with four non-steroidal anti-inflammatory drugs (naproxen, ibuprofen, diclofenac and ketoprofen) under different redox conditions (aerobic, anoxic, anaerobic and sulfate-reducing conditions) in order to assess abiotic and biotic degradation in a river water/sediment system. The river water was sampled from Sperchios River and the sediment was collected from the banks of a rural stream where the discharge point of a wastewater treatmen...
Source: Journal of Hazardous Materials - November 26, 2016 Category: Environmental Health Source Type: research