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Therapy: Statin Therapy
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The effect of statins on the differentiation and function of central nervous system cells
Curr Med Chem. 2023 Mar 8. doi: 10.2174/0929867330666230308121645. Online ahead of print.ABSTRACTStatins (3-hydroxy-3-methylglutaryl-CoA reductase inhibitors) reduce plasma cholesterol and improve endothelium-dependent vasodilation, inflammation, and oxidative stress. The effect of statins on the central nervous system (CNS), particularly on cognition and neurological disorders such as cerebral ischemic stroke, multiple sclerosis (MS), and Alzheimer's disease (AD), has received increasing attention in recent years, both within the scientific community and in the media. This review aims to provide an updated discussion on t...
Source: Current Medicinal Chemistry - March 9, 2023 Category: Chemistry Authors: Sajjad Chamani Leila Mobasheri Shadi Zerehpoosh Ali Naghizadeh Alice P McCloskey Manfredi Rizzo Tannaz Jamialahmadi Amirhossein Sahebkar Source Type: research
Atherosclerotic patients with diabetes mellitus may break through the threshold of healthy TMAO levels formed by long-term statins therapy
CONCLUSION: Diabetics have abnormally high plasma TMAO levels even under continuous statins treatment, which may contribute to the development and progression of atherosclerosis. Therefore, it is necessary to focus on monitoring TMAO levels in diabetic patients to reduce adverse cardiovascular events in diabetic patients.PMID:36879744 | PMC:PMC9984437 | DOI:10.1016/j.heliyon.2023.e13657
Source: Atherosclerosis - March 7, 2023 Category: Cardiology Authors: Hao Liang Anqi Yu Zheng Wang Na Zhang Qingsong Wang Haichao Gao Junhui Gao Xinjun Wang Hong Wang Source Type: research
Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients
CONCLUSIONS: Among statin-intolerant patients, treatment with bempedoic acid was associated with a lower risk of major adverse cardiovascular events (death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke, or coronary revascularization). (Funded by Esperion Therapeutics; CLEAR Outcomes ClinicalTrials.gov number, NCT02993406.).PMID:36876740 | DOI:10.1056/NEJMoa2215024
Source: Atherosclerosis - March 6, 2023 Category: Cardiology Authors: Steven E Nissen A Michael Lincoff Danielle Brennan Kausik K Ray Denise Mason John J P Kastelein Paul D Thompson Peter Libby Leslie Cho Jorge Plutzky Harold E Bays Patrick M Moriarty Venu Menon Diederick E Grobbee Michael J Louie Chien-Feng Chen Na Li LeAn Source Type: research
Treat-to-Target or High-Intensity Statin in Patients With Coronary Artery Disease
This randomized clinical trial compares the efficacy of a treat-to-target low-density lipoprotein cholesterol (LDL-C) strategy of 50 to 70 mg/dL as the goal vs high-intensity statin therapy for the 3-year composite of death, myocardial infarction, stroke, or coronary revascularization in patients with coronary artery disease.
Source: JAMA - Journal of the American Medical Association - March 6, 2023 Category: General Medicine Source Type: research
Eliminating Medication Copayments for Low-income Older Adults at High Cardiovascular Risk: A Randomized Controlled Trial
Conclusions: In low-income adults at high cardiovascular risk, eliminating copayments (average $35 a month) did not improve clinical outcomes or reduce healthcare costs, despite a modest improvement in adherence to medications.PMID:36871215 | DOI:10.1161/CIRCULATIONAHA.123.064188
Source: Circulation - March 5, 2023 Category: Cardiology Authors: David J T Campbell Chad Mitchell Brenda R Hemmelgarn Marcello Tonelli Peter Faris Jianguo Zhang Ross T Tsuyuki Jane Fletcher Flora Au Scott Klarenbach Derek V Exner Braden J Manns Interdisciplinary Chronic Disease Collaboration Source Type: research
Self-management Support Using Advertising Principles for Older Low Income Adults at High Cardiovascular Risk: a Randomized Controlled Trial
Conclusions: In low-income older adults, a tailored SMES program using advertising principles reduced the rate of clinical outcomes compared with usual care, though the mechanisms of improvement are unclear and further studies are required.PMID:36871212 | DOI:10.1161/CIRCULATIONAHA.123.064189
Source: Circulation - March 5, 2023 Category: Cardiology Authors: David J T Campbell Marcello Tonelli Brenda R Hemmelgarn Peter Faris Jianguo Zhang Flora Au Ross T Tsuyuki Chad Mitchell Raj Pannu Tavis Campbell Noah Ivers Jane Fletcher Derek V Exner Braden J Manns Interdisciplinary Chronic Disease Collaboration Source Type: research
Eliminating Medication Copayments for Low-income Older Adults at High Cardiovascular Risk: A Randomized Controlled Trial
Conclusions: In low-income adults at high cardiovascular risk, eliminating copayments (average $35 a month) did not improve clinical outcomes or reduce healthcare costs, despite a modest improvement in adherence to medications.PMID:36871215 | DOI:10.1161/CIRCULATIONAHA.123.064188
Source: Circulation - March 5, 2023 Category: Cardiology Authors: David J T Campbell Chad Mitchell Brenda R Hemmelgarn Marcello Tonelli Peter Faris Jianguo Zhang Ross T Tsuyuki Jane Fletcher Flora Au Scott Klarenbach Derek V Exner Braden J Manns Interdisciplinary Chronic Disease Collaboration Source Type: research
Self-management Support Using Advertising Principles for Older Low Income Adults at High Cardiovascular Risk: a Randomized Controlled Trial
Conclusions: In low-income older adults, a tailored SMES program using advertising principles reduced the rate of clinical outcomes compared with usual care, though the mechanisms of improvement are unclear and further studies are required.PMID:36871212 | DOI:10.1161/CIRCULATIONAHA.123.064189
Source: Circulation - March 5, 2023 Category: Cardiology Authors: David J T Campbell Marcello Tonelli Brenda R Hemmelgarn Peter Faris Jianguo Zhang Flora Au Ross T Tsuyuki Chad Mitchell Raj Pannu Tavis Campbell Noah Ivers Jane Fletcher Derek V Exner Braden J Manns Interdisciplinary Chronic Disease Collaboration Source Type: research
Here ’s an Alternative to Statins for Lowering Cholesterol
Statins have revolutionized heart disease by lowering cholesterol effectively—by up to 50% or more. But anywhere from 7% to 29% of people who take them may be more susceptible to its side effects, which include weakening of muscles and pain, and decide they can’t tolerate them. In a recent study published in JAMA Network Open, for example, researchers at Brigham and Women’s Hospital reported that more than 20% of patients seen at the hospital from 2000 to 2018 who were recommended to take statins refused to take them, and those who refused took three times as long to lower their LDL cholesterol to target ...
Source: TIME: Health - March 4, 2023 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized healthscienceclimate heart health Source Type: news
Young Patients Undergoing Carotid Endarterectomy Have Increased Rates of Recurrent Disease and Late Neurologic Events
CONCLUSIONS: Young patients undergoing CEA are more likely to be African American, female, and active smokers. They are more likely to present symptomatically and undergo non-elective CEA. Although perioperative outcomes are similar, younger patients are more likely to experience carotid occlusion or restenosis as well as subsequent neurological events, during relatively short follow-up. These data suggest that younger CEA patients may require more diligent follow-up, and a continued aggressive approach to medical management of atherosclerosis to prevent future events related to the operated artery, given the particularly ...
Source: Atherosclerosis - March 4, 2023 Category: Cardiology Authors: Molly Ratner Karan Garg Heepeel Chang William Johnson Mikel Sadek Thomas Maldonado Neal Cayne Jeffrey Siracuse Glenn Jacobowitz Caron Rockman Source Type: research
Evaluation and subgroup analysis of the efficacy and safety of intensive rosuvastatin therapy combined with dual antiplatelet therapy in patients with acute ischemic stroke
ConclusionsWithout increasing bleeding and statin-associated adverse events, intensive rosuvastatin therapy plus 7-day DAPT significantly reduced the risk of recurrent stroke, especially for subgroups with high-risk factors.Clinical trial registration. China Clinical Trial Registration Center (ChiCTR1800017809).
Source: European Journal of Clinical Pharmacology - March 1, 2023 Category: Drugs & Pharmacology Source Type: research
Does aspirin have a place in primary cardiovascular prevention by the polypill ? Simulation study on a realistic virtual population
CONCLUSION: Until proven otherwise, aspirin has only a limited place in individuals between 35 and 65 years without a cardiovascular history. We showed how simulating therapeutic strategies on a realistic virtual population could be used for best applying available evidence.PMID:36841655 | DOI:10.1016/j.therap.2023.01.011
Source: Therapie - February 25, 2023 Category: Psychiatry & Psychology Authors: Mor Fall Guillaume Grenet Hai-Ha Le Behrouz Kassa ï Jean-Christophe Lega R émy Boussageon Sabine Mainbourg Ivanny Marchant Johanne Gafsi Amadou Moctar Dieye Fran çois Gueyffier Source Type: research
