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Total 4067 results found since Jan 2013.
Development and validation of predictive model based on deep learning method for classification of dyslipidemia in Chinese medicine
ConclusionsThis study successfully developed a well-performing classification prediction model for dyslipidemia with MOPS, transforming the syndrome diagnosis problem in TCM into a prediction and classification problem in artificial intelligence. Patients with dyslipidemia of MOPS can be accurately recognized through limited information from patients. We also screened out significant diagnostic factors for composing diagnostic rules of dyslipidemia with MOPS. The study is an avant-garde attempt at introducing the deep-learning method into the research of TCM, which provides a useful reference for the extension of deep lear...
Source: Health Information Science and Systems - April 6, 2023 Category: Information Technology Source Type: research
Combination Moderate-Intensity Statin and Ezetimibe Therapy for Elderly Patients With Atherosclerosis
CONCLUSIONS: Moderate-intensity statin with ezetimibe combination therapy showed similar cardiovascular benefits to those of high-intensity statin monotherapy with lower intolerance-related drug discontinuation or dose reduction in elderly patients with ASCVD having a higher risk of intolerance, nonadherence, and discontinuation with high-intensity statin therapy. (RAndomized Comparison of Efficacy and Safety of Lipid-lowerING With Statin Monotherapy Versus Statin/Ezetimibe Combination for High-risk Cardiovascular Diseases [RACING Trial]; NCT03044665).PMID:37019580 | DOI:10.1016/j.jacc.2023.02.007
Source: Atherosclerosis - April 5, 2023 Category: Cardiology Authors: Sang-Hyup Lee Yong-Joon Lee Jung Ho Heo Seung-Ho Hur Hyun Hee Choi Kyung-Jin Kim Ju Han Kim Keun-Ho Park Jung Hee Lee Yu Jeong Choi Seung-Jun Lee Sung-Jin Hong Chul-Min Ahn Byeong-Keuk Kim Young-Guk Ko Donghoon Choi Myeong-Ki Hong Yangsoo Jang Jung-Sun Ki Source Type: research
Statins for extension of disability-free survival and primary prevention of cardiovascular events among older people: protocol for a randomised controlled trial in primary care (STAREE trial)
Introduction
The world is undergoing a demographic transition to an older population. Preventive healthcare has reduced the burden of chronic illness at younger ages but there is limited evidence that these advances can improve health at older ages. Statins are one class of drug with the potential to prevent or delay the onset of several causes of incapacity in older age, particularly major cardiovascular disease (CVD). This paper presents the protocol for the STAtins in Reducing Events in the Elderly (STAREE) trial, a randomised double-blind placebo-controlled trial examining the effects of statins in community dwelling o...
Source: BMJ Open - April 3, 2023 Category: General Medicine Authors: Zoungas, S., Curtis, A., Spark, S., Wolfe, R., McNeil, J. J., Beilin, L., Chong, T. T.-J., Cloud, G., Hopper, I., Kost, A., Nelson, M., Nicholls, S. J., Reid, C. M., Ryan, J., Tonkin, A., Ward, S. A., Wierzbicki, A., On behalf of STAREE investigator group Tags: Open access, Cardiovascular medicine Source Type: research
Development and validation of dynamic models to predict postdischarge mortality risk in patients with acute myocardial infarction: results from China Acute Myocardial Infarction Registry
Conclusions
We established dynamic risk prediction models incorporating adverse event and medications. The nomograms may be useful instruments to help prospective risk assessment and management of AMI.
Trial registration number
NCT01874691.
Source: BMJ Open - March 29, 2023 Category: General Medicine Authors: Lv, J., Wang, C., Gao, X., Yang, J., Zhang, X., Ye, Y., Dong, Q., Fu, R., Sun, H., Yan, X., Zhao, Y., Wang, Y., Xu, H., Yang, Y., on behalf of the China Acute Myocardial Infarction Registry study group Tags: Open access, Cardiovascular medicine Source Type: research
The effect of intensive statin therapy in non-symptomatic intracranial arteries: The STAMINA-MRI sub-study
ConclusionIntensive statin therapy produced a favorable morphological change in cerebral arteries of not only the target arterial segment but also non-symptomatic arterial segments. The change in cerebral arterial luminal diameter was influenced by the baseline SBP and was dependent on the topographic distribution of the cerebral arteries.Clinical Trial Registration: ClinicalTrials.gov, identifier NCT02458755.
Source: Frontiers in Neurology - March 28, 2023 Category: Neurology Source Type: research
Effect of PCSK9 inhibition in combination with statin therapy on intracranial atherosclerotic stenosis: A high-resolution MRI study
This study aimed to determine the effects of PCSK9i on intracranial plaques in moderate-intensity statin-treated individuals with ICAS.METHODS: This prospective, observational study monitored the imaging and clinical outcomes of individuals with ICAS who were consecutively treated with moderate-intensity statins with or without PCSK9i. Individuals underwent monthly visits and repeat high-resolution MRI (HR-MRI) at week 12. The primary outcome was a change in HR-MRI after 12 weeks of treatment and the secondary outcome was major vascular events during follow-up.RESULTS: Forty-nine individuals were studied (PCSK9i group: 26 ...
Source: Atherosclerosis - March 27, 2023 Category: Cardiology Authors: Lingshan Wu Qianqian Kong Hao Huang Shabei Xu Wensheng Qu Ping Zhang Zhiyuan Yu Xiang Luo Source Type: research
Differential association between apolipoprotein B and LDL cholesterol and cerebral atherosclerosis according to pre-stroke statin use
CONCLUSIONS: ApoB was consistently associated with ICAS, particularly symptomatic stenosis, in both statin-naïve and statin-treated patients. The close association between ApoB levels and residual risk in statin-treated patients could be partially explained by these results.PMID:36966561 | DOI:10.1016/j.atherosclerosis.2023.03.014
Source: Atherosclerosis - March 26, 2023 Category: Cardiology Authors: Minyoul Baik Hyo Suk Nam Ji Hoe Heo Hye Sun Lee Young Dae Kim Source Type: research
Role of sirtuins in attenuating plaque vulnerability in atherosclerosis
Mol Cell Biochem. 2023 Mar 23:1-12. doi: 10.1007/s11010-023-04714-2. Online ahead of print.ABSTRACTAtherosclerosis is characterized by the development of intimal plaque, thrombosis, and stenosis of the vessel lumen causing decreased blood flow and hypoxia precipitating angina. Chronic inflammation in the stable plaque renders it unstable and rupture of unstable plaques results in the formation of emboli leading to hypoxia/ischemia to the organs by occluding the terminal branches and precipitate myocardial infarction and stroke. Such delibitating events could be controlled by the strategies that prevent plaque development o...
Source: Molecular and Cellular Biochemistry - March 23, 2023 Category: Biochemistry Authors: Prathosh Velpuri Vikrant Rai Devendra K Agrawal Source Type: research
Differential association between apolipoprotein B and LDL cholesterol and cerebral atherosclerosis according to pre-stroke statin use
To reduce cardiovascular risk, low-density lipoprotein cholesterol (LDL-C) is the primary target of statin treatment, while apolipoprotein B (ApoB) is secondary. We investigated the association between atherosclerotic stenosis and LDL-C or ApoB levels and whether a difference in association exists according to pre-admission statin use in ischemic stroke patients.
Source: Atherosclerosis - March 19, 2023 Category: Cardiology Authors: Minyoul Baik, Hyo Suk Nam, Ji Hoe Heo, Hye Sun Lee, Young Dae Kim Source Type: research
Straight from the heart: Mysterious lipids may predict cardiac problems better than cholesterol
Stephanie Blendermann, 65, had good reason to worry about heart disease. Three of her sisters died in their 40s or early 50s from heart attacks, and her father needed surgery to bypass clogged arteries. She also suffered from an autoimmune disorder that results in chronic inflammation and boosts the odds of developing cardiovascular illnesses. “I have an interesting medical chart,” says Blendermann, a real estate agent in Prior Lake, Minnesota.
Yet Blendermann’s routine lab results weren’t alarming. At checkups, her low-density lipoprotein (LDL), or “bad,” cholesterol hovered around the 100 milligrams-per-...
Source: Science of Aging Knowledge Environment - March 16, 2023 Category: Geriatrics Source Type: research
Top Studies From the 2023 International Stroke Conference Top Studies From the 2023 International Stroke Conference
Studies on stroke thrombectomy, statins, and imaging are among Dr Hans-Christoph Diener ' s top picks from the 2023 International Stroke Conference.Medscape Neurology
Source: Medscape Radiology Headlines - March 14, 2023 Category: Radiology Tags: Neurology & Neurosurgery Commentary Source Type: news
