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Risk Factors of Ischemic Stroke and Subsequent Outcome in Patients Receiving Hemodialysis Clinical Sciences
Conclusions— Incidence of stroke is high in patients with ESRD on hemodialysis with high case-fatality. Incident hemodialysis patients had the highest stroke incidence. Many, but not all, important risk factors commonly associated with stroke in the general population were not associated with stroke in patients receiving hemodialysis.
Source: Stroke - August 24, 2015 Category: Neurology Authors: Findlay, M. D., Thomson, P. C., Fulton, R. L., Solbu, M. D., Jardine, A. G., Patel, R. K., Stevens, K. K., Geddes, C. C., Dawson, J., Mark, P. B. Tags: Cerebrovascular disease/stroke, Risk Factors for Stroke, Epidemiology Clinical Sciences Source Type: research
Association Between Serum Phosphate Levels and Stroke Risk in Patients Undergoing Hemodialysis: The Q-Cohort Study Clinical Sciences
Conclusions— Higher serum phosphate levels were associated with an increased risk of brain hemorrhage, whereas low levels were associated with an increased risk of brain infarction in hemodialysis patients. These results suggest the importance of managing serum phosphate levels within an appropriate range in hemodialysis patients. Clinical Trial Registration— URL: http://www.umin.ac.jp/. Unique identifier: UMIN000000556.
Source: Stroke - August 21, 2016 Category: Neurology Authors: Yamada, S., Tsuruya, K., Taniguchi, M., Tokumoto, M., Fujisaki, K., Hirakata, H., Fujimi, S., Kitazono, T. Tags: Cardiovascular Disease, Epidemiology, Risk Factors, Intracranial Hemorrhage, Ischemic Stroke Clinical Sciences Source Type: research
Acute Renal Failure Is Associated With Higher Death and Disability in Patients With Acute Ischemic Stroke: Analysis of Nationwide Inpatient Sample Brief Reports
Conclusions— ARF in patients with AIS is associated with significantly higher rates of moderate to severe disability at discharge and in-hospital mortality.
Source: Stroke - April 28, 2014 Category: Neurology Authors: Saeed, F., Adil, M. M., Khursheed, F., Daimee, U. A., Branch, L. A., Vidal, G. A., Qureshi, A. I. Tags: Acute Cerebral Infarction Brief Reports Source Type: research
Chronic Kidney Disease and Bleeding Complications After Intravenous Thrombolytic Therapy for Acute Ischemic Stroke Original Articles
Conclusions— Presence of CKD among patients with IS treated with intravenous tissue-type plasminogen activator is associated with higher unadjusted odds of symptomatic intracranial hemorrhage or serious systemic hemorrhage, but this is explained by non-CKD related factors.
Source: Circulation: Cardiovascular Quality and Outcomes - November 18, 2014 Category: Cardiology Authors: Ovbiagele, B., Smith, E. E., Schwamm, L. H., Grau-Sepulveda, M. V., Saver, J. L., Bhatt, D. L., Hernandez, A. F., Peterson, E. D., Fonarow, G. C. Tags: Cerebrovascular disease/stroke, Risk Factors, Acute Cerebral Infarction, Thrombolysis Original Articles Source Type: research
Multi‐modal CT in acute stroke: wait for a serum creatinine before giving intravenous contrast? No!
ConclusionsThe incidence of CIN is low when MMCT is used routinely to assess acute stroke patients. In this population, CIN was a biochemical phenomenon that did not have clinical manifestations, cause chronic kidney disease, require dialysis, or negatively impact on 90‐day mRS outcomes. Renal profiling and waiting for a baseline serum‐creatinine are an unnecessary delay to emergency reperfusion treatment.
Source: International Journal of Stroke - August 26, 2015 Category: Neurology Authors: Timothy E. Ang, Andrew Bivard, Christopher Levi, Henry Ma, Chung Y. Hsu, Bruce Campbell, Geoffrey Donnan, Stephen M. Davis, Mark Parsons Tags: Research Source Type: research
Dialysis Requiring Acute Kidney Injury in Acute Cerebrovascular Accident Hospitalizations Clinical Sciences
Conclusions— Incidence of AKI-D complicating hospitalizations with cerebrovascular accident continues to grow and is associated with increased mortality and adverse discharge. This highlights the need for early diagnosis, better risk stratification, and preparedness for need for complex long-term care in this vulnerable population.
Source: Stroke - October 26, 2015 Category: Neurology Authors: Nadkarni, G. N., Patel, A. A., Konstantinidis, I., Mahajan, A., Agarwal, S. K., Kamat, S., Annapureddy, N., Benjo, A., Thakar, C. V. Tags: Cerebrovascular disease/stroke, Acute Cerebral Hemorrhage, Acute Cerebral Infarction, Acute Stroke Syndromes Clinical Sciences Source Type: research
Renal Dysfunction Is Associated With Poststroke Discharge Disposition and In-Hospital Mortality Clinical Sciences
Background and Purpose—Kidney disease is a frequent comorbidity in patients presenting with acute ischemic stroke. We evaluated whether the estimated glomerular filtration rate (eGFR) on admission is associated with poststroke in-hospital mortality or discharge disposition.Methods—In this cohort study, data from ischemic stroke patients in Get With The Guidelines–Stroke linked to fee-for-service Medicare data were analyzed. The Modification of Diet in Renal Disease study equation was used to calculate the eGFR (mL/min/1.73 m2). Dialysis was identified by International Classification of Diseases, Ninth Revision codes....
Source: Stroke - January 22, 2017 Category: Neurology Authors: Nada El Husseini, Gregg C. Fonarow, Eric E. Smith, Christine Ju, Lee H. Schwamm, Adrian F. Hernandez, Phillip J. Schulte, Ying Xian, Larry B. Goldstein Tags: Mortality/Survival, Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research
Warfarin Use in Patients With Atrial Fibrillation Undergoing Hemodialysis Clinical Sciences
Conclusions—Our findings suggest that warfarin should be used carefully in hemodialysis patients, given the higher risk of hemorrhagic events and the lack of ability to prevent thromboembolic complications.
Source: Stroke - August 28, 2017 Category: Neurology Authors: Chang-Yun Yoon, Juhwan Noh, Jong Hyun Jhee, Tae Ik Chang, Ea Wha Kang, Youn Kyung Kee, Hyoungnae Kim, Seohyun Park, Hae-Ryong Yun, Su-Young Jung, Hyung Jung Oh, Jung Tak Park, Seung Hyeok Han, Shin-Wook Kang, Changsoo Kim, Tae-Hyun Yoo Tags: Arrhythmias, Clinical Studies, Nephrology and Kidney, Intracranial Hemorrhage, Ischemic Stroke Original Contributions Source Type: research
Cerebrovascular Accidents During Mechanical Circulatory Support Clinical Sciences
Conclusions—Stroke is a major cause of morbidity and mortality in patients on LVAD support. Chronic obstructive pulmonary disease increases the risk of ischemic stroke, whereas dialysis may increase the risk of hemorrhagic stroke. Although any stroke increases mortality, post-LVAD hemorrhagic stroke was associated with higher mortality compared with ischemic stroke.
Source: Stroke - April 23, 2018 Category: Neurology Authors: Saef Izzy, Daniel B. Rubin, Firas S. Ahmed, Feras Akbik, Simone Renault, Katelyn W. Sylvester, Henrikas Vaitkevicius, Jennifer A. Smallwood, Michael M. Givertz, Steven K. Feske Tags: Heart Failure, Complications, Quality and Outcomes, Intracranial Hemorrhage, Ischemic Stroke Original Contributions Source Type: research
Risk Factors and Outcomes of Cerebral Stroke in End-Stage Renal Disease Patients Receiving Hemodialysis
This study investigated the stroke features and risk factors in hemodialysis (HD) patients. Methods: All end-stage renal disease patients undergoing HD at Teraoka Memorial Hospital dialysis center were identified, with 195 recruited. Baseline clinical characteristics were collected, and the clinical outcomes and related factors of stroke in HD patients were retrospectively analyzed.
Source: Journal of Stroke and Cerebrovascular Diseases - February 5, 2020 Category: Neurology Authors: Yuki Shinya, Satoru Miyawaki, Isao Kumagai, Takehiro Sugiyama, Atsumi Takenobu, Nobuhito Saito, Akira Teraoka Source Type: research
Patterns of Care Quality and Prognosis Among Hospitalized Ischemic Stroke Patients With Chronic Kidney Disease Health Services and Outcomes Research
Conclusions Despite higher in-hospital mortality rates, ischemic stroke patients with CKD, especially those with greater severity of renal dysfunction, were less likely to receive important guideline-recommended therapies.
Source: JAHA:Journal of the American Heart Association - June 5, 2014 Category: Cardiology Authors: Ovbiagele, B., Schwamm, L. H., Smith, E. E., Grau-Sepulveda, M. V., Saver, J. L., Bhatt, D. L., Hernandez, A. F., Peterson, E. D., Fonarow, G. C. Tags: Health Services and Outcomes Research Source Type: research
Evidence for the Prevention and Treatment of Stroke in Dialysis Patients
Abstract The risks of both ischemic and hemorrhagic stroke are particularly high in dialysis patients of any age and outcomes are poor. It is therefore important to identify strategies that safely minimize stroke risk in this population. Observational studies have been unable to clarify the relative importance of traditional stroke risk factors such as blood pressure and cholesterol in those on dialysis, and are affected by biases that usually make them an inappropriate source of data on which to base therapeutic decisions. Well‐conducted randomized trials are not susceptible to such biases and can reliably investigate t...
Source: Seminars In Dialysis - May 1, 2014 Category: Hematology Authors: William Herrington, Richard Haynes, Natalie Staplin, Jonathan Emberson, Colin Baigent, Martin Landray Tags: Review Source Type: research
Review Stroke and cerebrovascular diseases in patients with chronic kidney disease
Chronic kidney disease, defined as a reduced glomerular filtration rate or increased urinary albumin excretion, is recognised as a rapidly growing global health burden, and increasing evidence suggests that it contributes to the risk and severity of cerebrovascular diseases. In particular, chronic kidney disease is an established risk factor for stroke and is also strongly associated with subclinical cerebrovascular abnormalities and cognitive impairment, partly because it shares several traditional and non-traditional risk factors, and sometimes uraemia-related and dialysis-related factors, with cerebrovascular diseases.
Source: Lancet Neurology - July 14, 2014 Category: Neurology Authors: Kazunori Toyoda, Toshiharu Ninomiya Tags: Review Source Type: research
Predictors of early and late stroke following cardiac surgery.
We examined the rate and predictors of long-term stroke in a cohort of patients who underwent cardiac surgery. METHODS: We obtained linked data for patients who underwent cardiac surgery in the province of Ontario between 1996 and 2006. We analyzed the incidence of stroke and death up to 2 years postoperatively. RESULTS: Of 108 711 patients, 1.8% (95% confidence interval [CI] 1.7%-1.9%) had a stroke perioperatively, and 3.6% (95% CI 3.5%-3.7%) had a stroke within the ensuing 2 years. The strongest predictors of both early and late stroke were advanced age (≥ 65 year; adjusted hazard ratio [HR] for all stroke 1....
Source: cmaj - July 21, 2014 Category: Journals (General) Authors: Whitlock R, Healey JS, Connolly SJ, Wang J, Danter MR, Tu JV, Novick R, Fremes S, Teoh K, Khera V, Yusuf S Tags: CMAJ Source Type: research
Evidence for the Prevention and Treatment of Stroke in Dialysis Patients.
Abstract The risks of both ischemic and hemorrhagic stroke are particularly high in dialysis patients of any age and outcomes are poor. It is therefore important to identify strategies that safely minimize stroke risk in this population. Observational studies have been unable to clarify the relative importance of traditional stroke risk factors such as blood pressure and cholesterol in those on dialysis, and are affected by biases that usually make them an inappropriate source of data on which to base therapeutic decisions. Well-conducted randomized trials are not susceptible to such biases and can reliably invest...
Source: Seminars in Dialysis - July 7, 2014 Category: Urology & Nephrology Authors: Herrington W, Haynes R, Staplin N, Emberson J, Baigent C, Landray M Tags: Semin Dial Source Type: research
The Impact of Acute Kidney Injury on the Long-term Risk of Stroke Kidney in Cardiovascular Disease
Conclusions The patients who recovered from AKI had a higher incidence of developing incident stroke and mortality than the patients without AKI, and the impact was similar to diabetes. Our results suggest that a public health initiative is needed to enhance postdischarge follow-up of renal function and to control the subsequent incidence of stroke among patients who recover from AKI after dialysis.
Source: JAHA:Journal of the American Heart Association - July 15, 2014 Category: Cardiology Authors: Wu, V.-C., Wu, P.-C., Wu, C.-H., Huang, T.-M., Chang, C.-H., Tsai, P.-R., Ko, W.-J., Chen, L., Wang, C.-Y., Chu, T.-S., Wu, K.-D., The National Taiwan University Study Group on Acute Renal Failure (NSARF) Group Tags: Kidney in Cardiovascular Disease Source Type: research
Incidence and prediction of ischemic stroke among atrial fibrillation patients with end-stage renal disease requiring dialysis
Renal dysfunction is a significant risk factor for ischemic stroke in atrial fibrillation (AF). However, the incidence of ischemic stroke and how to predict its occurrence among AF patients with end-stage renal disease (ESRD) are unclear.
Source: Heart Rhythm - June 18, 2014 Category: Cardiology Authors: Tze-Fan Chao, Chia-Jen Liu, Kang-Ling Wang, Yenn-Jiang Lin, Shih-Lin Chang, Li-Wei Lo, Yu-Feng Hu, Ta-Chuan Tuan, Fa-Po Chung, Jo-Nan Liao, Tzeng-Ji Chen, Gregory Y.H. Lip, Shih-Ann Chen Source Type: research
Outcomes of endovascular versus intravenous thrombolytic treatment for acute ischemic stroke in dialysis patients.
CONCLUSIONS: The odds of both in-hospital mortality and moderate to severe disability were lower with endovascular treatment in dialysis patients. Such data support the preferential use of endovascular treatment in this patient population. PMID: 25262635 [PubMed - as supplied by publisher]
Source: The International Journal of Artificial Organs - September 27, 2014 Category: Transplant Surgery Authors: Saeed F, Adil MM, Piracha BH, Qureshi AI Tags: Int J Artif Organs Source Type: research
Relationship between Stroke and Mortality in Dialysis Patients.
CONCLUSIONS: Dialysis recipients have high mortality after a stroke with corresponding decrements in remaining years of life. Poststroke mortality does not differ by race. PMID: 25318759 [PubMed - as supplied by publisher]
Source: Clinical Journal of the American Society of Nephrology : CJASN - October 15, 2014 Category: Urology & Nephrology Authors: Wetmore JB, Phadnis MA, Ellerbeck EF, Shireman TI, Rigler SK, Mahnken JD Tags: Clin J Am Soc Nephrol Source Type: research
The impact of comorbidity on survival after hemorrhagic stroke among dialysis patients: a nationwide population-based study
Conclusions: Dialysis patients who have history of prior stroke, diabetes and malignancy have worse survival than patients without these comorbidities. Attention must focus on providing optimal medical care after hemorrhagic stroke for these target groups to reduce mortality.
Source: BMC Nephrology - November 27, 2014 Category: Urology & Nephrology Authors: Chun-Yu LinChih-Chiang ChienHung-An ChenFu-Mei SuJhi-Joung WangChe-Chuan WangChin-Chen ChuYeong-Jang Lin Source Type: research
Effect of aspirin for ischemic stroke in patients with dialysis
Source: International Journal of Stroke - December 10, 2014 Category: Neurology Authors: T. Kawada Tags: Letter to the editor Source Type: research
Effectiveness and safety of antiplatelet in stroke patients with end‐stage renal disease undergoing dialysis
Source: International Journal of Stroke - December 10, 2014 Category: Neurology Authors: Chung‐Yu Chen Tags: Letter to the editor Source Type: research
Response to letter regarding article, "warfarin use and the risk for stroke and bleeding in patients with atrial fibrillation undergoing dialysis".
PMID: 25539527 [PubMed - in process]
Source: Circulation - December 23, 2014 Category: Cardiology Authors: Shah M, Avgil Tsadok M, Jackevicius CA, Essebag V, Eisenberg MJ, Rahme E, Humphries KH, Tu JV, Behlouli H, Guo H, Pilote L Tags: Circulation Source Type: research
Letter by qureshi et Al regarding article, "warfarin use and the risk for stroke and bleeding in patients with atrial fibrillation undergoing dialysis".
PMID: 25539526 [PubMed - in process]
Source: Circulation - December 23, 2014 Category: Cardiology Authors: Qureshi W, Alirhayim Z, Khalid F Tags: Circulation Source Type: research
Warfarin use, mortality, bleeding and stroke in haemodialysis patients with atrial fibrillation
Conclusions In our population of HD patients with AF, the mortality is very high. OAT is not associated with increased mortality, while antiplatelet drugs are. OAT seems, on the contrary, associated with a better survival; however, it does not decrease the incidence of ischaemic stroke, whereas it increases the incidence of bleeding. Bleeding risk is lower in subjects in whom the INR is kept within the therapeutic range.
Source: Nephrology Dialysis Transplantation - February 23, 2015 Category: Urology & Nephrology Authors: Genovesi, S., Rossi, E., Gallieni, M., Stella, A., Badiali, F., Conte, F., Pasquali, S., Bertoli, S., Ondei, P., Bonforte, G., Pozzi, C., Rebora, P., Valsecchi, M. G., Santoro, A. Tags: Intra- and Extracorporeal Treatments of Kidney Failure Source Type: research
Anticoagulation therapy: Balancing the risks of stroke and bleeding in CKD
Nature Reviews Nephrology 11, 200 (2015). doi:10.1038/nrneph.2015.14 Authors: Arman Qamar & Deepak L. Bhatt Whether anticoagulation with warfarin is safe and reduces risk of stroke in patients with atrial fibrillation and chronic kidney disease is unclear. A recent observational study shows a net clinical benefit of warfarin—without increased risk of bleeding—in this population, including in patients on dialysis.
Source: Nature Reviews Nephrology - February 10, 2015 Category: Urology & Nephrology Authors: Arman QamarDeepak L. Bhatt Tags: News and Views Source Type: research
The Risks of Stroke and Bleeding for Warfarin Use in Hemodialysis Patients with Atrial Fibrillation: A Systemic Review and A Meta-Analysis
Conclusion This meta-analysis suggested that warfarin should not be recommended for the routine treatment of HD patients with AF.
Source: Nutrition, Metabolism and Cardiovascular Diseases - April 3, 2015 Category: Nutrition Source Type: research
Effect of antithrombotic and antiplatelet agents for ischemic stroke in atrial fibrillation patients with dialysis
With great interest, we read Chen et al. study about antithrombotic agents in patients with end stage renal disease (ESRD) and atrial fibrillation (AF) . The authors found that anti-platelet or warfarin treatment could not lower the risk of ischemic stroke in patients with ESRD. We have some concerns about this study.
Source: International Journal of Cardiology - April 28, 2015 Category: Cardiology Authors: Chin-Wei Hsu, Yaw-Bin Huang, Chung-Yu Chen Tags: Letter to the Editor Source Type: research
Reduced Stroke Risk After Parathyroidectomy in End-Stage Renal Disease: A 13-Year Population-Based Cohort Study
Abstract: Research information on the risk of stroke in patients with dialysis-dependent end-stage renal disease (ESRD) who have undergone parathyroidectomy (PTX) is scant. We used a nationwide health insurance claims database to select all patients with dialysis-dependent ESRD age 18 years and older for the study population. Of the patients with ESRD, we selected 1083 patients who had undergone PTX between 1998 and 2006 as the PTX group and frequency-matched 1083 patients with ESRD by sex, age, years since the disease diagnosis, and the year of undergoing PTX as the non-PTX group. We used a multivariate Cox proportional h...
Source: Medicine - June 1, 2015 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Chronic kidney disease and the risk of stroke: a systematic review and meta-analysis
Conclusions Stroke risk increases linearly and additively with declining GFR and increasing albuminuria. CKD staging may also be a useful clinical tool for identifying people who may benefit most from interventions to reduce cardiovascular risk.
Source: Nephrology Dialysis Transplantation - June 22, 2015 Category: Urology & Nephrology Authors: Masson, P., Webster, A. C., Hong, M., Turner, R., Lindley, R. I., Craig, J. C. Tags: Chronic Kidney Disease Source Type: research
Warfarin use and the risks of stroke and bleeding in hemodialysis patients with atrial fibrillation: A systematic review and a meta-analysis
Conclusion This meta-analysis suggested that warfarin should not be recommended for the routine treatment of HD patients with AF.
Source: Nutrition, Metabolism and Cardiovascular Diseases - July 20, 2015 Category: Nutrition Source Type: research
Risk of Stroke in Patients with ESRD.
CONCLUSIONS: People with ESRD have a substantially higher risk of stroke, particularly women and young people, and hemorrhagic stroke. Future work could investigate effective and safe interventions for primary and secondary prevention of stroke in people with ESRD. PMID: 26209158 [PubMed - as supplied by publisher]
Source: Clinical Journal of the American Society of Nephrology : CJASN - July 24, 2015 Category: Urology & Nephrology Authors: Masson P, Kelly PJ, Craig JC, Lindley RI, Webster AC Tags: Clin J Am Soc Nephrol Source Type: research
Incidence and predictors of ischemic stroke during hospitalization for congestive heart failure
Abstract Heart failure (HF) increases the risk of ischemic stroke. Data regarding the incidence and predictors of ischemic stroke during hospitalization for HF are limited. The study population of this retrospective cohort study consisted of patients with congestive HF, consecutively admitted to our center from October 2010 to April 2014. We excluded patients complicated with acute myocardial infarction, infective endocarditis, and takotsubo cardiomyopathy. We also excluded those with dialysis or mechanical circulatory support. We investigated the incidence of ischemic stroke during hospitalization for HF. Thereaf...
Source: Heart and Vessels - July 29, 2015 Category: Cardiology Source Type: research
Risk of major cardiovascular events in patients with hemodialysis or peritoneal dialysis with special reference to stroke
Kim et al. determined the incidence rates of major adverse cardiac and cerebrovascular events (MACCE) and compared several types of events between hemodialysis (HD) patients and peritoneal dialysis (PD) patients . The authors handled 22,892 HD patients and 7,387 PD patients in Korea by intention-to-treat method, and median follow-up period was 21.5 months. The risk of several cardiac events in PD patients was significantly higher than that in HD patients. In contrast, the incidence rate of non-fatal hemorrhagic stroke in HD patients showed significantly higher than that in PD patients, and there was no significant diffe...
Source: International Journal of Cardiology - September 21, 2015 Category: Cardiology Authors: Tomoyuki Kawada Source Type: research
Difference in stroke incidence between Korean and Japanese patients initiating dialysis — era or ethnic effect?
We thank Tomoyuki Kawada for the letter in response to our recent article . First, we would like to focus on the differences in epidemiologic characteristics of stroke between our study population and those enrolled in a previous study conducted in Japan . As indicated, the main difference in the findings between the two studies was that the proportion of hemorrhagic stroke among the total stroke events was substantially higher in the Japanese study than in our study (52% vs. 21%). Although the definite reasons for this difference remain uncertain, adding to the possible association kindly suggested by Kawada, some s...
Source: International Journal of Cardiology - September 18, 2015 Category: Cardiology Authors: Hyunwook Kim, Dong-Ryeol Ryu Tags: Correspondence Source Type: research
Impact of dialysis modality on the survival of patients with end-stage renal disease and prior stroke
Conclusions PD was associated with overall poorer survival among patients with diabetes, ESRD and prior stroke and with similar overall survival among patients with ESRD and prior stroke, but without diabetes, compared with HD.
Source: International Urology and Nephrology - November 11, 2015 Category: Urology & Nephrology Source Type: research
Patient survival and technique failure in continuous ambulatory peritoneal dialysis patients with prior stroke.
Conclusions: Continuous ambulatory peritoneal dialysis patients with prior stroke had high rates of all-cause mortality and technique failure compared with those without prior stroke. Older age, lower BMI, and time to the first episode of peritonitis were independent risk factors of all-cause mortality in patients with prior stroke. PMID: 26634563 [PubMed - as supplied by publisher]
Source: Peritoneal Dialysis International - December 7, 2015 Category: Urology & Nephrology Tags: Perit Dial Int Source Type: research
Warfarin use and incidence of stroke in Japanese hemodialysis patients with atrial fibrillation
Abstract Atrial fibrillation (AF) is one of the major risk factor for ischemic stroke, and oral anticoagulation is generally indicated for prevention of stroke. However, the utility of oral anticoagulation for AF in dialysis patients remains controversial. In this single-center, retrospective, observational study, data from 1120 patients on maintenance hemodialysis were analyzed. Baseline medical data were collected from dialysis records including age, gender, the cause of end-stage renal disease, dialysis vintage, and comorbidities. We evaluated outcomes including stroke, major hemorrhage, and death. A total of 1...
Source: Heart and Vessels - December 8, 2015 Category: Cardiology Source Type: research
Modulation of stroke risk in chronic kidney disease
Stroke is the second most common cause of death and the leading cause of neurological disability worldwide, with huge economic costs and tragic human consequences. Both chronic kidney disease (CKD) and end-stage kidney disease are associated with a significantly increased risk of stroke. However, to date this has generated far less interest compared with the better-recognized links between cardiac and renal disease. Common risk factors for stroke, such as hypertension, hypercholesterolaemia, smoking and atrial fibrillation, are shared with the general population but are more prevalent in renal patients. In addition, factor...
Source: CKJ: Clinical Kidney Journal - January 20, 2016 Category: Urology & Nephrology Authors: Arnold, J., Sims, D., Ferro, C. J. Tags: CARDIOVASCULAR NEPHROLOGY Source Type: research
Warfarin Use and Risk of Stroke in Patients With Atrial Fibrillation Undergoing Hemodialysis: A Meta-Analysis
Abstract: In spite of the substantial burden of atrial fibrillation and associated elevated ischemic stroke risk in patients undergoing hemodialysis, the role of warfarin in these high-risk patients remains uncertain. Our objective was to clarify the association between warfarin use and risk of stroke for patients with atrial fibrillation undergoing dialysis. PubMed and Embase from January 1966 to January 2015 were searched to identify relevant studies. Inclusion criteria were cohort studies, patients with atrial fibrillation undergoing hemodialysis, and reported quantitative estimates of the multivariate adjusted relativ...
Source: Medicine - February 1, 2016 Category: Internal Medicine Tags: Research Article: Meta-Analysis of Observ Studies in Epidemiology Source Type: research
Variables affecting Stroke Outcome for TPA received between 3 to 4.5 hours (P2.301)
Conclusions: Age, NIHSS and renal dysfunction were significantly associated with worse outcome in patients who had received t-PA between 3 to 4.5 hours. Our findings were consistent but more robust than previous studies showing poorer outcome with renal dysfunction (Meta-analysis OR1.06 NS). After controlling for age and NIHSS, diabetes or hypertension did not additionally contribute to poor outcome. Prognostic and risk stratification scales are useful as predictors of outcome but do not imply efficacy of t-PA therapy or lack thereof.Disclosure: Dr. Yeo has nothing to disclose. Dr. McCane has nothing to disclose. Dr. Katz ...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Yeo, C., McCane, D., Katz, L., Ling, K., Capetillo, A., Bledsoe, D., Chiu, D. Tags: Acute Therapy: IV t-PA Source Type: research
Meta-Analysis of Anticoagulation Use, Stroke, Thromboembolism, Bleeding and Mortality in Patients with Atrial Fibrillation on Dialysis
Atrial fibrillation (AF) is common in patients on dialysis. While randomized trials of anticoagulation for AF have demonstrated striking reductions in stroke, these trials did not recruit dialysis patients. We thus undertook this systematic review and meta-analysis of observational studies. Electronic databases were searched for studies including AF patients on dialysis that reported observational associations of anticoagulation use. Twenty-one studies involving 530,031 individuals and 31,611 AF patients on dialysis were identified.
Source: The American Journal of Cardiology - April 12, 2016 Category: Cardiology Authors: Christopher X. Wong, Ayodele Odutayo, Connor A. Emdin, Ned J. Kinnear, Michelle T. Sun Source Type: research
Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation
Publication date: Available online 11 May 2016 Source:The Lancet Neurology Author(s): Ángel Chamorro, Ulrich Dirnagl, Xabier Urra, Anna M Planas Treatments for acute ischaemic stroke continue to evolve after the superior value of endovascular thrombectomy was confirmed over systemic thrombolysis. Unfortunately, numerous neuroprotective drugs have failed to show benefit in the treatment of acute ischaemic stroke, making the search for new treatments imperative. Increased awareness of the relevance of rigorous preclinical testing, and appropriate selection of study participants, might overcome the barriers to progress...
Source: The Lancet Neurology - May 11, 2016 Category: Neurology Source Type: research
Risk factors and outcome of Stroke in renal transplant recipients
This article is protected by copyright. All rights reserved.
Source: Clinical Transplantation - May 23, 2016 Category: Transplant Surgery Authors: Mark D. Findlay, Peter C. Thomson, Rachael MacIsaac, Alan G. Jardine, Rajan K. Patel, Kathryn K. Stevens, Elaine Rutherford, Marc Clancy, Colin C. Geddes, Jesse Dawson, Patrick B. Mark Tags: Original Article Source Type: research
Ischaemic stroke in patients with atrial fibrillation with chronic kidney disease undergoing peritoneal dialysis
Conclusion In CKD patients on PD with AF, who had similar ischaemic stroke risk as non-CKD counterparts, warfarin therapy is associated with reduction in risk of ischaemic stroke without a higher risk of ICH.
Source: Europace - May 24, 2016 Category: Cardiology Authors: Chan, P.-H., Huang, D., Yip, P.-S., Hai, J., Tse, H.-F., Chan, T.-M., Lip, G. Y. H., Lo, W.-K., Siu, C.-W. Tags: Atrial fibrillation Source Type: research
Meta-Analysis of Anticoagulation Use, Stroke, Thromboembolism, Bleeding, and Mortality in Patients With Atrial Fibrillation on Dialysis
Atrial fibrillation (AF) is common in patients on dialysis. Although randomized trials of anticoagulation for AF have demonstrated striking reductions in stroke, these trials did not recruit patients on dialysis. We thus undertook this systematic review and meta-analysis of observational studies including patients with AF on dialysis that reported associations of anticoagulation use. Twenty studies involving 529,741 subjects and 31,321 patients with AF on dialysis were identified. Anticoagulation was associated with a 45% (95% CI 13% to 88%) increased risk of any stroke, reflecting a nonsignificant 13% (95% CI −4% to 34...
Source: The American Journal of Cardiology - April 12, 2016 Category: Cardiology Authors: Christopher X. Wong, Ayodele Odutayo, Connor A. Emdin, Ned J. Kinnear, Michelle T. Sun Tags: Arrhythmias and Conduction Disturbances Source Type: research
Electrolyte disturbances and risk factors of acute kidney injury patients receiving dialysis in exertional heat stroke
Exertional heat stroke (EHS) is a life-threatening illness and leads to multi-organ dysfunction including acute kidney injury (AKI). The clinical significance of abnormal electrolytes and renal outcomes in ESH...
Source: BMC Nephrology - June 6, 2016 Category: Urology & Nephrology Authors: Bancha Satirapoj, Suramanat Kongthaworn, Panbubpa Choovichian and Ouppatham Supasyndh Source Type: research
Stroke Heroes 2016
The American Heart Association/American Stroke Association's Puget Sound Division, along with our sponsor Medtronic, congratulates the honorees for this year's Stroke Hero Awards. We had amazing stories sent to us. Thank you to all of you who submitted a nomination. Here are some of the inspiring individuals honored this year as a Stroke Hero. AMY MOORE, Stroke Survivor Amy is described as a truly an inspiring person who has never let her stroke stop her from accomplishing her goals. Her stroke was diagnosed at six months of age and left her legally blind. Amy learned Braille during her first two years of high school an...
Source: Healthy Living - The Huffington Post - July 12, 2016 Category: Consumer Health News Source Type: news
Risk Factors for Stroke in People with End-Stage Kidney Disease: A Cohort Study
Conclusions: These findings could be used to establish reliable estimates of the risk of stroke in people with ESKD and identify those who are most likely to benefit from preventive treatments.Cerebrovasc Dis 2016;42:428-438
Source: Cerebrovascular Diseases - August 9, 2016 Category: Neurology Source Type: research
Vitamin K antagonists for stroke prevention in hemodialysis patients with atrial fibrillation: a systematic review and meta-analysis
Conclusion Our meta-analysis revealed a trend for a reduction of the risk of ischemic stroke in hemodialysis patients with AF treated with VKA. The true protective effect may have been underestimated, owing to inclusion of low-risk patients not expected to benefit from anticoagulation and to suboptimal anticoagulation. However, assessment of the overall effect of VKA in hemodialysis patients should also take into account the increased risk of bleeding, in particular of hemorrhagic stroke. Whether new oral anticoagulants provide a better benefit–risk ratio in hemodialysis patients should be the subject of future trials.
Source: American Heart Journal - October 4, 2016 Category: Cardiology Source Type: research