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Cholesterol-lowering jab 'shows promise' for heart disease
Conclusion This mouse study evaluated the potential of the AT04A vaccine to lower cholesterol levels and potentially reduce or prevent heart disease. The results were promising, showing that mice given the vaccine produced antibodies against the enzyme that stops LDL cholesterol being cleared from the body. This resulted in reduced total and LDL blood cholesterol levels, as well as reduced atherosclerosis. No major safety concerns or side effects were reported. Following this research, AT04A has now moved on to a phase I clinical trial. A small number of people will be given the vaccine to see if it's safe for use in huma...
Source: NHS News Feed - June 20, 2017 Category: Consumer Health News Tags: Food/diet Heart/lungs Source Type: news

Will a cholesterol-busting vaccine work for humans?
Conclusion The first thing to keep in mind is this is an early-stage study in the development of a vaccine to lower cholesterol. The study found some of the experimental vaccines the researchers developed had an effect on the cholesterol levels of mice and monkeys to varying degrees. They now need to do further work to show the vaccine is effective and can be used safely in humans. Many drugs have very different effects in humans than they do in other animals. The use of statins to lower cholesterol and reduce the chances of a heart attack or stroke is well established and effective for many people. Although there is ongo...
Source: NHS News Feed - November 12, 2015 Category: Consumer Health News Tags: Heart/lungs Medication Source Type: news

Get the flu vaccine, reduce your risk of death
Last year was a lousy year for the flu vaccine. Hospitalizations for flu hit a nine-year high, and the vaccine prevented flu in only 23% of all recipients, compared with 50% to 60% of recipients in prior years. Why does the flu vaccine work well in some winters and not others? The flu vaccine primes the immune system to attack two proteins on the surface of the influenza A virus, hemagglutinin (H) and neuraminidase (N). Different flu strains have different combinations of these proteins — for example, the strains targeted by recent flu vaccines are H3N2 and H1N1. Unfortunately, the influenza virus is microbiology’s ans...
Source: New Harvard Health Information - September 15, 2015 Category: Consumer Health News Authors: John Ross, MD, FIDSA Tags: Cold and Flu Vaccines Flu Shot flu vaccine Source Type: news