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Total 3777 results found since Jan 2013.

Recurrent Stroke with Rapid Development of Intracranial Artery Stenosis and Subsequent Successful Mechanical Thrombectomy in Essential Thrombocythemia
Intern Med. 2023 Jul 26. doi: 10.2169/internalmedicine.2189-23. Online ahead of print.ABSTRACTEssential thrombocythemia is a myeloproliferative neoplasm. Ischemic stroke is frequently the first manifestation of essential thrombocythemia. We herein report a patient with JAK2V617 mutation-positive essential thrombocythemia who developed recurrent ischemic stroke with rapid development of intracranial artery stenosis and subsequently underwent successful mechanical thrombectomy. The high JAK2V617F allele burden in our patient (58.4%) may have affected the patient's condition. We discuss similar reports in the literature and t...
Source: Internal Medicine - July 26, 2023 Category: Internal Medicine Authors: Yuji Kato Shohei Iijima Shinya Kohyama Tomoya Maeda Tsugumi Sato Shinichi Takahashi Satoshi Suda Source Type: research

Stroke: causes and clinical features
Stroke is a clinically defined syndrome of acute, focal neurological deficit attributed to vascular injury (infarction, haemorrhage) of the central nervous system. It is the second leading cause of death and disability worldwide. Stroke is not a single disease but is caused by a wide range of risk factors, disease processes and mechanisms. Hypertension is the most important modifiable risk factor, although its contribution differs for different subtypes. Most (85%) strokes are ischaemic, predominantly caused by small vessel arteriolosclerosis, cardioembolism and large artery athero-thromboembolism.
Source: Medicine - July 25, 2023 Category: Internal Medicine Authors: Stephen JX. Murphy, David J. Werring Tags: Acute neurology Source Type: research

Stroke: management and prevention
Acute stroke treatment requires clear protocols to rapidly triage patients – using appropriate investigations – for mechanical thrombectomy and intravenous thrombolysis. Computed tomography (CT) excludes haemorrhage, CT angiography locates the occluded vessel, and CT perfusion and perfusion magnetic resonance imaging identify viable tissue. An organized approach to str oke care in a specialist environment reduces disability and saves lives. Adoption of a ‘care bundle’ approach, including the active management of pyrexia and hyperglycaemia, and early screening for swallowing difficulties, is beneficial.
Source: Medicine - July 25, 2023 Category: Internal Medicine Authors: Gina Hadley, Ivie I. Gbinigie, Joyce S. Balami, Alastair M. Buchan Tags: Acute neurology Source Type: research

Assessment of bidirectional relationships between brain imaging-derived phenotypes and stroke: a Mendelian randomization study
Stroke is a major cause of mortality and long-term disability worldwide. Whether the associations between brain imaging-derived phenotypes (IDPs) and stroke are causal is uncertain.
Source: BMC Medicine - July 25, 2023 Category: Internal Medicine Authors: Ke Yu, Xiao-Feng Chen, Jing Guo, Sen Wang, Xiao-Ting Huang, Yan Guo, Shan-Shan Dong and Tie-Lin Yang Tags: Research article Source Type: research

Comparative Effectiveness of Sodium-Glucose Cotransporter-2 Inhibitors for Recurrent Gout Flares and Gout-Primary Emergency Department Visits and Hospitalizations : A General Population Cohort Study
CONCLUSION: Among patients with gout, SGLT2is may reduce recurrent flares and gout-primary ED visits and hospitalizations and may provide cardiovascular benefits.PRIMARY FUNDING SOURCE: National Institute of Arthritis and Musculoskeletal and Skin Diseases.PMID:37487215 | DOI:10.7326/M23-0724
Source: Annals of Internal Medicine - July 24, 2023 Category: Internal Medicine Authors: Natalie McCormick Chio Yokose Jie Wei Na Lu Deborah J Wexler J Antonio Avi ña-Zubieta Mary A De Vera Yuqing Zhang Hyon K Choi Source Type: research

Ataxia and hyperkinetic movement disorders
Hyperkinetic movement disorders comprise excessive involuntary movements, the different types of movement having characteristic clinical features. Ataxia is a disorder of impaired coordination and balance, most commonly caused by cerebellar pathology. Sensory ataxia occurs when the pathways conveying proprioceptive sensory information are impaired. Chorea is a random writhing involuntary movement that can be caused by acute medical causes such as stroke and hyperglycaemia. Huntington disease is the most common cause of progressive chorea.
Source: Medicine - July 24, 2023 Category: Internal Medicine Authors: Christopher Kobylecki Tags: Movement disorders Source Type: research

Effects of digital-based interventions on muscular strength in adults: a systematic review, meta-analysis and meta-regression of randomized controlled trials with quality of evidence assessment
CONCLUSIONS: Overall, DBI may serve as an effective method to improve measures of strength in adults, regardless of their health status as well as the type of digital device, the presence of human-computer interaction, and the age of participants. In addition, the DBI was found to be more effective than traditional training or rehabilitation methods.KEY MESSAGESDigital-based intervention (DBI) is effective in improving measures of muscular strength in adults regardless of participants' health statusDBIs were equally effective for strength improvements in lower and upper limbsAlthough, DBIs were found to be effective in imp...
Source: Annals of Medicine - July 15, 2023 Category: Internal Medicine Authors: Armin Paravlic Luka Šlosar Ensar Abazovic Uros Marusic Source Type: research

Probabilistic graphical modelling using Bayesian networks for predicting clinical outcome after posterior decompression in patients with degenerative cervical myelopathy
CONCLUSIONS: The causal predictors of surgical outcome for DCM were sex, dementia and PreJOA score. Therefore, PGM may be a useful personalized medicine tool for predicting the outcome of patients with DCM.PMID:37435966 | DOI:10.1080/07853890.2023.2232999
Source: Annals of Medicine - July 12, 2023 Category: Internal Medicine Authors: Dong Ah Shin Sun-Ho Lee Sohee Oh Changwon Yoo Hee-Jin Yang Ikchan Jeon Sung Bae Park Source Type: research

Cytomegalovirus viremia in an 11-year-old child with sickle cell disease manifested only with fever: a case report
CONCLUSION: This case highlights the need to consider CMV infection in the differential diagnosis of every case of fever of unknown origin, regardless of the patient's immune status.PMID:37427240 | PMC:PMC10328612 | DOI:10.1097/MS9.0000000000000877
Source: Annals of Medicine - July 10, 2023 Category: Internal Medicine Authors: Mahfoud Eid Abd Ghanem Elias Saloum Source Type: research