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Total 21549 results found since Jan 2013.

Treatment of basilar artery stenosis with an Apollo balloon-expandable stent: a single-centre experience with 61 consecutive cases
In this study, the Apollo BES appeared to be feasible for BA stenosis. Our experience may be valuable for reducing the number of complications. However, further study is needed.
Source: Acta Neurologica Belgica - February 25, 2020 Category: Neurology Source Type: research

Transcranial direct current stimulation improves the swallowing function in patients with cricopharyngeal muscle dysfunction following a brainstem stroke
ConclusionThe bihemispheric anodal tDCS combined with simultaneous catheter balloon dilatation and conventional swallowing therapy effectively improves the swallowing function in patients with CPD caused by a brainstem stroke. tDCS may be an effective adjuvant therapy in CPD rehabilitation.
Source: Neurological Sciences - February 24, 2020 Category: Neurology Source Type: research

Association of Black Race With Early Recurrence After Minor Ischemic Stroke or Transient Ischemic Attack
This secondary analysis of the POINT randomized clinical trial examines the association between race and risk of early ischemic stroke recurrence after a minor ischemic stroke or transient ischemic attack among US participants.
Source: JAMA Neurology - February 24, 2020 Category: Neurology Source Type: research

Neurological Pupil Index as an Indicator of Neurological Worsening in Large Hemispheric Strokes
ConclusionsQuantitative monitoring of the pupillary response using an automated pupillometer could be a useful and noninvasive tool for detecting neurological deterioration due to cerebral edema in large hemispheric stroke patients.
Source: Neurocritical Care - February 24, 2020 Category: Neurology Source Type: research

Diagnostic Accuracy of Glial Fibrillary Acidic Protein and Ubiquitin Carboxy - Terminal Hydrolase - L1 Serum Concentrations for Differentiating Acute Intracerebral Hemorrhage from Ischemic Stroke
ConclusionsGFAP may differentiate ICH from ischemic stroke and stroke mimics. A point-of-care test to distinguish between ischemic and hemorrhagic strokes might facilitate triage to different treatment pathways or locations, or be used to select patients for trials of ultra-early interventions.
Source: Neurocritical Care - February 24, 2020 Category: Neurology Source Type: research

Carotid Revascularization and Its Effect on Cognitive Function: A Prospective Nonrandomized Multicenter Clinical Study
Background: There is conflicting data on the effect of carotid revascularization on cognitive function. Objective: To examine cerebral blood flow and cognitive function after carotid revascularization. Methods: Patients with unilateral, asymptomatic hemodynamically significant carotid artery stenosis (80% by computed tomography angiography or magnetic resonance angiography) were eligible. Cerebral blood flow was measured preoperatively and 1 month postoperatively using quantitative phase contrast magnetic resonance angiography.
Source: Journal of Stroke and Cerebrovascular Diseases - February 24, 2020 Category: Neurology Authors: Jenna L. Whooley, Brandon C. David, Henry H Woo, Brian L. Hoh, Kevin B. Raftery, Adnan Hussain Siddiqui, Michael Westerveld, Sepideh Amin-Hanjani, Zoher Ghogawala Source Type: research

Multiple Border-Zone Infarcts Triggered by Influenza A Virus Infection in a Patient With Cerebral Autosomal Dominant Arteriopathy Presenting With Subcortical Infarcts and Leukoencephalopathy
We report the case of a 41-year-old woman with CADASIL who developed multiple border-zone infarcts due to influenza A virus infection. The patient had no apparent history or episode of stroke or altered consciousness following the onset of respiratory symptoms, which were due to the influenza A infection.
Source: Journal of Stroke and Cerebrovascular Diseases - February 24, 2020 Category: Neurology Authors: Keisuke Mizutani, Keita Sakurai, Ikuko Mizuta, Toshiki Mizuno, Hiroyuki Yuasa Tags: Case Report Source Type: research

Multinucleated Giant Cells in Experimental Intracerebral Hemorrhage
In conclusion, MGCs represent a macrophage/microglia subtype with strong phagocytosis capacity. MGCs exhibited not only an M2 but also an M1 phenotype and appeared involved in hemoglobin degradation. Anti-CD47 antibody boosted the number of MGCs, which may contribute to enhance hematoma clearance. Understanding the exact roles of MGCs in ICH may reveal novel targets for ICH treatment.
Source: Translational Stroke Research - February 23, 2020 Category: Neurology Source Type: research

Amantadine and memantine: a comprehensive review for acquired brain injury.
Authors: Ma HM, Zafonte RD Abstract This comprehensive review discusses clinical studies of patients following brain injuries (traumatic, acquired, or stroke), who have been treated with amantadine or memantine. Both amantadine and memantine are commonly used in the acute rehabilitation setting following brain injuries, despite their lack of FDA-approval for neuro-recovery. Given the broad utilization of such agents, there is a need to review the evidence supporting this common off-label prescribing. The purpose of this review is to describe the mechanisms of action for memantine and amantadine, as well as to compl...
Source: Brain Injury - February 22, 2020 Category: Neurology Tags: Brain Inj Source Type: research

Use of Middle Cerebral Artery Visualization with Coronal Computed Tomography to Access Target Artery in Mechanical Thrombectomy
We examined whether visualization of the middle cerebral artery (MCA) by coronal images of nonenhanced computed tomography (coronal CT) provides useful preoperative information on the vessel course in the setting of MT. Methods and Results: We retrospectively studied 29 patients with ischemic stroke of the internal carotid artery and MCA occlusion who were admitted to our hospital within 4.5 hours from stroke onset and underwent MT.
Source: Journal of Stroke and Cerebrovascular Diseases - February 22, 2020 Category: Neurology Authors: Yuichiro Ohya, Takeshi Uwatoko, Taichiro Mizokami, Kenichi Matsumoto, Go Hashimoto, Hiroshi Sugimori Source Type: research

Prospectively Collected Cardiovascular Biomarkers and White Matter Hyperintensity Volume in Ischemic Stroke Patients
Background: Few prospective cohort studies collect detailed information on stroke characteristics among individuals who experience ischemic stroke, including white matter hyperintensity volume, and thus cannot explore how prospectively collected biomarkers prior to the stroke influence white matter hyperintensity volume. We explored the association between a large panel of prospectively collected lipid and inflammatory biomarkers and white matter hyperintensity volume among participants in the Women's Health Study with incident ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - February 22, 2020 Category: Neurology Authors: Pamela M. Rist, Nancy R. Cook, Julie E. Buring, Kathryn M. Rexrode, Natalia S. Rost Source Type: research

Wake-up stroke: thrombolysis reduces ischemic lesion volume and neurological deficit
ConclusionsrTPA in WUS patients selected with CT and/or CTP resulted in reduced ischemic infarct volume on follow-up CT and better functional outcome without increment of intracranial hemorrhages and in-hospital mortality.
Source: Journal of Neurology - February 21, 2020 Category: Neurology Source Type: research

Modeling Mixed Vascular and Alzheimer ’s Dementia Using Focal Subcortical Ischemic Stroke in Human ApoE4-TR:5XFAD Transgenic Mice
AbstractSubcortical white matter ischemic lesions are increasingly recognized to have pathologic overlap in individuals with Alzheimer ’s disease (AD). The interaction of white matter ischemic lesions with amyloid pathology seen in AD is poorly characterized. We designed a novel mouse model of subcortical white matter ischemic stroke and AD that can inform our understanding of the cellular and molecular mechanisms of mixed vascul ar and AD dementia. Subcortical white matter ischemic stroke underlying forelimb motor cortex was induced by local stereotactic injection of an irreversible eNOS inhibitor. Subcortical white mat...
Source: Translational Stroke Research - February 21, 2020 Category: Neurology Source Type: research

Are There Trigger Points in the Spastic Muscles? Electromyographical Evidence of Dry Needling Effects on Spastic Finger Flexors in Chronic Stroke
The purpose was to examine the immediate effects of dry needling to spastic finger muscles in chronic stroke. Ten chronic stroke patients with spasticity in finger flexors participated in this experiment. Dry needling to the flexor digitorum superficialis (FDS) muscle was performed under ultrasound guidance for about 30 s (about 100 times). Clinical assessment and intramuscular needle EMG readings were made before and immediately after dry needling. Immediately after needling, the FDS muscle was felt less tight to palpation and the proximal phalangeal joint rested in a less flexed position (p = 0.036). The MAS score decrea...
Source: Frontiers in Neurology - February 21, 2020 Category: Neurology Source Type: research

Predicting Early Post-stroke Aphasia Outcome From Initial Aphasia Severity
Conclusions: Initial aphasia severity was the best predictor of early post-stroke aphasia outcome, whereas lesion measures, though highly correlated, show less influence on the prediction model. We suggest that factors predicting early recovery may differ from those involved in long-term recovery.
Source: Frontiers in Neurology - February 21, 2020 Category: Neurology Source Type: research

Management of Spasticity After Traumatic Brain Injury in Children
Traumatic brain injury is a common cause of disability worldwide. In fact, trauma is the second most common cause of death and disability, still today. Traumatic brain injury affects nearly 475 000 children in the United States alone. Globally it is estimated that nearly 2 million people are affected by traumatic brain injuries every year. The mechanism of injury differs between countries in the developing world, where low velocity injuries and interpersonal violence dominates, and high-income countries where high velocity injuries are more common. Traumatic brain injury is not only associated with acute problems, but pati...
Source: Frontiers in Neurology - February 21, 2020 Category: Neurology Source Type: research

Neuroprotective effects of miR-532-5p against ischemic stroke
In this study, we established anin vivo middle cerebral artery occlusion (MCAO) model in mice. The expression level of miR-532-5p, neurological score, infarct area, neuronal apoptosis, and phosphoinositide 3-kinase (PI3K)/Akt signaling pathway-related molecules were examined. Low miR-532-5p levels and high phosphatase and tensin homolog deleted on chromosome 10 (PTEN) levels were detected in the mouse MCAO model. MiR-532-5p overexpression improved neurological dysfunction, reduced the infarct area, attenuated neuronal injury and apoptosis, and promoted the activation of the PI3K/Akt signaling pathway in MCAO mice. In vitro...
Source: Metabolic Brain Disease - February 21, 2020 Category: Neurology Source Type: research

The influence of statins on the risk of post-stroke epilepsy
ConclusionAdequate treatment with statins after stroke may lower the risk of PSE.
Source: Neurological Sciences - February 21, 2020 Category: Neurology Source Type: research

Value of thrombus imaging in predicting the outcomes of patients with large-vessel occlusive strokes after endovascular therapy
ConclusionImaging of thrombus can be used as an aseessment tool to predict the outcomes and it needs further studies in the future.
Source: Neurological Sciences - February 21, 2020 Category: Neurology Source Type: research

Relationship Between Vascular Risk Factors and Location of Intracranial Atherosclerosis in the SAMMPRIS Trial
Background: Previous studies have reported that different locations of intracranial atherosclerosis (ICAS) are associated with different demographic features and vascular risk factors. We aimed to examine this observation in the Stenting and Aggressive Medical Management for Preventing Recurrent stroke in Intracranial Stenosis (SAMMPRIS) trial population. Methods: SAMMPRIS was a randomized controlled trial that enrolled 451 patients with recent transient ischemic attack or stroke-related due to severe (70%-99%) stenosis of a major intracranial artery.
Source: Journal of Stroke and Cerebrovascular Diseases - February 21, 2020 Category: Neurology Authors: Eyad Almallouhi, Sami Al Kasab, Lidia Yamada, Renee' H. Martin, Tanya N. Turan, Marc I. Chimowitz Source Type: research

A Case of Subcortical Hemorrhage in the Left Temporal Lobe Caused by Multiple Dural Arteriovenous Fistulas
We present a case of TS-SS dAVF and ACC dAVF that developed subcortical hemorrhage of left temporal lobe. A 66-year-old woman with no past history was transferred to our hospital for sudden-onset consciousness disturbance, and was urgently admitted after the detection of a subcortical hemorrhage in the left temporal lobe.
Source: Journal of Stroke and Cerebrovascular Diseases - February 21, 2020 Category: Neurology Authors: Ryo Usui, Daisuke Ishima, Yuki Abe, Yu Sato, Ayato Kimura, Takuma Kimoto, Makoto Nagashima, Tomomi Adachi, Naomi Nagata, Jun Niki, Daisuke Yamamoto, Tsugio Akutsu, Kazutoshi Nishiyama Tags: Case Report Source Type: research

Prevalence of a Multiple Territory Stroke Pattern After Intravenous Thrombolysis
Background: It has been proposed that the presence of a multiple territory stroke pattern (MTSP) on brain imaging may aid identification of patients with covert atrial fibrillation (AF). However, it is uncertain whether this association holds true among patients treated with intravenous recombinant tissue plasminogen activator (rtPA) because clot fragmentation may affect MTSP prevalence. Methods/Design: Retrospective analysis of 149 acute ischemic stroke patients treated with intravenous rtPA who underwent brain MRI.
Source: Journal of Stroke and Cerebrovascular Diseases - February 21, 2020 Category: Neurology Authors: Muhammad Umer Azeem, Muhammad Nagy, Malgorzata M. Miller, Mehdi Ghasemi, Abdul Mikati, Brian Silver, Majaz Moonis, Nils Henninger Source Type: research

Unstable Carotid Plaque as a Phenotype of Chronic Systemic Inflammation Enhances Renal Insufficiency
In this study, we explored the association between the unstable plaques and preoperative CKD in patients who underwent carotid endarterectomy (CEA)/carotid artery stenting (CAS). Furthermore, this study also aimed to explore whether there is a difference in the aggravation of renal function with the presence of stable or unstable plaques. Patients and Methods: The study included 90 patients who underwent CEA/CAS for carotid artery stenosis.
Source: Journal of Stroke and Cerebrovascular Diseases - February 21, 2020 Category: Neurology Authors: Daina Kashiwazaki, Kunitaka Maruyama, Shusuke Yamamoto, Hisayasu Saito, Naoki Akioka, Naoya Kuwayama, Kyo Noguchi, Satoshi Kuroda Source Type: research

Statin Pretreatment Might Be Associated with Decreased Myocardial Injury After Ischemic Stroke
In this study, we aimed at investigating the association between statin pretreatment and poststroke myocardial injury. Methods: Six hundred seventy-one patients diagnosed as acute ischemic stroke were enrolled. According to the histories of statin pretreatment before stroke, patients were categorized into nonstatin (n  = 474) and statin groups (n = 197), with the latter further divided into low-dosage, standard-dosage, and high-dosage subgroups according the dosages of statins.
Source: Journal of Stroke and Cerebrovascular Diseases - February 21, 2020 Category: Neurology Authors: Ke-Wu Wang, Chao Feng, Yin-Fei Wu, Jing Huang, Wen-Bo Xiao, Shu-Dong Xia Source Type: research

A Propensity Score-Matched Comparison of Readmission Rates Associated With Microsurgical Clipping and Endovascular Treatment of Ruptured Intracranial Aneurysms
Background: In the treatment of aneurysmal subarachnoid hemorrhage (aSAH), microsurgical clipping, and endovascular therapy (EVT) with coiling are modalities for securing the ruptured aneurysm. Little data is available regarding associated readmission rates. We sought to determine whether readmission rates differed according to treatment modality for ruptured intracranial aneurysms. Methods: The Nationwide Readmissions Database (NRD) was used to identify adults who experienced aSAH and underwent clipping or EVT.
Source: Journal of Stroke and Cerebrovascular Diseases - February 21, 2020 Category: Neurology Authors: Haydn Hoffman, Muhammad S. Jalal, Lawrence S. Chin Source Type: research

Effectiveness of Paroxetine for Poststroke Depression: A Meta-Analysis
Objective: The purpose of our study is to evaluate the efficacy of paroxetine in poststroke depression (PSD) patients by conducting a meta-analysis. Methods: We searched Web of Science (science and social science citation index), PubMed, the Cochrane Central Register of Controlled Trials, Embase up to August 2019. Randomized controlled trials that paroxetine compared to other antidepressants or control treatments as monotherapy for patients with PSD. Results: This review identified a total of 4 studies including 212 patients.
Source: Journal of Stroke and Cerebrovascular Diseases - February 21, 2020 Category: Neurology Authors: Lijuan Li, Zhifen Han, Lingxin Li, Lin Han, Bo Yan Source Type: research

Endovascular Treatment for Acute Basilar Artery Occlusion via a Nationwide Prospective Registry
This nonrandomized cohort study evaluates the association between endovascular treatment and the clinical outcomes of patients with stroke and acute basilar artery occlusion, compared with patients who received standard medical treatment only.
Source: JAMA Neurology - February 20, 2020 Category: Neurology Source Type: research

Equitable access to stroke care in Canada - the geographic conundrum.
PMID: 32077393 [PubMed - as supplied by publisher]
Source: The Canadian Journal of Neurological Sciences - February 20, 2020 Category: Neurology Authors: Butt A, Jeerakathil T Tags: Can J Neurol Sci Source Type: research

Immediate kinematic and muscle activity changes after a single robotic exoskeleton walking session post-stroke.
Conclusions: EKSO training appears capable of altering gait in people with chronic stroke and a viable intervention to reduce gait dysfunction post-stroke. PMID: 32077382 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - February 20, 2020 Category: Neurology Authors: Swank C, Almutairi S, Wang-Price S, Gao F Tags: Top Stroke Rehabil Source Type: research

Translational Genomics in Neurocritical Care: a Review
AbstractTranslational genomics represents a broad field of study that combines genome and transcriptome-wide studies in humans and model systems to refine our understanding of human biology and ultimately identify new ways to treat and prevent disease. The approaches to translational genomics can be broadly grouped into two methodologies, forward and reverse genomic translation. Traditional (forward) genomic translation begins with model systems and aims at using unbiased genetic associations in these models to derive insight into biological mechanisms that may also be relevant in human disease. Reverse genomic translation...
Source: Neurotherapeutics - February 20, 2020 Category: Neurology Source Type: research

Review on the Diagnosis and Treatment of Reversible Cerebral Vasoconstriction Syndrome in Children and Adolescents
Semin Neurol DOI: 10.1055/s-0040-1702942Reversible cerebral vasoconstriction syndrome (RCVS) is a clinical–radiologic diagnosis that affects children and adolescents, but it is much more frequently reported in adults. Clinically, patients present with severe and commonly recurrent thunderclap headaches. Typical precipitating triggers include vasoactive substances, serotonergic agents, and the postpartum period. There may be associated neurologic complications at presentation or in the weeks following, such as convexity subarachnoid hemorrhage, stroke, cerebral edema, cervical artery dissection (CeAD), and seizures. Angio...
Source: Seminars in Neurology - February 20, 2020 Category: Neurology Authors: Qubty, William Irwin, Samantha Lee Fox, Christine K. Tags: Review Article Source Type: research

Safety and efficacy of GABAA α5 antagonist S44819 in patients with ischaemic stroke: a multicentre, double-blind, randomised, placebo-controlled trial
Publication date: March 2020Source: The Lancet Neurology, Volume 19, Issue 3Author(s): Hugues Chabriat, Claudio L Bassetti, Ute Marx, Marie-Laure Audoli-Inthavong, Aurore Sors, Estelle Lambert, Marine Wattez, Dirk M Hermann, Katharina ALTHAUS, Sergi AMARO, Hee-Joon BAE, Zbigniew BAK, Leonardo BARBARINI, Pietro BASSI, Rodrigo BAZAN, Daniel BERECZKI, Tomasz BERKOWICZ, Joerg BERROUSCHOT, Dylan BLACQUIERE, Waldemar BROLASummaryBackgroundS44819, a selective GABAA α5 receptor antagonist, reduces tonic post-ischaemic inhibition of the peri-infarct cortex. S44819 improved stroke recovery in rodents and increased cortical excitabi...
Source: The Lancet Neurology - February 19, 2020 Category: Neurology Source Type: research

Issues important to the design of stroke recovery trials
Publication date: March 2020Source: The Lancet Neurology, Volume 19, Issue 3Author(s): Steven C Cramer
Source: The Lancet Neurology - February 19, 2020 Category: Neurology Source Type: research

CADASIL as Multiple Sclerosis Mimic: a 48-year-old man with severe leukoencephalopathy and spinal cord involvement.
Publication date: Available online 19 February 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Francesco Motolese, Mariagrazia Rossi, Emma Gangemi, Anna Bersano, Emma Scelzo, Vincenzo Di Lazzaro, Fioravante CaponeAbstractCerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a common cause of inherited stroke in young adults. CADASIL causes extensive white matter T2 hyperintensities at brain MRI, in particular involving anterior-temporal lobes and external capsules; usually, there is no spinal cord involvement. Since CADASIL clinical spectrum is heterogeneous ...
Source: Multiple Sclerosis and Related Disorders - February 19, 2020 Category: Neurology Source Type: research

Virtual reality therapy for upper limb rehabilitation in patients with stroke: a meta-analysis of randomized clinical trials.
Conclusion: VR appears to be a promising therapeutic technology for UL motor rehabilitation in patients with stroke. PMID: 32064964 [PubMed - as supplied by publisher]
Source: Brain Injury - February 19, 2020 Category: Neurology Tags: Brain Inj Source Type: research

Prolactin attenuates global cerebral ischemic injury in rat model by conferring neuroprotection.
Conclusion: Prolactin is able to ameliorate ischemia-reperfusion injury in rat brain and might be a potent candidate for further neuro-therapeutics development. PMID: 32064956 [PubMed - as supplied by publisher]
Source: Brain Injury - February 19, 2020 Category: Neurology Tags: Brain Inj Source Type: research

Agreement and differences regarding family functioning between patients with acquired brain injury and their partners.
CONCLUSIONS: Health care professionals should assess family functioning after stroke in both patients and their partners, and any discrepancies should be discussed with both members of the patient-partner dyad. PMID: 32064947 [PubMed - as supplied by publisher]
Source: Brain Injury - February 19, 2020 Category: Neurology Tags: Brain Inj Source Type: research

Vascular-brain Injury Progression after Stroke (VIPS) study: concept for understanding racial and geographic determinants of cognitive decline after stroke
Cognitive impairment and dementia (CID) are major public health problems with substantial personal, social, and financial burdens. African Americans are at a heightened risk for Vascular Cognitive Impairment (VCI) compared to European Americans. Recent lines of evidence also suggest a high burden of Post-stroke VCI among indigenous Africans. A better understanding of the cause(s) of the racial disparity in CID, specifically VCI, is needed in order to develop strategies to reduce it.We propose and discuss the conceptual framework for a unique tri-population, trans-continental study titled The Vascular brain Injury Progressi...
Source: Journal of the Neurological Sciences - February 19, 2020 Category: Neurology Authors: Fred Stephen Sarfo, Rufus Akinyemi, George Howard, Virginia J. Howard, Kolawole Wahab, Mary Cushman, Deborah A. Levine, Adesola Ogunniyi, Fred Unverzagt, Mayowa Owolabi, Bruce Ovbiagele Tags: Review Article Source Type: research

A calcium channel or angiotensin converting enzyme inhibitor/angiotensin receptor blocker regime to reduced blood pressure variability in acute ischaemic stroke (CAARBS): A feasibility trial
Trials of lowering blood pressure in patients with acute ischaemic stroke not undergoing thrombolysis have not demonstrated improved outcomes with intervention. Rather than absolute levels, it may be that blood pressure variability is important. However, there are no prospective randomised trials investigating the benefit of reducing blood pressure variability in this patient group.
Source: Journal of the Neurological Sciences - February 19, 2020 Category: Neurology Authors: William J. Davison, Karen Appiah, Thompson G. Robinson, Iain J. McGurgan, Peter M. Rothwell, John F. Potter Source Type: research

Mechanical Thrombectomy for Patients with In-Hospital Ischemic Stroke: A Case-Control Study
Background and Aim: Patients with in-hospital acute ischemic stroke (AIS) have, in general, worse outcomes compared to those presenting from the community, partly attributed to the numerous contraindications to intravenous thrombolysis. We aimed to identify and analyze a group of patients with in-hospital AIS who remain suitable candidates for acute endovascular therapies. Methods: A retrospective 6-year data analysis was conducted in patients evaluated through the in-hospital stroke alert protocol in a single tertiary care university hospital to identify those with in-hospital AIS due to acute intracranial large vessel occlusion (ILVO).
Source: Journal of Stroke and Cerebrovascular Diseases - February 18, 2020 Category: Neurology Authors: Zachary Bulwa, Victor J. Del Brutto, Andrea Loggini, Faten El Ammar, Raisa C. Martinez, Gregory Christoforidis, James R. Brorson, Agnieszka A. Ardelt, Fernando D. Goldenberg Source Type: research

Locomotor training intensity after stroke: Effects of interval type and mode.
Conclusions: Both short and long-interval HIIT elicit high intensities but emphasize different dosing parameters. From these preliminary findings and previous studies, we hypothesize that overground and treadmill short-interval HIIT could be optimal for improving gait speed and overground long-interval HIIT could be optimal for improving gait endurance. PMID: 32063178 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - February 16, 2020 Category: Neurology Authors: Boyne P, Scholl V, Doren S, Carl D, Billinger SA, Reisman DS, Gerson M, Kissela B, Vannest J, Dunning K Tags: Top Stroke Rehabil Source Type: research

Acute Ischemic Stroke Outcome and Preceding Anticoagulation: Direct Oral Anticoagulants Versus Vitamin K Antagonists
Oral anticoagulation is recommended for primary and secondary prevention of cardioembolic acute ischemic stroke (AIS). In nonvalvular atrial fibrillation (AF), direct oral anticoagulants (DOAC) efficacy and safety have been largely proven and are recommended over vitamin K antagonists (VKA) by international guidelines.1-3 AIS in the setting of AF is more often disabling and leads to increased mortality compared with stroke in patients without AF.4
Source: Journal of Stroke and Cerebrovascular Diseases - February 14, 2020 Category: Neurology Authors: Sofia Fel ício Tavares, Inês Ferreira, Vanessa Chaves, Luis Flores, Cristina Correia, Jorge Almeida, Luísa Fonseca, Paulo Castro Chaves Source Type: research

The Value of Whole-Brain Perfusion Parameters Combined with Multiphase Computed Tomography Angiography in Predicting Hemorrhagic Transformation in Ischemic Stroke
Objective: To explore the value of whole-brain perfusion parameters combined with multiphase computed tomography angiography (MP-CTA) in predicting the hemorrhagic transformation (HT) of ischemic stroke. Methods: A total of 64 patients with ischemic stroke who underwent noncontrast computed tomography, computed tomography perfusion imaging, and computed tomography angiography before treatment from August 2017 to June 2019 were included retrospectively. The perfusion parameters cerebral blood volume (CBV), cerebral blood flow (CBF), time to peak (TTP), mean transit time (MTT), time to maximum (Tmax), and permeability surfac...
Source: Journal of Stroke and Cerebrovascular Diseases - February 14, 2020 Category: Neurology Authors: Xiang Li, Huan Liu, Wenbing Zeng, Xinghua Liu, Yun Wen, Qiuxia Xiong, Ran Yang Source Type: research

Early Cognitive Assessment Following Acute Stroke: Feasibility and Comparison between Mini-Mental State Examination and Montreal Cognitive Assessment
Objectives: Cognitive assessment is not performed routinely in the acute stroke setting. We investigated factors associated with cognitive impairment and the differences between the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores in patients with acute stroke. Methods: In this prospective study, 881 consecutive patients (median age, 73 years) with acute stroke were enrolled. Clinical characteristics, such as education, vascular risk factors, premorbid cognitive status using the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE), and stroke severity, were assessed.
Source: Journal of Stroke and Cerebrovascular Diseases - February 14, 2020 Category: Neurology Authors: Satoshi Suda, Kanako Muraga, Akiko Ishiwata, Takuya Nishimura, Junya Aoki, Takuya Kanamaru, Kentaro Suzuki, Yuki Sakamoto, Takehiro Katano, Koichiro Nagai, Seira Hatake, Sera Satoi, Noriko Matsumoto, Chikako Nito, Yasuhiro Nishiyama, Masahiro Mishina, Kaz Source Type: research

Prognostic Value of NT-proBNP After Ischemic Stroke: A Systematic Review and Meta-analysis of Prospective Cohort Studies
Background: Many studies have evaluated the relationship between N-terminal pro-brain natriuretic peptide (NT-proBNP) and its prognostic value in ischemic stroke. However, a widespread consensus has not been reached. Therefore, we completed a meta-analysis to evaluate the prognostic significance of NT-proBNP for mortality and functional outcome in patients with ischemic stroke. Methods: We performed a systematic search and review using the PubMed and EMBASE databases to identify literature that reported a correlation between NT-proBNP and mortality and functional outcome in ischemic stroke patients.
Source: Journal of Stroke and Cerebrovascular Diseases - February 14, 2020 Category: Neurology Authors: Yu-Hang Zhao, Hong Gao, Zhi-Yong Pan, Jie Li, Wen-Hong Huang, Ze-Fen Wang, Zhi-Qiang Li Source Type: research

Automated Continuous Electrocardiogram Monitoring Accelerates the Detection of Atrial Fibrillation after Ischemic Stroke or Transient Ischemic Attack on a Hyper Acute Stroke Unit
Background and Aim: Rapid and sensitive detection of atrial fibrillation (AF) is of paramount importance for initiation of adequate preventive therapy after stroke. Stroke Unit care includes continuous electrocardiogram monitoring (CEM) but the optimal exploitation of the recorded ECG traces is controversial. In this retrospective single-center study, we investigated whether an automated analysis of continuous electrocardiogram monitoring (ACEM), based on a software algorithm, accelerates the detection of AF in patients admitted to our Stroke Unit compared to the routine CEM.
Source: Journal of Stroke and Cerebrovascular Diseases - February 11, 2020 Category: Neurology Authors: Lucio D'Anna, Arindam Kar, Zoe Brown, Kirsten Harvey, Soma Banerjee, Eleni Korompoki, Roland Veltkamp Source Type: research

Health-related quality of life (HRQoL) after stroke: Positive relationship between lower extremity and balance recovery.
Conclusions: Our result shows that LE motor recovery impacts the QoL more than motor recovery of UE after 60 days of neurorehabilitation. This finding is strengthened by a positive regression between balance skills and QoL. PMID: 32041495 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - February 10, 2020 Category: Neurology Authors: Martino Cinnera A, Bonnì S, Pellicciari MC, Giorgi F, Caltagirone C, Koch G Tags: Top Stroke Rehabil Source Type: research

Apolipoproteins B and A1 in Ischemic Stroke Subtypes
Introduction: Elevated serum apolipoprotein B and the apolipoprotein B/A1 ratio have been associated with ischemic stroke and intracranial atherosclerotic disease. We sought to assess the relationship between serum levels of apolipoprotein B, apolipoprotein A1, and the apolipoprotein B/A1 ratio with ischemic stroke subtypes and large artery atherosclerosis location. Materials and Methods: We evaluated serum apolipoprotein B and apolipoprotein A1 levels in consecutive, statin-na ïve, adult ischemic stroke patients admitted to an academic medical center in southern India.
Source: Journal of Stroke and Cerebrovascular Diseases - February 10, 2020 Category: Neurology Authors: Rizwan Kalani, Soumya Krishnamoorthy, D. Deepa, Srinivas Gopala, Dorairaj Prabhakaran, David Tirschwell, P.N. Sylaja Source Type: research

Low Hemoglobin Levels at Admission Are Independently Associated with Cognitive Impairment after Ischemic Stroke: a Multicenter, Population-Based Study
AbstractData on the association between hemoglobin (Hb) levels and poststroke cognitive function are limited. We investigated the relationship between Hb concentrations at admission and poststroke cognitive function using a multicenter database. In total, 1081 patients were recruited from seven Chinese medical centers within 6  months after experiencing ischemic stroke. Cognitive status was evaluated with a series of brief neuropsychological tests. A subgroup of 439 patients from a single center was followed up for 4–6 years and was eventually reassessed with a cognitive test. The association between Hb and cognitive i...
Source: Translational Stroke Research - February 10, 2020 Category: Neurology Source Type: research

FasL-PDPK1 Pathway Promotes the Cytotoxicity of CD8 + T Cells During Ischemic Stroke
AbstractCD8+ T cells are recognized as key players in exacerbation of ischemic stroke; however, the underlying mechanism in modulating the function of CD8+ T cells has not been completely elucidated. Here, we uncovered that FasL enhanced the cytotoxicity of CD8+ T cells to neurons after ischemic stroke. Inactivation of FasL specific on CD8+ T cells protected against brain damage and neuron loss. Proteomic analysis identified that PDPK1 functioned downstream of FasL signaling and inhibition of PDPK1 effectively reduced cytotoxicity of CD8+ T cells and improved ischemic neurological deficits. Taken together, these results hi...
Source: Translational Stroke Research - February 8, 2020 Category: Neurology Source Type: research