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Procedure: Lung Transplant
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Total 372 results found since Jan 2013.
New Data From Two Large Studies Reinforce Effectiveness of Dual Pathway Inhibition (DPI) with XARELTO ® (rivaroxaban) Plus Aspirin in Patients with Coronary Artery Disease (CAD) and/or Peripheral Artery Disease (PAD)
RARITAN, N.J., May 23, 2022 – Findings from the XARELTO® (rivaroxaban) Phase 3 COMPASS Long-Term Open Label Extension (LTOLE) study and the XARELTO® in Combination with Acetylsalicylic Acid (XATOA) registry have been published in the European Society of Cardiology’s (ESC) European Heart Journal, Cardiovascular Pharmacotherapy. Additionally, the XATOA registry was presented at the American Congress of Cardiology’s 71st Annual Scientific Session (ACC.22). These studies provide further evidence supporting the role of dual pathway inhibition (DPI) with the XARELTO® vascular dose (2.5 mg twice daily plus aspirin 100 mg...
Source: Johnson and Johnson - May 23, 2022 Category: Pharmaceuticals Source Type: news
Atrioventricular plane displacement and regional function to predict outcome in pulmonary arterial hypertension
AbstractTo investigate if left and right atrioventricular plane displacement (AVPD) or regional contributions to SV are prognostic for outcome in patients with pulmonary arterial hypertension (PAH). Seventy-one patients with PAH and 20 sex- and age-matched healthy controls underwent CMR. Myocardial borders and RV insertion points were defined at end diastole and end systole in cine short-axis stacks to compute biventricular volumes, lateral (SVlat%) and septal (SVsept%) contribution to stroke volume. Eight atrioventricular points were defined at end diastole and end systole in 2-, 3- and 4-chamber cine long-axis views for ...
Source: The International Journal of Cardiovascular Imaging - April 23, 2022 Category: Radiology Source Type: research
Data from New VOYAGER PAD Analyses at ACC.22 Reinforce Benefit of XARELTO ® (rivaroxaban) Plus Aspirin in Patients with Peripheral Artery Disease (PAD) and Various Co-Morbid Conditions
RARITAN, N.J., April 1, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced data from new analyses from the Phase 3 VOYAGER PAD clinical trial reinforcing the benefit of the XARELTO® (rivaroxaban) vascular dose (2.5 mg twice daily plus aspirin 100 mg once daily) in reducing severe vascular events in patients with PAD after lower-extremity revascularization (LER), a procedure that restores blood flow to the legs. Data from the two analyses demonstrate the role that the XARELTO® vascular dose plays in PAD patients with and without chronic kidney disease (CKD) and in PAD patients with and ...
Source: Johnson and Johnson - April 1, 2022 Category: Pharmaceuticals Tags: Innovation Source Type: news
Comparing Velocity and Mean Arterial Pressure to Assess Pulsatility in Patients with Continuous Flow Left Ventricular Assist Devices
An increasing number of end-stage heart failure patients are supported by continuous-flow Left Ventricular Assist Devices (cfLVADs). In these patients, accurate assessment of arterial pulsatility remains a challenge because of diminished pulse pressure. Limited pulsatility in modern cfLVADs itself can be associated with adverse events such as stroke. Our study investigates the value of simultaneous arterial pressure and arterial blood velocity assessment in cfLVAD patients.
Source: The Journal of Heart and Lung Transplantation - April 1, 2022 Category: Transplant Surgery Authors: S. Emmanuel, A. Adji, P. Jansz, C. Hayward Tags: (871) Source Type: research
Computational Investigation of Outflow Graft Variation Impact on Hemocompatibility Profile in LVADs
This study, used a simulation-based approach to investigate the influence that the cannula orientation has in modulating flow conditions leading to HRAEs.
Source: The Journal of Heart and Lung Transplantation - April 1, 2022 Category: Transplant Surgery Authors: B.A. Zambrano, S. Ingram, M.R. Moreno, M. Kassi Tags: (1161) Source Type: research
Increased Nocturnal Arterial Stiffness is Associated with a Higher Risk of Stroke in LVAD Patients
In this study, we aimed to investigate whether increased arterial stiffness is associated with a higher risk of stroke in LVAD patients.
Source: The Journal of Heart and Lung Transplantation - April 1, 2022 Category: Transplant Surgery Authors: F. Castagna, G.M. Mondellini, B. McDonnell, A. Pinsino, M. Tiburcio, M. Pineda, K. Takeda, Y. Naka, A. Ladanyi, G.T. Sayer, N. Uriel, M. Yuzefpolskaya, J.Z. Willey, G. Parati, J. Cockcroft, P.C. Colombo Tags: (1148) Source Type: research
Optimization of Left Ventricle Size After VAD Implantation Prevents Incidence of Cerebral Infarction
Stroke after ventricular assist device (VAD) implantation is a critical complication. Previous studies have noted the distance between the inflow cannula and the left ventricular (LV) septum, as well as an angulation of the inflow cannula from the apical axis, related to the incidence of stroke. In the early phase after VAD implantation, diuresis is caused by improved renal blood flow, furthermore, rapid volume reduction of LV greatly changes circulating plasma volume, resulting in increased stroke risk; however, little is known about an appropriate indicator for the prevention of this phenomenon.
Source: The Journal of Heart and Lung Transplantation - April 1, 2022 Category: Transplant Surgery Authors: R. Ikeda, Y. Ichihara, Y. Yamada, S. Saito, T. Nishinaka, T. Shinkawa, H. Niinami Tags: (1142) Source Type: research
Stroke and Pump Thrombosis Following LVAD Implantation: The Impact of the Implantation Approach
The aim of this study is to investigate the impact of LVAD (left ventricular assist device) implantation technique on long-term mortality and morbidity, with special focus on stroke and pump thrombosis.
Source: The Journal of Heart and Lung Transplantation - April 1, 2022 Category: Transplant Surgery Authors: M. Nozdrzykowski Tags: (650) Source Type: research
Unique Findings of Myocardial Improvement with Lower Left Ventricular Assist Device Pump Speed
Currently, optimizing hemodynamics and unloading in patients with left ventricular assist device (LVAD) relies on echocardiography and right heart catherization guidance for pump speed adjustments. However, the ideal unloading strategy to maximize reverse remodelling is uncertain - whether to provide maximal pump support to unload the heart ( ‘rest’), or maximize ventricular work with partial pump support (‘work’). Using non-invasively derived PV loops, we sought to characterize the longitudinal changes in chamber contractile parameters stroke work (SW), peak systolic pressure (LVPmax) and peak LV elastance (Ees) a...
Source: The Journal of Heart and Lung Transplantation - April 1, 2022 Category: Transplant Surgery Authors: A. Gunawan, D. Robson, A. Ramanayake, R.J. Krishnaswamy, K. Kearney, K. Muthiah, P. Jain, A. Adji, C.S. Hayward Tags: (434) Source Type: research
A Prospective Randomized Trial Comparing Stroke Volume Measurements by Esophageal Doppler and Pulse-Contour Analysis During a Fluid Resuscitation Protocol in Brain-Dead Organ Donors
Maximizing stroke volume (SV) is the optimal method of fluid resuscitation. Both the esophageal doppler (EDM) and pulse contour analysis (PCA) are validated methods of measuring SV in critical patients, but neither have not been well-studied in the brain-dead (BD) donor. We have previously published our fluid resuscitation protocol in BD donors demonstrating a significant reduction in time on vasopressors from 16 hours in the control group to 2.9 hours in the protocol group. We performed a prospective randomized trial comparing the effectiveness of the EDM and PCA in this fluid resuscitation protocol in BD donors.
Source: The Journal of Heart and Lung Transplantation - April 1, 2022 Category: Transplant Surgery Authors: G.F. Marklin, W.D. Klinkenberg, B.S. Helmers, T. Ahrens Tags: (1061) Source Type: research
Who is at Risk for Seizures After Heart Transplantation?
Seizures may occur following heart transplantation (HTx), especially since tacrolimus can lower a seizure threshold. HTx recipients are also at high stroke risk given many patients have existing cerebrovascular disease. The purpose of the study was to assess the prevalence and risk factors for seizures in HTx recipients at our center.
Source: The Journal of Heart and Lung Transplantation - April 1, 2022 Category: Transplant Surgery Authors: M. Kittleson, J. Patel, D. Chang, T. Singer-Englar, N. Patel, L. Mishalani, S. Kim, D. Ramzy, L. Czer, J.A. Kobashigawa Tags: (776) Source Type: research
Central VA-ECMO Support without Full Anticoagulation is Feasible During Lung Transplant
In this study, we analyzed the feasibility of central VA-ECMO without full anticoagulation during lung transplantation. We also analyzed the incidence of morbidity including ischemic and thrombotic complications, stroke, and postoperative outcomes.
Source: The Journal of Heart and Lung Transplantation - April 1, 2022 Category: Transplant Surgery Authors: Y. Yagi, A. Manerikar, A. Bharat, C. Kurihara Tags: (911) Source Type: research
Carotid Endarterectomy Prior to Ventricular Assist Device Placement in a Patient with Cardiogenic Shock
Atherosclerotic disease in the cervical vessels may be a contraindication for implantation of left ventricular assist devices (LVADs). The occurrence of ischemic stroke represents an obstacle to rehabilitation, and its incidence seems to be higher in this population. Carotid endarterectomy (CEA) is a preferable surgical treatment in patients with high bleeding risk. This case report suggests that CEA followed by implantation of LVADs can be feasible.
Source: The Journal of Heart and Lung Transplantation - April 1, 2022 Category: Transplant Surgery Authors: M.S. Lira, R.C. Dantas, D.d. Belfort, S.R. Furquim, C.A. Arag ão, B.R. Gomes, B.S. Biselli, S.M. Ferreira, E.A. Bocchi Tags: (558) Source Type: research
Assessing Cardiac Recovery for Decommissioning of LVAD Support: Structure versus Function
Recovery of left ventricular (LV) function during LVAD support occurs in only 1-3% of patients. Assessment for recovery and LVAD removal is desirable given the risks of infection, stroke, and device malfunction. This case of a patient with an LVAD, with recovered LV systolic function but abnormal exercise hemodynamics, illustrates the potential utility of right heart catheterization studies for clinical decisions.
Source: The Journal of Heart and Lung Transplantation - April 1, 2022 Category: Transplant Surgery Authors: R.S. Gabarin, V. Gurtu, D.H. Brahmbhatt, F. Billia, S. Mak Tags: (550) Source Type: research
