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Total 249 results found since Jan 2013.

The Effect of Race on Stroke Incidence and Post-Stroke Mortality - The Stroke Paradox in LVAD Patients
Stroke is considered one of the major hurdles in applying Left Ventricular Assist Device (LVAD) technology to a broader population, and remains a leading cause of mortality and morbidity despite advances in both technology and management. In the general population, incidence of stroke in African Americans (AA) has been reported to be twice that of their Caucasian counterparts, and the mortality following stroke higher in AA. We sought to assess the effect of race on both rate of stroke, as well as post stroke survival in the LVAD population.
Source: The Journal of Heart and Lung Transplantation - March 31, 2020 Category: Transplant Surgery Authors: S.D. Rao, V. Troung, E. Chung, W.S. Mazur, D. Goldstien, U.P. Jorde, J. Teuteberg, S.R. Messe, C.S. Hayward, G.F. Egnaczyk, M.A. Acker, S.S. Sreenivas, J.E. Rame Tags: (212) Source Type: research

Stroke on Mechanical Support: Similar Survival but Higher Risk of Stroke Post-Transplant
Ventricular assist devices (VADs) increase waitlist survival, yet the risk of stroke is not trivial. There is a knowledge gap regarding the impact of these strokes on heart transplant outcomes. We sought to analyze how strokes during VAD support impact post-transplant (post-Tx) outcomes in children.
Source: The Journal of Heart and Lung Transplantation - March 31, 2020 Category: Transplant Surgery Authors: F. Zafar, L. Haney, K. Riggs, K. Thangappan, S. Chen, M. Mehegan, C. VanderPluym, D. Peng, A. Lorts, D.L. Morales Tags: (1188) Source Type: research

Elevated Outpatient C-Reactive Protein Independently Predicts Stroke and Gastrointestinal Bleeding in LVAD Patients
Inflammation and congestion may contribute to stroke and gastrointestinal bleeding (GIB) in LVAD pts. C-Reactive Protein (CRP), erythrocyte sedimentation rate (ESR), and N-terminal-pro B-type natriuretic peptide (NT-proBNP) are established biomarkers of inflammation and congestion. We aimed to investigate the association of these biomarkers with stroke and GIB in LVAD pts who survived to their first outpt visit.
Source: The Journal of Heart and Lung Transplantation - March 31, 2020 Category: Transplant Surgery Authors: Y. Brailovsky, A. Javaid, G.M. Mondellini, L. Braghieri, M. Tiburcio, N. Uriel, G.T. Sayer, V.K. Topkara, K. Takeda, Y. Naka, R.T. Demmer, M. Yuzefpolskaya, P.C. Colombo Tags: (996) Source Type: research

Acute Anticoagulation after Ischemic Stroke in Patients with Left Ventricular Assist Devices
Despite reductions in major adverse events with the latest generation of left ventricular assist devices (LVADs), the incidence of stroke remains high. The timing of anticoagulation resumption is controversial. We aim to explore practices of anticoagulation management following ischemic stroke in LVAD patients and identify optimal strategies.
Source: The Journal of Heart and Lung Transplantation - March 31, 2020 Category: Transplant Surgery Authors: C. Ibeh, D.L. Tirschwell, C. Mahr, C.J. Creutzfeldt Tags: (995) Source Type: research

Lack of Nocturnal Blood Pressure Reduction Increases the Risk of Stroke in Patients on Left Ventricular Assist Device Support
Lack of nocturnal blood pressure (BP) reduction (BP dipping) has been associated with cerebrovascular and cardiovascular events in the general population. However, the effect of a deranged circadian BP variability between day and night has never been studied in patients on left ventricular assist device (LVAD) support, where stroke still represents a major complication.We hypothesized that decreased BP dipping significantly increases the risk of stroke in patients on LVAD support.
Source: The Journal of Heart and Lung Transplantation - March 31, 2020 Category: Transplant Surgery Authors: F. Castagna, G.M. Mondellini, A. Pinsino, B.J. McDonnell, E.J. St öhr, A. Gaudig, A. Amlani, J. Nwokocha, R. Te-Frey, K. Takeda, H. Takayama, Y. Naka, J.Z. Willey, M. Yuzefpolskaya, G. Parati, J. Cockcroft, P.C. Colombo Tags: (993) Source Type: research

Stroke in Pediatric Ventricular Assist Device Patients-A PediMACS Registry Analysis
To characterize the occurrence of stroke in pediatric patients supported with ventricular assist devices.
Source: The Journal of Heart and Lung Transplantation - March 31, 2020 Category: Transplant Surgery Authors: R.A. Niebler, S.M. Amdani, B. Blume, R.S. Cantor, L. Deng, J.K. Kirklin, A. Lorts, D. Morales, D.N. Rosenthal, N.S. Ghanayem Tags: (297) Source Type: research

Association of LVAD Cannula Position with Stroke Risk
Stroke remains a major cause of morbidity and mortality in LVAD patients, with incidence upto to 22%. We hypothesized that certain LVAD cannula positions are associated with unfavourable flow patterns resulting in altered thrombogenicity, and therefore higher stroke risk.
Source: The Journal of Heart and Lung Transplantation - March 31, 2020 Category: Transplant Surgery Authors: T. Agrawal, H. Abdala, R.A. Gutierrez, R. Thaker, S. Xu, N. Fida, J. Kim, I. Hussain, B. Trachtenberg, A. Guha, A. Bhimaraj, M. Kassi Tags: (1045) Source Type: research

Understanding Risk Factors and Predictors for Stroke Subtypes in the ENDURANCE Trials
We report a comprehensive analysis of stroke subtypes in the ENDURANCE (DT) and ENDURANCE Supplemental (DT2) trials.
Source: The Journal of Heart and Lung Transplantation - January 27, 2020 Category: Transplant Surgery Authors: Sung-Min Cho, Randall C. Starling, Jeffrey Teuteberg, Joseph Rogers, Francis Pagani, Palak Shah, Ken Uchino, Nicholas Hiivala Tags: Original Clinical Science Source Type: research

Stroke Dysbiosis Index (SDI) in Gut Microbiome Are Associated With Brain Injury and Prognosis of Stroke
Conclusions: We developed an index to measure gut microbiota dysbiosis in stroke patients; this index was significantly correlated with patients' outcome and was causally related to outcome in a mouse model of stroke. Our model facilitates the potential clinical application of gut microbiota data in stroke and adds quantitative evidence linking the gut microbiota to stroke. Introduction Ischemic stroke imposes a heavy burden on society, with 24.9 million cases worldwide (1). Although intravenous thrombolysis and endovascular treatment greatly improve some patients' prognosis, the prognosis for most pa...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

World-Wide Efficacy of Bone Marrow Derived Mesenchymal Stromal Cells in Preclinical Ischemic Stroke Models: Systematic Review and Meta-Analysis
Conclusions: Our results show worldwide efficacy of BM-MSCs in improving functional outcomes in pre-clinical animal models of stroke and support testing these cells in clinical trials in various ranges of time windows using different delivery routes. The continued growing number of publications showing functional benefit of BM-MSCs are now adding limited value to an oversaturated literature spanning 18 years. Researchers should focus on identifying definitive mechanisms on how BM-MSCs lead to benefit in stroke models. Introduction Ischemic stroke is the 5th leading cause of death and the leading cause of long term di...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Medtronic touts stroke data for HeartWare LVAD
A retrospective analysis of two studies involved the HeartWare left-ventricular assist device Medtronic (NYSE:MDT) acquired in 2016 showed that managing blood pressure reduced the severity of strokes in patients implanted with the HVAD pump. The analysis, of “destination therapy” patients who are not candidates for a heart transplant, took data from the Endurance and Endurance Supplemental studies. Results were presented this week at the annual meeting of the International Society for Heart & Lung Transplantation in London, Medtronic said. The 465-patient Endurance Supplemental study compared 308 patients i...
Source: Mass Device - April 5, 2019 Category: Medical Devices Authors: Brad Perriello Tags: Cardiac Assist Devices Clinical Trials Featured Abbott HeartWare International Inc. Medtronic stjudemedical Thoratec Corp. Source Type: news

Stroke and death risk in ventricular assist device patients varies by ISHLT infection category: An INTERMACS analysis
Ventricular assist device (VAD) patients often experience infections, which increase the risk of stroke and mortality. Using the definitions of the International Society for Heart and Lung Transplantation (ISHLT), we have characterized differences in clinical outcomes for categories of infection: VAD-specific (e.g., pump component related); VAD-related (e.g., bloodstream infection, BSI); and non-VAD infections (e.g., pneumonia).
Source: The Journal of Heart and Lung Transplantation - April 2, 2019 Category: Transplant Surgery Authors: Palak Shah, Sarah E. Birk, Lauren B. Cooper, Mitchell A. Psotka, James K. Kirklin, Scott D. Barnett, Shalika B. Katugaha, Sheila Phillips, Mary M. Looby, Francis D. Pagani, Jennifer A. Cowger Tags: ORIGINAL CLINICAL SCIENCE Source Type: research

Increased Risk of Stroke and Death in Ventricular Assist Device Patients Varies by ISHLT Infection Category: An INTERMACS Analysis
Ventricular assist device (VAD) patients experience infections, which increase the risk of stroke and mortality. We aimed to characterize key differences in clinical outcomes for VAD patients based on the ISHLT categorization of infections: VAD-specific (e.g. pump component related), VAD-related (e.g. bloodstream infection, BSI) and non-VAD infections (e.g. pneumonia).
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: P. Shah, S.E. Birk, L.B. Cooper, M.A. Psotka, J.K. Kirklin, S.D. Barnett, S.B. Katugaha, S. Phillips, M.M. Looby, F.D. Pagani, J.A. Cowger Tags: 224 Source Type: research

Occurrence and Clinical Patterns of Stroke Based on Arterial Cannulation Strategy during Veno-Arterial Extracorporeal Membrane Oxygenation Support
Stroke is a major complication with potentially devastating consequences for patients receiving veno-arterial extracorporeal membrane oxygenation (VA-ECMO). Arterial cannulation sites for VA-ECMO include ascending aorta, axillary artery, and femoral artery. However, rates of stroke according to cannulation site are currently unknown. The purpose of this study was to investigate the association between occurrence and patterns of stroke with ECMO arterial cannulation sites.
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: M. Nishikawa, J. Willey, A.R. Garan, M. Cevasco, L. Witer, J. Sanchez, P. Kurlansky, A. Kirtane, D. Brodie, M. Yuzefpolskaya, P. Colombo, H. Takayama, Y. Naka, K. Takeda Tags: 148 Source Type: research

Impact of Stroke Onset Severity on 2-Year Survival in Destination Therapy Patients Supported by Centrifugal Flow versus Axial Flow Ventricular Assist Devices
The ENDURANCE Supplemental Trial (DT2) was designed to prospectively study whether improved blood pressure management would reduce the incidence of strokes in destination therapy patients receiving an HVAD. The trial not only demonstrated a significant reduction in hemorrhagic strokes, but also some reductions in stroke-related severity. This analysis seeks to study further the impact of stroke severity on 2-year survival in both the HVAD and control cohorts of DT2.
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: P. Shah, C. Mahr, J. Rogers, M. Kiernan, S. Boyce, N.A. Mokadam, F. Pagani, T. Vassiliades, J. Teuteberg Tags: 145 Source Type: research

Understanding Risk Factors for Stroke Subtypes in the ENDURANCE Trials
Stroke is one of the most devastating morbidities associated with left ventricular assist device (LVAD) support. Improved blood pressure management in LVAD patients has been shown to significantly reduce strokes, in particular hemorrhagic strokes. However, little is known regarding clinical risk factors for stroke subtypes.
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: S. Cho, R. Starling, J. Teuteberg, J. Rogers, F. Pagani, P. Shah, K. Uchino, T. Vassiliades Tags: 142 Source Type: research

Different Risk Factors for Ischemic and Hemorrhagic Stroke on Continuous Flow Left Ventricular Assist Device Support
Patients with end-stage heart failure on left ventricular assist devices are predisposed to stroke. Preoperative factors associated with increased stroke risk are poorly understood.
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: H.K. Lamba, M. Kim, L. Hart, B. Chou, C. Rao, S. Chatterjee, S. Sattee, F. Cheema, A. Civitello, R. Delgado, A. Nair, A. Shafii, G. Loor, T. Rosengart, O. Frazier, J. Morgan Tags: 402 Source Type: research

Carotid Artery Blood Flow and Its Association with Stroke during Left Ventricular Assist Device Support
Left ventricular assist device (LVAD) surgery is a life-prolonging therapy for advanced heart failure (HF). Despite many improvements over the years, LVADs continue to be associated with a high incidence of stroke and other vascular complications such as gastrointestinal bleeding (GIB). At present, the pathogenesis of these complications during LVAD support remains unclear. Abnormal structure and hemodynamics in large arteries are a potential contributor. We hypothesized that structural abnormalities and flow alterations will be significantly associated with stroke and a composite outcome of stroke, GIB, and death in HF pa...
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: M.E. Kiyatkin, A.M. Zuver, A. Gaudig, M. Tiburcio, B.J. McDonnell, M. Yuzefpolskaya, P.C. Colombo, E.J. St öhr, J.Z. Willey Tags: 401 Source Type: research

Current Smoking and Increased Risk of Stroke in Patients with Left Ventricular Assist Device
The purpose of this study was to analyze the impact of smoking status at the time of left ventricular assist device (LVAD) implantation on clinical outcomes including all-cause mortality, readmission and stroke.
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: S. Sherazi, I. Goldenberg, S. McNitt, V. Kutyifa, I. Gosev, K. Wood, L. Chen, S. Polonsky, H. Vidula, J. Alexis Tags: 400 Source Type: research

Influence of Device Type on Stroke Risk in Women Undergoing LVAD Implantation
Stroke risk after left ventricular assist device (LVAD) implantation seems to be increased in women. The role of device type has not previously been investigated. We hypothesized that stroke risk in female patients was influenced by LVAD device type.
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: R.J. Vela, J. Pruszynski, A. Amin, M. Drazner, L.C. Huffman, M. Peltz Tags: 398 Source Type: research

The Implication of HeartWare HVAD Inflow Cannula Angle on Stroke and Thrombus Rate
Stroke and ventricular assist device (VAD) pump thrombus are serious complications that have previously been thought to be related to surgical placement - namely VAD inflow cannula angle. Our aim with this study was to better elucidate the impact of post-operative HeartWare HVAD (left VAD) cannula inflow angle on stroke and thrombus rate within a single centre in Sydney, Australia.
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: S. Emmanuel, D. Aktuerk, A. Chowdhury, C. Hurwitz, L. Beiglari, P. Jansz, C. Hayward Tags: 1080 Source Type: research

Stroke After LVAD: Does Age Matter? A Sex-based Analysis
The risk of stroke in women with left ventricular assist devices (LVADs) appears to be higher than men. Some authors suggested that variances in hormonal influences occurring with age might contribute to the increased thrombotic profile potentially acquired by some women.
Source: The Journal of Heart and Lung Transplantation - March 31, 2018 Category: Transplant Surgery Authors: V. Blumer, G.A. Hernandez, M. Ortiz, V. Mehta, S. Chaparro Source Type: research

Increased Aortic Stiffness is Associated with Higher Rates of Stroke, GI-bleeding and Pump Thrombosis in Continuous-Flow Left Ventricular Assist Device Patients
In the general population, increased aortic stiffness (kAo) is associated with risk of cardiovascular events. Continuous-flow left ventricular assist device (CF-LVAD) pts have been reported to have increased kAo. The association between kAo and common adverse events (AEs), including stroke, gastrointestinal bleed (GIB) and pump thrombosis (PT) are unknown in CF-LVAD pts.
Source: The Journal of Heart and Lung Transplantation - March 31, 2018 Category: Transplant Surgery Authors: H. Rosenblum, A. Pinsino, R.T. Demmer, P.C. Colombo, M. Yuzefpolskaya, A.R. Garan, V.K. Topkara, A. Gaudig, M.T. Pineda, Y. Naka, H. Takayama, K. Takeda, F. Castagna, J.Z. Willey, B.J. McDonnell, J.R. Cockcroft, E.J. St öhr Source Type: research

Predictive Value of Mean Arterial Pressure Versus Systolic Blood Pressure and Visit-To-Visit Blood Pressure Variability for Stroke and Pump Thrombosis in HeartMate II Patients
Elevated blood pressure (BP) in pts on left ventricular assist device (LVAD) support is a risk factor for adverse events (AEs) such as stroke and pump thrombosis (PT). Current guidelines recommend a mean arterial pressure (MAP) ≤ 80mmHg. Above-median systolic BP (SBP) at discharge after HeartMate II (HMII) implant has been associated with an increased risk of stroke. We sought to 1) compare the predictive value of outpt MAP and SBP on AEs, 2) examine the association of visit-to-visit variability (VVV) of BP with AEs in H MII pts.
Source: The Journal of Heart and Lung Transplantation - March 31, 2018 Category: Transplant Surgery Authors: A. Pinsino, F. Castagna, J.Z. Willey, A.M. Zuver, M.A. Flannery, B. Cagliostro, J.R. Cockroft, A.R. Garan, V.K. Topkara, H. Takayama, K. Takeda, Y. Naka, R.T. Demmer, P.C. Colombo, M. Yuzefpolskaya Source Type: research

Risk Predictors for Ischemic Stroke in CF-LVAD Patients by Pump Flow Type
Risk of stroke continues to be a major adverse event post-LVAD implantation, limiting wider application and utility of the device. Even with aggressive blood pressure control, patients with LVADs are at higher risk of stroke due to combination of pump-dependent factors including loss of natural pulsatility, anticoagulation, and thrombosis risk from blood-pump interaction. We used a Bayesian Network machine-learning approach to derive comparative risk factors for ischemic stroke in patients with axial versus centrifugal flow pumps at 3 months post LVAD implant.
Source: The Journal of Heart and Lung Transplantation - March 31, 2018 Category: Transplant Surgery Authors: M. Kanwar, L. Lohmueller, R. Kormos, S. Bailey, C. Mcilvennan, S. Murali, J. Antaki Source Type: research

Blood Pressure Control as a Risk Factor for Stroke in LVAD Patients- Single Center Experience
The ENDURANCE trial suggested an increased stroke (CVA) risk in Heartware HVAD compared to Heartmate 2 (HM2); a risk that could be mitigated with improved blood pressure control as demonstrated in the ENDURANCE 2 supplemental study. We hypothesized that better blood pressure control reduced the stroke risk in all LVAD supported patients.
Source: The Journal of Heart and Lung Transplantation - March 31, 2018 Category: Transplant Surgery Authors: N.S. Clarke, R. Vela, J. Pruszynski, M. Drazner, L.C. Huffman, M. Peltz Source Type: research

Early Elevated Plasma Free Hemoglobin Predicts Occurrence of Thromboembolic Stroke during Venoarterial Extracorporeal Membrane Oxygenation Support
Hemolysis creates a prothrombotic state by platelet activation; however, its impact on thromboembolic (TE) stroke during venoarterial extracorporeal membrane oxygenation (VA ECMO) support is unknown.
Source: The Journal of Heart and Lung Transplantation - March 31, 2018 Category: Transplant Surgery Authors: O. Saeed, W. Jackobleff, T. Chinnadurai, S. Forest, S. Rangasamy, S. Madan, M. Aljoudi, Y. Xia, S.R. Patel, S. Vukelic, D.B. Sims, J. Shin, H.H. Billett, D.J. Goldstein, U.P. Jorde Source Type: research

Clinical Profile of Patients with Late Stroke after Left Ventricular Assist Device Implantation
Despite advances in left ventricular assist device (LVAD) therapy, stroke remains a relatively frequent complication and is associated with significant morbidity and mortality. In the early postoperative period, stroke may be related to patient demographics, operative factors and comorbid conditions. Less is known about strokes that occur greater than six months after LVAD implantation. The aim of this study was to describe the clinical profile of patients with late strokes.
Source: The Journal of Heart and Lung Transplantation - March 31, 2018 Category: Transplant Surgery Authors: J. Nnanabu, D. Rodgers, N. Sarswat, J. Raikhelkar, G. Kim, S. Kalantari, T. Ota, T. Song, C. Juricek, V. Jeevanandam, G. Sayer, N. Uriel Source Type: research

Increased Pump Speed is Associated with Reduced Rates of Stroke on HeartMate II LVAD Support
Higher pump speeds have recently been associated with reduced rates of pump thrombosis in the HeartMate II LVAD population. Whether pump speed is associated with stroke has not been well established. In this analysis we use a single center cohort to determine the association with discharge speed and all-cause stroke.
Source: The Journal of Heart and Lung Transplantation - March 31, 2018 Category: Transplant Surgery Authors: J.N. Schultz, R. Cogswell, M. Prtizker, E. Missov, K. Liao, J. Misialek, R. John Source Type: research

Stroke Volume Response to Exercise is Dependent on Disease Severity in Pulmonary Arterial Hypertension
This study aimed to describe changes in stroke volume (SV) during exercise in patients with pulmonary arterial hypertension (PAH) to allow for exercise-based risk stratification.
Source: The Journal of Heart and Lung Transplantation - March 31, 2018 Category: Transplant Surgery Authors: C. G öransson, N. Vejlstrup, J. Carlsen Source Type: research

Laterality of Cerebral Artery Hemodynamics in Continuous-Flow LVAD Patients: A Pilot Study in Relation to Stroke
A predominance of ischemic stroke in the right hemisphere among patients with continuous-flow left ventricular assist device (LVAD) support has been noted. The reasons for this clinical presentation are unknown, though others have hypothesized greater blood flow to the right common carotid artery. Since arterial pulsatility and blood velocity (as a surrogate for flow) have been associated with cerebrovascular complications, we hypothesized that significant differences in the pulsatility and/or Vmax of the left and right middle cerebral artery may be present in LVAD patients.
Source: The Journal of Heart and Lung Transplantation - March 31, 2018 Category: Transplant Surgery Authors: E.J. St öhr, A. Gaudig, A. Pinsino, F. Castagna, P.C. Colombo, M. Yuzefspolskaya, A.R. Garan, V.K. Topkara, H. Takayama, K. Takeda, Y. Naka, J.R. Cockroft, B.J. McDonnell, J.Z. Willey Source Type: research

Stroke Patterns and Implications for Ventricular Functional Remodeling in Left Ventricular Assist Systems
Ischemic stroke-related complications (particularly in the right hemisphere) are frequently encountered with Left Ventricular Assist Systems (LVAS). The neuro-cardiac axis may influence ventricular remodeling. However it remains unknown if stroke patterns are related to ventricular remodeling after facilitated hemodynamic support with LVAS. We hypothesized that strokes occurring in the right hemisphere, within the insula region, may enhance left ventricular remodeling through unopposed activation of the left insular region.
Source: The Journal of Heart and Lung Transplantation - March 31, 2018 Category: Transplant Surgery Authors: D.F. Snipelisky, P. Ivak, G. Stewart, M. Givertz, M. Pfeffer, J. Groarke, S. Singh, I. Netuka, M. Mehra Source Type: research

Early stroke post –heart transplant is associated with decreased survival in children
In this study we aimed to characterize early MNEs (stroke, isolated seizures not from stroke and posterior reversible leukoencephalopathy [PRES] within 1 year after primary pediatric HTx) and evaluate their impact on 1-year post-HTx survival. We hypothesized that early an MNE after HTx is associated with decreased 1-year patient survival.
Source: The Journal of Heart and Lung Transplantation - January 8, 2018 Category: Transplant Surgery Authors: Cheryl Cammock, Swati Choudhry, Chesney M. Castleberry, Noor Al-Hammadi, Pirooz Eghtesady, Charles E. Canter, Kathleen E. Simpson Tags: Original Clinical Science Source Type: research

Impact of a Modified Anti-Thrombotic Guideline On Stroke In Children Supported with A Pediatric Ventricular Assist Device
Stroke is the most feared complication associated with the Berlin Heart EXCOR ® Pediatric ventricular assist device (VAD), the most commonly used VAD in children, and affects one in three children. We sought to determine whether a modified anti-thrombotic guideline, involving more intense platelet inhibition and less reliance on platelet function testing, is associated with a lower incidence of stroke.
Source: The Journal of Heart and Lung Transplantation - May 20, 2017 Category: Transplant Surgery Authors: David N. Rosenthal, Chacy A. Lancaster, Doff B. McElhinney, Sharon Chen, MaryLyn Stein, Aileen Lin, Lan Doan, Jenna M. Murray, Mary Alice Gowan, Katsuhide Maeda, Olaf Reinhartz, Christopher S. Almond Source Type: research

Five-Year Follow-Up on Transplanted Organs From Donors After Brain Death After Acute Stroke.
CONCLUSIONS: The 5-year follow-up showed that organs from 14 brain-dead donors improved and saved 19 lives, with 17 patients receiving kidney transplants and 2 patients receiving liver transplants. Another 7 patients had only partially improved quality of life. PMID: 28447929 [PubMed - as supplied by publisher]
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - April 27, 2017 Category: Transplant Surgery Authors: Spatenkova V, Pokorna E, Suchomel P Tags: Exp Clin Transplant Source Type: research

Reported link between diet drinks and dementia and stroke is weak
Conclusion The researchers used data from a large ongoing cohort study to look for links between consumption of sugary and artificially sweetened drinks and risk of stroke or dementia. This cohort study benefits from the large overall sample size, long period of data collection, careful and valid diagnostic assessments, and adjustments for a number of confounders. However, care must be taken when interpreting these results – particularly if latching on to the maximal tripled risk figures reported in the media. There are several points to consider: Small numbers The new number of strokes and dementia in this study was sma...
Source: NHS News Feed - April 21, 2017 Category: Consumer Health News Tags: Food/diet Heart/lungs Neurology Source Type: news

ISHLT 2017: Medtronic HVAD trial misses primary endpoint, reports lowered stroke rates
Medtronic (NYSE:MDT) said today that results from the Endurance supplemental trial of its HVAD heart pump system did not meet its primary endpoint, but did report  lowered stroke rates compared to standard treatment. The trial aimed to evaluate the use of the HVAD system, which it picked up along with HeartWare last year, as a destination therapy for patients who require a left ventricular assist device and received improved blood pressure management, the Fridley, Minn.-based company said. Data from the study was presented at the 2017 International Society for Heart and Lung Transplantation Scientific Meeting in San Dieg...
Source: Mass Device - April 5, 2017 Category: Medical Equipment Authors: Fink Densford Tags: Cardiac Assist Devices Cardiovascular Clinical Trials HeartWare International Inc. Medtronic Source Type: news

GIMVECH: A Novel Risk Score for Stroke in the Perioperative Post Transplant Period
This study was undertaken to identify risk factors in this population during the perioperative post transplant period.
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: N. Nair, S. Yang, E. Gongora Source Type: research

Effect of a Multifaceted Team Management Approach on Survival and Stroke Rates in Heartmate 2 Recipients
We report the effect of a comprehensive HM II management strategy on survival and stroke rates.
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: U. Jorde, N. Siddiqi, A. Luke, D.B. Sims, O. Saeed, S.R. Patel, S. Murthy, J. Shin, S. Watts, E. Borukhov, S. Madan, S. Thompson, R. Bello, S. Forest, S. Vukelic, C. Nucci, S. Rangasamy, D. Goldstein Source Type: research

Characteristics and Outcome of Patients with Stroke After Lung Transplant Surgery in the Lung Allocation Score Era
With introduction of lung allocation (LAS) in 2005, increasingly sicker patients are being transplanted every year. The current study was conducted to determine the incidence of stroke early after lung transplantation (LT), describe the recipient characteristics that are independently associated with it and evaluate its impact on 1 year survival.
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: A. Banga, M. Mohanka, S. Bollineni, J. Mullins, V. Kaza, F. Torres Source Type: research

Does Type of Mechanical Circulatory Support Influence Stroke Risk in the Perioperative Post Transplant Period?
This study was undertaken to assess if the type of circulatory support device used has an impact on stroke risk in this population.
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: N. Nair, S. Yang, E. Gongora Source Type: research

(1205) Does Stroke in the Perioperative Post Cardiac Transplant Period Impact Survival?
This study addresses the effect of stroke on overall survival in this population.
Source: The Journal of Heart and Lung Transplantation - March 25, 2017 Category: Transplant Surgery Authors: N. Nair, S. Yang, E. Gongora Source Type: research

Risk Factors, Mortality and Timing of Ischemic and Hemorrhagic Stroke with Left Ventricular Assist Devices
Stroke is a major cause of mortality following left ventricular assist device (LVAD) placement.
Source: The Journal of Heart and Lung Transplantation - December 22, 2016 Category: Transplant Surgery Authors: Jennifer A. Frontera, Randall Starling, Sung-Min Cho, Amy S. Nowacki, Ken Uchino, M. Shazam Hussain, Maria Mountis, Nader Moazami Tags: Original Clinical Science Source Type: research

Risk factors, mortality, and timing of ischemic and hemorrhagic stroke with left ventricular assist devices
Stroke is a major cause of mortality after left ventricular assist device (LVAD) placement.
Source: The Journal of Heart and Lung Transplantation - December 22, 2016 Category: Transplant Surgery Authors: Jennifer A. Frontera, Randall Starling, Sung-Min Cho, Amy S. Nowacki, Ken Uchino, M. Shazam Hussain, Maria Mountis, Nader Moazami Tags: Original Clinical Science Source Type: research

Outcomes after stroke complicating left ventricular assist device
We present a large single-center experience on stroke outcome and transplant eligibility by stroke sub-type and severity in CF-LVAD patients.
Source: The Journal of Heart and Lung Transplantation - March 29, 2016 Category: Transplant Surgery Authors: Joshua Z. Willey, Michael V. Gavalas, Pauline N. Trinh, Melana Yuzefpolskaya, A. Reshad Garan, Allison P. Levin, Koji Takeda, Hiroo Takayama, Justin Fried, Yoshifumi Naka, Veli K. Topkara, Paolo C. Colombo Tags: Original Clinical Science Source Type: research

Outcomes After Stroke Complicating Left Ventricular Assist Device
We present a large single center experience on stroke outcome and transplant eligibility by stroke subtype and severity in CF-LVAD patients.
Source: The Journal of Heart and Lung Transplantation - March 29, 2016 Category: Transplant Surgery Authors: Joshua Z. Willey, Michael V. Gavalas, Pauline N. Trinh, Melana Yuzefpolskaya, A. Reshad Garan, Allison P. Levin, Koji Takeda, Hiroo Takayama, Justin Fried, Yoshifumi Naka, Veli K. Topkara, Paolo C. Colombo Source Type: research

Outcome, incidence and risk factors for stroke after pediatric heart transplantation: An analysis of the International Society for Heart and Lung Transplantation registry
In the registry of the International Society for Heart and Lung Transplantation (ISHLT), cerebrovascular accidents are the fifth most common cause for mortality after pediatric heart transplantation (PHTx), but details are lacking in the literature. The purpose of this analysis of the ISHLT registry was to determine the prevalence, risk factors and outcomes of stroke after PHTx.
Source: The Journal of Heart and Lung Transplantation - March 17, 2016 Category: Transplant Surgery Authors: Conall Thomas Morgan, Cedric Manlhiot, Brian W. McCrindle, Anne I. Dipchand Tags: Original Clinical Science Source Type: research

Stroke Volume Variation for the Evaluation of Circulating Blood Volume after Living Donor Liver Transplantation.
CONCLUSION: Postoperative fluid management using SVV may be especially useful after LDLT. Monitoring the circulating blood volume using a 10% SVV index is useful for avoiding lung edema after LT. PMID: 26897956 [PubMed - in process]
Source: Hepato-Gastroenterology - February 24, 2016 Category: Gastroenterology Tags: Hepatogastroenterology Source Type: research

Gender differences in the risk of stroke during support with continuous flow left ventricular assist device
There is increasing recognition that the risk of stroke after left ventricular assist device (LVAD) varies based on gender, with a higher risk in female patients. We reviewed our own data to determine gender differences in the risk of stroke.
Source: The Journal of Heart and Lung Transplantation - September 3, 2015 Category: Transplant Surgery Authors: Alanna A. Morris, Ann Pekarek, Kris Wittersheim, Robert T. Cole, Divya Gupta, Duc Nguyen, S. Raja Laskar, Javed Butler, Andrew Smith, J. David Vega Source Type: research